Project description DEENESFRITPL Significance of gut microbiota in inflammatory bowel diseases Immune-related inflammatory bowel diseases (IBD) include Crohn’s disease and ulcerative colitis, disorders characterised by gut inflammation. IBD incidence has increased in Western countries in recent decades, pointing to the role of environmental factors. The condition of gut microbiota and an alteration in intestinal and immune cell energy metabolism have been linked to the pathogenesis of IBD. The EU-funded ENERGISED project aims to identify the microorganisms and their metabolites impacting energy metabolism in the host cells and understand the significance of gut microbiota and metabolism alterations in IBD pathogenesis. The project objective is to design novel microbiota-based therapeutic strategies to regulate the host cell energy state in IBD cases. Show the project objective Hide the project objective Objective Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized byinappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a rolefor environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion ofpatients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis andidentification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as astrong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in thepathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunitysensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mountingthe appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that thealtered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims ofENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and themechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD anddesign new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use ofmultiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it willhave societal impacts due to the identification of new therapeutic strategies. Fields of science medical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesmicrobiology Keywords Microbiome cellular energy metabolism inflammatory bowel disease Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2021-COG - ERC CONSOLIDATOR GRANTS Call for proposal ERC-2021-COG See other projects for this call Funding Scheme HORIZON-ERC - HORIZON ERC Grants Coordinator SORBONNE UNIVERSITE Net EU contribution € 1 364 000,00 Address 21 rue de l'ecole de medecine 75006 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France Net EU contribution € 321 015,00 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 314 250,00 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
