Project description DEENESFRITPL A new environmentally friendly way of producing drugs Mechanochemistry is a pioneering, low-cost way of inducing chemical processes via mechanical stress. Potentially, it could be used to mitigate the considerable environmental impact of drug manufacturing because mechanochemistry is less energy-intensive, emits less CO2, and does not require chemical solvents. In a pilot scheme, the EU-funded IMPACTIVE project will develop mechanochemical processes to produce several active pharmaceutical ingredients used in drugs. If the concept is proven viable, drug manufacturing would then meet the new environmental stipulations imposed by the EU Green Deal. Results will be openly shared with pharmaceutical manufacturers and other interested parties to promote awareness and adoption of this potentially game-changing process. Show the project objective Hide the project objective Objective The environmental impact of the pharmaceutical industry is a huge problem. The production and use of pharmaceuticals cause high CO2 emissions, contamination of soils, biota, and water, and even dangers to human health through carcinogenic impurities. Especially the use of solvents is a major problem. The European Green Deal has led to strict regulations on environmental pollution by the pharma industry, causing manufacturers to move outside of the EU due to the high costs associated with green pharma. This results in supply chain fragility and low crisis preparedness in Europe. New methods to produce pharmaceuticals in a green, efficient, and economically friendly way are required.The IMPACTIVE project brings together the expertise and knowledge from two COST Actions and will develop novel green methods to produce active pharmaceutical ingredients (APIs) using mechanochemistry as a disruptive technology (as acknowledged by IUPAC). Mechanochemistry uses mechanical processes, such as ball milling, twin-screw extrusion, resonant acoustic mixing, and spray drying, to induce chemical reactions. The advantages of mechanochemistry include: no solvent use, high efficiency, low costs, and reduced energy use and CO2 emission. Upon completion of the project, we will provide proof-of-concept at a small pilot scale of the use of mechanochemistry to produce 6 APIs from 3 different families of compounds. Based on a recent study, switching to mechanochemistry can reduce terrestrial ecotoxicity and CO2 emissions by more than 85%, while production costs were reduced with 12%. The results of the IMPACTIVE project will thus enable pharmaceutical manufacturers to move back to Europe while minimizing environmental pollution.Through our strong dissemination and communication strategy we will ensure that the project?s results are shared with scientists, the pharmaceutical industry, and stakeholders from regulatory and public authorities to achieve maximum impact. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionengineering and technologychemical engineeringchemical process engineeringsocial scienceseconomics and businesseconomicssustainable economynatural scienceschemical sciences Keywords Mechanochemistry Green Chemistry API manufacturing Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine Topic(s) HORIZON-HLTH-2021-IND-07-01 - Green pharmaceuticals Call for proposal HORIZON-HLTH-2021-IND-07 See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator UNIVERSITE DE MONTPELLIER Net EU contribution € 1 945 046,00 Address 163 rue auguste broussonnet 34090 Montpellier France See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 Participants (15) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER France Net EU contribution € 59 377,00 Address 240 av du prof emile jeanbrau 34296 Montpellier cedex 5 See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 STICHTING RADBOUD UNIVERSITEIT Netherlands Net EU contribution € 450 000,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 44 587,50 UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium Net EU contribution € 420 000,00 Address Place de l universite 1 1348 Louvain la neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TALLINNA TEHNIKAÜLIKOOL Estonia Net EU contribution € 399 972,00 Address Ehitajate tee 5 12616 Tallinn See on map Region Eesti Eesti Põhja-Eesti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG Germany Net EU contribution € 336 150,00 Address Unter den eichen 87 12205 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 93 000,00 RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Germany Net EU contribution € 451 250,00 Address Templergraben 55 52062 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 32 500,00 MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG Germany Net EU contribution € 524 248,00 Address Kaiser wilhelm platz 1 45470 Muelheim an der ruhr See on map Region Nordrhein-Westfalen Düsseldorf Mülheim an der Ruhr Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,75 THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Ireland Net EU contribution € 699 441,00 Address College green trinity college D02 CX56 Dublin 2 See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israel Net EU contribution € 300 662,00 Address Senate building technion city 32000 Haifa See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE Italy Net EU contribution € 610 000,00 Address Via della lastruccia 3 50019 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITA DEGLI STUDI DI CAGLIARI Italy Net EU contribution € 40 000,00 Address Via universita 40 09124 Cagliari See on map Region Isole Sardegna Cagliari Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IST-ID ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E O DESENVOLVIMENTO Portugal Net EU contribution € 374 894,00 Address Avenida antonio jose de almeida 12 1000-043 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 56 724,75 DES SOLUTIO - SOLUCOES E CONSULTORIA CIENTIFICA LDA Portugal Net EU contribution € 271 165,00 Address Rua helena felix 20 2 recuado 2820 266 Charneca de caparica See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AGATA COMUNICACION CIENTIFICA SL Spain Net EU contribution € 371 875,00 Address Calle bajada del caleruco 26 bloque a planta 4 puerta d 39012 Santander See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noroeste Cantabria Cantabria Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AXLR SATT OCCITANIE MEDITERRANEE France Net EU contribution € 184 625,00 Address 950 rue saint priest csu bat 6 34090 Montpellier See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE Switzerland Net EU contribution € 0,00 Address Route de moutier 14 2800 Delemont See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Jura Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SIGMA-ALDRICH PRODUCTION GMBH Switzerland Net EU contribution € 0,00 Address Industriestrasse 25 9470 Buchs See on map Region Schweiz/Suisse/Svizzera Ostschweiz St. Gallen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NOVARTIS PHARMA AG Switzerland Net EU contribution € 0,00 Address Lichtstrasse 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 JOHNSON MATTHEY PLC Participation ended United Kingdom Net EU contribution € 0,00 Address Farringdon street 25 5th floor EC4A 4AB London See on map Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data