SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients

Deliverables

Characterization of HERVs transcriptional and protein expression profiles, immunophenotyping and cytokine storm (in swab and blood, flow- cytometry in blood, antibodies in plasma) in COVID-19 patients

Clinical panel

Definition of a first panel of clinical markers based on clinical and biochemical data

First communication report

Report on Communication and Outreach activities for the first half of the project

Publications

Characterization of COVID-19 and post-acute sequelae of SARS-CoV-2 infection cohort study: the role of CD169 as a biomarker of systemic dysfunction and its alteration respect to SARS-CoV-2 pandemic waves’

Author(s): Christian Maracchioni
Published in: 2023
Publisher: UNITOV

Human endogenous retroviruses in sepsis

Author(s): Claudia Matteucci
Published in: 2024
Publisher: Sepsis Trieste 2024

The potential contribution of flow cytometry to characterize and define extracellular vesicles: the experience in COVID-19 and post-acute sequelae of SARS-CoV-2 infection.

Author(s): Marialaura Fanelli, Vita Petrone, Rossella Chirico, Claudia Maria Radu, Claudia Matteucci and Antonella Minutolo
Published in: 2024
Publisher: EVIta 2024

The expression of CD169 and HLA-DR in blood cells and circulating microvesicles as a new tool for monitoring SARS-CoV-2 infection and Long COVID associated sequelae: lesson from pandemic waves.

Author(s): Marialaura Fanelli, Vita Petrone, Rossella Chirico, Christian Maracchioni, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Chiara Cipriani, Alexandre Lucas, Claudia M. Radu, Fabrice Malergue, Vincenzo Malagnino, Marco Iannetta, Emanuela Balestrieri, Loreda
Published in: 2024
Publisher: SIM Pavia 2024

Multi-parametric profile associated to human endogenous retroviruses defined COVID-19 with respect to Long COVID individuals highlighting the association with specific psychiatric and neurological symptoms.

Author(s): Antonella Minutolo, Vita Petrone, Marialaura Fanelli, Rossella Chirico, Martina Giudice, Chiara Cipriani, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Alexandre Lucas, Hervè Perron, Emanuela Balestrieri, Sandro Grelli
Published in: 2024
Publisher: SIM Pavia 2024

AI and Machine Learning-driven characterization models for post-COVID-19 condition: Enhancing personalized care in primary care settings.

Author(s): David Lerma Irureta, Fátima Méndez-López, Jesus Ibañez Ruiz, Jon Schoorlemmer, Carmen Vicente García, Rosa Magallon Botaya
Published in: 2025
Publisher: EUROPEAN GENERAL PRACTICE RESEARCH NETWORK

Characterization of T-cell immunodysfunction in COVID-19 patients and its persistent dysregulation in Long COVID individuals.

Author(s): Vita Petrone, Antonella Minutolo, Marialaura Fanelli, Rossella Chirico, Chiara Cipriani, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Emanuela Balestrieri, Alexandre Lucas, Sandro Grelli, Loredana Sarmati, Claudia Mat
Published in: 2024
Publisher: ISCCA Verona 2024

Multiparametric profile unravels the association of HERVs with immune dysfunction and inflammation in COVID-19 and with Long COVID psychiatric and neurological sequelae. ECV 2025

Author(s): Antonella Minutolo, Vita Petrone, Marialaura Fanelli, Rossella Chirico, Luigi Coppola, Martina Giudice, Chiara Cipriani, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Alexandre Lucas, Hervè Perron, Marco Iannetta, Emanuela Balestrieri, Loredana Sarm
Published in: 2025
Publisher: ECV 2025

CD169 and HLA-DR in blood cells and circulating extracellular vesicles in COVID-19 as markers infection and post-acute sequelae monitoring.

Author(s): Vita Petrone, Marialaura Fanelli, Rossella Chirico, Chiara Cipriani, Martina Giudice, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Fabrice Malergue, Emanuela Balestrieri, Loredana Sarmati, Sandro Grelli, Antonella Min
Published in: 2024
Publisher: Sepsis Trieste 2024

Dynamic expression of CD169 and HLA-DR in blood cells and circulating microvesicles in COVID-19 and Long COVID: newinsights by nanoscale flow cytometry.

Author(s): Matteucci Claudia, Minutolo Antonella.
Published in: 2024
Publisher: ISCCA Verona 2024

Impact of Persistent Symptoms on Quality of Life in Long COVID Patients: A Comparative Study

Author(s): David Lerma Irureta, Beatriz Omiste, Elsa Presa-Gutiérrez, Fátima Méndez-López, Rosa Magallon Botaya
Published in: 2024
Publisher: VE AME

Multi-parametric analysis associates human endogenous retroviruses to immune system impairment in COVID-19 and in long covid unravelling disease heterogeneity. A.

Author(s): Minutolo A, Petrone V, Fanelli M, Chirico R, Giudice M, Cipriani C, Coppola L, Teti E, Sorace C, Malagnino V, Lucas A, Perron H, Iannetta M, Balestrieri E, Grelli S, Sarmati L, Matteucci C.
Published in: 2024
Publisher: SIV Bologna 2024

Evaluation of myeloid activation markers in blood cells and circulating extracellular vesicles as new tool for monitoring SARS-CoV-2 infection and Long COVID associated sequelae

Author(s): Fanelli M., Petrone V., Chirico R., Maracchioni C., Coppola L., Sorace C., Chiara Cipriani C., Giudice M., Radu C.M., Teti E., Malagnino V., Iannetta M., Bernardini S., Balestrieri E., Sarmati L., Grelli S., Minutolo A. *, Matteucci C.
Published in: 2024
Publisher: CSEVP 2024

Crosstalk between human endogenous retroviruses and exogenous viruses

Author(s): Edoardo Pizzioli, Antonella Minutolo, Emanuela Balestrieri, Claudia Matteucci, Gkikas Magiorkinis, Branka Horvat
Published in: Microbes and Infection, 2024, ISSN 1286-4579
Publisher: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105427

Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers

Author(s): Bárbara Oliván-Blázquez, Marta Bona-Otal, Fátima Méndez-López, David Lerma-Irureta, Paula García-Izuel, Jesús Ibáñez-Ruiz, Alberto Montolío, María Ruiz-Herreros, Javier Godino, Beatriz Jimeno-Beltran, María del Mar Encabo-Berzosa, Izaskun Arenaz, Ana Medel-Martínez, Verónica Casado-Vicente, Mayte Coiras, Carlos Tellería-Orriols, Jon Schoorlemmer, Rosa Magallón-Botaya
Published in: iScience, Issue 27, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2024.110839

Programme des XXVIIes Journées francophones de virology 23, 24 & 25 avril 2025

Published in: Virologie, Issue 29, 2025, ISSN 1267-8694
Publisher: JLE
DOI: 10.1684/VIR.2025.1081

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

Author(s): B.Charvet, J.Brunel, J.Pierquin, M.Iampietro, D.Decimo, N.Queruel, A.Lucas, M.del Mar Encabo-Berzosa, I.Arenaz, T.P.Marmolejo, A.Gonzalez, A.C.Maldonado, C.Mathieu, P.Kury, J.Flores-Rivera, F.Torres-Ruiz, S.Avila-Rios, G.Salgado Montes de Oca,
Published in: iScience, Issue Volume 26 issue 11, 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.106604

Expression Profile of HERVs And Inflammatory Mediators Detected In Nasal Mucosa As Predictive Biomarker of COVID-19 Severity

Author(s): Petrone, V, Fanelli, M.L, Giudice M., Toschi, N., Conti, A., Maracchioni, C., Ianetta, M., Resta, C., Cipriani, C., Miele, M.T., Amati, F., Andreoni, M., Sarmati, L., Rogliani, P., Novelli, G., Garaci, E., Rasi, G., Sinibaldi Vallebona, P., Minutolo, A.,
Published in: Frontiers in Microbiology, Issue 22:14:1155624, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1155624

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Author(s): Marialaura Fanelli, Vita Petrone, Christian Maracchioni, Rossella Chirico, Chiara Cipriani, Luigi Coppola, Vincenzo Malagnino, Elisabetta Teti, Chiara Sorace, Marta Zordan, Pietro Vitale, Marco Iannetta, Emanuela Balestrieri, Guido Rasi, Sandro Grelli, Fabrice Malergue, Loredana Sarmati, Antonella Minutolo, Claudia Matteucci
Published in: Current Research in Microbial Sciences, Issue 6, 2024, ISSN 2666-5174
Publisher: Elsevier BV
DOI: 10.1016/J.CRMICR.2023.100215

HERV-W ENV transcription in B cells predicting symptomatic COVID-19 and risk for long COVID can express a full-length protein despite stop codon in mRNA from chromosome X via a ribosome readthrough

Author(s): Joanna Brunel, Julien Paganini, Melissa Galloux, Benjamin Charvet, Hervé Perron
Published in: Microbes and Infection, 2024, ISSN 1286-4579
Publisher: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105431

Thymosin Alpha 1 Restores the Immune Homeostasis in lymphocytes during Post-Acute Sequelae of SARS-CoV-2 infection

Author(s): A. Minutolo, V. Petrone, M. Fanelli, C. Maracchioni, M. Giudice, E. Teti, L. Coppola, C. Sorace, M. Iannetta, M.T. Miele, S. Bernardini, A. Mastino, P. Sinibaldi Vallebona, E. Balestrieri, M. Andreoni, L. Sarmati, S. Grelli, E. Garaci, C. Matteucci
Published in: Int Immunopharmacology, Issue 118:110055, 2023, ISSN 1878-1705
Publisher: ELSEVIER
DOI: 10.1016/j.intimp.2023.110055

International Journal of Molecular Sciences

Author(s): Balestrieri E, Corinaldesi E, Fabi M, Cipriani C, Giudice M, Conti A, Minutolo A, Petrone V, Fanelli M, Miele MT, Andreozzi L, Guida F, Filice E, Meli M, Grelli S, Rasi G, Toschi N, Torcetta F, Matteucci C, Lanari M, Sinibaldi-Vallebona P
Published in: Int J Mol Sci, Issue Int J Mol Sci, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015086

Limitations of current high-throughput sequencing technologies lead to biased expression estimates of endogenous retroviral elements

Author(s): Konstantina Kitsou, Aris Katzourakis, Gkikas Magiorkinis
Published in: NAR Genomics and Bioinformatics, Issue 6, 2024, ISSN 2631-9268
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NARGAB/LQAE081

Flow cytometry for extracellular vesicle characterization in COVID-19 and post-acute sequelae of SARS-CoV-2 infection

Author(s): Marialaura Fanelli; Vita Petrone; Rossella Chirico; Claudia Maria Radu; Antonella Minutolo; Claudia Matteucci
Published in: Extracellular Vesicles and Circulating Nucleic Acids, 2024, ISSN 2767-6641
Publisher: OAE Publishing Inc
DOI: 10.20517/EVCNA.2024.20

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms

Author(s): K.Gimenez-Orenga1, J. Pierquin, J.Brunel, B.Charvet, E.M.Martinez, H.Perron, E.Oltra
Published in: Frontiers in Immunology, Issue 13 eCollection 2022, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.1020064

Multidistrict Host–Pathogen Interaction during COVID-19 and the Development Post-Infection Chronic Inflammation

Author(s): Fanelli, M.; Petrone, V.; Buonifacio,M. Delibato,NE.; Balestrieri, E.; Grelli, S.; Minutolo,A.; Matteucci,C
Published in: Pathogens, Issue 1198, 2022, ISSN 2076-0817
Publisher: MDPI
DOI: 10.3390/pathogens11101198

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Author(s): Marialaura Fanelli; Vita Petrone; Christian Maracchioni; Rossella Chirico; Chiara Cipriani; Luigi Coppola; Vincenzo Malagnino; Elisabetta Teti; Chiara Sorace; Marta Zordan; Pietro Vitale; Marco Iannetta; Emanuela Balestrieri; Guido Rasi; Sandro Grelli; Fabrice Malergue; Loredana Sarmati; Antonella Minutolo; Claudia Matteucci
Published in: Current Research in Microbial Sciences, 2024, ISSN 2666-5174
Publisher: ELSEVIER
DOI: 10.1016/j.crmicr.2023.100215

Deliverables

Publications

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