Project description
Significance of gut microbiota in inflammatory bowel diseases
Immune-related inflammatory bowel diseases (IBD) include Crohn’s disease and ulcerative colitis, disorders characterised by gut inflammation. IBD incidence has increased in Western countries in recent decades, pointing to the role of environmental factors. The condition of gut microbiota and an alteration in intestinal and immune cell energy metabolism have been linked to the pathogenesis of IBD. The EU-funded ENERGISED project aims to identify the microorganisms and their metabolites impacting energy metabolism in the host cells and understand the significance of gut microbiota and metabolism alterations in IBD pathogenesis. The project objective is to design novel microbiota-based therapeutic strategies to regulate the host cell energy state in IBD cases.
Objective
Inflammatory bowel diseases (IBD), including Crohns disease and ulcerative colitis, are immune-related disorders characterized by
inappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a role
for environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion of
patients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis and
identification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as a
strong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in the
pathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunity
sensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mounting
the appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that the
altered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims of
ENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and the
mechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD and
design new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.
This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use of
multiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it will
have societal impacts due to the identification of new therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75006 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.