Description du projet
Un cadre analytique avancé cherche à surmonter les difficultés liées au codage et au stockage des données ADN
L’ADN stocke le code permettant de produire l’ensemble des protéines d’un organisme par l’intermédiaire de sa séquence de nucléotides. L’exploitation du matériau de stockage d’information de la vie, en guise d’alternative aux technologies de stockage optiques et magnétiques, pourrait offrir de nombreux avantages, notamment une capacité et une densité de stockage massives, une très grande stabilité et des besoins énergétiques minimaux. Des technologies de stockage basées sur l’ADN se profilent à l’horizon, mais les solutions de codage existantes sont confrontées à des défis importants et n’en sont qu’à un stade très précoce de développement. Le projet DNAStorage, financé par l’UE, développera un cadre analytique dédié à la synthèse, au stockage et au séquençage des brins d’ADN, qui aboutira à la conception de codes pour le stockage à long terme et la récupération des données enregistrées sur de l’ADN.
Objectif
DNA-based storage has attracted significant attention due to recent demonstrations of the viability of storing information in macromolecules. Unlike classical optical and magnetic storage technologies, DNA-based storage does not require electrical supply to maintain data integrity, and given the trends in cost decreases of DNA synthesis and sequencing, it is estimated that within the next decade DNA storage may become a highly competitive archiving technology. However, existing coding solutions to address various problems associated with implementations of DNA-based storage systems are very limited in their development.
The goal of this research is to develop coding methods and techniques by designing novel and advanced solutions that are specifically targeted for the unique structure and error behavior of DNA-based storage systems. The proposed analytical framework will allow to address coding-theoretic challenges arising in the context of synthesis, storage, and sequencing of DNA strands. To achieve these goals, we aim to design codes for clustering, trace-reconstruction techniques, error-correction codes, and constrained codes. These codes are applicable for long-term storage and recovery of data recorded in DNA, while overcoming the unique challenges associated with the DNA storage channel.
We expect that knowledge, techniques, and qualitative insights gained in our investigation will advance DNA storage technologies capable of accommodating the massive amounts of data. Furthermore, solving the proposed coding problems will require new methods and ideas that will also impact adjacent scientific disciplines such as bioinformatics, combinatorics, and theoretical computer science. Thus, the proposed investigation is likely to lead to the development of new paradigms and directions of research that may have far-reaching societal and economic impact. Lastly, the accompanying experimental testing will allow for practical as assessments of system performance and cost.
Champ scientifique
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régime de financement
HORIZON-ERC - HORIZON ERC GrantsInstitution d’accueil
32000 Haifa
Israël