Descripción del proyecto
Importancia de la microbiota intestinal en las enfermedades inflamatorias intestinales
Las enfermedades inflamatorias intestinales (EII) relacionadas con el sistema inmunitario incluyen la enfermedad de Crohn y la colitis ulcerosa, que son trastornos caracterizados por la inflamación intestinal. La incidencia de las EII ha aumentado en los países occidentales en las últimas décadas, lo que apunta al papel de los factores ambientales. El estado de la microbiota intestinal y una alteración del metabolismo energético de las células inmunitarias se han relacionado con la patogenia de las EII. El proyecto ENERGISED, financiado con fondos europeos, aspira a identificar los microorganismos y sus metabolitos que afectan al metabolismo energético de las células hospedadoras y comprender la importancia de la microbiota intestinal y de las alteraciones metabólicas en la patogenia de las EII. El objetivo del proyecto es diseñar nuevas estrategias terapéuticas basadas en la microbiota para regular el estado energético de la célula hospedadora en los casos de EII.
Objetivo
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized by
inappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a role
for environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion of
patients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis and
identification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as a
strong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in the
pathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunity
sensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mounting
the appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that the
altered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims of
ENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and the
mechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD and
design new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.
This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use of
multiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it will
have societal impacts due to the identification of new therapeutic strategies.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-ERC - HORIZON ERC GrantsInstitución de acogida
75006 Paris
Francia