Colouring the Dark in Fluorescence Light

Informations projet

CoDaFlight

N° de convention de subvention: 101047263

DOI

10.3030/101047263

Date de signature de la CE 2 Août 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2026

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 2 999 300,00

Contribution de l’UE

€ 2 999 300,00

Coordonné par

VRIJE UNIVERSITEIT BRUSSEL
Belgium

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Validation plan for tdFLI

Document with the plan to validate the first tdFLI instrument using standard tests as well as using pertinent phantoms

Validated initial time-domain imaging system

A report that the the first tdFLI instrument is validated for the set performance characteristics

Feedback from PoC about imaging system

Report with the feedback from the first demonstration of the power and advantages of in vivo NIR tdFLI to create better and novel imaging strategies in PoC. Early results from this deliverable will enable us to steer the technology development in the right direction to finalize a product that can be integrated in this workflow of clinical application supporting decision-making.

Project website and logo

Development and the operation of the projects website with information on social media links

Report on micro lenses for plenoptic

We wil report out on the microlenses geometry that will developed in this workpackage and how this will provide a plenoptic vision making possible tomographic reconstructions based on the distinct projections probed by different microlens/pixel elements. At the same time we report out on the isoplanatism at the different projections and if phase retrieval reconstructions can be performed, further enhancing accuracy of depth recovery and 3D image resolution.

Initial report on time-domain modelling, methods and illumination

We will write a report on the technological components of the tdFLI system and will actively adapt the components to each other to maximize the total performance to realize the envisioned breakthrough We will perform a topdown analysis of the global objective and extract from this the objectives and parameters for the individual components while studying and considering their interdependencies

Second report on time-domain modelling, methods and illumination

We will write a second report on the technological components of the tdFLI system and how we have adapted the components to each other to maximize the total performance to realize the envisioned breakthrough.

Demonstrators, pilots, prototypes (6)

Second tdFLI imaging sensors with micro lenses

Second batch of novel sensors with and without microlenses will be available for testing and use. We will in any case prepare a report in addition.

Initial time-domain imaging instrument

Demonstration of an imaging system consisting of a camera with current-assisted tdFLI image sensor, pulsed and structured laser illumination and running the developed algorithms on this platform.We will in any case prepare a report in addition.

Initial novel tdFLI imaging sensors with micro lenses

First novel sensors with and without microlenses will be available for testing and use We will in any case prepare a report in addition

Initial biocompatible static NIR FLT dyes

First biocompatible static dyes available for testing We will in any case prepare a report in addition

Initial biocompatible responsive NIR FLT-dyes

First biocompatible responsive dyes available for testing. We will in any case prepare a report in addition.

Second time-domain imaging instrument

Second and improved demonstration of an imaging system consisting of a camera with current-assisted tdFLI image sensor, pulsed and structured laser illumination and running the developed algorithms on this platform. We will in any case prepare a report in addition.

Other (1)

Initial real-time smart time-domain algorithms

First delivery of practical and smart algorithms in C++ in a platform independent way.We will in any case prepare a report in addition.

Publications

Peer reviewed articles (2)

Fluorescence Lifetime Endoscopy with a Nanosecond Time-Gated CAPS Camera with IRF-Free Deep Learning Method

Auteurs: Pooria Iranian; Thomas Lapauw; Thomas Van den Dries; Sevada Sahakian; Joris Wuts; Valéry Ann Jacobs; Jef Vandemeulebroucke; Maarten Kuijk; Hans Ingelberts
Publié dans: Sensors, 2025, ISSN 0000-0000
Éditeur: MDPI
DOI: 10.3390/S25020450

64×64 Pixel Current-Assisted Photonic Sampler Image Sensor and Camera System for Real-Time Fluorescence Lifetime Imaging

Auteurs: Thomas Van den Dries, Thomas Lapauw, Simone Janssen, Sevada Sahakian, Théo Lepoutte, Marcus Stroet, Sophie Hernot, Maarten Kuijk, Hans Ingelberts
Publié dans: IEEE Sensors Journal, Numéro 24, 2024, ISSN 1530-437X
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSEN.2024.3409418