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Leistungen
Expand the current Danish Sentinel Surveillance System to include blood samples from individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.Create a prospective cohort based on the Spanish Sentinel Surveillance System to include blood samplesfrom individuals with respiratory viral infections of concern, in order to “live monitor” emerging viral variants and investigate novel host-pathogen interactions.
We will prepare materials including (1) Project logo and a graphical chart to build the consortium signature and increase REACT visibility worldwide. (2) Slide templates edited with the project chart will be distributed to all partners. (3) A brochure and poster presenting the partners, the consortium, its objectives and expected results, contact and website details will be issued to support the dissemination activities of the project to the wider public (M3).
Project website and REACT materials (logo, templates and brochure) (öffnet in neuem Fenster)It will include the proposed innovations and knowledge to reach their final exploitation and, thus, make them available and delivered to the scientific community and to the society. The web site will count with a secure intranet system to have internal communications among REACT project members (M3).
The Data Manager will create a Data Management Plan (DMP), which will aim to maximise access to and re-use of research data gathered and produced through REACT where possible.The DMP will be reviewed and updated regularly during the project. This will be done in close collaboration with the Ethics Manager (EM).
Online meeting with existing EU projects to initiate collaboration (öffnet in neuem Fenster)Collaborate with existing initiatives such as the EU-funded ORCHESTRA project and the European COVID-19 Data Platform. Build on existing collaborations and platforms such as GISAID, ELIXIR, ICPerMed and 1+ Million Genomes Initiative.
Risk and Contingency Plan (öffnet in neuem Fenster)The PC will carefully observe any potential conflicts and risks related to both scientific delivery and the participants’ contractual obligations. Any conflict will be dealt with immediately and with the appropriate measures. With the assistance of the legal team at SSI, the coordinator will negotiate a Consortium Agreement (CA) with all participants prior to project start. This will ensure that all the participants are aware of their rights and obligations as well as processes for conflict resolution. The project’s identified risks will be monitored carefully, and if any issues should occur, these will be dealt with in a timely and efficient manner, taking all necessary precautions and steps to mitigate the risks. Moreover, the initial contingency plan will be updated annually by the Scientific Core Group, comprised of all WP leaders to ensure that it remains relevant and useful.
Create a grand overview of existing resources (öffnet in neuem Fenster)Integrate existing cohorts, collections and biobanks from the consortium partners. Denmark: RegH, Zealco, DTU and SSI cohorts, and the Danish National Biobank. Sweden: Karolinska cohorts. Spain: ISCIII-BBP coordinated by CNIO Biobank. As lead partner in this WP we will revise and harmonize all the cohorts samples and research information so as to integrate and share with participants from other WPs as required. The biorepository of biological samples from black South African hospitalized patients will be stored at the NICD; samples will be shipped as required to participants from other WPs.
A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from SARS-CoV-2 infected hospitalized black South African individuals with and without HIV-1 infection (öffnet in neuem Fenster)A repository of longitudinal plasma/serum, whole blood, swab, PBMCs and neutrophils from black South African individuals with and without HIV-1 infection (from Dec 2020 through different SARS-CoV-2 waves, dominated by specific viral variants (wave 1: ancestral D614G, wave 2: beta, wave 3: delta, and is ongoing). Recruitment complete; clinical data analysis, patient sample selection for D 7.2-7.4 (M12).
Ensure approvals and legal aspects of the use of already genotyped cohorts for this study.
Veröffentlichungen
Autoren:
Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Veröffentlicht in:
Star Protoc, 2022, ISSN 2666-1667
Herausgeber:
Cell Press, [2020]
DOI:
10.1016/j.xpro.2022.101872
Autoren:
Zarina Nauryzgaliyeva, Iphigénie Goux Corredera,Elena Garreta, and Nuria Montserrat*
Veröffentlicht in:
Front Cell Dev Biol., 2023, ISSN 2296-634X
Herausgeber:
Frontiers Media Sa
DOI:
10.3389/fcell.2023.1273923
Autoren:
Garreta E; Prado P; Stanifer ML; Monteil V; Marco A; Ullate-Agote A; Moya-Rull D; Vilas-Zornoza A; Tarantino C; Romero JP; Jonsson G; Oria R; Leopoldi A; Hagelkruys A; Gallo M; González F; Domingo-Pedrol P; Gavaldà A; Del Pozo CH; Hasan Ali O; Ventura-Agu
Veröffentlicht in:
Cell Metabolism, 2022, ISSN 1550-4131
Herausgeber:
Cell Press
DOI:
10.1016/j.cmet.2022.04.009
Autoren:
Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Veröffentlicht in:
Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Herausgeber:
Frontiers Media Sa
DOI:
10.3389/fcell.2022.948395
Autoren:
Goux Corredera, Iphigénie; Amato, Gaia; Moya-Rull, Daniel; Garreta, Elena; Montserrat, Nuria
Veröffentlicht in:
Kidney International, 2025, ISSN 0922-3444
Herausgeber:
Elsevier
DOI:
10.1016/j.kint.2025.01.043
Autoren:
Anisha Pahuja 1, Iphigénie Goux Corredera 1, Daniel Moya-Rull Elena Garreta , Nuria Montserrat
Veröffentlicht in:
Curr Opin Cell Biol ., 2024, ISSN 0955-0674
Herausgeber:
Curr Opin Cell Biol .
DOI:
10.1016/j.ceb.2023.102306
Autoren:
Garreta, Elena; Moya‐Rull, Daniel; Marco, Andrés; Amato, Gaia; Ullate‐Agote, Asier; Tarantino, Carolina; Gallo, Maria; Esporrín‐Ubieto, David; Centeno, Alberto; Vilas‐Zornoza, Amaia; Mestre, Rafael; Kalil, María; Gorroñogoitia, Izar; Zaldua, Ane Miren; Sanchez, Samuel; Izquierdo Reyes, Laura; Fernández‐Santos, María Eugenia; Prosper, Felipe; Montserrat, Nuria
Veröffentlicht in:
Advanced Materials, 2024, ISSN 1613-6810
Herausgeber:
Wiley - V C H Verlag GmbbH & Co.
DOI:
10.1002/ADMA.202400306
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