Mechanism of recharging exhausted T cells by skeletal muscles
Scientists associate the loss of skeletal muscle mass in chronic infection with impaired T cell function or T cell exhaustion, but the mechanisms of T cell restoration by muscle mass are not understood. Recent studies showed that skeletal muscles antagonised T cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus. Also, the spleen-derived exhausted CD8+ skeletal muscle-infiltrating lymphocytes formed clusters in muscles, restoring their potential and migrating back to lymphoid organs, providing long-term antiviral immunity. The EU-funded MuscleAntiVirus project aims to understand how skeletal muscles regulate antiviral CD8+ T cell function, metabolism, and migration. The objective is to uncover mechanisms of muscle-linked T cell ‘recharging’ and the therapeutic potential of increased muscle mass in chronic infections.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme