Immunogenic cell death (ICD) in the cancer-immune dialogue

Información del proyecto

ICD-Cancer

Identificador del acuerdo de subvención: 101052444

DOI

10.3030/101052444

Fecha de la firma de la CE 3 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UNIVERSITE PARIS CITE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data Management Plan

Drafting of Data Management plan

Publicaciones

Peer reviewed articles (22)

Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells

Autores: Jing Zhang, Christina Trojel-Hansen, Jianghuang Wang, Zili Zhang, Xing Wang, Yuhui Qiao, Huike Jiao, Mickaël Michaud, Oliver Kepp, Marja Jäättelä, Guido Kroemer, Qing Zhong
Publicado en: Cell Death & Disease, Edición 14, 2023, ISSN 2041-4889
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41419-023-05740-0

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Autores: Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer
Publicado en: Molecular Cancer, Edición 23, 2024, ISSN 1476-4598
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02189-3

Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses

Autores: Shuai Zhang; Liwei Zhao; Mengfei Guo; Peng Liu; Sijing Li; Wei Xie; Ai-Ling Tian; Jonathan G Pol; Hui Chen; Hui Pan; Misha Mao; Yumei Li; Laurence Zitvogel; Yang Jin; Oliver Kepp; Guido Kroemer
Publicado en: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Editor: BMC
DOI: 10.1136/jitc-2023-006785

New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma

Autores: Perez-Lanzon, Maria; Carbonnier, Vincent; Cordier, Pierre; De Palma, Fatima Domenica Elisa; Petrazzuolo, Adriana; Klein, Christophe; Arbaretaz, Floriane; Mangane, Khady; Stoll, Gautier; Martins, Isabelle; Fohrer Ting, Helene; Paillet, Juliette; Mouillet-Richard, Sophie; Le Corre, Delphine; Xiao, Wenjjin; Sroussi, Marine; Desdouets, Chantal; Laurent-Puig, Pierre; Pol, Jonathan; Lopez-Otin, Carlos; Maiuri, Maria Chiara; Kroemer, Guido
Publicado en: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Editor: BMC
DOI: 10.1136/jitc-2023-007117

Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis

Autores: Julie Le Naour, Léa Montégut, Yuhong Pan, Sarah Adriana Scuderi, Pierre Cordier, Adrien Joseph, Allan Sauvat, Valerio Iebba, Juliette Paillet, Gladys Ferrere, Ludivine Brechard, Claire Mulot, Grégory Dubourg, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Pierre-Laurent Puig, Guido Kroemer
Publicado en: OncoImmunology, Edición 12, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402X.2023.2237354

Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Autores: Léa Montégut, Peng Liu, Liwei Zhao, María Pérez-Lanzón, Hui Chen, Misha Mao, Shuai Zhang, Lisa Derosa, Julie Le Naour, Flavia Lambertucci, Silvia Mingoia, Uxía Nogueira-Recalde, Rafael Mena-Osuna, Irene Herranz-Montoya, Nabil Djouder, Sylvain Baulande, Hui Pan, Adrien Joseph, Meriem Messaoudene, Bertrand Routy, Marine Fidelle, Tarek Ben Ahmed, Olivier Caron, Pierre Busson, David Boulate, Mélanie Deschasaux-Tanguy, Nathalie Arnault, Jonathan G. Pol, Eliane Piaggio, Mathilde Touvier, Laurence Zitvogel, Suzette Delaloge, Isabelle Martins, Guido Kroemer
Publicado en: Molecular Cancer, Edición 23, 2024, ISSN 1476-4598
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s12943-024-02098-5

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Autores: Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg
Publicado en: OncoImmunology, Edición 12, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402X.2023.2219591

Cell Death and Differentiation

Autores: Peng Liu; Liwei Zhao; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Publicado en: Cell Death & Differentiation, 2023, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-023-01232-y

Targeting immunogenic cell stress and death for cancer therapy

Autores: Lorenzo Galluzzi; Emma Guilbaud; Darby Schmidt; Guido Kroemer; Francesco M. Marincola
Publicado en: Nature Reviews Drug Discovery, 2024, ISSN 2058-8437
Editor: Nature Publishing Group
DOI: 10.1038/s41573-024-00920-9

The danger theory of immunity revisited

Autores: Guido Kroemer, Léa Montégut, Oliver Kepp, Laurence Zitvogel
Publicado en: Nature Reviews Immunology, Edición 24, 2024, ISSN 1474-1733
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41577-024-01102-9

Neutralization of the autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) enhances anticancer immunosurveillance

Autores: Léa Montégut, Isabelle Martins, Guido Kroemer
Publicado en: Autophagy, Edición 20, 2024, ISSN 1554-8627
Editor: Informa UK Limited
DOI: 10.1080/15548627.2024.2411854

Autophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of Cushing syndrome

Autores: Hui Pan, Ai-Ling Tian, Fréderic Castinetti, Isabelle Martins, Oliver Kepp, Guido Kroemer
Publicado en: Autophagy, 2024, ISSN 1554-8627
Editor: Informa UK Limited
DOI: 10.1080/15548627.2024.2437649

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death

Autores: Karla Alvarez-Valadez, Allan Sauvat, Julien Diharce, Marion Leduc, Gautier Stoll, Lionel Guittat, Flavia Lambertucci, Juliette Paillet, Omar Motiño, Lucille Ferret, Alexandra Muller, Sabrina Forveille, Maria Chiara Maiuri, Oliver Kepp, Alexandre G de Brevern, Harald Wodrich, Jonathan G Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
Publicado en: Autophagy, 2024, ISSN 1554-8627
Editor: Informa UK Limited
DOI: 10.1080/15548627.2024.2440842

Immunosurveillance in clinical cancer management

Autores: Guido Kroemer, Timothy A. Chan, Alexander M. M. Eggermont, Lorenzo Galluzzi
Publicado en: CA: A Cancer Journal for Clinicians, Edición 74, 2024, ISSN 0007-9235
Editor: Wiley
DOI: 10.3322/caac.21818

Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer

Autores: Vincent Carbonnier, Julie Le Naour, Thomas Bachelot, Erika Vacchelli, Fabrice André, Suzette Delaloge, Guido Kroemer
Publicado en: OncoImmunology, Edición 12, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402X.2023.2189823

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair

Autores: Marta Kovatcheva, Elena Melendez, Dafni Chondronasiou, Federico Pietrocola, Raquel Bernad, Adrià Caballe, Alexandra Junza, Jordi Capellades, Adrián Holguín-Horcajo, Neus Prats, Sylvere Durand, Meritxell Rovira, Oscar Yanes, Camille Stephan-Otto Attolini, Guido Kroemer, Manuel Serrano
Publicado en: Nature Metabolism, Edición 5, 2023, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00916-6

AMPK activation induces immunogenic cell death in AML

Autores: Johanna Mondesir, Margherita Ghisi, Laura Poillet, Robert A. Bossong, Oliver Kepp, Guido Kroemer, Jean-Emmanuel Sarry, Jérôme Tamburini, Andrew A. Lane
Publicado en: Blood Advances, Edición 7, 2023, ISSN 2473-9529
Editor: American Society of Hematology
DOI: 10.1182/bloodadvances.2022009444

A Chemically Defined TLR3 Agonist with Anticancer Activity

Autores: Julie Le Naour, Sylvain Thierry, Sarah Adriana Scuderi, Mathilde Boucard-Jourdin, Peng Liu, Marc Bonnin, Yuhong Pan, Clémence Perret, Liwei Zhao, Misha Mao, Chloé Renoux, María Pérez-Lanzón, Baptiste Martin, Oliver Kepp, Guido Kroemer, Bettina Werlé
Publicado en: OncoImmunology, Edición 12, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402X.2023.2227510

Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells

Autores: Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Publicado en: Immunological Reviews, Edición 321, 2024, ISSN 0105-2896
Editor: Wiley
DOI: 10.1111/imr.13269

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome

Autores: Hui Pan, Ai-Ling Tian, Hui Chen, Yifan Xia, Allan Sauvat, Stephanie Moriceau, Flavia Lambertucci, Omar Motiño, Liwei Zhao, Peng Liu, Misha Mao, Sijing Li, Shuai Zhang, Adrien Joseph, Sylvère Durand, Fanny Aprahamian, Zeyu Luo, Yang Ou, Zhe Shen, Enfu Xue, Yuhong Pan, Vincent Carbonnier, Gautier Stoll, Sabrina Forveille, Marion Leduc, Giulia Cerrato, Alexandra Cerone, Maria Chiara Maiuri, Frederic Castinetti, Thierry Brue, Hongsheng Wang, Yuting Ma, Isabelle Martins, Oliver Kepp, Guido Kroemer
Publicado en: Nature Metabolism, Edición 6, 2024, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01170-0

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Autores: Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H.K. Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Publicado en: Cancer Discovery, Edición 13, 2023, ISSN 2159-8274
Editor: American Association for Cancer Research (AACR)
DOI: 10.1158/2159-8290.CD-22-1338

Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Autores: Léa Montégut, Isabelle Martins, Guido Kroemer
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402X.2024.2413200