Introducing deuterium for next generation chemical biology probes and direct imaging

Información del proyecto

deuterON

Identificador del acuerdo de subvención: 101042046

DOI

10.3030/101042046

Fecha de la firma de la CE 17 Mayo 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 499 469,00

Aportación de la UE

€ 1 499 469,00

Coordinado por

FORSCHUNGSVERBUND BERLIN EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (12)

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Autores: Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann
Publicado en: JCI Insight , 8 (10) , Article e164921. (2023), 2023, ISSN 2379-3708
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164921

Direct optical measurement of intramolecular distances with angstrom precision

Autores: Steffen J. Sahl, Jessica Matthias, Kaushik Inamdar, Michael Weber, Taukeer A. Khan, Christian Brüser, Stefan Jakobs, Stefan Becker, Christian Griesinger, Johannes Broichhagen, Stefan W. Hell
Publicado en: Science, Edición 386, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/science.adj7368

Fine-tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

Autores: Ann-Kathrin Rückert, Julia Ast, Annie Hasib, Daniela Nasteska, Katrina Viloria, Johannes Broichhagen, David J. Hodson
Publicado en: Diabetic Medicine, 2023, ISSN 1464-5491
Editor: Wiley
DOI: 10.1111/dme.15220

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Autores: Julia Ast; Daniela Nasteska; Nicholas H. F. Fine; Daniel J. Nieves; Zsombor Koszegi; Yann Lanoiselée; Federica Cuozzo; Katrina Viloria; Andrea Bacon; Nguyet T. Luu; Philip N. Newsome; Davide Calebiro; Dylan M. Owen; Johannes Broichhagen; David J. Hodson
Publicado en: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023), 2023, ISSN 2041-1723
Editor: NPG
DOI: 10.1038/s41467-022-35716-1

Deuteration as a general strategy to enhance azobenzene-based photopharmacology

Autores: Roßmann, K.; Gonzalez-Hernandez, A. J.; Bhujan, K.; Schattenberg, C.; Sun, H.; Börjesson, K.; Levitz, J.; Broichhagen, J.
Publicado en: Angewandte Chemie International Edition, 2024, ISSN 1521-3757
Editor: Wiley
DOI: 10.1002/anie.202408300

openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation

Autores: J. Lightley, S. Kumar, M. Q. Lim, E. Garcia, F. Görlitz, Y. Alexandrov, T. Parrado, C. Hollick, E. Steele, K. Roßmann, J. Graham, J. Broichhagen, I. A. McNeish, C. A. Roufosse, M. A. A. Neil, C. Dunsby, P. M. W. French
Publicado en: Journal of Microscopy, 2023, ISSN 1365-2818
Editor: Wiley
DOI: 10.1111/jmi.13219

Penta-ALFA-Tagged Substrates for Self-Labelling Tags Allow Signal Enhancement in Microscopy

Autores: Souvik Ghosh, Ramona Birke, Ashwin Karthick Natarajan, Johannes Broichhagen
Publicado en: Peptide Science, 2025, ISSN 2475-8817
Editor: Wiley
DOI: 10.1002/PSC.70015

Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

Autores: Florian Stockinger, Pascal Poc, Alexander Möhwald, Sandra Karch, Stephanie Häfner, Christian Alzheimer, Guillaume Sandoz, Tobias Huth, Johannes Broichhagen
Publicado en: Journal of Medicinal Chemistry, 2024, ISSN 1520-4804
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00339

Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

Autores: Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen
Publicado en: RSC Chemical Biology, 2025, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.1039/d4cb00209a

Deuterated oxazines are bright near-infrared fluorophores for mitochondrial imaging and single molecule spectroscopy

Autores: Blaise Gatin-Fraudet; Julius Seifert; Kris Sarach; Christina Holmboe Olesen; Ramona Birke; Sigrid Milles; Melissa Birol; Martin Lehmann; Johannes Broichhagen
Publicado en: Chemical Communications, 2025, ISSN 1364-548X
Editor: RSC
DOI: 10.1039/D4CC03807J

Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy

Autores: Trumpp, M; Oliveras, A; Gonschior, H; Ast, J; Hodson, DJ; Knaus, P; Lehmann, M; Birol, M; Broichhagen, J
Publicado en: Chemical Communications, 2022, ISSN 1364-548X
Editor: RSC
DOI: 10.17169/refubium-37374

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Autores: Shilleh, A. H.; Viloria, K.; Broichhagen, J.; Campbell, J. E.; Hodson, D. J.
Publicado en: Peptides, 2024, ISSN 1873-5169
Editor: Elsevier
DOI: 10.1016/j.peptides.2024.171179

Other (3)

Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

Autores: Maria Kowald, Sylvestre P. J. T. Bachollet, Fritz Benseler, Maria Steinecker, Sofia Kaushik, Tolga Soykan, Sun Siqi, Ramona Birke, Dragana Ilic, Nils Brose, Hanna Hrnberg, Martin Lehmann, Silvio O. Rizzoli, Johannes Broichhagen, Noa Lipstein
Publicado en: 2024, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.08.617143

Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses

Autores: Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
Publicado en: Neuron, 2024, ISSN 1097-4199
Editor: Cell Press
DOI: 10.1101/2024.01.15.575699

A one-step protocol to generate impermeable fluorescent HaloTag substrates for<i>in situ</i>live cell application and super-resolution imaging

Autores: Kilian Romann, Siqi Sun, Christina Holmboe Olesen, Maria Kowald, Eleni Tapp, Ulrich Pabst, Marie Bieck, Ramona Birke, Brenda C. Shields, PyeongHwa Jeong, Jiyong Hong, Michael R. Tadross, Joshua Levitz, Martin Lehmann, Noa Lipstein, Johannes Broichhagen
Publicado en: 2024, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.20.614087