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Risk and Resilience in Developmental Diversity and Mental Health

Project description

DEENESFRITPL

Reducing stigma and burden for people with mental health conditions

People with mental illness experience stigma, prejudice and discrimination. Often, their families are also targets. To reverse this trend, researchers are studying the associated risks and resilience. The EU-funded R2D2-MH project will propose a double paradigm shift to improve the well-being of people with mental health conditions and their families. By involving patients in the research, the project will start from a risk-focused approach to understand and promote resilience. It will also undertake a diagnosis-based approach and a developmental diversity approach that define well-being and functioning across the human lifespan. R2D2-MH will provide the largest European multiscale data set on early human brain development and mental health outcomes. It will also establish predictive models to guide personalised interventions.

Objective

Individuals with mental health (MH) conditions and their families, especially those with highly prevalent neurodevelopmental disorders (NDDs), are exposed to high levels of discrimination and stigma, which significantly affects their physical and mental well-being. Our world-leading collaborative group at the forefront of research in NDDs will launch a new project - ?Risk, Resilience and Developmental Diversity in Mental Health? (R2D2-MH). We propose a double paradigm shift to improve the wellbeing of people with MH conditions and their families. We will move (i) from risk-focused studies towards understanding and promoting resilience, and (ii) from a diagnosis-based approach to a developmental diversity approach that will define wellbeing and functioning across the human lifespan. R2D2-MH aims to identify genetic and environmental protective/resilience factors and how they influence developmental diversity and MH. We will investigate at multiple levels two highly prevalent early risks for MH conditions: prematurity and genetic liability for NDDs. Our project has four main ambitions 1. Provide the largest European multi-scale dataset on early human brain development and MH outcomes; 2 Identify biological mechanisms of resilience to the adverse effects of NDD; 3. Co-develop, with the stakeholders, new digital tools to increase participatory research/medicine and reduce stigma; 4. Establish predictive models to guide personalised interventions. R2D2-MH integrates interdisciplinary and complementary expertise across Europe, Israel, and Australia that covers ethics, epidemiology, sociology, genetics, cell biology, neuroscience, computational modelling, Information Technology, psychology, and psychiatry. Our research is highly engaged: it embeds participant and patient involvement in research to ensure that our expected outcomes are truly translational, and will help to reduce stigma and burden for individuals with MH conditions.

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Call for proposal

HORIZON-HLTH-2021-STAYHLTH-01

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Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT PASTEUR
Net EU contribution
€ 1 081 938,75
Address
Rue du docteur roux 25-28
75724 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Other funding
€ 0,00

Participants (16)

Partners (9)

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Last update: 4 September 2022

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Permalink: https://cordis.europa.eu/project/id/101057385

European Union, 2023