The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

Informations projet

UNDINE

N° de convention de subvention: 101057100

DOI

10.3030/101057100

Date de signature de la CE 20 Mai 2022

Date de début 1 Juin 2022

Date de fin 31 Mai 2026

Financé au titre de

• Health

Coût total

€ 6 718 138,75

Contribution de l’UE

€ 6 718 138,75

Coordonné par

AARHUS UNIVERSITET
Denmark

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (6)

Dissemination activities for the project in relation to work package 3

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Consortium website established

Website with name, logo, project description, and partner information available, plus posting of recent advances and upcoming events online.

Dissemination activities for the project in relation to work package 5

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 7

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 4

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 6

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Data sets, microdata, etc (2)

Characterisation of ancestry, age, and sex effects on immune responses to SARS-CoV-2

Quantification of the respective contribution of intrinsic factors, together with previous exposure, to the diversity of the immune response following SARS-CoV-2 infection.

Provision of a database for a second set of prospectively included patients

Precise listing of numbers of patients and clinical data prospectively included within different disease categories from all partner institutions.

Other (1)

Postdoc projects completed

Status and verification of publication and communication output.

Documents, reports (1)

Clinical case reports from all affiliated centers treating Long-COVID patients

Provide clinical evidence and specification of patient cohort disease criteria.

Publications

Peer reviewed articles (73)

Inherited human RelB deficiency impairs innate and adaptive immunity to infection

Auteurs: Tom Le Voyer, Majistor Raj Luxman Maglorius Renkilaraj, Kunihiko Moriya, Malena Pérez Lorenzo, Tina Nguyen, Liwei Gao, Tamar Rubin, Axel Cederholm, Masato Ogishi, Carlos A. Arango-Franco, Vivien Béziat, Romain Lévy, Mélanie Migaud, Franck Rapaport, Yuval Itan, Elissa K. Deenick, Irene Cortese, Andrea Lisco, Kaan Boztug, Laurent Abel, Stéphanie Boisson-Dupuis, Bertrand Boisson, Patrick Frosk, Cindy S. Ma, Nils Landegren, Fatih Celmeli, Jean-Laurent Casanova, Stuart G. Tangye, Anne Puel
Publié dans: Proceedings of the National Academy of Sciences, Numéro 121, 2024, ISSN 0027-8424
Éditeur: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2321794121

International Journal of Molecular Sciences

Auteurs: Arora et al.
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Basel MDPI Center 2000-
DOI: 10.3390/ijms232214057

Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies

Auteurs: Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti
Publié dans: The Journal of Infectious Diseases, Numéro 231, 2025, ISSN 0022-1899
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE321

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

Auteurs: Maxime Rotival, Lluis Quintana-Murci
Publié dans: Genes & Immunity, Numéro 25, 2024, ISSN 1476-5470
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41435-023-00249-0

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Auteurs: Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, Chaturaka Rodrigo, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Francesca Conti, Irene Cassaniti, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Davide Mileto, Alessandro Mancon, Laurent Abel, Anne Puel, Aurélie Cobat, Charles M. Rice, Dániel Cadar, Jonas Schmidt-Chanasit, Johannes F. Scheid, Jacob E. Lemieux, Eric S. Rosenberg, Marianna Agudelo, Stuart G. Tangye, Alessandro Borghesi, Guillaume André Durand, Emilie Duburcq-Gury, Braulio M. Valencia, Andrew R. Lloyd, Anna Nagy, Margaret M. MacDonald, Yannick Simonin, Shen-Ying Zhang, Jean-Laurent Casanova
Publié dans: Journal of Experimental Medicine, Numéro 221, 2024, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20240942

Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2

Auteurs: Patrizia Malaspina, Carla Jodice, Bianca Maria Ciminelli, Michela Biancolella, Vito Luigi Colona, Andrea Latini, Francesca Leonardis, Paola Rogliani, Antonio Novelli, Giuseppe Novelli, Andrea Novelletto
Publié dans: Human Genomics, Numéro 19, 2025, ISSN 1479-7364
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S40246-025-00719-8

From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

Auteurs: Casanova & Abel
Publié dans: Cell, 2022, ISSN 1097-4172
Éditeur: Cell
DOI: 10.1016/j.cell.2022.07.004

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Auteurs: Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez, Marie Materna, Daniel C. Lin, Baptiste Milisavljevic, Fernanda Vianna, Lucy Bizien, Lazaro Lorenzo, Marc Lecuit, Jean-David Pommier, Sevgi Keles, Tayfun Ozcelik, Sigifredo Pedraza-Sanchez, Nicolas de Prost, Loubna El Zein, Hassan Hammoud, Lisa F.P. Ng, Rabih Halwani, Narjes Saheb Sharif-Askari, Yu Lung Lau, Anthony R. Tam, Neha Singh, Sagar Bhattad, Yackov Berkun, Wasun Chantratita, Raúl Aguilar-López, Mohammad Shahrooei, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Ana Bertha Alcántara-Garduño, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Bolze, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Sotiriјa Duvlis, Xavier Duval, Munis Dündar, Soha Fakhreddine, Jacques Fellay, Carlos Flores, José Luis Franco, Guy Gorochov, Peter K. Gregersen, David Hagin, Rabih Halwani, María Teresa Herrera, Ivan Fan-Ngai Hung, Emmanuelle Jouanguy, Yu-Lung Lau, Daniel Leung, Tom Le-voyer, Davood Mansouri, Jesús Mercado-García, Isabelle Meyts, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Satoshi Okada, Firat Ozcelik, Tayfun Ozcelik, Rebeca Perez de Diego, Jordi Perez-Tur, Graziano Pesole, Anne Puel, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Manal Sbeity, Sahar Sedighzadeh, Mohammad Shahrooei, Pere Soler-Palacín, András N. Spaan, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Ibrahim Torktaz, Sophie Trouillet-Assant, Stuart E. Turvey, Furkan Uddin, Fernanda Sales Luiz Vianna, Donald C. Vinh, Oscar Zabaleta-Martínez, Qian Zhang, Shen-Ying Zhang, Jean-Laurent Casanova, null null, Chanreaksmey Eng, Kimrong Bun, MengHeng Oum, Patrice Piola, Arnaud Tarantola, Mey Channa, Veasna Duong, Philippe Buchy, Chris Gorman, Jean-David Pommier, Yoann Crabol, Philippe Dussart, M. Bunleat, M. Panha, M.Kanarith Sim, Em Bunnakea, Denis Laurent, Heng Sothy, Ky Santy, Anousone Douangnouvong, Danoy Chommanam, Khansoudaphone Phakhounthong, Manivanh Vongsouvath, Malee Seephone, Bountoy Sibounheunang, Sayaphet Rattanavong, Viengmon Davong, Malavanh Vongsouvath, Mayfong Mayxay, Audrey Dubot-Pérès, Paul N. Newton, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Dang Duc Anh, Do Quyen, Tran Thi Mai Hung, Nguyen Thi Thu Thuy, Luong Minh Tan, Anh Tuan Pham, Nguyen Hien, Do Thu Huong, Le Thanh Hai, Nguyen Van Lam, Pham Nhat An, Phan Huu Phuc, Phung Bich Thuy, Tran Thi Thu Huong, Chaw Su Hlaing, Aye Mya Min Aye, Cho Thair, Kyaw Linn, May July, Win Thein, Latt Latt Kyaw, Htay Htay Tin, Ommar Swe Tin, Khin Yi Oo, Yoann Crabol, Magali Herrant, Magali Lago, Maud Seguy, Marc Jouan, Lukas Hafner, Philippe Pérot, Marc Eloit, Marc Lecuit, Olivier Lortholary, Julien Capelle, Bruno Rosset, Veronique Chevalier, Jérôme Honnorat, Anne Laurie Pinto, Auey Dubot-Peres, Xavier de Lamballerie, Kevin Bleakley, Bernadette Murgue, Catherine Ferrant, Christian Devaux, Hervé Tissot-Dupont, Jean-Paul Moatti, Mayfong Mayxay, Pascal Bonnet, Didier Fontenille, Jean-François Delfraissy, Patrice Debré, Benoit Durand, Laurent Abel, Paul Bastard, Emmanuelle Jouanguy, Vivien Béziat, Peng Zhang, Charles M. Rice, Aurélie Cobat, Shen-Ying Zhang, Paul J. Hertzog, Jean-Laurent Casanova, Qian Zhang
Publié dans: Journal of Experimental Medicine, Numéro 222, 2024, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20241413

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Auteurs: Zhang et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220131

The Microbe, the Infection Enigma, and the Host

Auteurs: Jean-Laurent Casanova, Laurent Abel
Publié dans: Annual Review of Microbiology, Numéro 78, 2024, ISSN 0066-4227
Éditeur: Annual Reviews
DOI: 10.1146/ANNUREV-MICRO-092123-022855

Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage

Auteurs: Arora et al.
Publié dans: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Éditeur: The Lancet
DOI: 10.1016/S1473-3099(22)00831-3

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Auteurs: Bucciol et al.
Publié dans: Journal of Clinical Investigation, 2023, ISSN 1558-8238
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI168321

Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75

Auteurs: Arora et al.
Publié dans: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Éditeur: The Lancet
DOI: 10.1016/S1473-3099(22)00591-6

A sensitive assay for measuring whole-blood responses to type I IFNs

Auteurs: Adrian Gervais, Corentin Le Floc’h, Tom Le Voyer, Lucy Bizien, Jonathan Bohlen, Fatih Celmeli, Fahd Al Qureshah, Cécile Masson, Jérémie Rosain, Marwa Chbihi, Romain Lévy, Riccardo Castagnoli, Anya Rothenbuhler, Emmanuelle Jouanguy, Qian Zhang, Shen-Ying Zhang, Vivien Béziat, Jacinta Bustamante, Anne Puel, Paul Bastard, Jean-Laurent Casanova
Publié dans: Proceedings of the National Academy of Sciences, Numéro 121, 2024, ISSN 0027-8424
Éditeur: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2402983121

Journal of Interferon and Cytokine Research

Auteurs: Vanker et al.
Publié dans: Journal of Interferon & Cytokine Research, 2023, ISSN 1079-9907
Éditeur: Journal of Interferon & Cytokine Research
DOI: 10.1089/jir.2023.0003

IL-7–dependent and –independent lineages of IL-7R–dependent human T cells

Auteurs: Carlos A. Arango-Franco, Masato Ogishi, Susanne Unger, Ottavia M. Delmonte, Julio César Orrego, Ahmad Yatim, Margarita M. Velasquez-Lopera, Andrés F. Zea-Vera, Jonathan Bohlen, Marwa Chbihi, Antoine Fayand, Juan Pablo Sánchez, Julian Rojas, Yoann Seeleuthner, Tom Le Voyer, Quentin Philippot, Kathryn J. Payne, Adrian Gervais, Lucia V. Erazo-Borrás, Luis A. Correa-Londoño, Axel Cederholm, Alejandro Gallón-Duque, Pedro Goncalves, Jean-Marc Doisne, Liran Horev, Bénédicte Charmeteau-de Muylder, Jesús Á. Álvarez, Diana M. Arboleda, Lizet Pérez-Zapata, Estefanía Vásquez-Echeverri, Marcela Moncada-Vélez, Juan A. López, Yolanda Caicedo, Boaz Palterer, Pablo J. Patiño, Carlos J. Montoya, Matthieu Chaldebas, Peng Zhang, Tina Nguyen, Cindy S. Ma, Mohamed Jeljeli, Juan F. Alzate, Felipe Cabarcas, Taushif Khan, Darawan Rinchai, Jean-Luc Prétet, Bertrand Boisson, Nico Marr, Ruba Ibrahim, Vered Molho-Pessach, Stéphanie Boisson-Dupuis, Dimitra Kiritsi, João T. Barata, Nils Landegren, Bénédicte Neven, Laurent Abel, Andrea Lisco, Vivien Béziat, Emmanuelle Jouanguy, Jacinta Bustamante, James P. Di Santo, Stuart G. Tangye, Luigi D. Notarangelo, Rémi Cheynier, Ken Natsuga, Andrés A. Arias, José Luis Franco, Klaus Warnatz, Jean-Laurent Casanova, Anne Puel
Publié dans: Journal of Clinical Investigation, Numéro 134, 2024, ISSN 1558-8238
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI180251

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Auteurs: Fanny Saidoune, Danyel Lee, Jeremy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie-Anne Morren, Vivien Béziat, Shen-Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean-Laurent Casanova, Michel Gilliet, Ahmad Yatim
Publié dans: Journal of Experimental Medicine, Numéro 222, 2025, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20231467

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency

Auteurs: Yi-Hao Chan, Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan, Danyel Lee, Francesca Pinci, Stefano Volpi, Koji Nakajima, Vincent Bondet, Sanna Åkesson, Noopur V. Khobrekar, Aaron Bodansky, Likun Du, Tina Melander, Alice-Andrée Mariaggi, Yoann Seeleuthner, Tariq Shikh Saleh, Debanjana Chakravarty, Per Marits, Kerry Dobbs, Sofie Vonlanthen, Viktoria Hennings, Karolina Thörn, Darawan Rinchai, Lucy Bizien, Matthieu Chaldebas, Ali Sobh, Tayfun Özçelik, Sevgi Keles, Suzan A. AlKhater, Carolina Prando, Isabelle Meyts, null null, Paul Bastard, Alessandro Borghesi, Aziz Bousfiha, Oksana Boyarchuk, Petter Brodin, Jacinta Bustamante, Giorgio Casari, Rémi Chevalier, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Juan Carlos Aldave Becerra, Lisa Arkin, Evangelos Andreakos, Christian W. Thorball, Sara Espinosa, Carlos Flores, Amyrath Geraldo, Rabih Halwani, Nevin Hatipoğlu, Brahim Melaiki, Jacques Fellay, Alenka Gagro, Yuval Itan, Chandima Jeewandara, Filomeen Haerynck, Davood Mansouri, Leslie Naesens, Lisa F.P. Ng, Keisuke Okamoto, Pere Soler-Palacin, Laurent Renia, Aurora Pujol Onofre, Igor B. Resnick, José Luis Franco Restrepo, Jacques G. Rivière, Anna Scherbina, Anna Šedivá, Mikko R.J. Seppänen, Helen Su, Stuart G Tangye, Sehime G. Temel, Ahmad Abou Tayoun, Stuart Turvey, K.M. Furkan Uddin, Diederik van de Beek, Tom Le Voyer, Donald C. Vinh, Shen-Ying Zhang, Jean-Laurent Casanova, Michael R. Wilson, Jérémie Rosain, Emmanuelle Jouanguy, Mélodie Aubart, Laurent Abel, Trine H. Mogensen, Qiang Pan-Hammarström, Daxing Gao, Darragh Duffy, Aurélie Cobat, Stefan Berg, Luigi D. Notarangelo, Oliver Harschnitz, Charles M. Rice, Lorenz Studer, Jean-Laurent Casanova, Olov Ekwall, Shen-Ying Zhang
Publié dans: Journal of Experimental Medicine, Numéro 221, 2024, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20231725

Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants

Auteurs: Matthias Bruhn, Maureen Obara, Abdus Salam, Bibiana Costa, Annett Ziegler, Inken Waltl, Andreas Pavlou, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Axel Schambach, Ulrich Kalinke
Publié dans: European Journal of Immunology, Numéro 54, 2024, ISSN 0014-2980
Éditeur: Wiley
DOI: 10.1002/EJI.202451056

Pharmaceuticals

Auteurs: Centofanti et al.
Publié dans: Pharmaceuticals (Basel), 2024, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16020240

The “Black Swan Principle” and the Genetics of Complex Diseases

Auteurs: Giuseppe Novelli, Juergen K V Reichardt
Publié dans: Top Italian Scientists Journal, Numéro 1, 2024, ISSN 3033-5132
Éditeur: Top Italian Scientists
DOI: 10.62684/YEWJ9912

Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia

Auteurs: Philippot et al.
Publié dans: Journal of Clinical Immunology, 2023, ISSN 2576-0572
Éditeur: Cmepub.com
DOI: 10.1007/s10875-023-01512-9

Human autoantibodies neutralizing type I IFNs: From 1981 to 2023

Auteurs: Paul Bastard, Adrian Gervais, Tom Le Voyer, Quentin Philippot, Aurélie Cobat, Jérémie Rosain, Emmanuelle Jouanguy, Laurent Abel, Shen‐Ying Zhang, Qian Zhang, Anne Puel, Jean‐Laurent Casanova
Publié dans: Immunological Reviews, Numéro 322, 2024, ISSN 0105-2896
Éditeur: Wiley
DOI: 10.1111/IMR.13304

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Auteurs: Lee et al.
Publié dans: Science, 2022, ISSN 1095-9203
Éditeur: Science
DOI: 10.1126/science.abo3627

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Auteurs: Zhang et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220514

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Auteurs: Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, null null, Alessandro Aiuti, Laia Alsina, Evangelos Andreakos, Ana de Andrés Martín, Catherine M. Biggs, Alessandro Borghesi, Amed Aziz Bousfiha, Daniel Blazquez-Gamero, Petter Brodin, Giorgio Casari, Antonio Condino-Neto, Jacques Fellay, Carlos Flores, Guy Gorochov, Emine Hafize Erdeniz, Lennart Hammarström, Yolanda Jordan Garcia, Adem Karbuz, Adam Klocperk, Paloma Lapuente-Suanzes, Yu-Lung Lau, Cheng Leung, Davood Mansouri, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Keisuke Okamoto, Satoshi Okada, Qiang Pan-Hammarström, Graziano Pesole, Laurent Renia, Carlos Rodriguez-Gallego, Anna Sediva, Mohammad Shahrooei, Pere Soler-Palacin, András N. Spaan, Gonul Tanir, Ahmad Abou Tayoun, Şehime G. Temel, Donald C. Vinh, null null, Aubrey Cunnington, Jethro Herberg, Myrsini Kaforou, Victoria J. Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D'Souza, Leire Estramia Elorrieta, Diego Estrada-Rivadeneyra, Rachel Galassini, Dominic Habgood-Coote, Shea Hamilton, Heather Jackson, James Kavangh, Ila Keren, Mahdi Moradi Marjaneh, Stephanie Menikou, Samuel Nichols, Ruud Nijman, Ivana Pennisi, Oliver Powell, Ruth Reid, Priyen Shah, Ortensia Vito, Elizabeth Whittaker, Clare Wilson, Rebecca Womersley, Ami Abdulla, Sarah Darnell, Sobia Mustafa, Pantelis Georgiou, Jesus-Rodriguez Manzano, Nicolas Moser, Michael Carter, Shane Tibby, Jonathan Cohen, Francesca Davis, Julia Kenny, Paul Wellman, Marie White, Matthew Fish, Aislinn Jennings, Manu Shankar-Hari, Katy Fidler, Dan Agranoff, Vivien Richmond, Mathhew Seal, Saul Faust, Dan Owen, Ruth Ensom, Sarah McKay, Mariya Shaji, Rachel Schranz, Prita Rughni, Amutha Anpanthar, Susan Liebeschuetz, Anna Riddell, Divya Divakaran, Louise Han, Nosheen Khalid, Ivone Lancoma Malcolm, Jessica Schofield, Teresa Simagan, Mark Peters, Alasdair Bamford, Lauran O'Neill, Nazima Pathan, Esther Daubney, Deborah White, Melissa Heightman, Sarah Eisen, Terry Segal, Lucy Wellings, Simon B. Drysdale, Nicole Branch, Lisa Hamzah, Heather Jarman, Maggie Nyirenda, Lisa Capozzi, Emma Gardiner, Robert Moots, Magda Nasher, Anita Hanson, Michelle Linforth, Sean O'Riordan, Don Ellis, Akash Deep, Ivan Caro, Fiona Shackley, Arianna Bellini, Stuart Gormley, Samira Neshat, Barnaby Scholefield, Ceri Robbins, Helen Winmill, Stéphane C. Paulus, Andrew J. Pollard, Mark Anthony, Sarah Hopton, Danielle Miller, Zoe Oliver, Sally Beer, Bryony Ward, Shrija Shrestha, Meeru Gurung, Puja Amatya, Bhishma Pokhrel, Sanjeev Man Bijukchhe, Madhav Chandra Gautam, Sarah Kelly, Peter O'Reilly, Sonu Shrestha, Federico Martinón-Torres, Antonio Salas, Fernando Álvez González, Sonia Ares Gómez, Xabier Bello, Mirian B
Publié dans: Journal of Experimental Medicine, Numéro 221, 2024, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20240699

Pathogens

Auteurs: Skouboe et al.
Publié dans: Pathogens, 2022, ISSN 2076-0817
Éditeur: Basel MDPI AG 2012-
DOI: 10.3390/pathogens12020310

Health Care Personnel Workdays Lost and Direct Health Care Salary Costs Incurred due to COVID-19 Infection in the Age of Widespread Vaccine Availability

Auteurs: Liam Townsend, Paddy Gillespie, Jonathan McGrath, Claire Kenny, null null, Lorraine Doherty, Lisa Domegan, Niall Conlon, Greg Martin, Cillian de Gascun, Joan Gallagher, Mary Keogan, Noirin Noonan, Cliona O’Farrelly, David Byrne, Colm Bergin, Catherine Fleming
Publié dans: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE223

Humoral immunity after mRNA SARS-CoV-2 omicron JN.1 vaccination

Auteurs: Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Publié dans: The Lancet Infectious Diseases, Numéro 24, 2025, ISSN 1473-3099
Éditeur: Elsevier BV
DOI: 10.1016/S1473-3099(24)00603-0

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

Auteurs: Budhadev et al.
Publié dans: JACS Au, 2023, ISSN 2691-3704
Éditeur: Washington, DC American Chemical Society [2021]-
DOI: 10.1021/jacsau.3c00163

Smoking changes adaptive immunity with persistent effects

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PCSK3 Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-γ Gene Expression

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Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

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Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination

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Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants.

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Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

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COVID-19 annual update: a narrative review

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Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy

Auteurs: Patricia Resa-Infante, Itziar Erkizia, Xabier Muñiz-Trabudua, Federica Linty, Arthur E.H. Bentlage, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Theo Rispens, Gestur Vidarsson, Javier Martinez-Picado
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Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D

Auteurs: Prerna Arora, Lu Zhang, Inga Nehlmeier, Amy Kempf, Luise Graichen, Eike Kreitz, Anzhalika Sidarovich, Cheila Rocha, Sabine Gärtner, Michael Winkler, Sebastian Schulz, Hans-Martin Jäck, Markus Hoffmann, Stefan Pöhlmann
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Nature Communications

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Ancient DNA as a tool for medical research

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Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia

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Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID

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Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

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Omicron sublineage BQ.1.1 resistance to monoclonal antibodies

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The genetic and evolutionary determinants of COVID-19 susceptibility

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Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage

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Immune responses to SARS-CoV-2 infection and vaccination in children

Auteurs: Brodin, Petter
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Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

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Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants

Auteurs: Liam Townsend, Jean Dunne, Jacklyn Sui, Carla Sanchez Perez, Matt McElheron, Cian Reid, William McCormack, Colm Bergin, Catherine Fleming, Cliona O'Farrelly, Gareth Brady, Niall Conlon
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Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19

Auteurs: Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
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Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

Auteurs: Matthias Bruhn, Maureen Obara, Abhishek Chiyyeadu, Bibiana Costa, Abdus Salam, Annett Ziegler, Inken Waltl, Andreas Pavlou, Agnes Bonifacius, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Britta Eiz-Vesper, Axel Schambach, Ulrich Kalinke
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The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

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SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency

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Variation of the 3’RR1 HS1.2 Enhancer and Its Genomic Context

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Human life within a narrow range: The lethal ups and downs of type I interferons

Auteurs: Yanick J. Crow, Jean-Laurent Casanova
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The ouroboros of autoimmunity

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COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients

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Host cell entry and neutralisation sensitivity of the emerging SARS-CoV-2 variant LP.8.1

Auteurs: Lu Zhang, Amy Kempf, Inga Nehlmeier, Nianzhen Chen, Metodi V Stankov, Christine Happle, Alexandra Dopfer-Jablonka, Georg M N Behrens, Markus Hoffmann, Stefan Pöhlmann
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Dissecting human population variation in single-cell responses to SARS-CoV-2

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Genome Medicine

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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

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A Dynamic and Effective Peptide-Based Strategy for Promptly Addressing Emerging SARS-CoV-2 Variants of Concern

Auteurs: Michela Murdocca, Isabella Romeo, Gennaro Citro, Andrea Latini, Federica Centofanti, Antonella Bugatti, Francesca Caccuri, Arnaldo Caruso, Francesco Ortuso, Stefano Alcaro, Federica Sangiuolo, Giuseppe Novelli
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Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α

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Immune responses following BNT162b2 XBB.1.5 vaccination in patients on haemodialysis in Germany

Auteurs: Anne Cossmann, Markus Hoffmann, Metodi V Stankov, Karsten Lürken, Gema Morillas Ramos, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
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Impact of socioeconomic status on healthy immune responses in humans

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Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3

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Publié dans: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Éditeur: Elsevier
DOI: 10.1016/S1473-3099(23)00547-9

Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype

Auteurs: Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant
Publié dans: European Journal of Immunology, Numéro 55, 2025, ISSN 0014-2980
Éditeur: Wiley
DOI: 10.1002/EJI.202451516

Human determinants of age-dependent patterns of death from infection

Auteurs: Laurent Abel, Jean-Laurent Casanova
Publié dans: Immunity, Numéro 57, 2024, ISSN 1074-7613
Éditeur: Elsevier BV
DOI: 10.1016/J.IMMUNI.2024.05.020

Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia

Auteurs: Garcia-Carcia et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220170

Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children

Auteurs: Bucciol et al.
Publié dans: Journal of Allergy and Clinical Immunology, 2023, ISSN 2772-8293
Éditeur: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2023.02.003

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Auteurs: Sokal et al.
Publié dans: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220258