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Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life

Objective

Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice. In contrast, ATT is often continued until death, resulting in excess bleeding, higher healthcare costs, and increased disease burden. SERENITY will develop an information-driven, palliative care shared decision-making process enabled by a user-friendly, easily accessible, web-based shared decision support tool (SDST) that will facilitate treatment decisions regarding appropriate use of ATT in cancer patients at the end of life. SERENITY will use a comprehensive approach consisting of a combination of realist review, flash mob research, three epidemiologic studies in NL, UK, and DK, and qualitative interviews. The results of these studies will be used in a Delphi process to reach consensus on the optimal design of the intervention. Using the consensus reached in the Delphi process, the SDST will be designed to be patient-specific with adaption to gender, cancer-related, cultural, and socioeconomic factors. Proceeding, the SDST will be tested and optimised in a Randomised Clinical Trial. A targeted implementation and exploitation plan will be developed to enable the use of the SERENITY approach across Europe, as well as incorporation in national and pan-European clinical guidelines and policies. The intervention will ultimately lead to appropriate use of ATT, prevention of bleeding complications, and considerable cost savings in addition to improved quality of life and treatment satisfaction of patients, their carers, and involved healthcare professionals. The intervention will empower cancer patients and their carers, enabling them to make their own choices. The intervention will reduce the disease burden of hundreds of thousands of people living with cancer receiving palliative care each year, throughout all EU regions.

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Net EU contribution
€ 1 726 107,50
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (12)

CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU
France
Net EU contribution
€ 52 550,00
Address

42055 Saint Etienne

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Loire
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 135 555,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 167 578,00
Address
Langenbeckstrasse 1
55131 Mainz

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,75
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 627 906,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,25
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
Net EU contribution
€ 210 000,00
Address
Carrer Rossello 149
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 127 500,00
Address
Calle Villarroel 170
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRUM MEDYCZNE KSZTALCENIA PODYPLOMOWEGO
Poland
Net EU contribution
€ 144 000,00
Address
Marymoncka 99/103
01 813 Warszawa

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SOCIETA PER L'ASSISTENZA AL MALATO ONCOLOGICO TERMINALE ONLUS
Italy
Net EU contribution
€ 249 025,00
Address
Via Mariano Rumor 10
97100 Ragusa

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Region
Isole Sicilia Ragusa
Activity type
Other
Non-EU contribution
€ 0,00
TODAYTOMORROW B.V.
Netherlands
Net EU contribution
€ 477 737,00
Address
Hofplein 19
3032 AC Rotterdam

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,50
REGION NORDJYLLAND (NORTH DENMARK REGION)
Denmark
Net EU contribution
€ 350 010,00
Address
Niels Bohrs Vej 30
9220 Aalborg

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Region
Danmark Nordjylland Nordjylland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 180 812,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
ASSOCIATION FRANCOPHONE POUR LES SOINS ONCOLOGIQUES DE SUPPORT
France
Net EU contribution
€ 34 750,00
Address
76, Rue Marcel Sembat
33323 Begles

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Other
Non-EU contribution
€ 0,00