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Skeletal Muscles Antagonize T Cell Exhaustion in Chronic Viral Infections

Project description

Mechanism of recharging exhausted T cells by skeletal muscles

Scientists associate the loss of skeletal muscle mass in chronic infection with impaired T cell function or T cell exhaustion, but the mechanisms of T cell restoration by muscle mass are not understood. Recent studies showed that skeletal muscles antagonised T cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus. Also, the spleen-derived exhausted CD8+ skeletal muscle-infiltrating lymphocytes formed clusters in muscles, restoring their potential and migrating back to lymphoid organs, providing long-term antiviral immunity. The EU-funded MuscleAntiVirus project aims to understand how skeletal muscles regulate antiviral CD8+ T cell function, metabolism, and migration. The objective is to uncover mechanisms of muscle-linked T cell ‘recharging’ and the therapeutic potential of increased muscle mass in chronic infections.

Coordinator

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Net EU contribution
€ 2 000 000,00
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Germany

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 0,00