AI powered Data Curation & Publishing Virtual Assistant

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Communication Toolkit
Report from user survey with personas canva
Description of use cases
Update of Report on dissemination and communication activities 1
Definition on data quality & performance metrics
Report on dissemination and communication activities
Update of Business requirements (D1.3) for G2

Update of Business requirements (D1.3) for G2

Business requirements for R1

Business requirements for G!

Update of Report (D1.2) from user survey with personas canvas
Definition of assessment study including test scenarios & metrics, and study initiation package

Report 2 from external Ethics Advisory Board

Report 1 from external Ethics Advisory Board (including names and CVs of member)
Information governance framework and instruments
Regulatory conformance analysis of the AI development pipeline
Data Management Plan

Update to Annotation guidelines, tools & training
Annotation guidelines, tools & training
G1 of the AIDAVA prototype
Solution Design Document for G1
Global Data Sharing Standard
VA architecture (Application and Technical)
Update of Solution Design Document (D2.3) for G2

Audio-visual material
Public project website

Pubblicazioni

Improving Patient Engagement in Phase 2 Clinical Trials With a Trial-Specific Patient Decision Aid: Development and Usability Study

Autori: Iva Halilaj, Relinde Lieverse, Cary Oberije, Lizza Hendriks, Charlotte Billiet, Ines Joye, Brice Van Eeckhout, Anke Wind, Anshu Ankolekar, Philippe Lambin
Pubblicato in: Journal of Medical Internet Research, Numero 27, 2025, ISSN 1438-8871
Editore: JMIR Publications Inc.
DOI: 10.2196/71817

Radiomics Quality Score 2.0: towards radiomics readiness levels and clinical translation for personalized medicine

Autori: Philippe Lambin, Henry C. Woodruff, Shruti Atul Mali, Xian Zhong, Sheng Kuang, Elizaveta Lavrova, Hamza Khan, Karim Lekadir, Alex Zwanenburg, Joseph Deasy, Maciej Bobowicz, Luis Marti-Bonmati, Andrew Maidment, Michel Dumontier, Paul E. Kinahan, J. Martijn Nobel, Sina Amirrajab, Zohaib Salahuddin
Pubblicato in: Nature Reviews Clinical Oncology, Numero 22, 2025, ISSN 1759-4774
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41571-025-01067-1

AI for life: Trends in artificial intelligence for biotechnology

Autori: Andreas Holzinger, Katharina Keiblinger, Petr Holub, Kurt Zatloukal, Heimo Müller
Pubblicato in: New Biotechnology, Numero 74, 2023, ISSN 1871-6784
Editore: Elsevier BV
DOI: 10.1016/J.NBT.2023.02.001

AI for life: Trends in artificial intelligence for biotechnology

Autori: Holzinger A, Keiblinger K, Holub P, Zatloukal K, Müller H.
Pubblicato in: New Biotechnology, 2023, ISSN 1871-6784
Editore: Elsevier
DOI: 10.1016/J.NBT.2023.02.001

Artificial intelligence based data curation: enabling a patient-centric European health data space

Autori: Isabelle de Zegher; Kerli Norak; Kerli Norak; Dominik Steiger; Heimo Müller; Dipak Kalra; Bart Scheenstra; Isabella Cina; Stefan Schulz; Stefan Schulz; Kanimozhi Uma; Petros Kalendralis; Eno-Martin Lotman; Martin Benedikt; Michel Dumontier; Remzi Celebi
Pubblicato in: Frontiers in Medicine, 2024, ISSN 2296-858X
Editore: Frontiers Media SA
DOI: 10.3389/FMED.2024.1365501

Reply to ‘Radiomics Quality Score 2.0: what changed from version 1.0 and why it matters’

Autori: Philippe Lambin, Zohaib Salahuddin
Pubblicato in: Nature Reviews Clinical Oncology, Numero 23, 2025, ISSN 1759-4774
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41571-025-01096-W

Toward human-level concept learning: Pattern benchmarking for AI algorithms

Autori: Holzinger A, Saranti A, Angerschmid A, Finzel B, Schmid U, Mueller H
Pubblicato in: Patterns, 2023, ISSN 2666-3899
Editore: Cell Press Elsevier Inc.
DOI: 10.1016/j.patter.2023.100788

SynthMedic: Utilizing large language models for synthetic discharge summary generation, correction and validation

Autori: Georgi Grazhdanski, Vasil Vasilev, Sylvia Vassileva, Dimitar Taskov, Izabel Antova, Ivan Koychev, Svetla Boytcheva
Pubblicato in: Journal of Biomedical Informatics, Numero 170, 2026, ISSN 1532-0464
Editore: Elsevier BV
DOI: 10.1016/J.JBI.2025.104906

An AI-powered data curation and publishing virtual assistant: usability and explainability/causability of, and patient interest in the first-generation prototype

Autori: Rutger van Mierlo, Wenjie Liang, Kerli Norak, Michaela Kargl, Mall Maasik, Anne-Lore Bynens, Markus Plass, Markus Kreuzthaler, Martin Benedikt, Laura Hochstenbach, Arnoud van 't Hof, Remzi Celebi, Andre Dekker, Isabelle de Zegher, Petros Kalendralis, null null
Pubblicato in: Frontiers in Digital Health, Numero 7, 2025, ISSN 2673-253X
Editore: Frontiers Media SA
DOI: 10.3389/FDGTH.2025.1629413

PLoS ONE

Autori: Mali, Shruti Atul; Rad, Nastaran Mohammadian; Woodruff, Henry C.; Depeursinge, Adrien; Andrearczyk, Vincent; Lambin, Philippe
Pubblicato in: PLOS One, 2025, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/JOURNAL.PONE.0322365

Combining Deep Learning and Handcrafted Radiomics for Classification of Suspicious Lesions on Contrast-enhanced Mammograms

Autori: Manon P. L. Beuque, Marc B. I. Lobbes, Yvonka van Wijk, Yousif Widaatalla, Sergey Primakov, Michael Majer, Corinne Balleyguier, Henry C. Woodruff, Philippe Lambin
Pubblicato in: Radiology, Numero 307, 2023, ISSN 0033-8419
Editore: Radiological Society of North America (RSNA)
DOI: 10.1148/RADIOL.221843

Leveraging hand-crafted radiomics on multicenter FLAIR MRI for predicting disability worsening in people with multiple sclerosis

Autori: Hamza Khan, Henry C. Woodruff, Diana L. Giraldo, Lorin Werthen-Brabants, Shruti Atul Mali, Sina Amirrajab, Edward De Brouwer, Veronica Popescu, Bart Van Wijmeersch, Oliver Gerlach, Jan Sijbers, Liesbet M. Peeters, Philippe Lambin
Pubblicato in: Frontiers in Neuroscience, Numero 19, 2025, ISSN 1662-453X
Editore: Frontiers Media SA
DOI: 10.3389/FNINS.2025.1610401

Knowledge graph embedding and alignment of incomplete electronic health records for critical care applications

Autori: Shervin Mehryar, Michel Dumontier
Pubblicato in: Journal of Biomedical Semantics, Numero 17, 2026, ISSN 2041-1480
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13326-026-00351-Y

Disambiguation of acronyms in clinical narratives with large language models

Autori: Amila Kugic; Stefan Schulz; Markus Kreuzthaler
Pubblicato in: Journal of the American Medical Informatics Association, 2024, ISSN 1527-974X
Editore: Oxford University Press
DOI: 10.1093/JAMIA/OCAE157

Deep Learning of Multimodal Ultrasound: Stratifying the Response to Neoadjuvant Chemotherapy in Breast Cancer Before Treatment

Autori: Gu J, Zhong X, Fang C, Lou W, Fu P, Woodruff HC, Wang B, Jiang T, Lambin P.
Pubblicato in: The Oncologist, 2024, ISSN 1083-7159
Editore: Oxford University Press
DOI: 10.1093/oncolo/oyad227

Generating Explanations in Medical Question-Answering by Expectation Maximization Inference over Evidence

Autori: Wei Sun, Mingxiao Li, Damien Sileo, Jesse Davis, Marie-Francine Moens
Pubblicato in: ACM Transactions on Computing for Healthcare, Numero 6, 2025, ISSN 2637-8051
Editore: Association for Computing Machinery (ACM)
DOI: 10.1145/3712296

Impact of synthetic data on training a deep learning model for lesion detection and classification in contrast-enhanced mammography

Autori: Astrid Van Camp, Henry C. Woodruff, Lesley Cockmartin, Marc Lobbes, Michael Majer, Corinne Balleyguier, Nicholas W. Marshall, Hilde Bosmans, Philippe Lambin
Pubblicato in: Journal of Medical Imaging, Numero 12, 2025, ISSN 2329-4302
Editore: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JMI.12.S2.S22006

An automated toolbox for microcalcification cluster modeling for mammographic imaging

Autori: Astrid Van Camp, Eva Punter, Katrien Houbrechts, Lesley Cockmartin, Renate Prevos, Nicholas W. Marshall, Henry C. Woodruff, Philippe Lambin, Hilde Bosmans
Pubblicato in: Medical Physics, Numero 52, 2025, ISSN 0094-2405
Editore: Wiley
DOI: 10.1002/MP.17521

Generating Explanations in Medical Question-Answering by Expectation Maximization Inference over Evidence

Assessing Data Quality in Heterogeneous Health Care Integration: Simulation Study of the AIDAVA Framework

Autori: Jens Declerck, Ömer Durukan Kılıç, Ensar Emir Erol, Shervin Mehryar, Dipak Kalra, Isabelle de Zegher, Remzi Celebi
Pubblicato in: JMIR Medical Informatics, Numero 13, 2026, ISSN 2291-9694
Editore: JMIR Publications Inc.
DOI: 10.2196/75275

Imaging the hallmarks of cancer

Autori: Jan Grimm, Fabian Kiessling, Kevin M. Brindle, Douglas Hanahan, Sanjay K. Jain, Philippe Lambin, Twan Lammers, King C. Li, I. Jolanda M. de Vries, Wolfgang A. Weber, Bettina Weigelin, Bernd J. Pichler
Pubblicato in: Nature Reviews Cancer, Numero 26, 2026, ISSN 1474-175X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41568-026-00950-Y

A pre-trained foundation model framework for multiplanar MRI classification of extramural vascular invasion and mesorectal fascia invasion in rectal cancer

Autori: Yumeng Zhang, Shruti Atul Mali, Danial Khan, Sina Amirrajab, Eduardo Ibor-Crespo, Ana Jimenez-Pastor, Gloria Ribas, Silvia Flor-Arnal, Marta Zerunian, Christophe Aubé, Luis Martí-Bonmatí, Zohaib Salahuddin, Philippe Lambin
Pubblicato in: Insights into Imaging, Numero 17, 2026, ISSN 1869-4101
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13244-026-02296-3

FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare

Autori: Lekadir, Karim; Feragen, Aasa; Fofanah, Abdul Joseph; Frangi, Alejandro F; Buyx, Alena; Emelie, Anais; Lara, Andrea; Porras, Antonio R; Chan, An-Wen; Navarro, Arcadi; Glocker, Ben; Botwe, Benard O; Khanal, Bishesh; Beger, Brigit; Wu, Carol C; Cintas, Celia; Langlotz, Curtis P; Rueckert, Daniel; Mzurikwao, Deogratias; Fotiadis, Dimitrios I; Zhussupov, Doszhan; Ferrante, Enzo; Meijering, Erik; Weicken, Eva; González, Fabio A; Asselbergs, Folkert W; Prior, Fred; Krestin, Gabriel P; Collins, Gary; Tegenaw, Geletaw S; Kaissis, Georgios; Misuraca, Gianluca; Tsakou, Gianna; Dwivedi, Girish; Kondylakis, Haridimos; Jayakody, Harsha; Woodruf, Henry C; Mayer, Horst Joachim; Aerts, Hugo JWL; Walsh, Ian; Chouvarda, Ioanna; Buvat, Irène; Tributsch, Isabell; Rekik, Islem; Duncan, James; Kalpathy-Cramer, Jayashree; Zahir, Jihad; Park, Jinah; Mongan, John; Gichoya, Judy W; Schnabel, Julia A; Kushibar, Kaisar; Riklund, Katrine; Mori, Kensaku; Marias, Kostas; Amugongo, Lameck M; Fromont, Lauren A; Maier-Hein, Lena; Alberich, Leonor Cerdá; Rittner, Leticia; Phiri, Lighton; Marrakchi-Kacem, Linda; Donoso-Bach, Lluís; Martí-Bonmatí, Luis; Cardoso, M Jorge; Bobowicz, Maciej; Shabani, Mahsa; Tsiknakis, Manolis; Zuluaga, Maria A; Bielikova, Maria; Fritzsche, Marie-Christine; Camacho, Marina; Linguraru, Marius George; Wenzel, Markus; De Bruijne, Marleen; Tolsgaard, Martin G; Ghassemi, Marzyeh; Ashrafuzzaman, Md; Goisauf, Melanie; Yaqub, Mohammad; Abadía, Mónica Cano; Mahmoud, Mukhtar M E; Elattar, Mustafa; Rieke, Nicola; Papanikolaou, Nikolaos; Lazrak, Noussair; Díaz, Oliver; Salvado, Olivier; Pujol, Oriol; Sall, Ousmane; Guevara, Pamela; Gordebeke, Peter; Lambin, Philippe; Brown, Pieta; Abolmaesumi, Purang; Dou, Qi; Lu, Qinghua; Osuala, Richard; Nakasi, Rose; Zhou, S Kevin; Napel, Sandy; Colantonio, Sara; Albarqouni, Shadi; Joshi, Smriti; Carter, Stacy; Klein, Stefan; Petersen, Steffen E; Aussó, Susanna; Awate, Suyash; Raviv, Tammy Riklin; Cook, Tessa; Mutsvangwa, Tinashe E M; Rogers, Wendy A; Niessen, Wiro J; Puig-Bosch, Xènia; Zeng, Yi; Mohammed, Yunusa G; Aquino, Yves Saint James; Salahuddin, Zohaib; Starmans, Martijn P A
Pubblicato in: BMJ, 2025, ISSN 0007-1447
Editore: BMJ Publishing Group
DOI: 10.48550/ARXIV.2309.12325

Improving Heart-Failure Predictive Tasks with Patient Health Knowledge Graphs and Sequential Graph Neural Networks

Autori: Shervin Mehryar, Michel Dumontier
Pubblicato in: Electronics, Numero 15, 2026, ISSN 2079-9292
Editore: MDPI AG
DOI: 10.3390/ELECTRONICS15102189

Cancers

Autori: Yousif Widaatalla; Tom Wolswijk; Muhammad Danial Khan; Iva Halilaj; Klara Mosterd; Henry C. Woodruff; Philippe Lambin
Pubblicato in: Cancers, 2025, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/CANCERS17050768

Predicting homologous recombination deficiency and treatment responses using a computed tomography-based foundation model: a preclinical study

Autori: Sheng Kuang, Lesley Schuitmaker, Min Wu, Zohaib Salahuddin, Alexander van der Wiel, Jella van de Laak, Natasja Lieuwes, Rianne Biemans, Jennifer Jung, Ala Yaromina, Ludwig J. Dubois, Henry C. Woodruff, Philippe Lambin
Pubblicato in: npj Precision Oncology, Numero 10, 2026, ISSN 2397-768X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41698-026-01322-3

Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 <sup>th</sup> immunorad conference

Autori: Pierre-Antoine Laurent; Fabrice André; Alexandre Bobard; Desiree Deandreis; Sandra Demaria; Stephane Depil; Stefan B. Eichmüller; Cristian Fernandez-Palomo; Floris Foijer; Lorenzo Galluzzi; Jérôme Galon; Matthias Guckenberger; Kevin J. Harrington; Fernanda G. Herrera; Peter E. Huber; Antoine Italiano; Sana D. Karam; Guido Kroemer; Philippe Lambin; Carola Leuschner; Alberto Mantovani; Etienne Meylan; Michele Mondini; Mikael J. Pittet; Jean-Pierre Pouget; Jordi Remon; Claus S. Sørensen; Christos Sotiriou; Claire Vanpouille-Box; Ralph R. Weichselbaum; James W. Welsh; Laurence Zitvogel; Silvia C. Formenti; Eric Deutsch
Pubblicato in: OncoImmunology, 2024, ISSN 2162-402X
Editore: Taylor and Francis Ltd.
DOI: 10.48620/84672

Kommunikationsfähigkeit und Interoperabilität von Gesundheitsdaten in einem vernetzten Gesundheitssystem

Autori: Philipp Daumke, Christian Haverkamp, Simone Heckmann, Marcus Kuper, Annett Müller, Frank Oemig, Uta Ripperger, Stefan Sabutsch, André Sander & Stefan Schulz
Pubblicato in: Health Data Management, 2024
Editore: Springer Gabler, Wiesbaden
DOI: 10.1007/978-3-658-43236-2_41

Language Fusion for Parameter-Efficient Cross-lingual Transfer

Autori: Philipp Borchert, Ivan Vulić, Marie-Francine Moens, Jochen De Weerdt
Pubblicato in: Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2025
Editore: Association for Computational Linguistics
DOI: 10.18653/V1/2025.ACL-LONG.1255

SULO – a simplified upper-level ontology

Autori: Dumontier, Michel; Çelebi, Remzi; Gilani, Komal; de Zegher, Isabelle; Serafimova, Katerina; Costa, Catalina Martínez; Schulz, Stefan
Pubblicato in: CEUR Workshop Proceedings, Numero 4176, 2025
Editore: CEUR-WS

Towards Explainability in Automated Medical Code Prediction from Clinical Records

Autori: Kanimozhi Uma, Sumam Francis, Wei Sun, Marie-Francine Moens
Pubblicato in: Lecture Notes in Networks and Systems, Intelligent Systems and Applications, 2024
Editore: Springer, Cham
DOI: 10.1007/978-3-031-47718-8_40

Simulated image-specific microcalcification clusters and associated mass enhancement to enhance training of a deep learning model for cancer detection in contrast-enhanced mammography

Autori: Astrid Van Camp, Henry C. Woodruff, Lesley Cockmartin, Nicholas W. Marshall, Hilde Bosmans, Philippe Lambin
Pubblicato in: 17th International Workshop on Breast Imaging (IWBI 2024), 2024
Editore: SPIE
DOI: 10.1117/12.3026879

Toward a Unified Framework for Realizable Entities: Dispositions, Plans, and Beyond

Autori: Schulz, Stefan; Dumontier, Michel; Çelebi, Remzi; Serafimova, Katerina; Costa, Catalina Martínez
Pubblicato in: CEUR Workshop Proceedings, Numero 4176, 2025
Editore: CEUR-WS

Masking Language Model Mechanism with Event-Driven Knowledge Graphs for Temporal Relations Extraction from Clinical Narratives

Autori: Kanimozhi Uma, Sumam Francis, Marie-Francine Moens
Pubblicato in: Studies in Computational Intelligence, Complex Networks & Their Applications XII, 2024
Editore: Springer, Cham
DOI: 10.1007/978-3-031-53468-3_14

A two-method framework for aligning medical terminologies

Autori: Ostaszewski, Stan; Kılıç, Ömer Durukan; Erol, Ensar Emir; Dumontier, Michel; Celebi, Remzi
Pubblicato in: CEUR Workshop Proceedings, ISSN 1613-0073
Editore: CEUR-WS.org

Towards principles of ontology-based annotation of clinical narratives

Autori: Schulz S, Del-Pinto W, Han L, Kreuzthaler M, Aghaei S, Nenadic G
Pubblicato in: 2023, ISSN 1613-0073
Editore: CEUR-WS

Simulated image-specific microcalcification clusters and associated mass enhancement to enhance training of a deep learning model for cancer detection in contrast-enhanced mammography

Mitigating Negative Interference in Multilingual Knowledge Editing through Null-Space Constraints

Autori: Wei Sun, Tingyu Qu, Mingxiao Li, Jesse Davis, Marie-Francine Moens
Pubblicato in: Findings of the Association for Computational Linguistics: ACL 2025, 2025
Editore: Association for Computational Linguistics
DOI: 10.18653/V1/2025.FINDINGS-ACL.460

Biomedical Ontology Matching using Relational Graph Neural Networks and RDFs Meta-Path Rules

Autori: Mehryar, Shervin; Loesch, Julie; Pinckers, Emma; van den Akker, Alan; Damoiseaux, Yannick; Stavrinopoulos, Athanasios; Prianikov, Nikola; Celebi, Remzi
Pubblicato in: CEUR Workshop Proceedings, Numero 4196, 2025
Editore: CEUR-WS

Unraveling Clinical Insights: A Lightweight and Interpretable Approach for Multimodal and Multilingual Knowledge Integration

Autori: Uma, Kanimozhi ; Moens, Marie Francine
Pubblicato in: Proceedings of the First Workshop on Patient-Oriented Language Processing (CL4Health)@ LREC-COLING 2024, 2024
Editore: European Language Resources Association (ELRA)

Semantic Annotation of Tabular Data for Machine-to-Machine Interoperability via Neuro-Symbolic Anchoring

Autori: Mehryar S, Celebi R
Pubblicato in: 2023, ISSN 1613-0073
Editore: CEUR-WS

Weakly-supervised Argument Mining with Boundary Refinement and Relation Denoising

Autori: Wei Sun, Mingxiao Li, Jesse Davis, Elena Cabrio, Serena Villata, Marie-Francine Moens
Pubblicato in: Proceedings of the Ninth Fact Extraction and VERification Workshop (FEVER), 2026
Editore: Association for Computational Linguistics
DOI: 10.18653/V1/2026.FEVER-1.1

A Resolution-Alignment-Completeness System for Diagnosis Code Imputation in Clinical Knowledge Graphs

Autori: Mehryar, Shervin; Erten, Özge; Asamov, Tsvetan; Boytcheva, Svetla; Çelebi, Remzi
Pubblicato in: CEUR Workshop Proceedings, Numero 4196, 2025
Editore: CEUR-WS

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