The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

Deliverables

Website with name, logo, project description, and partner information available, plus posting of recent advances and upcoming events online.

Clinical case reports from all affiliated centers treating Long-COVID patients

Provide clinical evidence and specification of patient cohort disease criteria.

Publications

International Journal of Molecular Sciences

Author(s): Arora et al.
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Basel MDPI Center 2000-
DOI: 10.3390/ijms232214057

From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

Author(s): Casanova & Abel
Published in: Cell, 2022, ISSN 1097-4172
Publisher: Cell
DOI: 10.1016/j.cell.2022.07.004

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Author(s): Zhang et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220131

Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage

Author(s): Arora et al.
Published in: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Publisher: The Lancet
DOI: 10.1016/S1473-3099(22)00831-3

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Author(s): Bucciol et al.
Published in: Journal of Clinical Investigation, 2023, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI168321

Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75

Author(s): Arora et al.
Published in: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Publisher: The Lancet
DOI: 10.1016/S1473-3099(22)00591-6

Pharmaceuticals

Author(s): Centofanti et al.
Published in: Pharmaceuticals (Basel), 2024, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16020240

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Author(s): Lee et al.
Published in: Science, 2022, ISSN 1095-9203
Publisher: Science
DOI: 10.1126/science.abo3627

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Author(s): Zhang et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220514

Pathogens

Author(s): Skouboe et al.
Published in: Pathogens, 2022, ISSN 2076-0817
Publisher: Basel MDPI AG 2012-
DOI: 10.3390/pathogens12020310

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

Author(s): Budhadev et al.
Published in: JACS Au, 2023, ISSN 2691-3704
Publisher: Washington, DC American Chemical Society [2021]-
DOI: 10.1021/jacsau.3c00163

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Author(s): Tangye et al.
Published in: Journal of Allergy and Clinical Immunology, 2022, ISSN 2772-8293
Publisher: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2022.11.010

Nature Communications

Author(s): Hoffmann et al.
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39147-4

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

Author(s): von Gunten et al.
Published in: Frontiers in Immunology, 2023, ISSN 2832-4404
Publisher: Lausanne Frontiers Media S.A. 2010-
DOI: 10.48350/181810

Omicron sublineage BQ.1.1 resistance to monoclonal antibodies

Author(s): Arora et al.
Published in: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Publisher: The Lancet
DOI: 10.1016/S1473-3099(22)00733-2

The genetic and evolutionary determinants of COVID-19 susceptibility

Author(s): Kerner et al.
Published in: European Journal of Human Genetics, 2022, ISSN 1476-5438
Publisher: Nature
DOI: 10.1038/s41431-022-01141-7

COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients

Author(s): Murdocca et al.
Published in: Viruses, 2023, ISSN 1999-4915
Publisher: Basel MDPI 2009-
DOI: 10.3390/v15071417

Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α

Author(s): Mathian et al.
Published in: Annals of the Rheumatic Diseases, 2022, ISSN 1468-2060
Publisher: BMJ Group on behalf of the European League Against Rheumatism
DOI: 10.1136/ard-2022-222549

Viruses

Author(s): Campos-Gonzalez et al.
Published in: Viruses, 2024, ISSN 1999-4915
Publisher: Basel MDPI 2009-
DOI: 10.3390/v15030789

Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3

Author(s): Zhang et al.
Published in: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Publisher: Elsevier
DOI: 10.1016/S1473-3099(23)00547-9

Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children

Author(s): Bucciol et al.
Published in: Journal of Allergy and Clinical Immunology, 2023, ISSN 2772-8293
Publisher: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2023.02.003

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Author(s): Sokal et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220258

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