The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

Información del proyecto

UNDINE

Identificador del acuerdo de subvención: 101057100

DOI

10.3030/101057100

Fecha de la firma de la CE 20 Mayo 2022

Fecha de inicio 1 Junio 2022

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• Health

Coste total

€ 6 718 138,75

Aportación de la UE

€ 6 718 138,75

Coordinado por

AARHUS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (6)

Dissemination activities for the project in relation to work package 3

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Consortium website established

Website with name, logo, project description, and partner information available, plus posting of recent advances and upcoming events online.

Dissemination activities for the project in relation to work package 5

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 7

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 4

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Dissemination activities for the project in relation to work package 6

"Presentation in local/national radio/television outlining the projects goals, activities, results and its implications for public health. To also consider hosting a ""Night of Science"" event."

Data sets, microdata, etc (2)

Characterisation of ancestry, age, and sex effects on immune responses to SARS-CoV-2

Quantification of the respective contribution of intrinsic factors, together with previous exposure, to the diversity of the immune response following SARS-CoV-2 infection.

Provision of a database for a second set of prospectively included patients

Precise listing of numbers of patients and clinical data prospectively included within different disease categories from all partner institutions.

Other (1)

Postdoc projects completed

Status and verification of publication and communication output.

Documents, reports (1)

Clinical case reports from all affiliated centers treating Long-COVID patients

Provide clinical evidence and specification of patient cohort disease criteria.

Publicaciones

Peer reviewed articles (73)

Inherited human RelB deficiency impairs innate and adaptive immunity to infection

Autores: Tom Le Voyer, Majistor Raj Luxman Maglorius Renkilaraj, Kunihiko Moriya, Malena Pérez Lorenzo, Tina Nguyen, Liwei Gao, Tamar Rubin, Axel Cederholm, Masato Ogishi, Carlos A. Arango-Franco, Vivien Béziat, Romain Lévy, Mélanie Migaud, Franck Rapaport, Yuval Itan, Elissa K. Deenick, Irene Cortese, Andrea Lisco, Kaan Boztug, Laurent Abel, Stéphanie Boisson-Dupuis, Bertrand Boisson, Patrick Frosk, Cindy S. Ma, Nils Landegren, Fatih Celmeli, Jean-Laurent Casanova, Stuart G. Tangye, Anne Puel
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2321794121

International Journal of Molecular Sciences

Autores: Arora et al.
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Basel MDPI Center 2000-
DOI: 10.3390/ijms232214057

Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies

Autores: Federica Barzaghi, Camilla Visconti, Giovanni Battista Pipitone, Simone Bondesan, Giulia Molli, Stefania Giannelli, Claudia Sartirana, Vito Lampasona, Elena Bazzigaluppi, Cristina Brigatti, Adrian Gervais, Paul Bastard, Chiara Tassan Din, Chiara Molinari, Lorenzo Piemonti, Jean-Laurent Casanova, Paola Carrera, Giorgio Casari, Alessandro Aiuti
Publicado en: The Journal of Infectious Diseases, Edición 231, 2025, ISSN 0022-1899
Editor: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE321

Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk

Autores: Maxime Rotival, Lluis Quintana-Murci
Publicado en: Genes & Immunity, Edición 25, 2024, ISSN 1476-5470
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41435-023-00249-0

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Autores: Adrian Gervais, Paul Bastard, Lucy Bizien, Céline Delifer, Pierre Tiberghien, Chaturaka Rodrigo, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Francesca Conti, Irene Cassaniti, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Davide Mileto, Alessandro Mancon, Laurent Abel, Anne Puel, Aurélie Cobat, Charles M. Rice, Dániel Cadar, Jonas Schmidt-Chanasit, Johannes F. Scheid, Jacob E. Lemieux, Eric S. Rosenberg, Marianna Agudelo, Stuart G. Tangye, Alessandro Borghesi, Guillaume André Durand, Emilie Duburcq-Gury, Braulio M. Valencia, Andrew R. Lloyd, Anna Nagy, Margaret M. MacDonald, Yannick Simonin, Shen-Ying Zhang, Jean-Laurent Casanova
Publicado en: Journal of Experimental Medicine, Edición 221, 2024, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20240942

Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2

Autores: Patrizia Malaspina, Carla Jodice, Bianca Maria Ciminelli, Michela Biancolella, Vito Luigi Colona, Andrea Latini, Francesca Leonardis, Paola Rogliani, Antonio Novelli, Giuseppe Novelli, Andrea Novelletto
Publicado en: Human Genomics, Edición 19, 2025, ISSN 1479-7364
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S40246-025-00719-8

From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

Autores: Casanova & Abel
Publicado en: Cell, 2022, ISSN 1097-4172
Editor: Cell
DOI: 10.1016/j.cell.2022.07.004

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Autores: Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada-Velez, Marie Materna, Daniel C. Lin, Baptiste Milisavljevic, Fernanda Vianna, Lucy Bizien, Lazaro Lorenzo, Marc Lecuit, Jean-David Pommier, Sevgi Keles, Tayfun Ozcelik, Sigifredo Pedraza-Sanchez, Nicolas de Prost, Loubna El Zein, Hassan Hammoud, Lisa F.P. Ng, Rabih Halwani, Narjes Saheb Sharif-Askari, Yu Lung Lau, Anthony R. Tam, Neha Singh, Sagar Bhattad, Yackov Berkun, Wasun Chantratita, Raúl Aguilar-López, Mohammad Shahrooei, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Ana Bertha Alcántara-Garduño, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Paul Bastard, Alexandre Bolze, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Sotiriјa Duvlis, Xavier Duval, Munis Dündar, Soha Fakhreddine, Jacques Fellay, Carlos Flores, José Luis Franco, Guy Gorochov, Peter K. Gregersen, David Hagin, Rabih Halwani, María Teresa Herrera, Ivan Fan-Ngai Hung, Emmanuelle Jouanguy, Yu-Lung Lau, Daniel Leung, Tom Le-voyer, Davood Mansouri, Jesús Mercado-García, Isabelle Meyts, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Satoshi Okada, Firat Ozcelik, Tayfun Ozcelik, Rebeca Perez de Diego, Jordi Perez-Tur, Graziano Pesole, Anne Puel, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Manal Sbeity, Sahar Sedighzadeh, Mohammad Shahrooei, Pere Soler-Palacín, András N. Spaan, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Ibrahim Torktaz, Sophie Trouillet-Assant, Stuart E. Turvey, Furkan Uddin, Fernanda Sales Luiz Vianna, Donald C. Vinh, Oscar Zabaleta-Martínez, Qian Zhang, Shen-Ying Zhang, Jean-Laurent Casanova, null null, Chanreaksmey Eng, Kimrong Bun, MengHeng Oum, Patrice Piola, Arnaud Tarantola, Mey Channa, Veasna Duong, Philippe Buchy, Chris Gorman, Jean-David Pommier, Yoann Crabol, Philippe Dussart, M. Bunleat, M. Panha, M.Kanarith Sim, Em Bunnakea, Denis Laurent, Heng Sothy, Ky Santy, Anousone Douangnouvong, Danoy Chommanam, Khansoudaphone Phakhounthong, Manivanh Vongsouvath, Malee Seephone, Bountoy Sibounheunang, Sayaphet Rattanavong, Viengmon Davong, Malavanh Vongsouvath, Mayfong Mayxay, Audrey Dubot-Pérès, Paul N. Newton, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Dang Duc Anh, Do Quyen, Tran Thi Mai Hung, Nguyen Thi Thu Thuy, Luong Minh Tan, Anh Tuan Pham, Nguyen Hien, Do Thu Huong, Le Thanh Hai, Nguyen Van Lam, Pham Nhat An, Phan Huu Phuc, Phung Bich Thuy, Tran Thi Thu Huong, Chaw Su Hlaing, Aye Mya Min Aye, Cho Thair, Kyaw Linn, May July, Win Thein, Latt Latt Kyaw, Htay Htay Tin, Ommar Swe Tin, Khin Yi Oo, Yoann Crabol, Magali Herrant, Magali Lago, Maud Seguy, Marc Jouan, Lukas Hafner, Philippe Pérot, Marc Eloit, Marc Lecuit, Olivier Lortholary, Julien Capelle, Bruno Rosset, Veronique Chevalier, Jérôme Honnorat, Anne Laurie Pinto, Auey Dubot-Peres, Xavier de Lamballerie, Kevin Bleakley, Bernadette Murgue, Catherine Ferrant, Christian Devaux, Hervé Tissot-Dupont, Jean-Paul Moatti, Mayfong Mayxay, Pascal Bonnet, Didier Fontenille, Jean-François Delfraissy, Patrice Debré, Benoit Durand, Laurent Abel, Paul Bastard, Emmanuelle Jouanguy, Vivien Béziat, Peng Zhang, Charles M. Rice, Aurélie Cobat, Shen-Ying Zhang, Paul J. Hertzog, Jean-Laurent Casanova, Qian Zhang
Publicado en: Journal of Experimental Medicine, Edición 222, 2024, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20241413

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Autores: Zhang et al.
Publicado en: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220131

The Microbe, the Infection Enigma, and the Host

Autores: Jean-Laurent Casanova, Laurent Abel
Publicado en: Annual Review of Microbiology, Edición 78, 2024, ISSN 0066-4227
Editor: Annual Reviews
DOI: 10.1146/ANNUREV-MICRO-092123-022855

Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage

Autores: Arora et al.
Publicado en: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Editor: The Lancet
DOI: 10.1016/S1473-3099(22)00831-3

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Autores: Bucciol et al.
Publicado en: Journal of Clinical Investigation, 2023, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI168321

Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75

Autores: Arora et al.
Publicado en: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Editor: The Lancet
DOI: 10.1016/S1473-3099(22)00591-6

A sensitive assay for measuring whole-blood responses to type I IFNs

Autores: Adrian Gervais, Corentin Le Floc’h, Tom Le Voyer, Lucy Bizien, Jonathan Bohlen, Fatih Celmeli, Fahd Al Qureshah, Cécile Masson, Jérémie Rosain, Marwa Chbihi, Romain Lévy, Riccardo Castagnoli, Anya Rothenbuhler, Emmanuelle Jouanguy, Qian Zhang, Shen-Ying Zhang, Vivien Béziat, Jacinta Bustamante, Anne Puel, Paul Bastard, Jean-Laurent Casanova
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2402983121

Journal of Interferon and Cytokine Research

Autores: Vanker et al.
Publicado en: Journal of Interferon & Cytokine Research, 2023, ISSN 1079-9907
Editor: Journal of Interferon & Cytokine Research
DOI: 10.1089/jir.2023.0003

IL-7–dependent and –independent lineages of IL-7R–dependent human T cells

Autores: Carlos A. Arango-Franco, Masato Ogishi, Susanne Unger, Ottavia M. Delmonte, Julio César Orrego, Ahmad Yatim, Margarita M. Velasquez-Lopera, Andrés F. Zea-Vera, Jonathan Bohlen, Marwa Chbihi, Antoine Fayand, Juan Pablo Sánchez, Julian Rojas, Yoann Seeleuthner, Tom Le Voyer, Quentin Philippot, Kathryn J. Payne, Adrian Gervais, Lucia V. Erazo-Borrás, Luis A. Correa-Londoño, Axel Cederholm, Alejandro Gallón-Duque, Pedro Goncalves, Jean-Marc Doisne, Liran Horev, Bénédicte Charmeteau-de Muylder, Jesús Á. Álvarez, Diana M. Arboleda, Lizet Pérez-Zapata, Estefanía Vásquez-Echeverri, Marcela Moncada-Vélez, Juan A. López, Yolanda Caicedo, Boaz Palterer, Pablo J. Patiño, Carlos J. Montoya, Matthieu Chaldebas, Peng Zhang, Tina Nguyen, Cindy S. Ma, Mohamed Jeljeli, Juan F. Alzate, Felipe Cabarcas, Taushif Khan, Darawan Rinchai, Jean-Luc Prétet, Bertrand Boisson, Nico Marr, Ruba Ibrahim, Vered Molho-Pessach, Stéphanie Boisson-Dupuis, Dimitra Kiritsi, João T. Barata, Nils Landegren, Bénédicte Neven, Laurent Abel, Andrea Lisco, Vivien Béziat, Emmanuelle Jouanguy, Jacinta Bustamante, James P. Di Santo, Stuart G. Tangye, Luigi D. Notarangelo, Rémi Cheynier, Ken Natsuga, Andrés A. Arias, José Luis Franco, Klaus Warnatz, Jean-Laurent Casanova, Anne Puel
Publicado en: Journal of Clinical Investigation, Edición 134, 2024, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI180251

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Autores: Fanny Saidoune, Danyel Lee, Jeremy Di Domizio, Corentin Le Floc’h, Raphael Jenelten, Jérémie Le Pen, Vincent Bondet, Ana Joncic, Marie-Anne Morren, Vivien Béziat, Shen-Ying Zhang, Emmanuelle Jouanguy, Darragh Duffy, Charles M. Rice, Curdin Conrad, Jacques Fellay, Jean-Laurent Casanova, Michel Gilliet, Ahmad Yatim
Publicado en: Journal of Experimental Medicine, Edición 222, 2025, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20231467

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency

Autores: Yi-Hao Chan, Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan, Danyel Lee, Francesca Pinci, Stefano Volpi, Koji Nakajima, Vincent Bondet, Sanna Åkesson, Noopur V. Khobrekar, Aaron Bodansky, Likun Du, Tina Melander, Alice-Andrée Mariaggi, Yoann Seeleuthner, Tariq Shikh Saleh, Debanjana Chakravarty, Per Marits, Kerry Dobbs, Sofie Vonlanthen, Viktoria Hennings, Karolina Thörn, Darawan Rinchai, Lucy Bizien, Matthieu Chaldebas, Ali Sobh, Tayfun Özçelik, Sevgi Keles, Suzan A. AlKhater, Carolina Prando, Isabelle Meyts, null null, Paul Bastard, Alessandro Borghesi, Aziz Bousfiha, Oksana Boyarchuk, Petter Brodin, Jacinta Bustamante, Giorgio Casari, Rémi Chevalier, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Juan Carlos Aldave Becerra, Lisa Arkin, Evangelos Andreakos, Christian W. Thorball, Sara Espinosa, Carlos Flores, Amyrath Geraldo, Rabih Halwani, Nevin Hatipoğlu, Brahim Melaiki, Jacques Fellay, Alenka Gagro, Yuval Itan, Chandima Jeewandara, Filomeen Haerynck, Davood Mansouri, Leslie Naesens, Lisa F.P. Ng, Keisuke Okamoto, Pere Soler-Palacin, Laurent Renia, Aurora Pujol Onofre, Igor B. Resnick, José Luis Franco Restrepo, Jacques G. Rivière, Anna Scherbina, Anna Šedivá, Mikko R.J. Seppänen, Helen Su, Stuart G Tangye, Sehime G. Temel, Ahmad Abou Tayoun, Stuart Turvey, K.M. Furkan Uddin, Diederik van de Beek, Tom Le Voyer, Donald C. Vinh, Shen-Ying Zhang, Jean-Laurent Casanova, Michael R. Wilson, Jérémie Rosain, Emmanuelle Jouanguy, Mélodie Aubart, Laurent Abel, Trine H. Mogensen, Qiang Pan-Hammarström, Daxing Gao, Darragh Duffy, Aurélie Cobat, Stefan Berg, Luigi D. Notarangelo, Oliver Harschnitz, Charles M. Rice, Lorenz Studer, Jean-Laurent Casanova, Olov Ekwall, Shen-Ying Zhang
Publicado en: Journal of Experimental Medicine, Edición 221, 2024, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20231725

Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants

Autores: Matthias Bruhn, Maureen Obara, Abdus Salam, Bibiana Costa, Annett Ziegler, Inken Waltl, Andreas Pavlou, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Axel Schambach, Ulrich Kalinke
Publicado en: European Journal of Immunology, Edición 54, 2024, ISSN 0014-2980
Editor: Wiley
DOI: 10.1002/EJI.202451056

Pharmaceuticals

Autores: Centofanti et al.
Publicado en: Pharmaceuticals (Basel), 2024, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph16020240

The “Black Swan Principle” and the Genetics of Complex Diseases

Autores: Giuseppe Novelli, Juergen K V Reichardt
Publicado en: Top Italian Scientists Journal, Edición 1, 2024, ISSN 3033-5132
Editor: Top Italian Scientists
DOI: 10.62684/YEWJ9912

Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia

Autores: Philippot et al.
Publicado en: Journal of Clinical Immunology, 2023, ISSN 2576-0572
Editor: Cmepub.com
DOI: 10.1007/s10875-023-01512-9

Human autoantibodies neutralizing type I IFNs: From 1981 to 2023

Autores: Paul Bastard, Adrian Gervais, Tom Le Voyer, Quentin Philippot, Aurélie Cobat, Jérémie Rosain, Emmanuelle Jouanguy, Laurent Abel, Shen‐Ying Zhang, Qian Zhang, Anne Puel, Jean‐Laurent Casanova
Publicado en: Immunological Reviews, Edición 322, 2024, ISSN 0105-2896
Editor: Wiley
DOI: 10.1111/IMR.13304

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Autores: Lee et al.
Publicado en: Science, 2022, ISSN 1095-9203
Editor: Science
DOI: 10.1126/science.abo3627

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Autores: Zhang et al.
Publicado en: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220514

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Autores: Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. Netea, Antonio Condino-Neto, Yu Lung Lau, Esmeralda Núñez Cuadros, Julie Toubiana, Marisol Holanda Pena, Frédéric Rieux-Laucat, Charles-Edouard Luyt, Filomeen Haerynck, Jean Louis Mège, Samya Chakravorty, Elie Haddad, Marie-Paule Morin, Özge Metin Akcan, Sevgi Keles, Melike Emiroglu, Gulsum Alkan, Sadiye Kübra Tüter Öz, Sefika Elmas Bozdemir, Guillaume Morelle, Alla Volokha, Yasemin Kendir-Demirkol, Betul Sözeri, Taner Coskuner, Aysun Yahsi, Belgin Gulhan, Saliha Kanik-Yuksek, Gulsum Iclal Bayhan, Aslinur Ozkaya-Parlakay, Osman Yesilbas, Nevin Hatipoglu, Tayfun Ozcelik, Alexandre Belot, Emilie Chopin, Vincent Barlogis, Esra Sevketoglu, Emin Menentoglu, Zeynep Gokce Gayretli Aydin, Marketa Bloomfield, Suzan A. AlKhater, Cyril Cyrus, Yuriy Stepanovskiy, Anastasiia Bondarenko, Fatma Nur Öz, Meltem Polat, Jiří Fremuth, Jan Lebl, Amyrath Geraldo, Emmanuelle Jouanguy, null null, Alessandro Aiuti, Laia Alsina, Evangelos Andreakos, Ana de Andrés Martín, Catherine M. Biggs, Alessandro Borghesi, Amed Aziz Bousfiha, Daniel Blazquez-Gamero, Petter Brodin, Giorgio Casari, Antonio Condino-Neto, Jacques Fellay, Carlos Flores, Guy Gorochov, Emine Hafize Erdeniz, Lennart Hammarström, Yolanda Jordan Garcia, Adem Karbuz, Adam Klocperk, Paloma Lapuente-Suanzes, Yu-Lung Lau, Cheng Leung, Davood Mansouri, Trine H. Mogensen, Lisa F.P. Ng, Antonio Novelli, Giuseppe Novelli, Keisuke Okamoto, Satoshi Okada, Qiang Pan-Hammarström, Graziano Pesole, Laurent Renia, Carlos Rodriguez-Gallego, Anna Sediva, Mohammad Shahrooei, Pere Soler-Palacin, András N. Spaan, Gonul Tanir, Ahmad Abou Tayoun, Şehime G. Temel, Donald C. Vinh, null null, Aubrey Cunnington, Jethro Herberg, Myrsini Kaforou, Victoria J. Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D'Souza, Leire Estramia Elorrieta, Diego Estrada-Rivadeneyra, Rachel Galassini, Dominic Habgood-Coote, Shea Hamilton, Heather Jackson, James Kavangh, Ila Keren, Mahdi Moradi Marjaneh, Stephanie Menikou, Samuel Nichols, Ruud Nijman, Ivana Pennisi, Oliver Powell, Ruth Reid, Priyen Shah, Ortensia Vito, Elizabeth Whittaker, Clare Wilson, Rebecca Womersley, Ami Abdulla, Sarah Darnell, Sobia Mustafa, Pantelis Georgiou, Jesus-Rodriguez Manzano, Nicolas Moser, Michael Carter, Shane Tibby, Jonathan Cohen, Francesca Davis, Julia Kenny, Paul Wellman, Marie White, Matthew Fish, Aislinn Jennings, Manu Shankar-Hari, Katy Fidler, Dan Agranoff, Vivien Richmond, Mathhew Seal, Saul Faust, Dan Owen, Ruth Ensom, Sarah McKay, Mariya Shaji, Rachel Schranz, Prita Rughni, Amutha Anpanthar, Susan Liebeschuetz, Anna Riddell, Divya Divakaran, Louise Han, Nosheen Khalid, Ivone Lancoma Malcolm, Jessica Schofield, Teresa Simagan, Mark Peters, Alasdair Bamford, Lauran O'Neill, Nazima Pathan, Esther Daubney, Deborah White, Melissa Heightman, Sarah Eisen, Terry Segal, Lucy Wellings, Simon B. Drysdale, Nicole Branch, Lisa Hamzah, Heather Jarman, Maggie Nyirenda, Lisa Capozzi, Emma Gardiner, Robert Moots, Magda Nasher, Anita Hanson, Michelle Linforth, Sean O'Riordan, Don Ellis, Akash Deep, Ivan Caro, Fiona Shackley, Arianna Bellini, Stuart Gormley, Samira Neshat, Barnaby Scholefield, Ceri Robbins, Helen Winmill, Stéphane C. Paulus, Andrew J. Pollard, Mark Anthony, Sarah Hopton, Danielle Miller, Zoe Oliver, Sally Beer, Bryony Ward, Shrija Shrestha, Meeru Gurung, Puja Amatya, Bhishma Pokhrel, Sanjeev Man Bijukchhe, Madhav Chandra Gautam, Sarah Kelly, Peter O'Reilly, Sonu Shrestha, Federico Martinón-Torres, Antonio Salas, Fernando Álvez González, Sonia Ares Gómez, Xabier Bello, Mirian B
Publicado en: Journal of Experimental Medicine, Edición 221, 2024, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20240699

Pathogens

Autores: Skouboe et al.
Publicado en: Pathogens, 2022, ISSN 2076-0817
Editor: Basel MDPI AG 2012-
DOI: 10.3390/pathogens12020310

Health Care Personnel Workdays Lost and Direct Health Care Salary Costs Incurred due to COVID-19 Infection in the Age of Widespread Vaccine Availability

Autores: Liam Townsend, Paddy Gillespie, Jonathan McGrath, Claire Kenny, null null, Lorraine Doherty, Lisa Domegan, Niall Conlon, Greg Martin, Cillian de Gascun, Joan Gallagher, Mary Keogan, Noirin Noonan, Cliona O’Farrelly, David Byrne, Colm Bergin, Catherine Fleming
Publicado en: The Journal of Infectious Diseases, 2024, ISSN 0022-1899
Editor: Oxford University Press (OUP)
DOI: 10.1093/INFDIS/JIAE223

Humoral immunity after mRNA SARS-CoV-2 omicron JN.1 vaccination

Autores: Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Publicado en: The Lancet Infectious Diseases, Edición 24, 2025, ISSN 1473-3099
Editor: Elsevier BV
DOI: 10.1016/S1473-3099(24)00603-0

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein

Autores: Budhadev et al.
Publicado en: JACS Au, 2023, ISSN 2691-3704
Editor: Washington, DC American Chemical Society [2021]-
DOI: 10.1021/jacsau.3c00163

Smoking changes adaptive immunity with persistent effects

Autores: Violaine Saint-André, Bruno Charbit, Anne Biton, Vincent Rouilly, Céline Possémé, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy, null null, Laurent Abel, Andres Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf-Bensussan, Ana Cumano, Christophe D’Enfert, Caroline Demangel, Ludovic Deriano, Marie-Agnès Dillies, James Di Santo, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Hercberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Frédérique Michel, Hugo Mouquet, Cliona O’Farrelly, Antonio Rausell, Frédéric Rieux-Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Christophe Zimmer
Publicado en: Nature, Edición 626, 2024, ISSN 0028-0836
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41586-023-06968-8

PCSK3 Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-γ Gene Expression

Autores: Latini et al.
Publicado en: Genes, Edición 14 (5), 981, 2023, ISSN 2073-4425
Editor: Basel Multidisciplinary Digital Publishing Institute (MDPI) 2010-
DOI: 10.3390/genes14050981

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

Autores: Paul Bastard, Adrian Gervais, Maki Taniguchi, Liisa Saare, Karita Särekannu, Tom Le Voyer, Quentin Philippot, Jérémie Rosain, Lucy Bizien, Takaki Asano, Marina Garcia-Prat, Alba Parra-Martínez, Mélanie Migaud, Miyuki Tsumura, Francesca Conti, Alexandre Belot, Jacques G. Rivière, Tomohiro Morio, Junko Tanaka, Etienne Javouhey, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Yacine Tandjaoui-Lambiotte, Simon Escoda, Maya Husain, Qiang Pan-Hammarström, Lennart Hammarström, Gloria Ahlijah, Anthony Abi Haidar, Camille Soudee, Vincent Arseguel, Hassan Abolhassani, Sabina Sahanic, Ivan Tancevski, Yoko Nukui, Seiichi Hayakawa, George P. Chrousos, Athanasios Michos, Elizabeth-Barbara Tatsi, Filippos Filippatos, Agusti Rodriguez-Palmero, Jesus Troya, Imran Tipu, Isabelle Meyts, Lucie Roussel, Sisse Rye Ostrowski, Laire Schidlowski, Carolina Prando, Antonio Condino-Neto, Nathalie Cheikh, Ahmed A. Bousfiha, Jalila El Bakkouri, null null, Sergio Aguilera-Albesa, Suzan A. AlKhater, Gulsum Alkan, Riccardo Castagnoli, Cyril Cyrus, Sefika Elmas Bozdemir, Melike Emiroglu, Belgin Gulhan, Emine Hafize Erdeniz, Nevin Hatipoglu, Gülsün Iclal Bayhan, Petr Jabandziev, Saliha Kanik Yuksek, Adem Karbuz, Şadiye Kübra Tüter Öz, Gian Luigi Marseglia, Ozge Metin Akcan, Ahmet Osman Kılıç, Aslinur Ozkaya Parlakay, Maria Papadaki, Katerina Slaba, Esra Sevketoglu, Juan Valencia-Ramos, Aysun Yahşi, null null, Antonio Aguilera Guirao, Julián Álvarez Escudero, Antonio Antela López, Gema Barbeito Castiñeiras, Xabier Bello Paderne, Miriam Ben García, María Victoria Carral García, Miriam Cebey López, Amparo Coira Nieto, Mónica Conde Pájaro, José Javier Costa Alcalde, María José Currás Tuala, Ana Isabel Dacosta Urbieta, Blanca Díaz Esteban, María Jesús Domínguez Santalla, Cristina Fernández Pérez, Juan Fernández Villaverde, Cristóbal Galbán Rodríguez, José Luis García Allut, Luisa García Vicente, Elena Giráldez Vázquez, Alberto Gómez Carballa, José Gómez Rial, Francisco Javier González Barcala, Beatriz Guerra Liñares, Pilar Leboráns Iglesias, Beatriz Lence Massa, Marta Lendoiro Fuentes, Montserrat López Franco, Ana López Lago, Federico Martinón-Torres, Antonio Salas, Daniel Navarro De la Cruz, Eloína Núñez Masid, Juan Bautista Ortolá Devesa, Jacobo Pardo Seco, María Pazo Núñez, Marisa Pérez del Molino Bernal, Hugo Pérez Freixo, Lidia Piñeiro Rodríguez, Sara Pischedda, Manuel Portela Romero, Antonio Pose Reino, Gloria María Prada Hervella, Teresa Queiro Verdes, Lorenzo Redondo Collazo, Patricia Regueiro Casuso, Susana Rey García, Sara Rey Vázquez, Vanessa Riveiro Blanco, Irene Rivero Calle, Carmen Rivero Velasco, Nuria Rodríguez Núñez, Carmen Rodríguez-Tenreiro Sánchez, Eva Saborido Paz, José Miguel Sadiki Orayyou, Carla Saito Villanueva, Sonia Serén Fernández, Pablo Souto Sanmartín, Manuel Taboada Muñiz, Rocío Trastoy Pena, Mercedes Treviño Castellano, Luis Valdés Cuadrado, Pablo Varela García, María Soledad Vilas Iglesias, Sandra Viz Lasheras, Rocio Ferreiro-Iglesias, Iria Bastón-Rey, Cristina Calviño-Suárez, null null, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean-Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein
Publicado en: Journal of Experimental Medicine, Edición 221, 2024, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/JEM.20231353

Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination

Autores: Metodi V Stankov, Markus Hoffmann, Rodrigo Gutierrez Jauregui, Anne Cossmann, Gema Morillas Ramos, Theresa Graalmann, Emily Jo Winter, Michaela Friedrichsen, Inga Ravens, Tamara Ilievska, Jasmin Ristenpart, Anja Schimrock, Stefanie Willenzon, Gerrit Ahrenstorf, Torsten Witte, Reinhold Förster, Amy Kempf, Stefan Pöhlmann, Swantje I Hammerschmidt, Alexandra Dopfer-Jablonka, Georg M N Behrens
Publicado en: The Lancet Infectious Diseases, Edición 24, 2024, ISSN 1473-3099
Editor: Elsevier BV
DOI: 10.1016/S1473-3099(23)00690-4

Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants.

Autores: Cobat et al.
Publicado en: Annual Review of Biomedical Data Science, Edición 6, 2023, ISSN 2574-3414
Editor: Annual Reviews
DOI: 10.1146/annurev-biodatasci-020222-021705

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Autores: Tangye et al.
Publicado en: Journal of Allergy and Clinical Immunology, 2022, ISSN 2772-8293
Editor: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2022.11.010

COVID-19 annual update: a narrative review

Autores: Biancolella et al.
Publicado en: Hum Genomics, 2023, ISSN 1479-7364
Editor: London BioMed Central
DOI: 10.1186/s40246-023-00515-2

Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy

Autores: Patricia Resa-Infante, Itziar Erkizia, Xabier Muñiz-Trabudua, Federica Linty, Arthur E.H. Bentlage, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Theo Rispens, Gestur Vidarsson, Javier Martinez-Picado
Publicado en: Biomedicine &amp; Pharmacotherapy, Edición 175, 2025, ISSN 0753-3322
Editor: Elsevier BV
DOI: 10.1016/J.BIOPHA.2024.116726

Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D

Autores: Prerna Arora, Lu Zhang, Inga Nehlmeier, Amy Kempf, Luise Graichen, Eike Kreitz, Anzhalika Sidarovich, Cheila Rocha, Sabine Gärtner, Michael Winkler, Sebastian Schulz, Hans-Martin Jäck, Markus Hoffmann, Stefan Pöhlmann
Publicado en: Journal of Virology, Edición 99, 2025, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.01230-24

Nature Communications

Autores: Hoffmann et al.
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39147-4

Ancient DNA as a tool for medical research

Autores: Kerner et al.
Publicado en: Nature Medicine, 2023, ISSN 1546-170X
Editor: Nature
DOI: 10.1038/s41591-023-02244-4

Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia

Autores: Su et al.
Publicado en: Annual Review of Immunology, 2023, ISSN 1545-3278
Editor: Annual Reviews
DOI: 10.1146/annurev-immunol-101921-050835

Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID

Autores: Kristoffer Skaalum Hansen, Sofie Eg Jørgensen, Cagla Cömert, Berit Schiøttz‐Christensen, Peter Bross, Jane Agergaard, Steffen Leth, Lars Østergaard, Johan Palmfeldt, Rikke Katrine Jentoft Olsen, Trine H. Mogensen
Publicado en: Journal of Medical Virology, Edición 97, 2025, ISSN 0146-6615
Editor: Wiley
DOI: 10.1002/JMV.70275

Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

Autores: von Gunten et al.
Publicado en: Frontiers in Immunology, 2023, ISSN 2832-4404
Editor: Lausanne Frontiers Media S.A. 2010-
DOI: 10.48350/181810

Omicron sublineage BQ.1.1 resistance to monoclonal antibodies

Autores: Arora et al.
Publicado en: The Lancet Infectious Diseases, 2022, ISSN 1474-4457
Editor: The Lancet
DOI: 10.1016/S1473-3099(22)00733-2

The genetic and evolutionary determinants of COVID-19 susceptibility

Autores: Kerner et al.
Publicado en: European Journal of Human Genetics, 2022, ISSN 1476-5438
Editor: Nature
DOI: 10.1038/s41431-022-01141-7

Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage

Autores: Nehlmeier et al.
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 2042-0226
Editor: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01030-z

Immune responses to SARS-CoV-2 infection and vaccination in children

Autores: Brodin, Petter
Publicado en: Seminars in Immunology, 2023, ISSN 1096-3618
Editor: Elsevir
DOI: 10.1016/j.smim.2023.101794

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

Autores: Hoffmann et al.
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1038/s41423-023-00988-0

Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants

Autores: Liam Townsend, Jean Dunne, Jacklyn Sui, Carla Sanchez Perez, Matt McElheron, Cian Reid, William McCormack, Colm Bergin, Catherine Fleming, Cliona O'Farrelly, Gareth Brady, Niall Conlon
Publicado en: Clinical Immunology, Edición 268, 2024, ISSN 1521-6616
Editor: Elsevier BV
DOI: 10.1016/J.CLIM.2024.110371

Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19

Autores: Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
Publicado en: Biology Direct, Edición 19, 2024, ISSN 1745-6150
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13062-024-00523-9

Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation

Autores: Matthias Bruhn, Maureen Obara, Abhishek Chiyyeadu, Bibiana Costa, Abdus Salam, Annett Ziegler, Inken Waltl, Andreas Pavlou, Agnes Bonifacius, Markus Hoffmann, Theresa Graalmann, Stefan Pöhlmann, Britta Eiz-Vesper, Axel Schambach, Ulrich Kalinke
Publicado en: Journal of Infection, Edición 88, 2024, ISSN 0163-4453
Editor: Elsevier BV
DOI: 10.1016/J.JINF.2023.10.020

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

Autores: Marie Materna, Ottavia M. Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E. Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A. Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc’h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A. Schramm, Sanjana Shah, John J. Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S. Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P. Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R. Regueiro, Maria L. Toribio, Judith R. Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C. Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E. Henrickson, Hervé Luche, Luigi D. Notarangelo, Jean-Laurent Casanova, Vivien Béziat
Publicado en: Science, Edición 383, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADH4059

SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency

Autores: Lu Zhang, Amy Kempf, Inga Nehlmeier, Anne Cossmann, Anja Richter, Najat Bdeir, Luise Graichen, Anna-Sophie Moldenhauer, Alexandra Dopfer-Jablonka, Metodi V. Stankov, Etienne Simon-Loriere, Sebastian R. Schulz, Hans-Martin Jäck, Luka Čičin-Šain, Georg M.N. Behrens, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann
Publicado en: Cell, Edición 187, 2025, ISSN 0092-8674
Editor: Elsevier BV
DOI: 10.1016/J.CELL.2023.12.025

Variation of the 3’RR1 HS1.2 Enhancer and Its Genomic Context

Autores: Carla Jodice, Patrizia Malaspina, Bianca Maria Ciminelli, Cristina Martinez-Labarga, Michela Biancolella, Giuseppe Novelli, Andrea Novelletto
Publicado en: Genes, Edición 15, 2024, ISSN 2073-4425
Editor: MDPI AG
DOI: 10.3390/GENES15070856

Human life within a narrow range: The lethal ups and downs of type I interferons

Autores: Yanick J. Crow, Jean-Laurent Casanova
Publicado en: Science Immunology, Edición 9, 2024, ISSN 2470-9468
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIIMMUNOL.ADM8185

The ouroboros of autoimmunity

Autores: Jean-Laurent Casanova, Jessica Peel, Jean Donadieu, Anna-Lena Neehus, Anne Puel, Paul Bastard
Publicado en: Nature Immunology, Edición 25, 2024, ISSN 1529-2908
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41590-024-01815-Y

COVID-19: S-Peptide RBD 484–508 Induces IFN-γ T-Cell Response in Naïve-to-Infection and Unvaccinated Subjects with Close Contact with SARS-CoV-2-Positive Patients

Autores: Murdocca et al.
Publicado en: Viruses, 2023, ISSN 1999-4915
Editor: Basel MDPI 2009-
DOI: 10.3390/v15071417

Host cell entry and neutralisation sensitivity of the emerging SARS-CoV-2 variant LP.8.1

Autores: Lu Zhang, Amy Kempf, Inga Nehlmeier, Nianzhen Chen, Metodi V Stankov, Christine Happle, Alexandra Dopfer-Jablonka, Georg M N Behrens, Markus Hoffmann, Stefan Pöhlmann
Publicado en: The Lancet Infectious Diseases, Edición 25, 2025, ISSN 1473-3099
Editor: Elsevier BV
DOI: 10.1016/S1473-3099(25)00113-6

Dissecting human population variation in single-cell responses to SARS-CoV-2

Autores: Bisiaux et al.
Publicado en: Nature, 2023, ISSN 1476-4687
Editor: Nature
DOI: 10.1038/s41586-023-06422-9

Genome Medicine

Autores: Matuozzo et al.
Publicado en: Genome Medicine, 2023, ISSN 1756-994X
Editor: [London] BioMed Central
DOI: 10.1186/s13073-023-01173-8

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Autores: Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Laurent Abel, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Jean-Laurent Casanova, Giorgio Casari, John Christodoulou, Aurélie Cobat, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Guy Gorochov, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, France Mentré, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F.P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Jean W. Pape, Rebeca Perez de Diego, Jordi Perez-Tur, David S. Perlin, Graziano Pesole, Anna M. Planas, Carolina Prando, Aurora Pujol, Anne Puel, Lluis Quintana-Murci, Sathishkumar Ramaswamy, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Anna Sediva, Mikko R.J. Seppänen, Mohammad Shahrooei, Anna Shcherbina, Ondrej Slaby, Andrew L. Snow, Pere Soler-Palacín, Vassili Soumelis, András N. Spaan, Ivan Tancevski, Stuart G. Tangye, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Pierre Tiberghien, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Joost Wauters, Mayana Zatz, Pawel Zawadzki, Qian Zhang, Shen-Ying Zhang, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Benleulmi-Chaachoua, Sebastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Helene Abergel, Fariza Abeud, Sophie Abgrall, Noemie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frederic Adnet, Sara Afritt, Helene Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Ait Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby-Laurent, Lucie Allard, Marie-Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, Marc Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, Caroline Aparicio, Gladys Aratus, Jean-Benoit Arlet, Jeremy Arzoine, Elisabeth Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Etienne Audureau, Christelle Nathalie Auger, Jean-Charles Auregan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran-Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthelemy, Jean-Luc Baudel, Camille Baudry, Elodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltran, Ruben Benainous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Berard, Que
Publicado en: Human Genetics and Genomics Advances, Edición 5, 2025, ISSN 2666-2477
Editor: Elsevier BV
DOI: 10.1016/J.XHGG.2024.100300

A Dynamic and Effective Peptide-Based Strategy for Promptly Addressing Emerging SARS-CoV-2 Variants of Concern

Autores: Michela Murdocca, Isabella Romeo, Gennaro Citro, Andrea Latini, Federica Centofanti, Antonella Bugatti, Francesca Caccuri, Arnaldo Caruso, Francesco Ortuso, Stefano Alcaro, Federica Sangiuolo, Giuseppe Novelli
Publicado en: Pharmaceuticals, Edición 17, 2025, ISSN 1424-8247
Editor: MDPI AG
DOI: 10.3390/PH17070891

Lower disease activity but higher risk of severe COVID-19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α

Autores: Mathian et al.
Publicado en: Annals of the Rheumatic Diseases, 2022, ISSN 1468-2060
Editor: BMJ Group on behalf of the European League Against Rheumatism
DOI: 10.1136/ARD-2022-222549

Immune responses following BNT162b2 XBB.1.5 vaccination in patients on haemodialysis in Germany

Autores: Anne Cossmann, Markus Hoffmann, Metodi V Stankov, Karsten Lürken, Gema Morillas Ramos, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Georg M N Behrens, Alexandra Dopfer-Jablonka
Publicado en: The Lancet Infectious Diseases, Edición 24, 2025, ISSN 1473-3099
Editor: Elsevier BV
DOI: 10.1016/S1473-3099(23)00783-1

Impact of socioeconomic status on healthy immune responses in humans

Autores: Anthony Bertrand, Jamie Sugrue, Tianai Lou, Nollaig M Bourke, Lluis Quintana‐Murci, Violaine Saint‐André, Cliona O'Farrelly, Darragh Duffy, null null
Publicado en: Immunology &amp; Cell Biology, Edición 102, 2024, ISSN 0818-9641
Editor: Wiley
DOI: 10.1111/IMCB.12789

Viruses

Autores: Campos-Gonzalez et al.
Publicado en: Viruses, 2024, ISSN 1999-4915
Editor: Basel MDPI 2009-
DOI: 10.3390/v15030789

Neutralisation sensitivity of SARS-CoV-2 lineages EG.5.1 and XBB.2.3

Autores: Zhang et al.
Publicado en: The Lancet Infectious Diseases, 2023, ISSN 1474-4457
Editor: Elsevier
DOI: 10.1016/S1473-3099(23)00547-9

Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype

Autores: Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant
Publicado en: European Journal of Immunology, Edición 55, 2025, ISSN 0014-2980
Editor: Wiley
DOI: 10.1002/EJI.202451516

Human determinants of age-dependent patterns of death from infection

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Publicado en: Immunity, Edición 57, 2024, ISSN 1074-7613
Editor: Elsevier BV
DOI: 10.1016/J.IMMUNI.2024.05.020

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Publicado en: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220170

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Publicado en: Journal of Allergy and Clinical Immunology, 2023, ISSN 2772-8293
Editor: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2023.02.003

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Publicado en: Journal of Experimental Medicine, 2022, ISSN 1540-9538
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220258