Immunogenic cell death (ICD) in the cancer-immune dialogue

Informazioni relative al progetto

ICD-Cancer

ID dell’accordo di sovvenzione: 101052444

DOI

10.3030/101052444

Data della firma CE 3 Dicembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

UNIVERSITE PARIS CITE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

Data Management Plan

Drafting of Data Management plan

Pubblicazioni

Peer reviewed articles (22)

Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells

Autori: Jing Zhang, Christina Trojel-Hansen, Jianghuang Wang, Zili Zhang, Xing Wang, Yuhui Qiao, Huike Jiao, Mickaël Michaud, Oliver Kepp, Marja Jäättelä, Guido Kroemer, Qing Zhong
Pubblicato in: Cell Death & Disease, Numero 14, 2023, ISSN 2041-4889
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41419-023-05740-0

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Autori: Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer
Pubblicato in: Molecular Cancer, Numero 23, 2024, ISSN 1476-4598
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02189-3

Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses

Autori: Shuai Zhang; Liwei Zhao; Mengfei Guo; Peng Liu; Sijing Li; Wei Xie; Ai-Ling Tian; Jonathan G Pol; Hui Chen; Hui Pan; Misha Mao; Yumei Li; Laurence Zitvogel; Yang Jin; Oliver Kepp; Guido Kroemer
Pubblicato in: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Editore: BMC
DOI: 10.1136/jitc-2023-006785

New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma

Autori: Perez-Lanzon, Maria; Carbonnier, Vincent; Cordier, Pierre; De Palma, Fatima Domenica Elisa; Petrazzuolo, Adriana; Klein, Christophe; Arbaretaz, Floriane; Mangane, Khady; Stoll, Gautier; Martins, Isabelle; Fohrer Ting, Helene; Paillet, Juliette; Mouillet-Richard, Sophie; Le Corre, Delphine; Xiao, Wenjjin; Sroussi, Marine; Desdouets, Chantal; Laurent-Puig, Pierre; Pol, Jonathan; Lopez-Otin, Carlos; Maiuri, Maria Chiara; Kroemer, Guido
Pubblicato in: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Editore: BMC
DOI: 10.1136/jitc-2023-007117

Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis

Autori: Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 12, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402X.2023.2237354

Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Autori: Léa Montégut, Peng Liu, Liwei Zhao, María Pérez-Lanzón, Hui Chen, Misha Mao, Shuai Zhang, Lisa Derosa, Julie Le Naour, Flavia Lambertucci, Silvia Mingoia, Uxía Nogueira-Recalde, Rafael Mena-Osuna, Irene Herranz-Montoya, Nabil Djouder, Sylvain Baulande, Hui Pan, Adrien Joseph, Meriem Messaoudene, Bertrand Routy, Marine Fidelle, Tarek Ben Ahmed, Olivier Caron, Pierre Busson, David Boulate, Mélanie Deschasaux-Tanguy, Nathalie Arnault, Jonathan G. Pol, Eliane Piaggio, Mathilde Touvier, Laurence Zitvogel, Suzette Delaloge, Isabelle Martins, Guido Kroemer
Pubblicato in: Molecular Cancer, Numero 23, 2024, ISSN 1476-4598
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02098-5

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Autori: Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg
Pubblicato in: OncoImmunology, Numero 12, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402X.2023.2219591

Cell Death and Differentiation

Autori: Peng Liu; Liwei Zhao; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Pubblicato in: Cell Death & Differentiation, 2023, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-023-01232-y

Targeting immunogenic cell stress and death for cancer therapy

Autori: Lorenzo Galluzzi; Emma Guilbaud; Darby Schmidt; Guido Kroemer; Francesco M. Marincola
Pubblicato in: Nature Reviews Drug Discovery, 2024, ISSN 2058-8437
Editore: Nature Publishing Group
DOI: 10.1038/s41573-024-00920-9

The danger theory of immunity revisited

Autori: Guido Kroemer, Léa Montégut, Oliver Kepp, Laurence Zitvogel
Pubblicato in: Nature Reviews Immunology, Numero 24, 2024, ISSN 1474-1733
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41577-024-01102-9

Neutralization of the autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) enhances anticancer immunosurveillance

Autori: Léa Montégut, Isabelle Martins, Guido Kroemer
Pubblicato in: Autophagy, Numero 20, 2024, ISSN 1554-8627
Editore: Informa UK Limited
DOI: 10.1080/15548627.2024.2411854

Autophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of Cushing syndrome

Autori: Hui Pan, Ai-Ling Tian, Fréderic Castinetti, Isabelle Martins, Oliver Kepp, Guido Kroemer
Pubblicato in: Autophagy, 2024, ISSN 1554-8627
Editore: Informa UK Limited
DOI: 10.1080/15548627.2024.2437649

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death

Autori: Karla Alvarez-Valadez, Allan Sauvat, Julien Diharce, Marion Leduc, Gautier Stoll, Lionel Guittat, Flavia Lambertucci, Juliette Paillet, Omar Motiño, Lucille Ferret, Alexandra Muller, Sabrina Forveille, Maria Chiara Maiuri, Oliver Kepp, Alexandre G de Brevern, Harald Wodrich, Jonathan G Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
Pubblicato in: Autophagy, 2024, ISSN 1554-8627
Editore: Informa UK Limited
DOI: 10.1080/15548627.2024.2440842

Immunosurveillance in clinical cancer management

Autori: Guido Kroemer, Timothy A. Chan, Alexander M. M. Eggermont, Lorenzo Galluzzi
Pubblicato in: CA: A Cancer Journal for Clinicians, Numero 74, 2024, ISSN 0007-9235
Editore: Wiley
DOI: 10.3322/caac.21818

Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer

Autori: Vincent Carbonnier, Julie Le Naour, Thomas Bachelot, Erika Vacchelli, Fabrice André, Suzette Delaloge, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 12, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402X.2023.2189823

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Autori: Marta Kovatcheva, Elena Melendez, Dafni Chondronasiou, Federico Pietrocola, Raquel Bernad, Adrià Caballe, Alexandra Junza, Jordi Capellades, Adrián Holguín-Horcajo, Neus Prats, Sylvere Durand, Meritxell Rovira, Oscar Yanes, Camille Stephan-Otto Attolini, Guido Kroemer, Manuel Serrano
Pubblicato in: Nature Metabolism, Numero 5, 2023, ISSN 2522-5812
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00916-6

AMPK activation induces immunogenic cell death in AML

Autori: Johanna Mondesir, Margherita Ghisi, Laura Poillet, Robert A. Bossong, Oliver Kepp, Guido Kroemer, Jean-Emmanuel Sarry, Jérôme Tamburini, Andrew A. Lane
Pubblicato in: Blood Advances, Numero 7, 2023, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2022009444

A Chemically Defined TLR3 Agonist with Anticancer Activity

Autori: Julie Le Naour, Sylvain Thierry, Sarah Adriana Scuderi, Mathilde Boucard-Jourdin, Peng Liu, Marc Bonnin, Yuhong Pan, Clémence Perret, Liwei Zhao, Misha Mao, Chloé Renoux, María Pérez-Lanzón, Baptiste Martin, Oliver Kepp, Guido Kroemer, Bettina Werlé
Pubblicato in: OncoImmunology, Numero 12, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402X.2023.2227510

Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells

Autori: Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Pubblicato in: Immunological Reviews, Numero 321, 2024, ISSN 0105-2896
Editore: Wiley
DOI: 10.1111/imr.13269

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome

Autori: Hui Pan, Ai-Ling Tian, Hui Chen, Yifan Xia, Allan Sauvat, Stephanie Moriceau, Flavia Lambertucci, Omar Motiño, Liwei Zhao, Peng Liu, Misha Mao, Sijing Li, Shuai Zhang, Adrien Joseph, Sylvère Durand, Fanny Aprahamian, Zeyu Luo, Yang Ou, Zhe Shen, Enfu Xue, Yuhong Pan, Vincent Carbonnier, Gautier Stoll, Sabrina Forveille, Marion Leduc, Giulia Cerrato, Alexandra Cerone, Maria Chiara Maiuri, Frederic Castinetti, Thierry Brue, Hongsheng Wang, Yuting Ma, Isabelle Martins, Oliver Kepp, Guido Kroemer
Pubblicato in: Nature Metabolism, Numero 6, 2024, ISSN 2522-5812
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01170-0

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Autori: Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H.K. Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Pubblicato in: Cancer Discovery, Numero 13, 2023, ISSN 2159-8274
Editore: American Association for Cancer Research (AACR)
DOI: 10.1158/2159-8290.CD-22-1338

Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Autori: Léa Montégut, Isabelle Martins, Guido Kroemer
Pubblicato in: OncoImmunology, Numero 13, 2024, ISSN 2162-402X
Editore: Informa UK Limited
DOI: 10.1080/2162402X.2024.2413200