Innovative Mechanochemical Processes to synthesize green ACTIVE pharmaceutical ingredients.

Project Information

IMPACTIVE

Grant agreement ID: 101057286

DOI

10.3030/101057286

EC signature date 23 May 2022

Start date 1 October 2022

End date 30 September 2026

Funded under

• Health

Total cost

€ 7 665 520,00

EU contribution

€ 7 438 705,00

Coordinated by

UNIVERSITE DE MONTPELLIER
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Data Management Plan

Data Management plan (DMP) will be developed, aiming to maximise access to and re-use of research data gathered and produced wherever possible.

Communication, Dissemination & Outreach Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed.Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens and other target groups.Due date: month 12, and updated yearly month 24, 36 and 48 or when needed.

Websites, patent fillings, videos etc. (1)

Website and communication material

Website and branding guidelines launched; Initial communication material released

Publications

Peer reviewed articles (7)

Mechanochemistry in Europe: where we come from and where we are now

Author(s): Juan José Sáenz de la Torre, Leyre Flamarique, Fernando Gomollon-Bel, Evelina Colacino
Published in: Open Research Europe, 2025, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/OPENRESEUROPE.19848.1

Sustainable Beckmann Rearrangement using Bead-Milling Technology: The Route to Paracetamol

Author(s): Geib, R.; Colacino, E.; Gremaud, L.
Published in: ChemSusChem, 2024, ISSN 1864-564X
Publisher: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/cssc.202301921

Multigram‐scale organic synthesis by Resonant Acoustic Mixing. Application to the Sustainable Preparation of Active Pharmaceutical Ingredients.

Author(s): Christos Chatzigiannis, Stefania Scalzullo, Evelina Colacino, Maria Elena Rivas-Velazco
Published in: ChemSusChem, 2025, ISSN 1864-5631
Publisher: Wiley
DOI: 10.1002/CSSC.202500110

Protecting-Group-Free Mechanosynthesis of Amides from Hydroxycarboxylic Acids: Application to the Synthesis of Imatinib

Author(s): Tatsiana Nikonovich, Tatsiana Jarg, Jevgenija Martõnova, Artjom Kudrjašov, Danylo Merzhyievskyi, Marina Kudrjašova, Fabrice Gallou, Riina Aav, Dzmitry Kananovich
Published in: RSC Mechanochemistry, 2024, ISSN 2976-8683
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4MR00006D

Behind the Science: Bead-Mill Technology for Greener Paracetamol Synthesis

Author(s): Colacino, E., Gremaud, L., Kostner, V.
Published in: Chemistry Views, 2024, ISSN 2751-4765
Publisher: Chemistry Europe
DOI: 10.1002/chemv.202400019

Green metrics in mechanochemistry

Author(s): Fantozzi, Nicolas; Volle, Jean-Noël; Porcheddu, Andrea; Virieux, David; Garcia, Felipe; Colacino, Evelina
Published in: Chemical Society Reviews, Issue 52, 2023, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/D2CS00997H

Scalability of Pharmaceutical Co-Crystal Formation by Mechanochemistry in Batch

Author(s): Bodach, Alexander; PORTET, Anaïs; Winkelmann, Frederik; Bastian, Herrmann; Gallou, Fabrice; Ponnusamy, Ettigounder; VIRIEUX, David; Colacino, Evelina; Felderhoff, Michael
Published in: ChemSusChem, 2023, ISSN 1864-5631
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cssc.202301220

Book chapters (1)

Green Chemistry Tools in Mechanochemistry

Author(s): Andrea Casagrande, Allan Niidu, Riina Aav, Dzmitry Kananovich, Evelina Colacino
Published in: Encyclopedia of Green Chemistry, 2025, ISBN 978-0-443-28923-1
Publisher: Elsevier

Other (1)

Protecting-Group-Free Mechanosynthesis of Amides from Hydroxycarboxylic Acids: Application to the Synthesis of Imatinib

Author(s): Nikonovich, Tatsiana; Jarg, Tatsiana; Martõnova, Jevgenija; Kudrjašov, Artjom; Merzhyievskyi, Danylo; Kudrjašova, Marina; Gallou, Fabrice; Aav, Riina; Kananovich, Dzmitry
Published in: ChemRxiv, 2023, ISSN 2573-2293
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2023-d4nxn