SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients

Información del proyecto

HERVCOV

Identificador del acuerdo de subvención: 101057302

DOI 10.3030/101057302

Fecha de la firma de la CE 2 Junio 2022

Fecha de inicio 1 Julio 2022

Fecha de finalización 30 Junio 2027

Financiado con arreglo a

• Health

Coste total € 6 846 157,00

Aportación de la UE € 6 846 157,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Resultado final

Documents, reports (1)

Clinical panel

Definition of a first panel of clinical markers based on clinical and biochemical data

Publicaciones

Peer reviewed articles (7)

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

Autores: B.Charvet, J.Brunel, J.Pierquin, M.Iampietro, D.Decimo, N.Queruel, A.Lucas, M.del Mar Encabo-Berzosa, I.Arenaz, T.P.Marmolejo, A.Gonzalez, A.C.Maldonado, C.Mathieu, P.Kury, J.Flores-Rivera, F.Torres-Ruiz, S.Avila-Rios, G.Salgado Montes de Oca,
Publicado en: iScience, Edición Volume 26 issue 11, 2023, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2023.106604

Expression Profile of HERVs And Inflammatory Mediators Detected In Nasal Mucosa As Predictive Biomarker of COVID-19 Severity

Autores: Petrone, V, Fanelli, M.L, Giudice M., Toschi, N., Conti, A., Maracchioni, C., Ianetta, M., Resta, C., Cipriani, C., Miele, M.T., Amati, F., Andreoni, M., Sarmati, L., Rogliani, P., Novelli, G., Garaci, E., Rasi, G., Sinibaldi Vallebona, P., Minutolo, A.,
Publicado en: Frontiers in Microbiology, Edición 22:14:1155624, 2023, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1155624

Thymosin Alpha 1 Restores the Immune Homeostasis in lymphocytes during Post-Acute Sequelae of SARS-CoV-2 infection

Autores: A. Minutolo, V. Petrone, M. Fanelli, C. Maracchioni, M. Giudice, E. Teti, L. Coppola, C. Sorace, M. Iannetta, M.T. Miele, S. Bernardini, A. Mastino, P. Sinibaldi Vallebona, E. Balestrieri, M. Andreoni, L. Sarmati, S. Grelli, E. Garaci, C. Matteucci
Publicado en: Int Immunopharmacology, Edición 118:110055, 2023, ISSN 1878-1705
Editor: ELSEVIER
DOI: 10.1016/j.intimp.2023.110055

International Journal of Molecular Sciences

Autores: Balestrieri E, Corinaldesi E, Fabi M, Cipriani C, Giudice M, Conti A, Minutolo A, Petrone V, Fanelli M, Miele MT, Andreozzi L, Guida F, Filice E, Meli M, Grelli S, Rasi G, Toschi N, Torcetta F, Matteucci C, Lanari M, Sinibaldi-Vallebona P
Publicado en: Int J Mol Sci, Edición Int J Mol Sci, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015086

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms

Autores: K.Gimenez-Orenga1, J. Pierquin, J.Brunel, B.Charvet, E.M.Martinez, H.Perron, E.Oltra
Publicado en: Frontiers in Immunology, Edición 13 eCollection 2022, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.1020064

Multidistrict Host–Pathogen Interaction during COVID-19 and the Development Post-Infection Chronic Inflammation

Autores: Fanelli, M.; Petrone, V.; Buonifacio,M. Delibato,NE.; Balestrieri, E.; Grelli, S.; Minutolo,A.; Matteucci,C
Publicado en: Pathogens, Edición 1198, 2022, ISSN 2076-0817
Editor: MDPI
DOI: 10.3390/pathogens11101198

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Autores: Marialaura Fanelli; Vita Petrone; Christian Maracchioni; Rossella Chirico; Chiara Cipriani; Luigi Coppola; Vincenzo Malagnino; Elisabetta Teti; Chiara Sorace; Marta Zordan; Pietro Vitale; Marco Iannetta; Emanuela Balestrieri; Guido Rasi; Sandro Grelli; Fabrice Malergue; Loredana Sarmati; Antonella Minutolo; Claudia Matteucci
Publicado en: Current Research in Microbial Sciences, 2024, ISSN 2666-5174
Editor: ELSEVIER
DOI: 10.1016/j.crmicr.2023.100215