Introducing deuterium for next generation chemical biology probes and direct imaging

Project Information

deuterON

Grant agreement ID: 101042046

DOI

10.3030/101042046

EC signature date 17 May 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 469,00

EU contribution

€ 1 499 469,00

Coordinated by

FORSCHUNGSVERBUND BERLIN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Author(s): Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann
Published in: JCI Insight , 8 (10) , Article e164921. (2023), 2023, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164921

Direct optical measurement of intramolecular distances with angstrom precision

Author(s): Steffen J. Sahl, Jessica Matthias, Kaushik Inamdar, Michael Weber, Taukeer A. Khan, Christian Brüser, Stefan Jakobs, Stefan Becker, Christian Griesinger, Johannes Broichhagen, Stefan W. Hell
Published in: Science, Issue 386, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/science.adj7368

Fine-tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

Author(s): Ann-Kathrin Rückert, Julia Ast, Annie Hasib, Daniela Nasteska, Katrina Viloria, Johannes Broichhagen, David J. Hodson
Published in: Diabetic Medicine, 2023, ISSN 1464-5491
Publisher: Wiley
DOI: 10.1111/dme.15220

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Author(s): Julia Ast; Daniela Nasteska; Nicholas H. F. Fine; Daniel J. Nieves; Zsombor Koszegi; Yann Lanoiselée; Federica Cuozzo; Katrina Viloria; Andrea Bacon; Nguyet T. Luu; Philip N. Newsome; Davide Calebiro; Dylan M. Owen; Johannes Broichhagen; David J. Hodson
Published in: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023), 2023, ISSN 2041-1723
Publisher: NPG
DOI: 10.1038/s41467-022-35716-1

Deuteration as a general strategy to enhance azobenzene-based photopharmacology

Author(s): Roßmann, K.; Gonzalez-Hernandez, A. J.; Bhujan, K.; Schattenberg, C.; Sun, H.; Börjesson, K.; Levitz, J.; Broichhagen, J.
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3757
Publisher: Wiley
DOI: 10.1002/anie.202408300

openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation

Author(s): J. Lightley, S. Kumar, M. Q. Lim, E. Garcia, F. Görlitz, Y. Alexandrov, T. Parrado, C. Hollick, E. Steele, K. Roßmann, J. Graham, J. Broichhagen, I. A. McNeish, C. A. Roufosse, M. A. A. Neil, C. Dunsby, P. M. W. French
Published in: Journal of Microscopy, 2023, ISSN 1365-2818
Publisher: Wiley
DOI: 10.1111/jmi.13219

Penta-ALFA-Tagged Substrates for Self-Labelling Tags Allow Signal Enhancement in Microscopy

Author(s): Souvik Ghosh, Ramona Birke, Ashwin Karthick Natarajan, Johannes Broichhagen
Published in: Peptide Science, 2025, ISSN 2475-8817
Publisher: Wiley
DOI: 10.1002/PSC.70015

Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

Author(s): Florian Stockinger, Pascal Poc, Alexander Möhwald, Sandra Karch, Stephanie Häfner, Christian Alzheimer, Guillaume Sandoz, Tobias Huth, Johannes Broichhagen
Published in: Journal of Medicinal Chemistry, 2024, ISSN 1520-4804
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00339

Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

Author(s): Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen
Published in: RSC Chemical Biology, 2025, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cb00209a

Deuterated oxazines are bright near-infrared fluorophores for mitochondrial imaging and single molecule spectroscopy

Author(s): Blaise Gatin-Fraudet; Julius Seifert; Kris Sarach; Christina Holmboe Olesen; Ramona Birke; Sigrid Milles; Melissa Birol; Martin Lehmann; Johannes Broichhagen
Published in: Chemical Communications, 2025, ISSN 1364-548X
Publisher: RSC
DOI: 10.1039/D4CC03807J

Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy

Author(s): Trumpp, M; Oliveras, A; Gonschior, H; Ast, J; Hodson, DJ; Knaus, P; Lehmann, M; Birol, M; Broichhagen, J
Published in: Chemical Communications, 2022, ISSN 1364-548X
Publisher: RSC
DOI: 10.17169/refubium-37374

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Author(s): Shilleh, A. H.; Viloria, K.; Broichhagen, J.; Campbell, J. E.; Hodson, D. J.
Published in: Peptides, 2024, ISSN 1873-5169
Publisher: Elsevier
DOI: 10.1016/j.peptides.2024.171179

Other (3)

Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

Author(s): Maria Kowald, Sylvestre P. J. T. Bachollet, Fritz Benseler, Maria Steinecker, Sofia Kaushik, Tolga Soykan, Sun Siqi, Ramona Birke, Dragana Ilic, Nils Brose, Hanna Hrnberg, Martin Lehmann, Silvio O. Rizzoli, Johannes Broichhagen, Noa Lipstein
Published in: 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.08.617143

Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses

Author(s): Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
Published in: Neuron, 2024, ISSN 1097-4199
Publisher: Cell Press
DOI: 10.1101/2024.01.15.575699

A one-step protocol to generate impermeable fluorescent HaloTag substrates for<i>in situ</i>live cell application and super-resolution imaging

Author(s): Kilian Romann, Siqi Sun, Christina Holmboe Olesen, Maria Kowald, Eleni Tapp, Ulrich Pabst, Marie Bieck, Ramona Birke, Brenda C. Shields, PyeongHwa Jeong, Jiyong Hong, Michael R. Tadross, Joshua Levitz, Martin Lehmann, Noa Lipstein, Johannes Broichhagen
Published in: 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.20.614087