AI powered Data Curation & Publishing Virtual Assistant

Informations projet

AIDAVA

N° de convention de subvention: 101057062

DOI

10.3030/101057062

Projet clôturé

Date de signature de la CE 19 Mai 2022

Date de début 1 Septembre 2022

Date de fin 31 Août 2026

Financé au titre de

• Health

Coût total

€ 7 720 615,23

Contribution de l’UE

€ 7 720 615,00

Coordonné par

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Communication Toolkit
Report from user survey with personas canva
Description of use cases
Update of Report on dissemination and communication activities 1
Definition on data quality & performance metrics
Report on dissemination and communication activities
Update of Business requirements (D1.3) for G2

Update of Business requirements (D1.3) for G2

Business requirements for R1

Business requirements for G!

Update of Report (D1.2) from user survey with personas canvas
Definition of assessment study including test scenarios & metrics, and study initiation package

Other (5)

Report 2 from external Ethics Advisory Board

Report 2 from external Ethics Advisory Board

Report 1 from external Ethics Advisory Board (including names and CVs of member)
Information governance framework and instruments
Regulatory conformance analysis of the AI development pipeline
Data Management Plan

Demonstrators, pilots, prototypes (7)

Update to Annotation guidelines, tools & training
Annotation guidelines, tools & training
G1 of the AIDAVA prototype
Solution Design Document for G1
Global Data Sharing Standard
VA architecture (Application and Technical)
Update of Solution Design Document (D2.3) for G2

Websites, patent fillings, videos etc. (2)

Audio-visual material
Public project website

Publications

Peer reviewed articles (27)

Improving Patient Engagement in Phase 2 Clinical Trials With a Trial-Specific Patient Decision Aid: Development and Usability Study

Auteurs: Iva Halilaj, Relinde Lieverse, Cary Oberije, Lizza Hendriks, Charlotte Billiet, Ines Joye, Brice Van Eeckhout, Anke Wind, Anshu Ankolekar, Philippe Lambin
Publié dans: Journal of Medical Internet Research, Numéro 27, 2025, ISSN 1438-8871
Éditeur: JMIR Publications Inc.
DOI: 10.2196/71817

Radiomics Quality Score 2.0: towards radiomics readiness levels and clinical translation for personalized medicine

Auteurs: Philippe Lambin, Henry C. Woodruff, Shruti Atul Mali, Xian Zhong, Sheng Kuang, Elizaveta Lavrova, Hamza Khan, Karim Lekadir, Alex Zwanenburg, Joseph Deasy, Maciej Bobowicz, Luis Marti-Bonmati, Andrew Maidment, Michel Dumontier, Paul E. Kinahan, J. Martijn Nobel, Sina Amirrajab, Zohaib Salahuddin
Publié dans: Nature Reviews Clinical Oncology, Numéro 22, 2025, ISSN 1759-4774
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41571-025-01067-1

AI for life: Trends in artificial intelligence for biotechnology

Auteurs: Andreas Holzinger, Katharina Keiblinger, Petr Holub, Kurt Zatloukal, Heimo Müller
Publié dans: New Biotechnology, Numéro 74, 2023, ISSN 1871-6784
Éditeur: Elsevier BV
DOI: 10.1016/J.NBT.2023.02.001

AI for life: Trends in artificial intelligence for biotechnology

Auteurs: Holzinger A, Keiblinger K, Holub P, Zatloukal K, Müller H.
Publié dans: New Biotechnology, 2023, ISSN 1871-6784
Éditeur: Elsevier
DOI: 10.1016/J.NBT.2023.02.001

Artificial intelligence based data curation: enabling a patient-centric European health data space

Auteurs: Isabelle de Zegher; Kerli Norak; Kerli Norak; Dominik Steiger; Heimo Müller; Dipak Kalra; Bart Scheenstra; Isabella Cina; Stefan Schulz; Stefan Schulz; Kanimozhi Uma; Petros Kalendralis; Eno-Martin Lotman; Martin Benedikt; Michel Dumontier; Remzi Celebi
Publié dans: Frontiers in Medicine, 2024, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/FMED.2024.1365501

Reply to ‘Radiomics Quality Score 2.0: what changed from version 1.0 and why it matters’

Auteurs: Philippe Lambin, Zohaib Salahuddin
Publié dans: Nature Reviews Clinical Oncology, Numéro 23, 2025, ISSN 1759-4774
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41571-025-01096-W

Toward human-level concept learning: Pattern benchmarking for AI algorithms

Auteurs: Holzinger A, Saranti A, Angerschmid A, Finzel B, Schmid U, Mueller H
Publié dans: Patterns, 2023, ISSN 2666-3899
Éditeur: Cell Press Elsevier Inc.
DOI: 10.1016/j.patter.2023.100788

SynthMedic: Utilizing large language models for synthetic discharge summary generation, correction and validation

Auteurs: Georgi Grazhdanski, Vasil Vasilev, Sylvia Vassileva, Dimitar Taskov, Izabel Antova, Ivan Koychev, Svetla Boytcheva
Publié dans: Journal of Biomedical Informatics, Numéro 170, 2026, ISSN 1532-0464
Éditeur: Elsevier BV
DOI: 10.1016/J.JBI.2025.104906

An AI-powered data curation and publishing virtual assistant: usability and explainability/causability of, and patient interest in the first-generation prototype

Auteurs: Rutger van Mierlo, Wenjie Liang, Kerli Norak, Michaela Kargl, Mall Maasik, Anne-Lore Bynens, Markus Plass, Markus Kreuzthaler, Martin Benedikt, Laura Hochstenbach, Arnoud van 't Hof, Remzi Celebi, Andre Dekker, Isabelle de Zegher, Petros Kalendralis, null null
Publié dans: Frontiers in Digital Health, Numéro 7, 2025, ISSN 2673-253X
Éditeur: Frontiers Media SA
DOI: 10.3389/FDGTH.2025.1629413

PLoS ONE

Auteurs: Mali, Shruti Atul; Rad, Nastaran Mohammadian; Woodruff, Henry C.; Depeursinge, Adrien; Andrearczyk, Vincent; Lambin, Philippe
Publié dans: PLOS One, 2025, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/JOURNAL.PONE.0322365

Combining Deep Learning and Handcrafted Radiomics for Classification of Suspicious Lesions on Contrast-enhanced Mammograms

Auteurs: Manon P. L. Beuque, Marc B. I. Lobbes, Yvonka van Wijk, Yousif Widaatalla, Sergey Primakov, Michael Majer, Corinne Balleyguier, Henry C. Woodruff, Philippe Lambin
Publié dans: Radiology, Numéro 307, 2023, ISSN 0033-8419
Éditeur: Radiological Society of North America (RSNA)
DOI: 10.1148/RADIOL.221843

Leveraging hand-crafted radiomics on multicenter FLAIR MRI for predicting disability worsening in people with multiple sclerosis

Auteurs: Hamza Khan, Henry C. Woodruff, Diana L. Giraldo, Lorin Werthen-Brabants, Shruti Atul Mali, Sina Amirrajab, Edward De Brouwer, Veronica Popescu, Bart Van Wijmeersch, Oliver Gerlach, Jan Sijbers, Liesbet M. Peeters, Philippe Lambin
Publié dans: Frontiers in Neuroscience, Numéro 19, 2025, ISSN 1662-453X
Éditeur: Frontiers Media SA
DOI: 10.3389/FNINS.2025.1610401

Knowledge graph embedding and alignment of incomplete electronic health records for critical care applications

Auteurs: Shervin Mehryar, Michel Dumontier
Publié dans: Journal of Biomedical Semantics, Numéro 17, 2026, ISSN 2041-1480
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13326-026-00351-Y

Disambiguation of acronyms in clinical narratives with large language models

Auteurs: Amila Kugic; Stefan Schulz; Markus Kreuzthaler
Publié dans: Journal of the American Medical Informatics Association, 2024, ISSN 1527-974X
Éditeur: Oxford University Press
DOI: 10.1093/JAMIA/OCAE157

Deep Learning of Multimodal Ultrasound: Stratifying the Response to Neoadjuvant Chemotherapy in Breast Cancer Before Treatment

Auteurs: Gu J, Zhong X, Fang C, Lou W, Fu P, Woodruff HC, Wang B, Jiang T, Lambin P.
Publié dans: The Oncologist, 2024, ISSN 1083-7159
Éditeur: Oxford University Press
DOI: 10.1093/oncolo/oyad227

Generating Explanations in Medical Question-Answering by Expectation Maximization Inference over Evidence

Auteurs: Wei Sun, Mingxiao Li, Damien Sileo, Jesse Davis, Marie-Francine Moens
Publié dans: ACM Transactions on Computing for Healthcare, Numéro 6, 2025, ISSN 2637-8051
Éditeur: Association for Computing Machinery (ACM)
DOI: 10.1145/3712296

Impact of synthetic data on training a deep learning model for lesion detection and classification in contrast-enhanced mammography

Auteurs: Astrid Van Camp, Henry C. Woodruff, Lesley Cockmartin, Marc Lobbes, Michael Majer, Corinne Balleyguier, Nicholas W. Marshall, Hilde Bosmans, Philippe Lambin
Publié dans: Journal of Medical Imaging, Numéro 12, 2025, ISSN 2329-4302
Éditeur: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JMI.12.S2.S22006

An automated toolbox for microcalcification cluster modeling for mammographic imaging

Auteurs: Astrid Van Camp, Eva Punter, Katrien Houbrechts, Lesley Cockmartin, Renate Prevos, Nicholas W. Marshall, Henry C. Woodruff, Philippe Lambin, Hilde Bosmans
Publié dans: Medical Physics, Numéro 52, 2025, ISSN 0094-2405
Éditeur: Wiley
DOI: 10.1002/MP.17521

Generating Explanations in Medical Question-Answering by Expectation Maximization Inference over Evidence

Auteurs: Wei Sun, Mingxiao Li, Damien Sileo, Jesse Davis, Marie-Francine Moens
Publié dans: ACM Transactions on Computing for Healthcare, Numéro 6, 2025, ISSN 2637-8051
Éditeur: Association for Computing Machinery (ACM)
DOI: 10.1145/3712296

Assessing Data Quality in Heterogeneous Health Care Integration: Simulation Study of the AIDAVA Framework

Auteurs: Jens Declerck, Ömer Durukan Kılıç, Ensar Emir Erol, Shervin Mehryar, Dipak Kalra, Isabelle de Zegher, Remzi Celebi
Publié dans: JMIR Medical Informatics, Numéro 13, 2026, ISSN 2291-9694
Éditeur: JMIR Publications Inc.
DOI: 10.2196/75275

Imaging the hallmarks of cancer

Auteurs: Jan Grimm, Fabian Kiessling, Kevin M. Brindle, Douglas Hanahan, Sanjay K. Jain, Philippe Lambin, Twan Lammers, King C. Li, I. Jolanda M. de Vries, Wolfgang A. Weber, Bettina Weigelin, Bernd J. Pichler
Publié dans: Nature Reviews Cancer, Numéro 26, 2026, ISSN 1474-175X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41568-026-00950-Y

A pre-trained foundation model framework for multiplanar MRI classification of extramural vascular invasion and mesorectal fascia invasion in rectal cancer

Auteurs: Yumeng Zhang, Shruti Atul Mali, Danial Khan, Sina Amirrajab, Eduardo Ibor-Crespo, Ana Jimenez-Pastor, Gloria Ribas, Silvia Flor-Arnal, Marta Zerunian, Christophe Aubé, Luis Martí-Bonmatí, Zohaib Salahuddin, Philippe Lambin
Publié dans: Insights into Imaging, Numéro 17, 2026, ISSN 1869-4101
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13244-026-02296-3

FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare

Auteurs: Lekadir, Karim; Feragen, Aasa; Fofanah, Abdul Joseph; Frangi, Alejandro F; Buyx, Alena; Emelie, Anais; Lara, Andrea; Porras, Antonio R; Chan, An-Wen; Navarro, Arcadi; Glocker, Ben; Botwe, Benard O; Khanal, Bishesh; Beger, Brigit; Wu, Carol C; Cintas, Celia; Langlotz, Curtis P; Rueckert, Daniel; Mzurikwao, Deogratias; Fotiadis, Dimitrios I; Zhussupov, Doszhan; Ferrante, Enzo; Meijering, Erik; Weicken, Eva; González, Fabio A; Asselbergs, Folkert W; Prior, Fred; Krestin, Gabriel P; Collins, Gary; Tegenaw, Geletaw S; Kaissis, Georgios; Misuraca, Gianluca; Tsakou, Gianna; Dwivedi, Girish; Kondylakis, Haridimos; Jayakody, Harsha; Woodruf, Henry C; Mayer, Horst Joachim; Aerts, Hugo JWL; Walsh, Ian; Chouvarda, Ioanna; Buvat, Irène; Tributsch, Isabell; Rekik, Islem; Duncan, James; Kalpathy-Cramer, Jayashree; Zahir, Jihad; Park, Jinah; Mongan, John; Gichoya, Judy W; Schnabel, Julia A; Kushibar, Kaisar; Riklund, Katrine; Mori, Kensaku; Marias, Kostas; Amugongo, Lameck M; Fromont, Lauren A; Maier-Hein, Lena; Alberich, Leonor Cerdá; Rittner, Leticia; Phiri, Lighton; Marrakchi-Kacem, Linda; Donoso-Bach, Lluís; Martí-Bonmatí, Luis; Cardoso, M Jorge; Bobowicz, Maciej; Shabani, Mahsa; Tsiknakis, Manolis; Zuluaga, Maria A; Bielikova, Maria; Fritzsche, Marie-Christine; Camacho, Marina; Linguraru, Marius George; Wenzel, Markus; De Bruijne, Marleen; Tolsgaard, Martin G; Ghassemi, Marzyeh; Ashrafuzzaman, Md; Goisauf, Melanie; Yaqub, Mohammad; Abadía, Mónica Cano; Mahmoud, Mukhtar M E; Elattar, Mustafa; Rieke, Nicola; Papanikolaou, Nikolaos; Lazrak, Noussair; Díaz, Oliver; Salvado, Olivier; Pujol, Oriol; Sall, Ousmane; Guevara, Pamela; Gordebeke, Peter; Lambin, Philippe; Brown, Pieta; Abolmaesumi, Purang; Dou, Qi; Lu, Qinghua; Osuala, Richard; Nakasi, Rose; Zhou, S Kevin; Napel, Sandy; Colantonio, Sara; Albarqouni, Shadi; Joshi, Smriti; Carter, Stacy; Klein, Stefan; Petersen, Steffen E; Aussó, Susanna; Awate, Suyash; Raviv, Tammy Riklin; Cook, Tessa; Mutsvangwa, Tinashe E M; Rogers, Wendy A; Niessen, Wiro J; Puig-Bosch, Xènia; Zeng, Yi; Mohammed, Yunusa G; Aquino, Yves Saint James; Salahuddin, Zohaib; Starmans, Martijn P A
Publié dans: BMJ, 2025, ISSN 0007-1447
Éditeur: BMJ Publishing Group
DOI: 10.48550/ARXIV.2309.12325

Improving Heart-Failure Predictive Tasks with Patient Health Knowledge Graphs and Sequential Graph Neural Networks

Auteurs: Shervin Mehryar, Michel Dumontier
Publié dans: Electronics, Numéro 15, 2026, ISSN 2079-9292
Éditeur: MDPI AG
DOI: 10.3390/ELECTRONICS15102189

Cancers

Auteurs: Yousif Widaatalla; Tom Wolswijk; Muhammad Danial Khan; Iva Halilaj; Klara Mosterd; Henry C. Woodruff; Philippe Lambin
Publié dans: Cancers, 2025, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS17050768

Predicting homologous recombination deficiency and treatment responses using a computed tomography-based foundation model: a preclinical study

Auteurs: Sheng Kuang, Lesley Schuitmaker, Min Wu, Zohaib Salahuddin, Alexander van der Wiel, Jella van de Laak, Natasja Lieuwes, Rianne Biemans, Jennifer Jung, Ala Yaromina, Ludwig J. Dubois, Henry C. Woodruff, Philippe Lambin
Publié dans: npj Precision Oncology, Numéro 10, 2026, ISSN 2397-768X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41698-026-01322-3

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 ^th immunorad conference

Auteurs: Pierre-Antoine Laurent; Fabrice André; Alexandre Bobard; Desiree Deandreis; Sandra Demaria; Stephane Depil; Stefan B. Eichmüller; Cristian Fernandez-Palomo; Floris Foijer; Lorenzo Galluzzi; Jérôme Galon; Matthias Guckenberger; Kevin J. Harrington; Fernanda G. Herrera; Peter E. Huber; Antoine Italiano; Sana D. Karam; Guido Kroemer; Philippe Lambin; Carola Leuschner; Alberto Mantovani; Etienne Meylan; Michele Mondini; Mikael J. Pittet; Jean-Pierre Pouget; Jordi Remon; Claus S. Sørensen; Christos Sotiriou; Claire Vanpouille-Box; Ralph R. Weichselbaum; James W. Welsh; Laurence Zitvogel; Silvia C. Formenti; Eric Deutsch
Publié dans: OncoImmunology, 2024, ISSN 2162-402X
Éditeur: Taylor and Francis Ltd.
DOI: 10.48620/84672

Book chapters (1)

Kommunikationsfähigkeit und Interoperabilität von Gesundheitsdaten in einem vernetzten Gesundheitssystem

Auteurs: Philipp Daumke, Christian Haverkamp, Simone Heckmann, Marcus Kuper, Annett Müller, Frank Oemig, Uta Ripperger, Stefan Sabutsch, André Sander & Stefan Schulz
Publié dans: Health Data Management, 2024
Éditeur: Springer Gabler, Wiesbaden
DOI: 10.1007/978-3-658-43236-2_41

Conference proceedings (15)

Language Fusion for Parameter-Efficient Cross-lingual Transfer

Auteurs: Philipp Borchert, Ivan Vulić, Marie-Francine Moens, Jochen De Weerdt
Publié dans: Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2025
Éditeur: Association for Computational Linguistics
DOI: 10.18653/V1/2025.ACL-LONG.1255

SULO – a simplified upper-level ontology

Auteurs: Dumontier, Michel; Çelebi, Remzi; Gilani, Komal; de Zegher, Isabelle; Serafimova, Katerina; Costa, Catalina Martínez; Schulz, Stefan
Publié dans: CEUR Workshop Proceedings, Numéro 4176, 2025
Éditeur: CEUR-WS

Towards Explainability in Automated Medical Code Prediction from Clinical Records

Auteurs: Kanimozhi Uma, Sumam Francis, Wei Sun, Marie-Francine Moens
Publié dans: Lecture Notes in Networks and Systems, Intelligent Systems and Applications, 2024
Éditeur: Springer, Cham
DOI: 10.1007/978-3-031-47718-8_40

Simulated image-specific microcalcification clusters and associated mass enhancement to enhance training of a deep learning model for cancer detection in contrast-enhanced mammography

Auteurs: Astrid Van Camp, Henry C. Woodruff, Lesley Cockmartin, Nicholas W. Marshall, Hilde Bosmans, Philippe Lambin
Publié dans: 17th International Workshop on Breast Imaging (IWBI 2024), 2024
Éditeur: SPIE
DOI: 10.1117/12.3026879

Toward a Unified Framework for Realizable Entities: Dispositions, Plans, and Beyond

Auteurs: Schulz, Stefan; Dumontier, Michel; Çelebi, Remzi; Serafimova, Katerina; Costa, Catalina Martínez
Publié dans: CEUR Workshop Proceedings, Numéro 4176, 2025
Éditeur: CEUR-WS

Masking Language Model Mechanism with Event-Driven Knowledge Graphs for Temporal Relations Extraction from Clinical Narratives

Auteurs: Kanimozhi Uma, Sumam Francis, Marie-Francine Moens
Publié dans: Studies in Computational Intelligence, Complex Networks & Their Applications XII, 2024
Éditeur: Springer, Cham
DOI: 10.1007/978-3-031-53468-3_14

A two-method framework for aligning medical terminologies

Auteurs: Ostaszewski, Stan; Kılıç, Ömer Durukan; Erol, Ensar Emir; Dumontier, Michel; Celebi, Remzi
Publié dans: CEUR Workshop Proceedings, ISSN 1613-0073
Éditeur: CEUR-WS.org

Towards principles of ontology-based annotation of clinical narratives

Auteurs: Schulz S, Del-Pinto W, Han L, Kreuzthaler M, Aghaei S, Nenadic G
Publié dans: 2023, ISSN 1613-0073
Éditeur: CEUR-WS

Simulated image-specific microcalcification clusters and associated mass enhancement to enhance training of a deep learning model for cancer detection in contrast-enhanced mammography

Auteurs: Astrid Van Camp, Henry C. Woodruff, Lesley Cockmartin, Nicholas W. Marshall, Hilde Bosmans, Philippe Lambin
Publié dans: 17th International Workshop on Breast Imaging (IWBI 2024), 2024
Éditeur: SPIE
DOI: 10.1117/12.3026879

Mitigating Negative Interference in Multilingual Knowledge Editing through Null-Space Constraints

Auteurs: Wei Sun, Tingyu Qu, Mingxiao Li, Jesse Davis, Marie-Francine Moens
Publié dans: Findings of the Association for Computational Linguistics: ACL 2025, 2025
Éditeur: Association for Computational Linguistics
DOI: 10.18653/V1/2025.FINDINGS-ACL.460

Biomedical Ontology Matching using Relational Graph Neural Networks and RDFs Meta-Path Rules

Auteurs: Mehryar, Shervin; Loesch, Julie; Pinckers, Emma; van den Akker, Alan; Damoiseaux, Yannick; Stavrinopoulos, Athanasios; Prianikov, Nikola; Celebi, Remzi
Publié dans: CEUR Workshop Proceedings, Numéro 4196, 2025
Éditeur: CEUR-WS

Unraveling Clinical Insights: A Lightweight and Interpretable Approach for Multimodal and Multilingual Knowledge Integration

Auteurs: Uma, Kanimozhi ; Moens, Marie Francine
Publié dans: Proceedings of the First Workshop on Patient-Oriented Language Processing (CL4Health)@ LREC-COLING 2024, 2024
Éditeur: European Language Resources Association (ELRA)

Semantic Annotation of Tabular Data for Machine-to-Machine Interoperability via Neuro-Symbolic Anchoring

Auteurs: Mehryar S, Celebi R
Publié dans: 2023, ISSN 1613-0073
Éditeur: CEUR-WS

Weakly-supervised Argument Mining with Boundary Refinement and Relation Denoising

Auteurs: Wei Sun, Mingxiao Li, Jesse Davis, Elena Cabrio, Serena Villata, Marie-Francine Moens
Publié dans: Proceedings of the Ninth Fact Extraction and VERification Workshop (FEVER), 2026
Éditeur: Association for Computational Linguistics
DOI: 10.18653/V1/2026.FEVER-1.1

A Resolution-Alignment-Completeness System for Diagnosis Code Imputation in Clinical Knowledge Graphs

Auteurs: Mehryar, Shervin; Erten, Özge; Asamov, Tsvetan; Boytcheva, Svetla; Çelebi, Remzi
Publié dans: CEUR Workshop Proceedings, Numéro 4196, 2025
Éditeur: CEUR-WS