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Innovative Mechanochemical Processes to synthesize green ACTIVE pharmaceutical ingredients.

Objective

The environmental impact of the pharmaceutical industry is a huge problem. The production and use of pharmaceuticals cause high CO2 emissions, contamination of soils, biota, and water, and even dangers to human health through carcinogenic impurities. Especially the use of solvents is a major problem. The European Green Deal has led to strict regulations on environmental pollution by the pharma industry, causing manufacturers to move outside of the EU due to the high costs associated with green pharma. This results in supply chain fragility and low crisis preparedness in Europe. New methods to produce pharmaceuticals in a green, efficient, and economically friendly way are required.

The IMPACTIVE project brings together the expertise and knowledge from two COST Actions and will develop novel green methods to produce active pharmaceutical ingredients (APIs) using mechanochemistry as a disruptive technology (as acknowledged by IUPAC). Mechanochemistry uses mechanical processes, such as ball milling, twin-screw extrusion, resonant acoustic mixing, and spray drying, to induce chemical reactions.

The advantages of mechanochemistry include: no solvent use, high efficiency, low costs, and reduced energy use and CO2 emission. Upon completion of the project, we will provide proof-of-concept at a small pilot scale of the use of mechanochemistry to produce 6 APIs from 3 different families of compounds. Based on a recent study, switching to mechanochemistry can reduce terrestrial ecotoxicity and CO2 emissions by more than 85%, while production costs were reduced with 12%. The results of the IMPACTIVE project will thus enable pharmaceutical manufacturers to move back to Europe while minimizing environmental pollution.Through our strong dissemination and communication strategy we will ensure that the project?s results are shared with scientists, the pharmaceutical industry, and stakeholders from regulatory and public authorities to achieve maximum impact.

Coordinator

UNIVERSITE DE MONTPELLIER
Net EU contribution
€ 1 945 046,00
Address
163 Rue Auguste Broussonnet
34090 Montpellier
France

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25

Participants (15)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
France
Net EU contribution
€ 59 377,00
Address
240 Av Du Prof Emile Jeanbrau
34296 Montpellier Cedex 5

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 450 000,00
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 44 587,50
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Net EU contribution
€ 420 000,00
Address
Place De L Universite 1
1348 Louvain La Neuve

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Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TALLINNA TEHNIKAÜLIKOOL
Estonia
Net EU contribution
€ 399 972,00
Address
Ehitajate Tee 5
12616 Tallinn

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG
Germany
Net EU contribution
€ 336 150,00
Address
Unter Den Eichen 87
12205 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Non-EU contribution
€ 93 000,00
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
Net EU contribution
€ 451 250,00
Address
Templergraben 55
52062 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 32 500,00
MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Germany
Net EU contribution
€ 524 248,00
Address
Kaiser Wilhelm Platz 1
45470 Muelheim An Der Ruhr

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Region
Nordrhein-Westfalen Düsseldorf Mülheim an der Ruhr
Activity type
Research Organisations
Non-EU contribution
€ 0,75
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 699 441,00
Address
College Green Trinity College
D02 CX56 Dublin 2

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Net EU contribution
€ 300 662,00
Address
Senate Building Technion City
32000 Haifa

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE
Italy
Net EU contribution
€ 610 000,00
Address
Via Della Lastruccia 3
50019 Firenze

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Region
Centro (IT) Toscana Firenze
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
Net EU contribution
€ 40 000,00
Address
Via Universita 40
09124 Cagliari

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Region
Isole Sardegna Cagliari
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E DESENVOLVIMENTO
Portugal
Net EU contribution
€ 374 894,00
Address
Avenida Rovisco Pais 1
1049 001 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 56 724,75
DES SOLUTIO - SOLUCOES E CONSULTORIA CIENTIFICA LDA
Portugal
Net EU contribution
€ 271 165,00
Address
Rua Helena Felix 20 2 Recuado
2820 266 Charneca De Caparica

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AGATA COMUNICACION CIENTIFICA SL
Spain
Net EU contribution
€ 371 875,00
Address
Calle Bajada Del Caleruco 26 Bloque A Planta 4 Puerta D
39012 Santander

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Cantabria Cantabria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AXLR SATT OCCITANIE MEDITERRANEE
France
Net EU contribution
€ 184 625,00
Address
950 Rue Saint Priest Csu Bat 6
34090 Montpellier

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00