The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

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Website with name, logo, project description, and partner information available, plus posting of recent advances and upcoming events online.

Clinical case reports from all affiliated centers treating Long-COVID patients

Provide clinical evidence and specification of patient cohort disease criteria.

Publications

International Journal of Molecular Sciences

Auteurs: Arora et al.
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Basel MDPI Center 2000-
DOI: 10.3390/ijms232214057

From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

Auteurs: Casanova & Abel
Publié dans: Cell, 2022, ISSN 1097-4172
Éditeur: Cell
DOI: 10.1016/j.cell.2022.07.004

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Auteurs: Zhang et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220131

Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage

Auteurs: Arora et al.
Publié dans: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Éditeur: The Lancet
DOI: 10.1016/S1473-3099(22)00831-3

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Auteurs: Bucciol et al.
Publié dans: Journal of Clinical Investigation, 2023, ISSN 1558-8238
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI168321

Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75

Auteurs: Arora et al.
Publié dans: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Éditeur: The Lancet
DOI: 10.1016/S1473-3099(22)00591-6

Pharmaceuticals

Auteurs: Centofanti et al.
Publié dans: Pharmaceuticals (Basel), 2024, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16020240

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Auteurs: Lee et al.
Publié dans: Science, 2022, ISSN 1095-9203
Éditeur: Science
DOI: 10.1126/science.abo3627

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Auteurs: Zhang et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220514

Pathogens

Auteurs: Skouboe et al.
Publié dans: Pathogens, 2022, ISSN 2076-0817
Éditeur: Basel MDPI AG 2012-
DOI: 10.3390/pathogens12020310

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

Auteurs: Budhadev et al.
Publié dans: JACS Au, 2023, ISSN 2691-3704
Éditeur: Washington, DC American Chemical Society [2021]-
DOI: 10.1021/jacsau.3c00163

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Auteurs: Tangye et al.
Publié dans: Journal of Allergy and Clinical Immunology, 2022, ISSN 2772-8293
Éditeur: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2022.11.010

Nature Communications

Auteurs: Hoffmann et al.
Publié dans: Nature Communications, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-39147-4

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

Auteurs: von Gunten et al.
Publié dans: Frontiers in Immunology, 2023, ISSN 2832-4404
Éditeur: Lausanne Frontiers Media S.A. 2010-
DOI: 10.48350/181810

Omicron sublineage BQ.1.1 resistance to monoclonal antibodies

Auteurs: Arora et al.
Publié dans: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Éditeur: The Lancet
DOI: 10.1016/S1473-3099(22)00733-2

The genetic and evolutionary determinants of COVID-19 susceptibility

Auteurs: Kerner et al.
Publié dans: European Journal of Human Genetics, 2022, ISSN 1476-5438
Éditeur: Nature
DOI: 10.1038/s41431-022-01141-7

COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients

Auteurs: Murdocca et al.
Publié dans: Viruses, 2023, ISSN 1999-4915
Éditeur: Basel MDPI 2009-
DOI: 10.3390/v15071417

Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α

Auteurs: Mathian et al.
Publié dans: Annals of the Rheumatic Diseases, 2022, ISSN 1468-2060
Éditeur: BMJ Group on behalf of the European League Against Rheumatism
DOI: 10.1136/ard-2022-222549

Viruses

Auteurs: Campos-Gonzalez et al.
Publié dans: Viruses, 2024, ISSN 1999-4915
Éditeur: Basel MDPI 2009-
DOI: 10.3390/v15030789

Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3

Auteurs: Zhang et al.
Publié dans: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Éditeur: Elsevier
DOI: 10.1016/S1473-3099(23)00547-9

Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children

Auteurs: Bucciol et al.
Publié dans: Journal of Allergy and Clinical Immunology, 2023, ISSN 2772-8293
Éditeur: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2023.02.003

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Auteurs: Sokal et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220258

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