The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

Project Information

UNDINE

Grant agreement ID: 101057100

DOI

10.3030/101057100

EC signature date 20 May 2022

Start date 1 June 2022

End date 31 May 2026

Funded under

• Health

Total cost

€ 6 718 138,75

EU contribution

€ 6 718 138,75

Coordinated by

AARHUS UNIVERSITET
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (6)

Dissemination activities for the project in relation to work package 3

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Consortium website established

Website with name, logo, project description, and partner information available, plus posting of recent advances and upcoming events online.

Dissemination activities for the project in relation to work package 5

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 7

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 4

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 6

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Data sets, microdata, etc (2)

Characterisation of ancestry, age, and sex effects on immune responses to SARS-CoV-2

Quantification of the respective contribution of intrinsic factors, together with previous exposure, to the diversity of the immune response following SARS-CoV-2 infection.

Provision of a database for a second set of prospectively included patients

Precise listing of numbers of patients and clinical data prospectively included within different disease categories from all partner institutions.

Other (1)

Postdoc projects completed

Status and verification of publication and communication output.

Documents, reports (1)

Clinical case reports from all affiliated centers treating Long-COVID patients

Provide clinical evidence and specification of patient cohort disease criteria.

Publications

Peer reviewed articles (73)

Inherited human RelB deficiency impairs innate and adaptive immunity to infection

Author(s): Tom Le Voyer, Majistor Raj Luxman Maglorius Renkilaraj, Kunihiko Moriya, Malena Pérez Lorenzo, Tina Nguyen, Liwei Gao, Tamar Rubin, Axel Cederholm, Masato Ogishi, Carlos A. Arango-Franco, Vivien Béziat, Romain Lévy, Mélanie Migaud, Franck Rapaport, Yuval Itan, Elissa K. Deenick, Irene Cortese, Andrea Lisco, Kaan Boztug, Laurent Abel, Stéphanie Boisson-Dupuis, Bertrand Boisson, Patrick Frosk, Cindy S. Ma, Nils Landegren, Fatih Celmeli, Jean-Laurent Casanova, Stuart G. Tangye, Anne Puel
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2321794121

International Journal of Molecular Sciences

Author(s): Arora et al.
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Basel MDPI Center 2000-
DOI: 10.3390/ijms232214057

Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies

Author(s): Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti
Published in: The Journal of Infectious Diseases, Issue 231, 2025, ISSN 0022-1899
Publisher: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE321

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

Author(s): Maxime Rotival, Lluis Quintana-Murci
Published in: Genes & Immunity, Issue 25, 2024, ISSN 1476-5470
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41435-023-00249-0

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Author(s): Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, Chaturaka Rodrigo, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Francesca Conti, Irene Cassaniti, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Davide Mileto, Alessandro Mancon, Laurent Abel, Anne Puel, Aurélie Cobat, Charles M. Rice, Dániel Cadar, Jonas Schmidt-Chanasit, Johannes F. Scheid, Jacob E. Lemieux, Eric S. Rosenberg, Marianna Agudelo, Stuart G. Tangye, Alessandro Borghesi, Guillaume André Durand, Emilie Duburcq-Gury, Braulio M. Valencia, Andrew R. Lloyd, Anna Nagy, Margaret M. MacDonald, Yannick Simonin, Shen-Ying Zhang, Jean-Laurent Casanova
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20240942

Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2

Author(s): Patrizia Malaspina, Carla Jodice, Bianca Maria Ciminelli, Michela Biancolella, Vito Luigi Colona, Andrea Latini, Francesca Leonardis, Paola Rogliani, Antonio Novelli, Giuseppe Novelli, Andrea Novelletto
Published in: Human Genomics, Issue 19, 2025, ISSN 1479-7364
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S40246-025-00719-8

From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

Author(s): Casanova & Abel
Published in: Cell, 2022, ISSN 1097-4172
Publisher: Cell
DOI: 10.1016/j.cell.2022.07.004

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Author(s): Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez, Marie Materna, Daniel C. Lin, Baptiste Milisavljevic, Fernanda Vianna, Lucy Bizien, Lazaro Lorenzo, Marc Lecuit, Jean-David Pommier, Sevgi Keles, Tayfun Ozcelik, Sigifredo Pedraza-Sanchez, Nicolas de Prost, Loubna El Zein, Hassan Hammoud, Lisa F.P. Ng, Rabih Halwani, Narjes Saheb Sharif-Askari, Yu Lung Lau, Anthony R. Tam, Neha Singh, Sagar Bhattad, Yackov Berkun, Wasun Chantratita, Raúl Aguilar-López, Mohammad Shahrooei, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Ana Bertha Alcántara-Garduño, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Bolze, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Sotiriјa Duvlis, Xavier Duval, Munis Dündar, Soha Fakhreddine, Jacques Fellay, Carlos Flores, José Luis Franco, Guy Gorochov, Peter K. Gregersen, David Hagin, Rabih Halwani, María Teresa Herrera, Ivan Fan-Ngai Hung, Emmanuelle Jouanguy, Yu-Lung Lau, Daniel Leung, Tom Le-voyer, Davood Mansouri, Jesús Mercado-García, Isabelle Meyts, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Satoshi Okada, Firat Ozcelik, Tayfun Ozcelik, Rebeca Perez de Diego, Jordi Perez-Tur, Graziano Pesole, Anne Puel, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Manal Sbeity, Sahar Sedighzadeh, Mohammad Shahrooei, Pere Soler-Palacín, András N. Spaan, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Ibrahim Torktaz, Sophie Trouillet-Assant, Stuart E. Turvey, Furkan Uddin, Fernanda Sales Luiz Vianna, Donald C. Vinh, Oscar Zabaleta-Martínez, Qian Zhang, Shen-Ying Zhang, Jean-Laurent Casanova, null null, Chanreaksmey Eng, Kimrong Bun, MengHeng Oum, Patrice Piola, Arnaud Tarantola, Mey Channa, Veasna Duong, Philippe Buchy, Chris Gorman, Jean-David Pommier, Yoann Crabol, Philippe Dussart, M. Bunleat, M. Panha, M.Kanarith Sim, Em Bunnakea, Denis Laurent, Heng Sothy, Ky Santy, Anousone Douangnouvong, Danoy Chommanam, Khansoudaphone Phakhounthong, Manivanh Vongsouvath, Malee Seephone, Bountoy Sibounheunang, Sayaphet Rattanavong, Viengmon Davong, Malavanh Vongsouvath, Mayfong Mayxay, Audrey Dubot-Pérès, Paul N. Newton, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Dang Duc Anh, Do Quyen, Tran Thi Mai Hung, Nguyen Thi Thu Thuy, Luong Minh Tan, Anh Tuan Pham, Nguyen Hien, Do Thu Huong, Le Thanh Hai, Nguyen Van Lam, Pham Nhat An, Phan Huu Phuc, Phung Bich Thuy, Tran Thi Thu Huong, Chaw Su Hlaing, Aye Mya Min Aye, Cho Thair, Kyaw Linn, May July, Win Thein, Latt Latt Kyaw, Htay Htay Tin, Ommar Swe Tin, Khin Yi Oo, Yoann Crabol, Magali Herrant, Magali Lago, Maud Seguy, Marc Jouan, Lukas Hafner, Philippe Pérot, Marc Eloit, Marc Lecuit, Olivier Lortholary, Julien Capelle, Bruno Rosset, Veronique Chevalier, Jérôme Honnorat, Anne Laurie Pinto, Auey Dubot-Peres, Xavier de Lamballerie, Kevin Bleakley, Bernadette Murgue, Catherine Ferrant, Christian Devaux, Hervé Tissot-Dupont, Jean-Paul Moatti, Mayfong Mayxay, Pascal Bonnet, Didier Fontenille, Jean-François Delfraissy, Patrice Debré, Benoit Durand, Laurent Abel, Paul Bastard, Emmanuelle Jouanguy, Vivien Béziat, Peng Zhang, Charles M. Rice, Aurélie Cobat, Shen-Ying Zhang, Paul J. Hertzog, Jean-Laurent Casanova, Qian Zhang
Published in: Journal of Experimental Medicine, Issue 222, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20241413

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Author(s): Zhang et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220131

The Microbe, the Infection Enigma, and the Host

Author(s): Jean-Laurent Casanova, Laurent Abel
Published in: Annual Review of Microbiology, Issue 78, 2024, ISSN 0066-4227
Publisher: Annual Reviews
DOI: 10.1146/ANNUREV-MICRO-092123-022855

Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage

Author(s): Arora et al.
Published in: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Publisher: The Lancet
DOI: 10.1016/S1473-3099(22)00831-3

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Author(s): Bucciol et al.
Published in: Journal of Clinical Investigation, 2023, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI168321

Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75

Author(s): Arora et al.
Published in: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Publisher: The Lancet
DOI: 10.1016/S1473-3099(22)00591-6

A sensitive assay for measuring whole-blood responses to type I IFNs

Author(s): Adrian Gervais, Corentin Le Floc’h, Tom Le Voyer, Lucy Bizien, Jonathan Bohlen, Fatih Celmeli, Fahd Al Qureshah, Cécile Masson, Jérémie Rosain, Marwa Chbihi, Romain Lévy, Riccardo Castagnoli, Anya Rothenbuhler, Emmanuelle Jouanguy, Qian Zhang, Shen-Ying Zhang, Vivien Béziat, Jacinta Bustamante, Anne Puel, Paul Bastard, Jean-Laurent Casanova
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2402983121

Journal of Interferon and Cytokine Research

Author(s): Vanker et al.
Published in: Journal of Interferon & Cytokine Research, 2023, ISSN 1079-9907
Publisher: Journal of Interferon & Cytokine Research
DOI: 10.1089/jir.2023.0003

IL-7–dependent and –independent lineages of IL-7R–dependent human T cells

Author(s): Carlos A. Arango-Franco, Masato Ogishi, Susanne Unger, Ottavia M. Delmonte, Julio César Orrego, Ahmad Yatim, Margarita M. Velasquez-Lopera, Andrés F. Zea-Vera, Jonathan Bohlen, Marwa Chbihi, Antoine Fayand, Juan Pablo Sánchez, Julian Rojas, Yoann Seeleuthner, Tom Le Voyer, Quentin Philippot, Kathryn J. Payne, Adrian Gervais, Lucia V. Erazo-Borrás, Luis A. Correa-Londoño, Axel Cederholm, Alejandro Gallón-Duque, Pedro Goncalves, Jean-Marc Doisne, Liran Horev, Bénédicte Charmeteau-de Muylder, Jesús Á. Álvarez, Diana M. Arboleda, Lizet Pérez-Zapata, Estefanía Vásquez-Echeverri, Marcela Moncada-Vélez, Juan A. López, Yolanda Caicedo, Boaz Palterer, Pablo J. Patiño, Carlos J. Montoya, Matthieu Chaldebas, Peng Zhang, Tina Nguyen, Cindy S. Ma, Mohamed Jeljeli, Juan F. Alzate, Felipe Cabarcas, Taushif Khan, Darawan Rinchai, Jean-Luc Prétet, Bertrand Boisson, Nico Marr, Ruba Ibrahim, Vered Molho-Pessach, Stéphanie Boisson-Dupuis, Dimitra Kiritsi, João T. Barata, Nils Landegren, Bénédicte Neven, Laurent Abel, Andrea Lisco, Vivien Béziat, Emmanuelle Jouanguy, Jacinta Bustamante, James P. Di Santo, Stuart G. Tangye, Luigi D. Notarangelo, Rémi Cheynier, Ken Natsuga, Andrés A. Arias, José Luis Franco, Klaus Warnatz, Jean-Laurent Casanova, Anne Puel
Published in: Journal of Clinical Investigation, Issue 134, 2024, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI180251

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Author(s): Fanny Saidoune, Danyel Lee, Jeremy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie-Anne Morren, Vivien Béziat, Shen-Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean-Laurent Casanova, Michel Gilliet, Ahmad Yatim
Published in: Journal of Experimental Medicine, Issue 222, 2025, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20231467

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency

Author(s): Yi-Hao Chan, Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan, Danyel Lee, Francesca Pinci, Stefano Volpi, Koji Nakajima, Vincent Bondet, Sanna Åkesson, Noopur V. Khobrekar, Aaron Bodansky, Likun Du, Tina Melander, Alice-Andrée Mariaggi, Yoann Seeleuthner, Tariq Shikh Saleh, Debanjana Chakravarty, Per Marits, Kerry Dobbs, Sofie Vonlanthen, Viktoria Hennings, Karolina Thörn, Darawan Rinchai, Lucy Bizien, Matthieu Chaldebas, Ali Sobh, Tayfun Özçelik, Sevgi Keles, Suzan A. AlKhater, Carolina Prando, Isabelle Meyts, null null, Paul Bastard, Alessandro Borghesi, Aziz Bousfiha, Oksana Boyarchuk, Petter Brodin, Jacinta Bustamante, Giorgio Casari, Rémi Chevalier, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Juan Carlos Aldave Becerra, Lisa Arkin, Evangelos Andreakos, Christian W. Thorball, Sara Espinosa, Carlos Flores, Amyrath Geraldo, Rabih Halwani, Nevin Hatipoğlu, Brahim Melaiki, Jacques Fellay, Alenka Gagro, Yuval Itan, Chandima Jeewandara, Filomeen Haerynck, Davood Mansouri, Leslie Naesens, Lisa F.P. Ng, Keisuke Okamoto, Pere Soler-Palacin, Laurent Renia, Aurora Pujol Onofre, Igor B. Resnick, José Luis Franco Restrepo, Jacques G. Rivière, Anna Scherbina, Anna Šedivá, Mikko R.J. Seppänen, Helen Su, Stuart G Tangye, Sehime G. Temel, Ahmad Abou Tayoun, Stuart Turvey, K.M. Furkan Uddin, Diederik van de Beek, Tom Le Voyer, Donald C. Vinh, Shen-Ying Zhang, Jean-Laurent Casanova, Michael R. Wilson, Jérémie Rosain, Emmanuelle Jouanguy, Mélodie Aubart, Laurent Abel, Trine H. Mogensen, Qiang Pan-Hammarström, Daxing Gao, Darragh Duffy, Aurélie Cobat, Stefan Berg, Luigi D. Notarangelo, Oliver Harschnitz, Charles M. Rice, Lorenz Studer, Jean-Laurent Casanova, Olov Ekwall, Shen-Ying Zhang
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20231725

Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants

Author(s): Matthias Bruhn, Maureen Obara, Abdus Salam, Bibiana Costa, Annett Ziegler, Inken Waltl, Andreas Pavlou, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Axel Schambach, Ulrich Kalinke
Published in: European Journal of Immunology, Issue 54, 2024, ISSN 0014-2980
Publisher: Wiley
DOI: 10.1002/EJI.202451056

Pharmaceuticals

Author(s): Centofanti et al.
Published in: Pharmaceuticals (Basel), 2024, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16020240

The “Black Swan Principle” and the Genetics of Complex Diseases

Author(s): Giuseppe Novelli, Juergen K V Reichardt
Published in: Top Italian Scientists Journal, Issue 1, 2024, ISSN 3033-5132
Publisher: Top Italian Scientists
DOI: 10.62684/YEWJ9912

Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia

Author(s): Philippot et al.
Published in: Journal of Clinical Immunology, 2023, ISSN 2576-0572
Publisher: Cmepub.com
DOI: 10.1007/s10875-023-01512-9

Human autoantibodies neutralizing type I IFNs: From 1981 to 2023

Author(s): Paul Bastard, Adrian Gervais, Tom Le Voyer, Quentin Philippot, Aurélie Cobat, Jérémie Rosain, Emmanuelle Jouanguy, Laurent Abel, Shen‐Ying Zhang, Qian Zhang, Anne Puel, Jean‐Laurent Casanova
Published in: Immunological Reviews, Issue 322, 2024, ISSN 0105-2896
Publisher: Wiley
DOI: 10.1111/IMR.13304

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Author(s): Lee et al.
Published in: Science, 2022, ISSN 1095-9203
Publisher: Science
DOI: 10.1126/science.abo3627

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Author(s): Zhang et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220514

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Author(s): Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, null null, Alessandro Aiuti, Laia Alsina, Evangelos Andreakos, Ana de Andrés Martín, Catherine M. Biggs, Alessandro Borghesi, Amed Aziz Bousfiha, Daniel Blazquez-Gamero, Petter Brodin, Giorgio Casari, Antonio Condino-Neto, Jacques Fellay, Carlos Flores, Guy Gorochov, Emine Hafize Erdeniz, Lennart Hammarström, Yolanda Jordan Garcia, Adem Karbuz, Adam Klocperk, Paloma Lapuente-Suanzes, Yu-Lung Lau, Cheng Leung, Davood Mansouri, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Keisuke Okamoto, Satoshi Okada, Qiang Pan-Hammarström, Graziano Pesole, Laurent Renia, Carlos Rodriguez-Gallego, Anna Sediva, Mohammad Shahrooei, Pere Soler-Palacin, András N. Spaan, Gonul Tanir, Ahmad Abou Tayoun, Şehime G. Temel, Donald C. Vinh, null null, Aubrey Cunnington, Jethro Herberg, Myrsini Kaforou, Victoria J. Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D'Souza, Leire Estramia Elorrieta, Diego Estrada-Rivadeneyra, Rachel Galassini, Dominic Habgood-Coote, Shea Hamilton, Heather Jackson, James Kavangh, Ila Keren, Mahdi Moradi Marjaneh, Stephanie Menikou, Samuel Nichols, Ruud Nijman, Ivana Pennisi, Oliver Powell, Ruth Reid, Priyen Shah, Ortensia Vito, Elizabeth Whittaker, Clare Wilson, Rebecca Womersley, Ami Abdulla, Sarah Darnell, Sobia Mustafa, Pantelis Georgiou, Jesus-Rodriguez Manzano, Nicolas Moser, Michael Carter, Shane Tibby, Jonathan Cohen, Francesca Davis, Julia Kenny, Paul Wellman, Marie White, Matthew Fish, Aislinn Jennings, Manu Shankar-Hari, Katy Fidler, Dan Agranoff, Vivien Richmond, Mathhew Seal, Saul Faust, Dan Owen, Ruth Ensom, Sarah McKay, Mariya Shaji, Rachel Schranz, Prita Rughni, Amutha Anpanthar, Susan Liebeschuetz, Anna Riddell, Divya Divakaran, Louise Han, Nosheen Khalid, Ivone Lancoma Malcolm, Jessica Schofield, Teresa Simagan, Mark Peters, Alasdair Bamford, Lauran O'Neill, Nazima Pathan, Esther Daubney, Deborah White, Melissa Heightman, Sarah Eisen, Terry Segal, Lucy Wellings, Simon B. Drysdale, Nicole Branch, Lisa Hamzah, Heather Jarman, Maggie Nyirenda, Lisa Capozzi, Emma Gardiner, Robert Moots, Magda Nasher, Anita Hanson, Michelle Linforth, Sean O'Riordan, Don Ellis, Akash Deep, Ivan Caro, Fiona Shackley, Arianna Bellini, Stuart Gormley, Samira Neshat, Barnaby Scholefield, Ceri Robbins, Helen Winmill, Stéphane C. Paulus, Andrew J. Pollard, Mark Anthony, Sarah Hopton, Danielle Miller, Zoe Oliver, Sally Beer, Bryony Ward, Shrija Shrestha, Meeru Gurung, Puja Amatya, Bhishma Pokhrel, Sanjeev Man Bijukchhe, Madhav Chandra Gautam, Sarah Kelly, Peter O'Reilly, Sonu Shrestha, Federico Martinón-Torres, Antonio Salas, Fernando Álvez González, Sonia Ares Gómez, Xabier Bello, Mirian B
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20240699

Pathogens

Author(s): Skouboe et al.
Published in: Pathogens, 2022, ISSN 2076-0817
Publisher: Basel MDPI AG 2012-
DOI: 10.3390/pathogens12020310

Health Care Personnel Workdays Lost and Direct Health Care Salary Costs Incurred due to COVID-19 Infection in the Age of Widespread Vaccine Availability

Author(s): Liam Townsend, Paddy Gillespie, Jonathan McGrath, Claire Kenny, null null, Lorraine Doherty, Lisa Domegan, Niall Conlon, Greg Martin, Cillian de Gascun, Joan Gallagher, Mary Keogan, Noirin Noonan, Cliona O’Farrelly, David Byrne, Colm Bergin, Catherine Fleming
Published in: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Publisher: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE223

Humoral immunity after mRNA SARS-CoV-2 omicron JN.1 vaccination

Author(s): Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Published in: The Lancet Infectious Diseases, Issue 24, 2025, ISSN 1473-3099
Publisher: Elsevier BV
DOI: 10.1016/S1473-3099(24)00603-0

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

Author(s): Budhadev et al.
Published in: JACS Au, 2023, ISSN 2691-3704
Publisher: Washington, DC American Chemical Society [2021]-
DOI: 10.1021/jacsau.3c00163

Smoking changes adaptive immunity with persistent effects

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Publisher: Springer Science and Business Media LLC
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PCSK3 Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-γ Gene Expression

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Published in: Genes, Issue 14 (5), 981, 2023, ISSN 2073-4425
Publisher: Basel Multidisciplinary Digital Publishing Institute (MDPI) 2010-
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Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

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Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/JEM.20231353

Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination

Author(s): Metodi V Stankov, Markus Hoffmann, Rodrigo Gutierrez Jauregui, Anne Cossmann, Gema Morillas Ramos, Theresa Graalmann, Emily Jo Winter, Michaela Friedrichsen, Inga Ravens, Tamara Ilievska, Jasmin Ristenpart, Anja Schimrock, Stefanie Willenzon, Gerrit Ahrenstorf, Torsten Witte, Reinhold Förster, Amy Kempf, Stefan Pöhlmann, Swantje I Hammerschmidt, Alexandra Dopfer-Jablonka, Georg M N Behrens
Published in: The Lancet Infectious Diseases, Issue 24, 2024, ISSN 1473-3099
Publisher: Elsevier BV
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Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants.

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Published in: Annual Review of Biomedical Data Science, Issue 6, 2023, ISSN 2574-3414
Publisher: Annual Reviews
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Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

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Published in: Journal of Allergy and Clinical Immunology, 2022, ISSN 2772-8293
Publisher: New York Elsevier, Inc.
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COVID-19 annual update: a narrative review

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Published in: Hum Genomics, 2023, ISSN 1479-7364
Publisher: London BioMed Central
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Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy

Author(s): Patricia Resa-Infante, Itziar Erkizia, Xabier Muñiz-Trabudua, Federica Linty, Arthur E.H. Bentlage, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Theo Rispens, Gestur Vidarsson, Javier Martinez-Picado
Published in: Biomedicine &amp; Pharmacotherapy, Issue 175, 2025, ISSN 0753-3322
Publisher: Elsevier BV
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Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D

Author(s): Prerna Arora, Lu Zhang, Inga Nehlmeier, Amy Kempf, Luise Graichen, Eike Kreitz, Anzhalika Sidarovich, Cheila Rocha, Sabine Gärtner, Michael Winkler, Sebastian Schulz, Hans-Martin Jäck, Markus Hoffmann, Stefan Pöhlmann
Published in: Journal of Virology, Issue 99, 2025, ISSN 0022-538X
Publisher: American Society for Microbiology
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Nature Communications

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Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
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Ancient DNA as a tool for medical research

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Published in: Nature Medicine, 2023, ISSN 1546-170X
Publisher: Nature
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Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia

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Published in: Annual Review of Immunology, 2023, ISSN 1545-3278
Publisher: Annual Reviews
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Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID

Author(s): Kristoffer Skaalum Hansen, Sofie Eg Jørgensen, Cagla Cömert, Berit Schiøttz‐Christensen, Peter Bross, Jane Agergaard, Steffen Leth, Lars Østergaard, Johan Palmfeldt, Rikke Katrine Jentoft Olsen, Trine H. Mogensen
Published in: Journal of Medical Virology, Issue 97, 2025, ISSN 0146-6615
Publisher: Wiley
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Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

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Published in: Frontiers in Immunology, 2023, ISSN 2832-4404
Publisher: Lausanne Frontiers Media S.A. 2010-
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Omicron sublineage BQ.1.1 resistance to monoclonal antibodies

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Published in: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Publisher: The Lancet
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The genetic and evolutionary determinants of COVID-19 susceptibility

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Published in: European Journal of Human Genetics, 2022, ISSN 1476-5438
Publisher: Nature
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Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage

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Published in: Cellular & Molecular Immunology, 2023, ISSN 2042-0226
Publisher: Chinese Society of Immunology
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Immune responses to SARS-CoV-2 infection and vaccination in children

Author(s): Brodin, Petter
Published in: Seminars in Immunology, 2023, ISSN 1096-3618
Publisher: Elsevir
DOI: 10.1016/j.smim.2023.101794

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

Author(s): Hoffmann et al.
Published in: Cellular & Molecular Immunology, 2023, ISSN 1540-9538
Publisher: Rockefeller University Press
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Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants

Author(s): Liam Townsend, Jean Dunne, Jacklyn Sui, Carla Sanchez Perez, Matt McElheron, Cian Reid, William McCormack, Colm Bergin, Catherine Fleming, Cliona O'Farrelly, Gareth Brady, Niall Conlon
Published in: Clinical Immunology, Issue 268, 2024, ISSN 1521-6616
Publisher: Elsevier BV
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Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19

Author(s): Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
Published in: Biology Direct, Issue 19, 2024, ISSN 1745-6150
Publisher: Springer Science and Business Media LLC
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Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

Author(s): Matthias Bruhn, Maureen Obara, Abhishek Chiyyeadu, Bibiana Costa, Abdus Salam, Annett Ziegler, Inken Waltl, Andreas Pavlou, Agnes Bonifacius, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Britta Eiz-Vesper, Axel Schambach, Ulrich Kalinke
Published in: Journal of Infection, Issue 88, 2024, ISSN 0163-4453
Publisher: Elsevier BV
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The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

Author(s): Marie Materna, Ottavia M. Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E. Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A. Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc’h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A. Schramm, Sanjana Shah, John J. Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S. Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P. Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R. Regueiro, Maria L. Toribio, Judith R. Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C. Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E. Henrickson, Hervé Luche, Luigi D. Notarangelo, Jean-Laurent Casanova, Vivien Béziat
Published in: Science, Issue 383, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADH4059

SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency

Author(s): Lu Zhang, Amy Kempf, Inga Nehlmeier, Anne Cossmann, Anja Richter, Najat Bdeir, Luise Graichen, Anna-Sophie Moldenhauer, Alexandra Dopfer-Jablonka, Metodi V. Stankov, Etienne Simon-Loriere, Sebastian R. Schulz, Hans-Martin Jäck, Luka Čičin-Šain, Georg M.N. Behrens, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann
Published in: Cell, Issue 187, 2025, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2023.12.025

Variation of the 3’RR1 HS1.2 Enhancer and Its Genomic Context

Author(s): Carla Jodice, Patrizia Malaspina, Bianca Maria Ciminelli, Cristina Martinez-Labarga, Michela Biancolella, Giuseppe Novelli, Andrea Novelletto
Published in: Genes, Issue 15, 2024, ISSN 2073-4425
Publisher: MDPI AG
DOI: 10.3390/GENES15070856

Human life within a narrow range: The lethal ups and downs of type I interferons

Author(s): Yanick J. Crow, Jean-Laurent Casanova
Published in: Science Immunology, Issue 9, 2024, ISSN 2470-9468
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIIMMUNOL.ADM8185

The ouroboros of autoimmunity

Author(s): Jean-Laurent Casanova, Jessica Peel, Jean Donadieu, Anna-Lena Neehus, Anne Puel, Paul Bastard
Published in: Nature Immunology, Issue 25, 2024, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-024-01815-Y

COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients

Author(s): Murdocca et al.
Published in: Viruses, 2023, ISSN 1999-4915
Publisher: Basel MDPI 2009-
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Host cell entry and neutralisation sensitivity of the emerging SARS-CoV-2 variant LP.8.1

Author(s): Lu Zhang, Amy Kempf, Inga Nehlmeier, Nianzhen Chen, Metodi V Stankov, Christine Happle, Alexandra Dopfer-Jablonka, Georg M N Behrens, Markus Hoffmann, Stefan Pöhlmann
Published in: The Lancet Infectious Diseases, Issue 25, 2025, ISSN 1473-3099
Publisher: Elsevier BV
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Dissecting human population variation in single-cell responses to SARS-CoV-2

Author(s): Bisiaux et al.
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature
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Genome Medicine

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Published in: Genome Medicine, 2023, ISSN 1756-994X
Publisher: [London] BioMed Central
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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

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Published in: Human Genetics and Genomics Advances, Issue 5, 2025, ISSN 2666-2477
Publisher: Elsevier BV
DOI: 10.1016/J.XHGG.2024.100300

A Dynamic and Effective Peptide-Based Strategy for Promptly Addressing Emerging SARS-CoV-2 Variants of Concern

Author(s): Michela Murdocca, Isabella Romeo, Gennaro Citro, Andrea Latini, Federica Centofanti, Antonella Bugatti, Francesca Caccuri, Arnaldo Caruso, Francesco Ortuso, Stefano Alcaro, Federica Sangiuolo, Giuseppe Novelli
Published in: Pharmaceuticals, Issue 17, 2025, ISSN 1424-8247
Publisher: MDPI AG
DOI: 10.3390/PH17070891

Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α

Author(s): Mathian et al.
Published in: Annals of the Rheumatic Diseases, 2022, ISSN 1468-2060
Publisher: BMJ Group on behalf of the European League Against Rheumatism
DOI: 10.1136/ARD-2022-222549

Immune responses following BNT162b2 XBB.1.5 vaccination in patients on haemodialysis in Germany

Author(s): Anne Cossmann, Markus Hoffmann, Metodi V Stankov, Karsten Lürken, Gema Morillas Ramos, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Published in: The Lancet Infectious Diseases, Issue 24, 2025, ISSN 1473-3099
Publisher: Elsevier BV
DOI: 10.1016/S1473-3099(23)00783-1

Impact of socioeconomic status on healthy immune responses in humans

Author(s): Anthony Bertrand, Jamie Sugrue, Tianai Lou, Nollaig M Bourke, Lluis Quintana‐Murci, Violaine Saint‐André, Cliona O'Farrelly, Darragh Duffy, null null
Published in: Immunology &amp; Cell Biology, Issue 102, 2024, ISSN 0818-9641
Publisher: Wiley
DOI: 10.1111/IMCB.12789

Viruses

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Published in: Viruses, 2024, ISSN 1999-4915
Publisher: Basel MDPI 2009-
DOI: 10.3390/v15030789

Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3

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Published in: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Publisher: Elsevier
DOI: 10.1016/S1473-3099(23)00547-9

Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype

Author(s): Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant
Published in: European Journal of Immunology, Issue 55, 2025, ISSN 0014-2980
Publisher: Wiley
DOI: 10.1002/EJI.202451516

Human determinants of age-dependent patterns of death from infection

Author(s): Laurent Abel, Jean-Laurent Casanova
Published in: Immunity, Issue 57, 2024, ISSN 1074-7613
Publisher: Elsevier BV
DOI: 10.1016/J.IMMUNI.2024.05.020

Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia

Author(s): Garcia-Carcia et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220170

Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children

Author(s): Bucciol et al.
Published in: Journal of Allergy and Clinical Immunology, 2023, ISSN 2772-8293
Publisher: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2023.02.003

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Author(s): Sokal et al.
Published in: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220258