Introducing deuterium for next generation chemical biology probes and direct imaging

Informazioni relative al progetto

deuterON

ID dell’accordo di sovvenzione: 101042046

DOI

10.3030/101042046

Data della firma CE 17 Maggio 2022

Data di avvio 1 Settembre 2022

Data di completamento 31 Agosto 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 499 469,00

Contributo UE

€ 1 499 469,00

Coordinato da

FORSCHUNGSVERBUND BERLIN EV
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (12)

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Autori: Alice Adriaenssens; Johannes Broichhagen; Anne de Bray; Julia Ast; Annie Hasib; Ben Jones; Alejandra Tomas; Natalie Figueredo Burgos; Orla Woodward; Jo Lewis; Elisabeth O’Flaherty; Kimberley El; Canqi Cui; Norio Harada; Nobuya Inagaki; Jonathan Campbell; Daniel Brierley; David J. Hodson; Ricardo Samms; Fiona Gribble; Frank Reimann
Pubblicato in: JCI Insight , 8 (10) , Article e164921. (2023), 2023, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.164921

Direct optical measurement of intramolecular distances with angstrom precision

Autori: Steffen J. Sahl, Jessica Matthias, Kaushik Inamdar, Michael Weber, Taukeer A. Khan, Christian Brüser, Stefan Jakobs, Stefan Becker, Christian Griesinger, Johannes Broichhagen, Stefan W. Hell
Pubblicato in: Science, Numero 386, 2024, ISSN 0036-8075
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/science.adj7368

Fine-tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

Autori: Ann-Kathrin Rückert, Julia Ast, Annie Hasib, Daniela Nasteska, Katrina Viloria, Johannes Broichhagen, David J. Hodson
Pubblicato in: Diabetic Medicine, 2023, ISSN 1464-5491
Editore: Wiley
DOI: 10.1111/dme.15220

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Autori: Julia Ast; Daniela Nasteska; Nicholas H. F. Fine; Daniel J. Nieves; Zsombor Koszegi; Yann Lanoiselée; Federica Cuozzo; Katrina Viloria; Andrea Bacon; Nguyet T. Luu; Philip N. Newsome; Davide Calebiro; Dylan M. Owen; Johannes Broichhagen; David J. Hodson
Pubblicato in: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023), 2023, ISSN 2041-1723
Editore: NPG
DOI: 10.1038/s41467-022-35716-1

Deuteration as a general strategy to enhance azobenzene-based photopharmacology

Autori: Roßmann, K.; Gonzalez-Hernandez, A. J.; Bhujan, K.; Schattenberg, C.; Sun, H.; Börjesson, K.; Levitz, J.; Broichhagen, J.
Pubblicato in: Angewandte Chemie International Edition, 2024, ISSN 1521-3757
Editore: Wiley
DOI: 10.1002/anie.202408300

openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation

Autori: J. Lightley, S. Kumar, M. Q. Lim, E. Garcia, F. Görlitz, Y. Alexandrov, T. Parrado, C. Hollick, E. Steele, K. Roßmann, J. Graham, J. Broichhagen, I. A. McNeish, C. A. Roufosse, M. A. A. Neil, C. Dunsby, P. M. W. French
Pubblicato in: Journal of Microscopy, 2023, ISSN 1365-2818
Editore: Wiley
DOI: 10.1111/jmi.13219

Penta-ALFA-Tagged Substrates for Self-Labelling Tags Allow Signal Enhancement in Microscopy

Autori: Souvik Ghosh, Ramona Birke, Ashwin Karthick Natarajan, Johannes Broichhagen
Pubblicato in: Peptide Science, 2025, ISSN 2475-8817
Editore: Wiley
DOI: 10.1002/PSC.70015

Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules

Autori: Florian Stockinger, Pascal Poc, Alexander Möhwald, Sandra Karch, Stephanie Häfner, Christian Alzheimer, Guillaume Sandoz, Tobias Huth, Johannes Broichhagen
Pubblicato in: Journal of Medicinal Chemistry, 2024, ISSN 1520-4804
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00339

Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization

Autori: Kilian Roßmann; Ramona Birke; Joshua Levitz; Ben Jones; Johannes Broichhagen
Pubblicato in: RSC Chemical Biology, 2025, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d4cb00209a

Deuterated oxazines are bright near-infrared fluorophores for mitochondrial imaging and single molecule spectroscopy

Autori: Blaise Gatin-Fraudet; Julius Seifert; Kris Sarach; Christina Holmboe Olesen; Ramona Birke; Sigrid Milles; Melissa Birol; Martin Lehmann; Johannes Broichhagen
Pubblicato in: Chemical Communications, 2025, ISSN 1364-548X
Editore: RSC
DOI: 10.1039/D4CC03807J

Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy

Autori: Trumpp, M; Oliveras, A; Gonschior, H; Ast, J; Hodson, DJ; Knaus, P; Lehmann, M; Birol, M; Broichhagen, J
Pubblicato in: Chemical Communications, 2022, ISSN 1364-548X
Editore: RSC
DOI: 10.17169/refubium-37374

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Autori: Shilleh, A. H.; Viloria, K.; Broichhagen, J.; Campbell, J. E.; Hodson, D. J.
Pubblicato in: Peptides, 2024, ISSN 1873-5169
Editore: Elsevier
DOI: 10.1016/j.peptides.2024.171179

Other (3)

Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

Autori: Maria Kowald, Sylvestre P. J. T. Bachollet, Fritz Benseler, Maria Steinecker, Sofia Kaushik, Tolga Soykan, Sun Siqi, Ramona Birke, Dragana Ilic, Nils Brose, Hanna Hrnberg, Martin Lehmann, Silvio O. Rizzoli, Johannes Broichhagen, Noa Lipstein
Pubblicato in: 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.10.08.617143

Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses

Autori: Hermany Munguba; Vanessa A. Gutzeit; Ipsit Srivastava; Melanie Kristt; Ashna Singh; Akshara Vijay; Anisul Arefin; Sonal Thukral; Johannes Broichhagen; Joseph M. Stujenske; Conor Liston; Joshua Levitz
Pubblicato in: Neuron, 2024, ISSN 1097-4199
Editore: Cell Press
DOI: 10.1101/2024.01.15.575699

A one-step protocol to generate impermeable fluorescent HaloTag substrates for<i>in situ</i>live cell application and super-resolution imaging

Autori: Kilian Romann, Siqi Sun, Christina Holmboe Olesen, Maria Kowald, Eleni Tapp, Ulrich Pabst, Marie Bieck, Ramona Birke, Brenda C. Shields, PyeongHwa Jeong, Jiyong Hong, Michael R. Tadross, Joshua Levitz, Martin Lehmann, Noa Lipstein, Johannes Broichhagen
Pubblicato in: 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.20.614087