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VALIDATING AI IN CLASSIFYING CANCER IN REAL-TIME SURGERY

Objective

Building on breakthrough research in the AI analysis of fluorescence and perfusion in cancer tissues, this project clinically validates the use of AI-driven imaging and decision support in real-time cancer surgery.

Cancer and healthy tissue have radically different local blood perfusion patterns. This perfusion can be captured using near-infrared video after systemic fluorophore (indocyanine green) injection. Analysis of the video can digitally identify regions of cancer by tracking the perfusion over the initial seconds after dye administration by comparing the fluorescence signal in these areas with those in adjacent normal tissue within the same endolaparoscopic field of view. Application of AI methods (including computer vision and machine learning techniques) has enabled this differential classification to occur in real time so that better, individualised surgical decisions can be taken during an operation.

In this project, we build up our existing AI solution research prototype into an operating room-standard surgical tool and validate its performance, reliability, usability and acceptance in five leading cancer surgery centres across Europe (500 patients). The validation studies address (a) generalisability across clinics; (b) biopsy and tumour identification; and (c) optimised resection of large (>3cm) rectal polyps, a key area of current surgical practice where the biggest clinical challenge ensuring accurate patient selection for curative therapy.

Training and education, communication and dissemination will be delivered by IRCAD, Europe's leading surgical education organisation.

Legal, regulatory and liability research (co-led by UCPH CeBIL Centre and PSU) and usability and acceptance research (led by surgical professional organisation EAES) will identify and address all obstacles to widespread use of this technology in particular, and of real-time AI in the operating-room in general. Draft clinical guidelines will be created for future EAES adoption.

Coordinator

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Net EU contribution
€ 1 730 882,00
Address
Belfield
4 Dublin
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1,75

Participants (10)

INSTITUT DE RECHERCHE CONTRE LES CANCERS DE L'APPAREIL DIGESTIF
France
Net EU contribution
€ 170 000,00
Address
Place De L'hopital 1
67091 Strasbourg Cedex

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Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STICHTING E.A.E.S
Netherlands
Net EU contribution
€ 410 000,00
Address
Luchthavenweg 81
5657 EA Eindhoven

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Other
Non-EU contribution
€ 0,00
PINTAIL LTD
Ireland
Net EU contribution
€ 400 000,00
Address
Springhill Avenue 77
A94 K542 Blackrock

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 513 357,00
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Net EU contribution
€ 310 000,00
Address
Via Giuseppe Verdi 8
10124 Torino

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Region
Nord-Ovest Piemonte Torino
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ZIEKENHUIS OOST-LIMBURG AUTONOME VERZORGINGSINSTELLING
Belgium
Net EU contribution
€ 310 000,00
Address
Schiepse Bos 6
3600 Genk

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Region
Vlaams Gewest Prov. Limburg (BE) Arr. Hasselt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ARCTUR RACUNALNISKI INZENIRING DOO
Slovenia
Net EU contribution
€ 1 008 500,00
Address
Industrijska Cesta 1a
5000 Nova Gorica

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Slovenija Zahodna Slovenija Goriška
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 310 000,00
Address
De Boelelaan 1117
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE PENNSYLVANIA STATE UNIVERSITY
United States
Net EU contribution
€ 505 977,00
Address
Technology Center Building 110
16802 7000 University Park Pa

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
KONVENT DER BARMHERZIGEN BRUDER GRAZ
Austria
Net EU contribution
€ 310 000,00
Address
Marschallgasse 12
8020 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00