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Yeast cell factory for mRNA bioproduction

Project description

Yeast-based bioproduction of RNA therapeutics

Ribonucleic acid (RNA) molecules are gaining momentum for the treatment of various conditions including in the generation of antiviral vaccines. However, RNA production relies on costly in vitro transcription methods. The EU-funded Yscript project proposes an alternative method for production of messenger RNA (mRNA) molecules, using yeast. Given the similarity in the structure between yeast and human mRNA, researchers will set up a technology for producing, isolating and purifying mRNA in yeast cells. This bioproduction platform will guarantee high purity and stability of target mRNA molecules – at a fraction of the cost. Importantly, it will lay the foundation for advancing the use of RNA therapeutics in medicine.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution
€ 577 090,00
Address
Rue Michel Ange 3
75794 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00

Participants (9)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE D'ORLEANS
France
Net EU contribution
€ 103 250,00
Address
Chateau De La Source
45067 Orleans Cedex 2

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Region
Centre — Val de Loire Centre — Val de Loire Loiret
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Net EU contribution
€ 423 157,50
Address
147 Rue De L'universite
75007 Paris Cedex 07

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INRAE TRANSFERT SAS
France
Net EU contribution
€ 112 500,00
Address
Rue Du Docteur Finlay 28
75015 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSIDADE DE AVEIRO
Portugal
Net EU contribution
€ 303 973,75
Address
Campus Universitário De Santiago
3810-193 Aveiro

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Region
Continente Centro (PT) Região de Aveiro
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSIDADE DA BEIRA INTERIOR
Portugal
Net EU contribution
€ 200 826,00
Address
Convento De Santo Antonio
6201 001 Covilha

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Region
Continente Centro (PT) Beiras e Serra da Estrela
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25
TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GEMEINNUTZIGE GMBH
Germany
Net EU contribution
€ 491 912,50
Address
Freiligrathstrasse 12
55131 Mainz

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 273 310,00
Address
Noskowskiego 12-14
61 704 Poznan

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Region
Makroregion północno-zachodni Wielkopolskie Miasto Poznań
Activity type
Research Organisations
Other funding
€ 0,00
SARTORIUS BIA SEPARATIONS, SEPARACIJSKE TEHNOLOGIJE, D.O.O.
Slovenia
Net EU contribution
€ 353 230,00
Address
Mirce 21
5270 Ajdovscina

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Region
Slovenija Zahodna Slovenija Goriška
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Net EU contribution
€ 239 000,00
Address
Heinrich-hertz-allee 1
66386 St Ingbert

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarpfalz-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00