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CORDIS - EU research results
CORDIS

Respiratory Host-Pathogen Interaction

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Expand the current sentinel system (opens in new window)

Expand the current Danish Sentinel Surveillance System to include blood samples from individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.Create a prospective cohort based on the Spanish Sentinel Surveillance System to include blood samplesfrom individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.

Dissemination & Communication strategy (opens in new window)

We will prepare materials including (1) Project logo and a graphical chart to build the consortium signature and increase REACT visibility worldwide. (2) Slide templates edited with the project chart will be distributed to all partners. (3) A brochure and poster presenting the partners, the consortium, its objectives and expected results, contact and website details will be issued to support the dissemination activities of the project to the wider public (M3).

Project website and REACT materials (logo, templates and brochure) (opens in new window)

It will include the proposed innovations and knowledge to reach their final exploitation and, thus, make them available and delivered to the scientific community and to the society. The web site will count with a secure intranet system to have internal communications among REACT project members (M3).

Data Management Plan (opens in new window)

The Data Manager will create a Data Management Plan (DMP), which will aim to maximise access to and re-use of research data gathered and produced through REACT where possible.The DMP will be reviewed and updated regularly during the project. This will be done in close collaboration with the Ethics Manager (EM).

Online meeting with existing EU projects to initiate collaboration (opens in new window)

Collaborate with existing initiatives such as the EU-funded ORCHESTRA project and the European COVID-19 Data Platform. Build on existing collaborations and platforms such as GISAID, ELIXIR, ICPerMed and 1+ Million Genomes Initiative.

Risk and Contingency Plan (opens in new window)

The PC will carefully observe any potential conflicts and risks related to both scientific delivery and the participants’ contractual obligations. Any conflict will be dealt with immediately and with the appropriate measures. With the assistance of the legal team at SSI, the coordinator will negotiate a Consortium Agreement (CA) with all participants prior to project start. This will ensure that all the participants are aware of their rights and obligations as well as processes for conflict resolution. The project’s identified risks will be monitored carefully, and if any issues should occur, these will be dealt with in a timely and efficient manner, taking all necessary precautions and steps to mitigate the risks. Moreover, the initial contingency plan will be updated annually by the Scientific Core Group, comprised of all WP leaders to ensure that it remains relevant and useful.

Create a grand overview of existing resources (opens in new window)

Integrate existing cohorts, collections and biobanks from the consortium partners. Denmark: RegH, Zealco, DTU and SSI cohorts, and the Danish National Biobank. Sweden: Karolinska cohorts. Spain: ISCIII-BBP coordinated by CNIO Biobank. As lead partner in this WP we will revise and harmonize all the cohorts samples and research information so as to integrate and share with participants from other WPs as required. The biorepository of biological samples from black South African hospitalized patients will be stored at the NICD; samples will be shipped as required to participants from other WPs.

A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from SARS-CoV-2 infected hospitalized black South African individuals with and without HIV-1 infection (opens in new window)

A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from black South African individuals with and without HIV-1 infection (from Dec 2020 through different SARS-CoV-2 waves, dominated by specific viral variants (wave 1: ancestral D614G, wave 2: beta, wave 3: delta, and is ongoing). Recruitment complete; clinical data analysis, patient sample selection for D 7.2-7.4 (M12).

Securing ethical and regulatory approvals for studying influenza and RSV (opens in new window)

Ensure approvals and legal aspects of the use of already genotyped cohorts for this study.

Publications

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells (opens in new window)

Author(s): Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Published in: Star Protoc, 2022, ISSN 2666-1667
Publisher: Cell Press, [2020]
DOI: 10.1016/j.xpro.2022.101872

Harnessing mechanobiology for kidney organoid research (opens in new window)

Author(s): Zarina Nauryzgaliyeva, Iphigénie Goux Corredera,Elena Garreta, and Nuria Montserrat*
Published in: Front Cell Dev Biol., 2023, ISSN 2296-634X
Publisher: Frontiers Media Sa
DOI: 10.3389/fcell.2023.1273923

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells (opens in new window)

Author(s): Garreta E; Prado P; Stanifer ML; Monteil V; Marco A; Ullate-Agote A; Moya-Rull D; Vilas-Zornoza A; Tarantino C; Romero JP; Jonsson G; Oria R; Leopoldi A; Hagelkruys A; Gallo M; González F; Domingo-Pedrol P; Gavaldà A; Del Pozo CH; Hasan Ali O; Ventura-Agu
Published in: Cell Metabolism, 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.04.009

Assessing kidney development and disease using kidney organoids and CRISPR engineering (opens in new window)

Author(s): Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Published in: Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media Sa
DOI: 10.3389/fcell.2022.948395

Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering (opens in new window)

Author(s): Goux Corredera, Iphigénie; Amato, Gaia; Moya-Rull, Daniel; Garreta, Elena; Montserrat, Nuria
Published in: Kidney International, 2025, ISSN 0922-3444
Publisher: Elsevier
DOI: 10.1016/j.kint.2025.01.043

Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells (opens in new window)

Author(s): Anisha Pahuja 1, Iphigénie Goux Corredera 1, Daniel Moya-Rull Elena Garreta , Nuria Montserrat
Published in: Curr Opin Cell Biol ., 2024, ISSN 0955-0674
Publisher: Curr Opin Cell Biol .
DOI: 10.1016/j.ceb.2023.102306

Small (opens in new window)

Author(s): Garreta, Elena; Moya‐Rull, Daniel; Marco, Andrés; Amato, Gaia; Ullate‐Agote, Asier; Tarantino, Carolina; Gallo, Maria; Esporrín‐Ubieto, David; Centeno, Alberto; Vilas‐Zornoza, Amaia; Mestre, Rafael; Kalil, María; Gorroñogoitia, Izar; Zaldua, Ane Miren; Sanchez, Samuel; Izquierdo Reyes, Laura; Fernández‐Santos, María Eugenia; Prosper, Felipe; Montserrat, Nuria
Published in: Advanced Materials, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/ADMA.202400306

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