SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients

Informacje na temat projektu

HERVCOV

Identyfikator umowy o grant: 101057302

DOI

10.3030/101057302

Data podpisania przez KE 2 Czerwca 2022

Data rozpoczęcia 1 Lipca 2022

Data zakończenia 30 Czerwca 2027

Finansowanie w ramach

• Health

Koszt całkowity

€ 6 846 157,00

Wkład UE

€ 6 846 157,00

Koordynowany przez

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (3)

HERV expression in COVID-19 patients

Characterization of HERVs transcriptional and protein expression profiles, immunophenotyping and cytokine storm (in swab and blood, flow- cytometry in blood, antibodies in plasma) in COVID-19 patients

Clinical panel

Definition of a first panel of clinical markers based on clinical and biochemical data

First communication report

Report on Communication and Outreach activities for the first half of the project

Publikacje

Thesis and dissertations (1)

Characterization of COVID-19 and post-acute sequelae of SARS-CoV-2 infection cohort study: the role of CD169 as a biomarker of systemic dysfunction and its alteration respect to SARS-CoV-2 pandemic waves’

Autorzy: Christian Maracchioni
Opublikowane w: 2023
Wydawca: UNITOV

Conference proceedings (12)

Human endogenous retroviruses in sepsis

Autorzy: Claudia Matteucci
Opublikowane w: 2024
Wydawca: Sepsis Trieste 2024

The potential contribution of flow cytometry to characterize and define extracellular vesicles: the experience in COVID-19 and post-acute sequelae of SARS-CoV-2 infection.

Autorzy: Marialaura Fanelli, Vita Petrone, Rossella Chirico, Claudia Maria Radu, Claudia Matteucci and Antonella Minutolo
Opublikowane w: 2024
Wydawca: EVIta 2024

The expression of CD169 and HLA-DR in blood cells and circulating microvesicles as a new tool for monitoring SARS-CoV-2 infection and Long COVID associated sequelae: lesson from pandemic waves.

Autorzy: Marialaura Fanelli, Vita Petrone, Rossella Chirico, Christian Maracchioni, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Chiara Cipriani, Alexandre Lucas, Claudia M. Radu, Fabrice Malergue, Vincenzo Malagnino, Marco Iannetta, Emanuela Balestrieri, Loreda
Opublikowane w: 2024
Wydawca: SIM Pavia 2024

Multi-parametric profile associated to human endogenous retroviruses defined COVID-19 with respect to Long COVID individuals highlighting the association with specific psychiatric and neurological symptoms.

Autorzy: Antonella Minutolo, Vita Petrone, Marialaura Fanelli, Rossella Chirico, Martina Giudice, Chiara Cipriani, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Alexandre Lucas, Hervè Perron, Emanuela Balestrieri, Sandro Grelli
Opublikowane w: 2024
Wydawca: SIM Pavia 2024

AI and Machine Learning-driven characterization models for post-COVID-19 condition: Enhancing personalized care in primary care settings.

Autorzy: David Lerma Irureta, Fátima Méndez-López, Jesus Ibañez Ruiz, Jon Schoorlemmer, Carmen Vicente García, Rosa Magallon Botaya
Opublikowane w: 2025
Wydawca: EUROPEAN GENERAL PRACTICE RESEARCH NETWORK

Characterization of T-cell immunodysfunction in COVID-19 patients and its persistent dysregulation in Long COVID individuals.

Autorzy: Vita Petrone, Antonella Minutolo, Marialaura Fanelli, Rossella Chirico, Chiara Cipriani, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Emanuela Balestrieri, Alexandre Lucas, Sandro Grelli, Loredana Sarmati, Claudia Mat
Opublikowane w: 2024
Wydawca: ISCCA Verona 2024

Multiparametric profile unravels the association of HERVs with immune dysfunction and inflammation in COVID-19 and with Long COVID psychiatric and neurological sequelae. ECV 2025

Autorzy: Antonella Minutolo, Vita Petrone, Marialaura Fanelli, Rossella Chirico, Luigi Coppola, Martina Giudice, Chiara Cipriani, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Alexandre Lucas, Hervè Perron, Marco Iannetta, Emanuela Balestrieri, Loredana Sarm
Opublikowane w: 2025
Wydawca: ECV 2025

CD169 and HLA-DR in blood cells and circulating extracellular vesicles in COVID-19 as markers infection and post-acute sequelae monitoring.

Autorzy: Vita Petrone, Marialaura Fanelli, Rossella Chirico, Chiara Cipriani, Martina Giudice, Luigi Coppola, Elisabetta Teti, Chiara Sorace, Vincenzo Malagnino, Marco Iannetta, Fabrice Malergue, Emanuela Balestrieri, Loredana Sarmati, Sandro Grelli, Antonella Min
Opublikowane w: 2024
Wydawca: Sepsis Trieste 2024

Dynamic expression of CD169 and HLA-DR in blood cells and circulating microvesicles in COVID-19 and Long COVID: newinsights by nanoscale flow cytometry.

Autorzy: Matteucci Claudia, Minutolo Antonella.
Opublikowane w: 2024
Wydawca: ISCCA Verona 2024

Impact of Persistent Symptoms on Quality of Life in Long COVID Patients: A Comparative Study

Autorzy: David Lerma Irureta, Beatriz Omiste, Elsa Presa-Gutiérrez, Fátima Méndez-López, Rosa Magallon Botaya
Opublikowane w: 2024
Wydawca: VE AME

Multi-parametric analysis associates human endogenous retroviruses to immune system impairment in COVID-19 and in long covid unravelling disease heterogeneity. A.

Autorzy: Minutolo A, Petrone V, Fanelli M, Chirico R, Giudice M, Cipriani C, Coppola L, Teti E, Sorace C, Malagnino V, Lucas A, Perron H, Iannetta M, Balestrieri E, Grelli S, Sarmati L, Matteucci C.
Opublikowane w: 2024
Wydawca: SIV Bologna 2024

Evaluation of myeloid activation markers in blood cells and circulating extracellular vesicles as new tool for monitoring SARS-CoV-2 infection and Long COVID associated sequelae

Autorzy: Fanelli M., Petrone V., Chirico R., Maracchioni C., Coppola L., Sorace C., Chiara Cipriani C., Giudice M., Radu C.M., Teti E., Malagnino V., Iannetta M., Bernardini S., Balestrieri E., Sarmati L., Grelli S., Minutolo A. *, Matteucci C.
Opublikowane w: 2024
Wydawca: CSEVP 2024

Peer reviewed articles (14)

Crosstalk between human endogenous retroviruses and exogenous viruses

Autorzy: Edoardo Pizzioli, Antonella Minutolo, Emanuela Balestrieri, Claudia Matteucci, Gkikas Magiorkinis, Branka Horvat
Opublikowane w: Microbes and Infection, 2024, ISSN 1286-4579
Wydawca: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105427

Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers

Autorzy: Bárbara Oliván-Blázquez, Marta Bona-Otal, Fátima Méndez-López, David Lerma-Irureta, Paula García-Izuel, Jesús Ibáñez-Ruiz, Alberto Montolío, María Ruiz-Herreros, Javier Godino, Beatriz Jimeno-Beltran, María del Mar Encabo-Berzosa, Izaskun Arenaz, Ana Medel-Martínez, Verónica Casado-Vicente, Mayte Coiras, Carlos Tellería-Orriols, Jon Schoorlemmer, Rosa Magallón-Botaya
Opublikowane w: iScience, Numer 27, 2025, ISSN 2589-0042
Wydawca: Elsevier BV
DOI: 10.1016/J.ISCI.2024.110839

Programme des XXVIIes Journées francophones de virology 23, 24 & 25 avril 2025

Opublikowane w: Virologie, Numer 29, 2025, ISSN 1267-8694
Wydawca: JLE
DOI: 10.1684/VIR.2025.1081

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

Autorzy: B.Charvet, J.Brunel, J.Pierquin, M.Iampietro, D.Decimo, N.Queruel, A.Lucas, M.del Mar Encabo-Berzosa, I.Arenaz, T.P.Marmolejo, A.Gonzalez, A.C.Maldonado, C.Mathieu, P.Kury, J.Flores-Rivera, F.Torres-Ruiz, S.Avila-Rios, G.Salgado Montes de Oca,
Opublikowane w: iScience, Numer Volume 26 issue 11, 2023, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2023.106604

Expression Profile of HERVs And Inflammatory Mediators Detected In Nasal Mucosa As Predictive Biomarker of COVID-19 Severity

Autorzy: Petrone, V, Fanelli, M.L, Giudice M., Toschi, N., Conti, A., Maracchioni, C., Ianetta, M., Resta, C., Cipriani, C., Miele, M.T., Amati, F., Andreoni, M., Sarmati, L., Rogliani, P., Novelli, G., Garaci, E., Rasi, G., Sinibaldi Vallebona, P., Minutolo, A.,
Opublikowane w: Frontiers in Microbiology, Numer 22:14:1155624, 2023, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fmicb.2023.1155624

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Autorzy: Marialaura Fanelli, Vita Petrone, Christian Maracchioni, Rossella Chirico, Chiara Cipriani, Luigi Coppola, Vincenzo Malagnino, Elisabetta Teti, Chiara Sorace, Marta Zordan, Pietro Vitale, Marco Iannetta, Emanuela Balestrieri, Guido Rasi, Sandro Grelli, Fabrice Malergue, Loredana Sarmati, Antonella Minutolo, Claudia Matteucci
Opublikowane w: Current Research in Microbial Sciences, Numer 6, 2024, ISSN 2666-5174
Wydawca: Elsevier BV
DOI: 10.1016/J.CRMICR.2023.100215

HERV-W ENV transcription in B cells predicting symptomatic COVID-19 and risk for long COVID can express a full-length protein despite stop codon in mRNA from chromosome X via a ribosome readthrough

Autorzy: Joanna Brunel, Julien Paganini, Melissa Galloux, Benjamin Charvet, Hervé Perron
Opublikowane w: Microbes and Infection, 2024, ISSN 1286-4579
Wydawca: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105431

Thymosin Alpha 1 Restores the Immune Homeostasis in lymphocytes during Post-Acute Sequelae of SARS-CoV-2 infection

Autorzy: A. Minutolo, V. Petrone, M. Fanelli, C. Maracchioni, M. Giudice, E. Teti, L. Coppola, C. Sorace, M. Iannetta, M.T. Miele, S. Bernardini, A. Mastino, P. Sinibaldi Vallebona, E. Balestrieri, M. Andreoni, L. Sarmati, S. Grelli, E. Garaci, C. Matteucci
Opublikowane w: Int Immunopharmacology, Numer 118:110055, 2023, ISSN 1878-1705
Wydawca: ELSEVIER
DOI: 10.1016/j.intimp.2023.110055

International Journal of Molecular Sciences

Autorzy: Balestrieri E, Corinaldesi E, Fabi M, Cipriani C, Giudice M, Conti A, Minutolo A, Petrone V, Fanelli M, Miele MT, Andreozzi L, Guida F, Filice E, Meli M, Grelli S, Rasi G, Toschi N, Torcetta F, Matteucci C, Lanari M, Sinibaldi-Vallebona P
Opublikowane w: Int J Mol Sci, Numer Int J Mol Sci, 2023, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015086

Limitations of current high-throughput sequencing technologies lead to biased expression estimates of endogenous retroviral elements

Autorzy: Konstantina Kitsou, Aris Katzourakis, Gkikas Magiorkinis
Opublikowane w: NAR Genomics and Bioinformatics, Numer 6, 2024, ISSN 2631-9268
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/NARGAB/LQAE081

Flow cytometry for extracellular vesicle characterization in COVID-19 and post-acute sequelae of SARS-CoV-2 infection

Autorzy: Marialaura Fanelli; Vita Petrone; Rossella Chirico; Claudia Maria Radu; Antonella Minutolo; Claudia Matteucci
Opublikowane w: Extracellular Vesicles and Circulating Nucleic Acids, 2024, ISSN 2767-6641
Wydawca: OAE Publishing Inc
DOI: 10.20517/EVCNA.2024.20

HERV-W ENV antigenemia and correlation of increased anti-SARS-CoV-2 immunoglobulin levels with post-COVID-19 symptoms

Autorzy: K.Gimenez-Orenga1, J. Pierquin, J.Brunel, B.Charvet, E.M.Martinez, H.Perron, E.Oltra
Opublikowane w: Frontiers in Immunology, Numer 13 eCollection 2022, 2022, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.1020064

Multidistrict Host–Pathogen Interaction during COVID-19 and the Development Post-Infection Chronic Inflammation

Autorzy: Fanelli, M.; Petrone, V.; Buonifacio,M. Delibato,NE.; Balestrieri, E.; Grelli, S.; Minutolo,A.; Matteucci,C
Opublikowane w: Pathogens, Numer 1198, 2022, ISSN 2076-0817
Wydawca: MDPI
DOI: 10.3390/pathogens11101198

Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves

Autorzy: Marialaura Fanelli; Vita Petrone; Christian Maracchioni; Rossella Chirico; Chiara Cipriani; Luigi Coppola; Vincenzo Malagnino; Elisabetta Teti; Chiara Sorace; Marta Zordan; Pietro Vitale; Marco Iannetta; Emanuela Balestrieri; Guido Rasi; Sandro Grelli; Fabrice Malergue; Loredana Sarmati; Antonella Minutolo; Claudia Matteucci
Opublikowane w: Current Research in Microbial Sciences, 2024, ISSN 2666-5174
Wydawca: ELSEVIER
DOI: 10.1016/j.crmicr.2023.100215