Immunogenic cell death (ICD) in the cancer-immune dialogue

Project Information

ICD-Cancer

Grant agreement ID: 101052444

DOI

10.3030/101052444

EC signature date 3 December 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UNIVERSITE PARIS CITE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management plan

Publications

Peer reviewed articles (22)

Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells

Author(s): Jing Zhang, Christina Trojel-Hansen, Jianghuang Wang, Zili Zhang, Xing Wang, Yuhui Qiao, Huike Jiao, Mickaël Michaud, Oliver Kepp, Marja Jäättelä, Guido Kroemer, Qing Zhong
Published in: Cell Death & Disease, Issue 14, 2023, ISSN 2041-4889
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41419-023-05740-0

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Author(s): Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer
Published in: Molecular Cancer, Issue 23, 2024, ISSN 1476-4598
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02189-3

Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses

Author(s): Shuai Zhang; Liwei Zhao; Mengfei Guo; Peng Liu; Sijing Li; Wei Xie; Ai-Ling Tian; Jonathan G Pol; Hui Chen; Hui Pan; Misha Mao; Yumei Li; Laurence Zitvogel; Yang Jin; Oliver Kepp; Guido Kroemer
Published in: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Publisher: BMC
DOI: 10.1136/jitc-2023-006785

New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma

Author(s): Perez-Lanzon, Maria; Carbonnier, Vincent; Cordier, Pierre; De Palma, Fatima Domenica Elisa; Petrazzuolo, Adriana; Klein, Christophe; Arbaretaz, Floriane; Mangane, Khady; Stoll, Gautier; Martins, Isabelle; Fohrer Ting, Helene; Paillet, Juliette; Mouillet-Richard, Sophie; Le Corre, Delphine; Xiao, Wenjjin; Sroussi, Marine; Desdouets, Chantal; Laurent-Puig, Pierre; Pol, Jonathan; Lopez-Otin, Carlos; Maiuri, Maria Chiara; Kroemer, Guido
Published in: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Publisher: BMC
DOI: 10.1136/jitc-2023-007117

Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis

Author(s): Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig, Guido Kroemer
Published in: OncoImmunology, Issue 12, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402X.2023.2237354

Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Author(s): Léa Montégut, Peng Liu, Liwei Zhao, María Pérez-Lanzón, Hui Chen, Misha Mao, Shuai Zhang, Lisa Derosa, Julie Le Naour, Flavia Lambertucci, Silvia Mingoia, Uxía Nogueira-Recalde, Rafael Mena-Osuna, Irene Herranz-Montoya, Nabil Djouder, Sylvain Baulande, Hui Pan, Adrien Joseph, Meriem Messaoudene, Bertrand Routy, Marine Fidelle, Tarek Ben Ahmed, Olivier Caron, Pierre Busson, David Boulate, Mélanie Deschasaux-Tanguy, Nathalie Arnault, Jonathan G. Pol, Eliane Piaggio, Mathilde Touvier, Laurence Zitvogel, Suzette Delaloge, Isabelle Martins, Guido Kroemer
Published in: Molecular Cancer, Issue 23, 2024, ISSN 1476-4598
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02098-5

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Author(s): Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg
Published in: OncoImmunology, Issue 12, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402X.2023.2219591

Cell Death and Differentiation

Author(s): Peng Liu; Liwei Zhao; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Published in: Cell Death & Differentiation, 2023, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-023-01232-y

Targeting immunogenic cell stress and death for cancer therapy

Author(s): Lorenzo Galluzzi; Emma Guilbaud; Darby Schmidt; Guido Kroemer; Francesco M. Marincola
Published in: Nature Reviews Drug Discovery, 2024, ISSN 2058-8437
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-024-00920-9

The danger theory of immunity revisited

Author(s): Guido Kroemer, Léa Montégut, Oliver Kepp, Laurence Zitvogel
Published in: Nature Reviews Immunology, Issue 24, 2024, ISSN 1474-1733
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41577-024-01102-9

Neutralization of the autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) enhances anticancer immunosurveillance

Author(s): Léa Montégut, Isabelle Martins, Guido Kroemer
Published in: Autophagy, Issue 20, 2024, ISSN 1554-8627
Publisher: Informa UK Limited
DOI: 10.1080/15548627.2024.2411854

Autophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of Cushing syndrome

Author(s): Hui Pan, Ai-Ling Tian, Fréderic Castinetti, Isabelle Martins, Oliver Kepp, Guido Kroemer
Published in: Autophagy, 2024, ISSN 1554-8627
Publisher: Informa UK Limited
DOI: 10.1080/15548627.2024.2437649

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death

Author(s): Karla Alvarez-Valadez, Allan Sauvat, Julien Diharce, Marion Leduc, Gautier Stoll, Lionel Guittat, Flavia Lambertucci, Juliette Paillet, Omar Motiño, Lucille Ferret, Alexandra Muller, Sabrina Forveille, Maria Chiara Maiuri, Oliver Kepp, Alexandre G de Brevern, Harald Wodrich, Jonathan G Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
Published in: Autophagy, 2024, ISSN 1554-8627
Publisher: Informa UK Limited
DOI: 10.1080/15548627.2024.2440842

Immunosurveillance in clinical cancer management

Author(s): Guido Kroemer, Timothy A. Chan, Alexander M. M. Eggermont, Lorenzo Galluzzi
Published in: CA: A Cancer Journal for Clinicians, Issue 74, 2024, ISSN 0007-9235
Publisher: Wiley
DOI: 10.3322/caac.21818

Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer

Author(s): Vincent Carbonnier, Julie Le Naour, Thomas Bachelot, Erika Vacchelli, Fabrice André, Suzette Delaloge, Guido Kroemer
Published in: OncoImmunology, Issue 12, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402X.2023.2189823

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Author(s): Marta Kovatcheva, Elena Melendez, Dafni Chondronasiou, Federico Pietrocola, Raquel Bernad, Adrià Caballe, Alexandra Junza, Jordi Capellades, Adrián Holguín-Horcajo, Neus Prats, Sylvere Durand, Meritxell Rovira, Oscar Yanes, Camille Stephan-Otto Attolini, Guido Kroemer, Manuel Serrano
Published in: Nature Metabolism, Issue 5, 2023, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00916-6

AMPK activation induces immunogenic cell death in AML

Author(s): Johanna Mondesir, Margherita Ghisi, Laura Poillet, Robert A. Bossong, Oliver Kepp, Guido Kroemer, Jean-Emmanuel Sarry, Jérôme Tamburini, Andrew A. Lane
Published in: Blood Advances, Issue 7, 2023, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2022009444

A Chemically Defined TLR3 Agonist with Anticancer Activity

Author(s): Julie Le Naour, Sylvain Thierry, Sarah Adriana Scuderi, Mathilde Boucard-Jourdin, Peng Liu, Marc Bonnin, Yuhong Pan, Clémence Perret, Liwei Zhao, Misha Mao, Chloé Renoux, María Pérez-Lanzón, Baptiste Martin, Oliver Kepp, Guido Kroemer, Bettina Werlé
Published in: OncoImmunology, Issue 12, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402X.2023.2227510

Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells

Author(s): Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Published in: Immunological Reviews, Issue 321, 2024, ISSN 0105-2896
Publisher: Wiley
DOI: 10.1111/imr.13269

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome

Author(s): Hui Pan, Ai-Ling Tian, Hui Chen, Yifan Xia, Allan Sauvat, Stephanie Moriceau, Flavia Lambertucci, Omar Motiño, Liwei Zhao, Peng Liu, Misha Mao, Sijing Li, Shuai Zhang, Adrien Joseph, Sylvère Durand, Fanny Aprahamian, Zeyu Luo, Yang Ou, Zhe Shen, Enfu Xue, Yuhong Pan, Vincent Carbonnier, Gautier Stoll, Sabrina Forveille, Marion Leduc, Giulia Cerrato, Alexandra Cerone, Maria Chiara Maiuri, Frederic Castinetti, Thierry Brue, Hongsheng Wang, Yuting Ma, Isabelle Martins, Oliver Kepp, Guido Kroemer
Published in: Nature Metabolism, Issue 6, 2024, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01170-0

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Author(s): Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H.K. Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Published in: Cancer Discovery, Issue 13, 2023, ISSN 2159-8274
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2159-8290.CD-22-1338

Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Author(s): Léa Montégut, Isabelle Martins, Guido Kroemer
Published in: OncoImmunology, Issue 13, 2024, ISSN 2162-402X
Publisher: Informa UK Limited
DOI: 10.1080/2162402X.2024.2413200