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CORDIS - Résultats de la recherche de l’UE
CORDIS

Respiratory Host-Pathogen Interaction

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Expand the current sentinel system (s’ouvre dans une nouvelle fenêtre)

Expand the current Danish Sentinel Surveillance System to include blood samples from individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.Create a prospective cohort based on the Spanish Sentinel Surveillance System to include blood samplesfrom individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.

Dissemination & Communication strategy (s’ouvre dans une nouvelle fenêtre)

We will prepare materials including (1) Project logo and a graphical chart to build the consortium signature and increase REACT visibility worldwide. (2) Slide templates edited with the project chart will be distributed to all partners. (3) A brochure and poster presenting the partners, the consortium, its objectives and expected results, contact and website details will be issued to support the dissemination activities of the project to the wider public (M3).

Project website and REACT materials (logo, templates and brochure) (s’ouvre dans une nouvelle fenêtre)

It will include the proposed innovations and knowledge to reach their final exploitation and, thus, make them available and delivered to the scientific community and to the society. The web site will count with a secure intranet system to have internal communications among REACT project members (M3).

Data Management Plan (s’ouvre dans une nouvelle fenêtre)

The Data Manager will create a Data Management Plan (DMP), which will aim to maximise access to and re-use of research data gathered and produced through REACT where possible.The DMP will be reviewed and updated regularly during the project. This will be done in close collaboration with the Ethics Manager (EM).

Online meeting with existing EU projects to initiate collaboration (s’ouvre dans une nouvelle fenêtre)

Collaborate with existing initiatives such as the EU-funded ORCHESTRA project and the European COVID-19 Data Platform. Build on existing collaborations and platforms such as GISAID, ELIXIR, ICPerMed and 1+ Million Genomes Initiative.

Risk and Contingency Plan (s’ouvre dans une nouvelle fenêtre)

The PC will carefully observe any potential conflicts and risks related to both scientific delivery and the participants’ contractual obligations. Any conflict will be dealt with immediately and with the appropriate measures. With the assistance of the legal team at SSI, the coordinator will negotiate a Consortium Agreement (CA) with all participants prior to project start. This will ensure that all the participants are aware of their rights and obligations as well as processes for conflict resolution. The project’s identified risks will be monitored carefully, and if any issues should occur, these will be dealt with in a timely and efficient manner, taking all necessary precautions and steps to mitigate the risks. Moreover, the initial contingency plan will be updated annually by the Scientific Core Group, comprised of all WP leaders to ensure that it remains relevant and useful.

Create a grand overview of existing resources (s’ouvre dans une nouvelle fenêtre)

Integrate existing cohorts, collections and biobanks from the consortium partners. Denmark: RegH, Zealco, DTU and SSI cohorts, and the Danish National Biobank. Sweden: Karolinska cohorts. Spain: ISCIII-BBP coordinated by CNIO Biobank. As lead partner in this WP we will revise and harmonize all the cohorts samples and research information so as to integrate and share with participants from other WPs as required. The biorepository of biological samples from black South African hospitalized patients will be stored at the NICD; samples will be shipped as required to participants from other WPs.

A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from SARS-CoV-2 infected hospitalized black South African individuals with and without HIV-1 infection (s’ouvre dans une nouvelle fenêtre)

A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from black South African individuals with and without HIV-1 infection (from Dec 2020 through different SARS-CoV-2 waves, dominated by specific viral variants (wave 1: ancestral D614G, wave 2: beta, wave 3: delta, and is ongoing). Recruitment complete; clinical data analysis, patient sample selection for D 7.2-7.4 (M12).

Securing ethical and regulatory approvals for studying influenza and RSV (s’ouvre dans une nouvelle fenêtre)

Ensure approvals and legal aspects of the use of already genotyped cohorts for this study.

Publications

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells (s’ouvre dans une nouvelle fenêtre)

Auteurs: Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Publié dans: Star Protoc, 2022, ISSN 2666-1667
Éditeur: Cell Press, [2020]
DOI: 10.1016/j.xpro.2022.101872

Harnessing mechanobiology for kidney organoid research (s’ouvre dans une nouvelle fenêtre)

Auteurs: Zarina Nauryzgaliyeva, Iphigénie Goux Corredera,Elena Garreta, and Nuria Montserrat*
Publié dans: Front Cell Dev Biol., 2023, ISSN 2296-634X
Éditeur: Frontiers Media Sa
DOI: 10.3389/fcell.2023.1273923

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells (s’ouvre dans une nouvelle fenêtre)

Auteurs: Garreta E; Prado P; Stanifer ML; Monteil V; Marco A; Ullate-Agote A; Moya-Rull D; Vilas-Zornoza A; Tarantino C; Romero JP; Jonsson G; Oria R; Leopoldi A; Hagelkruys A; Gallo M; González F; Domingo-Pedrol P; Gavaldà A; Del Pozo CH; Hasan Ali O; Ventura-Agu
Publié dans: Cell Metabolism, 2022, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2022.04.009

Assessing kidney development and disease using kidney organoids and CRISPR engineering (s’ouvre dans une nouvelle fenêtre)

Auteurs: Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Publié dans: Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers Media Sa
DOI: 10.3389/fcell.2022.948395

Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineering (s’ouvre dans une nouvelle fenêtre)

Auteurs: Goux Corredera, Iphigénie; Amato, Gaia; Moya-Rull, Daniel; Garreta, Elena; Montserrat, Nuria
Publié dans: Kidney International, 2025, ISSN 0922-3444
Éditeur: Elsevier
DOI: 10.1016/j.kint.2025.01.043

Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells (s’ouvre dans une nouvelle fenêtre)

Auteurs: Anisha Pahuja 1, Iphigénie Goux Corredera 1, Daniel Moya-Rull Elena Garreta , Nuria Montserrat
Publié dans: Curr Opin Cell Biol ., 2024, ISSN 0955-0674
Éditeur: Curr Opin Cell Biol .
DOI: 10.1016/j.ceb.2023.102306

Small (s’ouvre dans une nouvelle fenêtre)

Auteurs: Garreta, Elena; Moya‐Rull, Daniel; Marco, Andrés; Amato, Gaia; Ullate‐Agote, Asier; Tarantino, Carolina; Gallo, Maria; Esporrín‐Ubieto, David; Centeno, Alberto; Vilas‐Zornoza, Amaia; Mestre, Rafael; Kalil, María; Gorroñogoitia, Izar; Zaldua, Ane Miren; Sanchez, Samuel; Izquierdo Reyes, Laura; Fernández‐Santos, María Eugenia; Prosper, Felipe; Montserrat, Nuria
Publié dans: Advanced Materials, 2024, ISSN 1613-6810
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/ADMA.202400306

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