Finding therapeutic targets to fight Tau-induced neurodegeneration
Tauopathies represent a group of progressive neurodegenerative disorders that are characterised by the presence of Tau protein aggregates in the brain and by the absence of disease-modifying therapies. Remarkably, when hamsters and squirrels enter hibernation, they also display Tau pathology and synaptic loss, which are reversible, in contrast to progressive in the case of human dementia. The EU funded Hibernating_Synapses project aims to uncover the mechanisms of synaptic remodelling in the case of hibernation and explore the pathways that reverse synapse loss as a tool to counteract Tau induced synaptic decline in tauopathies. The project will identify the drivers of synaptic remodelling during hibernation and the human homologues of the hamster genes that reverse synaptic loss in the attempt to find the pathways rescuing Tau-induced neurodegeneration.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme