Project description
A novel B-cell immunotherapy
B lymphocytes exhibit diverse immunological functions, including antibody production and antigen presentation. Emerging evidence indicates that these cells also create niches known as B cell-associated tertiary lymphoid structures (TLS) that sustain an immune response. The role of TLS in cancer is only beginning to emerge, and understanding it requires further insight into cellular and spatial composition. Funded by the European Research Council, the BeaT-IT project aims to determine the factors that stimulate B cells and induce TLS. Researchers will employ novel polymeric biomaterials and test different agents and cells for their capacity to stimulate TLS formation. The materials can be further combined with immunotherapy or chemotherapy as a synergistic anticancer strategy.
Fields of science
- engineering and technologymaterials engineeringfibers
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicineimmunologyimmunotherapy
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- engineering and technologyindustrial biotechnologybiomaterials
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-AG - HORIZON Action Grant Budget-Based
Coordinator
52074 Aachen
Germany
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