Project description DEENESFRITPL Mechanisms of host epigenetic alterations during viral infection The EU-funded EPIVINF project aims to understand how acute viral infections alter the epigenetic regulation of host factors, governing immune control and neurological health. The study will focus on the HIV and SARS-CoV-2 human viral pathogens that affect people around the world and share common features that require further research. The researchers will employ advanced epigenetic analyses, immune monitoring, relevant animal models, samples from HIV and Covid-19 vaccine trials and integrated biosystem analyses to investigate how infections harness epigenetic mechanisms to change the adaptive and innate immune response and how these mechanisms may impact neurological health. The study also aims to identify the predisposing factors leading to specific clinical symptoms and how these could be employed as novel therapeutic targets. Show the project objective Hide the project objective Objective The EPIVINF project aims to gain a deep understanding of how acute viral infections alter the epigenetic regulation of host factors that are critical for immune control and neurological health. In particular, EPIVINF will address how acute viral infections impact epigenetic control of host proteins that drive virus-associated disease and/or are involved in the antiviral immune response and how such persistent, epigenetic marks are related to long-term disease evolution. EPIVINF will focus on two major human viral infections, HIV and SARS-CoV-2, both pathogens that affect millions of people around the world and which, despite well-known differences, share some intriguing features that demand further research. We hypothesize that a) defining individuals personal epigenetic profiles, b) assessing how they impact on the innate and adaptive immunity and c) analysing epigenetic control mechanisms in two different viral infections (HIV and SARS-CoV-2), will provide important insights into how different individuals react to different viral infections, how different infections may share similar mechanism that impact on the long term health outcomes, how these processes define the further disease course and, finally, how they could serve as targets for novel therapeutic interventions.To achieve these goals, we will use an panel of cutting-edge epigenetic analyses, immune monitoring tools, disease-relevant animal models, samples from unique human vaccine trials and integrated biosystems analyses to gain a deep understanding of how viral infections harness epigenetic mechanisms to change the adaptive and innate immune phenotype of infected individuals, not only during acute stages of the infection but potentially for live. The study includes extensive patient follow-up to identify factors that predispose to different clinical symptoms and disease progression. Fields of science medical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesbasic medicineneurologynatural sciencesbiological sciencesgeneticsepigenetics Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.4 - Infectious Diseases, including poverty-related and neglected diseases Topic(s) HORIZON-HLTH-2021-DISEASE-04-07 - Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2) Call for proposal HORIZON-HLTH-2021-DISEASE-04 See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA Net EU contribution € 2 244 625,00 Address Carretera de canyet 08916 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden Net EU contribution € 729 531,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 OSPEDALE SAN RAFFAELE SRL Italy Net EU contribution € 1 011 875,00 Address Via olgettina 60 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAT DES SAARLANDES Germany Net EU contribution € 809 750,00 Address Campus 66123 Saarbrucken See on map Region Saarland Saarland Regionalverband Saarbrücken Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 OMNISCOPE LIMITED Malta Net EU contribution € 1 538 137,00 Address 30/1, kenilworth court, sir augustus bartolo stree XBX 1093 Ta xbiex See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Malta Malta Malta Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES Spain Net EU contribution € 598 390,00 Address Ctra c-59 km 12 torre marimon 08140 Caldes de montbui barcelona See on map Region Este Cataluña Barcelona Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
