SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients

Project Information

HERVCOV

Grant agreement ID: 101057302

DOI 10.3030/101057302

EC signature date 2 June 2022

Start date 1 July 2022

End date 30 June 2027

Funded under

• Health

Total cost € 6 846 157,00

EU contribution € 6 846 157,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Deliverables

Documents, reports (1)

Clinical panel

Definition of a first panel of clinical markers based on clinical and biochemical data

Publications

Peer reviewed articles (7)

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

Author(s): B.Charvet, J.Brunel, J.Pierquin, M.Iampietro, D.Decimo, N.Queruel, A.Lucas, M.del Mar Encabo-Berzosa, I.Arenaz, T.P.Marmolejo, A.Gonzalez, A.C.Maldonado, C.Mathieu, P.Kury, J.Flores-Rivera, F.Torres-Ruiz, S.Avila-Rios, G.Salgado Montes de Oca,
Published in: iScience, Issue Volume 26 issue 11, 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.106604

Expression Profile of HERVs And Inflammatory Mediators Detected In Nasal Mucosa As Predictive Biomarker of COVID-19 Severity

Author(s): Petrone, V, Fanelli, M.L, Giudice M., Toschi, N., Conti, A., Maracchioni, C., Ianetta, M., Resta, C., Cipriani, C., Miele, M.T., Amati, F., Andreoni, M., Sarmati, L., Rogliani, P., Novelli, G., Garaci, E., Rasi, G., Sinibaldi Vallebona, P., Minutolo, A.,
Published in: Frontiers in Microbiology, Issue 22:14:1155624, 2023, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2023.1155624

Thymosin Alpha 1 Restores the Immune Homeostasis in lymphocytes during Post-Acute Sequelae of SARS-CoV-2 infection

Author(s): A. Minutolo, V. Petrone, M. Fanelli, C. Maracchioni, M. Giudice, E. Teti, L. Coppola, C. Sorace, M. Iannetta, M.T. Miele, S. Bernardini, A. Mastino, P. Sinibaldi Vallebona, E. Balestrieri, M. Andreoni, L. Sarmati, S. Grelli, E. Garaci, C. Matteucci
Published in: Int Immunopharmacology, Issue 118:110055, 2023, ISSN 1878-1705
Publisher: ELSEVIER
DOI: 10.1016/j.intimp.2023.110055

International Journal of Molecular Sciences

Author(s): Balestrieri E, Corinaldesi E, Fabi M, Cipriani C, Giudice M, Conti A, Minutolo A, Petrone V, Fanelli M, Miele MT, Andreozzi L, Guida F, Filice E, Meli M, Grelli S, Rasi G, Toschi N, Torcetta F, Matteucci C, Lanari M, Sinibaldi-Vallebona P
Published in: Int J Mol Sci, Issue Int J Mol Sci, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015086

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms

Author(s): K.Gimenez-Orenga1, J. Pierquin, J.Brunel, B.Charvet, E.M.Martinez, H.Perron, E.Oltra
Published in: Frontiers in Immunology, Issue 13 eCollection 2022, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.1020064

Multidistrict Host–Pathogen Interaction during COVID-19 and the Development Post-Infection Chronic Inflammation

Author(s): Fanelli, M.; Petrone, V.; Buonifacio,M. Delibato,NE.; Balestrieri, E.; Grelli, S.; Minutolo,A.; Matteucci,C
Published in: Pathogens, Issue 1198, 2022, ISSN 2076-0817
Publisher: MDPI
DOI: 10.3390/pathogens11101198

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Author(s): Marialaura Fanelli; Vita Petrone; Christian Maracchioni; Rossella Chirico; Chiara Cipriani; Luigi Coppola; Vincenzo Malagnino; Elisabetta Teti; Chiara Sorace; Marta Zordan; Pietro Vitale; Marco Iannetta; Emanuela Balestrieri; Guido Rasi; Sandro Grelli; Fabrice Malergue; Loredana Sarmati; Antonella Minutolo; Claudia Matteucci
Published in: Current Research in Microbial Sciences, 2024, ISSN 2666-5174
Publisher: ELSEVIER
DOI: 10.1016/j.crmicr.2023.100215