Decision support for prediction and management of Long Covid Syndrome (LCS)

Informations projet

Long Covid

N° de convention de subvention: 101057553

DOI

10.3030/101057553

Date de signature de la CE 23 Mai 2022

Date de début 1 Juin 2022

Date de fin 31 Mai 2026

Financé au titre de

• Health

Coût total

€ 6 549 674,79

Contribution de l’UE

€ 6 549 673,69

Coordonné par

HUS-YHTYMA
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Creation and composition of the independent ethics advisory board

The external clinical andvisory board will be appointed and consulted for every clinical action performed in the clinical trials planned to be executed in the project.

First version of CDE strategy

This document presents the first version of the dedicated LongCOVID Communication, Dissemination and Exploitation strategy based on the preliminary plan and KPIs included in the LongCOVID proposal. D8.1 identifies the different stakeholders along the whole value chain, their targeted dissemination activities and the set of tools to be used. From an exploitation perspective, this document presents the general strategy for the exploitation management of the project.

Report on epidemiology and commonness between Finland and Netherlands

We will gather together epidemiological evidence from Finland and the Netherlands to estimate the incidence of long Covid and its effect on the work ability of patients.

Data Management Plan

The Data Management Plan (DMP) will address the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable. It will describe what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved. We will use the latest template and guidelines provided by the Horizon Europe program and Online Manual.

Other (1)

Common data portal for LC cohort data

The deliverable envisions the base structure of the database with the definition of the endpoints to retrieve, send and store the data of LC cohort data. The API will be documented in Swagger and continuously updated as soon as new datapoints will be defined during the project runtime.

Websites, patent fillings, videos etc. (1)

Project website

This deliverable describes the website created for external communication about the LongCOVID project, presenting an overview of all sections and functionalities.

Publications

Peer reviewed articles (12)

Serum antineuronal antibodies in patients with post-COVID-19 condition − association to intensive care

Auteurs: Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso
Publié dans: Brain, Behavior, and Immunity, Numéro 129, 2025, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2025.05.026

Prognosis of patients with long COVID symptoms: a protocol for a longitudinal cohort study at a primary care referred outpatient clinic in Helsinki, Finland

Auteurs: Hélène Virrantaus, Helena Liira, Tatiana Posharina, Aleksandra Sulg, Teemu Mäntylä, Mari Kanerva, Sini Laakso, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Publié dans: BMJ Open, 2023, ISSN 2044-6055
Éditeur: BMJ Publishing Group Ltd.
DOI: 10.1136/BMJOPEN-2023-072935

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

Auteurs: Piia Karisola, Mari Kanerva, Aki Vuokko, Helena Liira, Shuyuan Wang, Kirsi Kvarnström, Mikko Varonen, Hille Suojalehto, Harri Alenius
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1500997

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

Auteurs: Lee Tatham; Anja Kipar; Jo Sharp; Edyta Kijak; Joanne Herriott; Megan Neary; Helen Box; Eduardo Gallardo Toledo; Anthony Valentijn; Helen Cox; Henry Pertinez; Paul Curley; Usman Arshad; Rajith Kumar Reddy Rajoli; Steve Rannard; James P. Stewart; Andrew Owen
Publié dans: Microbiology Spectrum, 2024, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/SPECTRUM.03916-23

Long COVID-associated symptoms prevalent in both SARS-CoV-2 positive and negative individuals: A prospective follow-up study

Auteurs: Anu Kantele, Juuso Paajanen, Jukka-Pekka Pietilä, Olli Vapalahti, Sari H. Pakkanen, Tinja Lääveri
Publié dans: New Microbes and New Infections, Numéro 56, 2023, ISSN 2052-2975
Éditeur: Elsevier BV
DOI: 10.1016/J.NMNI.2023.101209

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

Auteurs: Simon De Neck, Rebekah Penrice-Randal, Jordan J. Clark et al.
Publié dans: Viruses, 2023, ISSN 1999-4915
Éditeur: MDPI
DOI: 10.3390/v15081637

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

Auteurs: Ravi Ojha, Anmin Jiang, Elina Mäntylä, Tania Quirin, Naphak Modhira, Robert Witte, Arnaud Gaudin, Lisa De Zanetti, Rachel Sarah Gormal, Maija Vihinen-Ranta, Jason Mercer, Maarit Suomalainen, Urs F. Greber, Yohei Yamauchi, Pierre-Yves Lozach, Ari Helenius, Olli Vapalahti, Paul Young, Daniel Watterson, Frédéric A. Meunier, Merja Joensuu, Giuseppe Balistreri
Publié dans: PLOS Pathogens, Numéro 20, 2024, ISSN 1553-7374
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1012690

Genome-wide association study of long COVID

Auteurs: Vilma Lammi, Tomoko Nakanishi, Samuel E. Jones, Shea J. Andrews, Juha Karjalainen, Beatriz Cortés, Heath E. O’Brien, Ana Ochoa-Guzman, Brian E. Fulton-Howard, Martin Broberg, Hele H. Haapaniemi, Masahiro Kanai, Matti Pirinen, Axel Schmidt, Ruth E. Mitchell, Abdou Mousas, Massimo Mangino, Alicia Huerta-Chagoya, Nasa Sinnott-Armstrong, Elizabeth T. Cirulli, Marc Vaudel, Alex S. F. Kwong, Amit K. Maiti, Minttu M. Marttila, Daniel C. Posner, Alexis A. Rodriguez, Chiara Batini, Francesca Minnai, Anna R. Dearman, C. A. Robert Warmerdam, Celia B. Sequeros, Thomas W. Winkler, Daniel M. Jordan, Raimonds Rešcenko, Lorenzo Miano, Jacqueline M. Lane, Ryan K. Chung, Beatriz Guillen-Guio, Olivia C. Leavy, Laura Carvajal-Silva, Kevin Aguilar-Valdés, Erika Frangione, Lindsay Guare, Ekaterina Vergasova, Eirini Marouli, Pasquale Striano, Ummu Afeera Zainulabid, Ashutosh Kumar, Hajar Fauzan Ahmad, Ryuya Edahiro, Shuhei Azekawa, null null, null null, Mari E. K. Niemi, null null, null null, Janick St-Cyr, Darin Adra, Madeleine Durand, David Bujold, Guillaume Bourque, Ariane Boisclair, Mylene Bertrand, Daniel Auld, Laetitia Laurent, Solomia Yanishevsky, G. Mark Lathrop, Fangyi Shi, Simon Rousseau, Jiannis Ragoussis, Danielle Perley, Vincent Mooser, David R. Morrison, null null, Daniella Balla, Julia Heggemann, Sonja Schultz, Pari Behzad, Markus M. Nöthen, Abigail Miller, Max C. Pensel, Carlo Maj, null null, Kelly Cho, Tianxi Cai, Sudha K. Iyengar, null null, Carlos A. Aguilar Salinas, Seung Hyuk T. Lee, Hortensia Moreno-Macias, Päivi Pajukanta, Michelle Duran-Gomez, null null, Lill Trogstad, null null, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Colleen M. Kripke, null null, Sergi Papiol, Jens Wiltfang, Jochen Schneider, Thomas G. Schulze, Christof Winter, Ewa Wallin, Robert Frithiof, Fanny Senner, Christoph D. Spinner, Ulrike Protzer, Mattia Cordioli, Nikola S. Mueller, Andreas Dinkel, Janos L. Kalman, Tomislav Maricic, Kristina Adorjan, Miklos Lipcsey, Lisa Fricke, Ing-Marie Larsson, Urs Heilbronner, Monika Budde, Johanna Erber, null null, null null, Nicholas R. Harvey, null null, Vince Forgetta, null null, Benedict Hignell, null null, Yolanda Espinosa-Parrilla, Juan M. Saez Hidalgo, Estefania Nova-Lamperti, Scarlett Gutiérrez-Richards, Gerardo Donoso, Leslie C. Cerpa, Cesar A. Echeverria, Camilo Cabrera, Pamela Bocchieri, Macarena Fuentes-Guajardo, Christian A. Muñoz, Karen Y. Oróstica, Alvaro Figueroa, Lissette G. Guajardo, Iskra A. Signore, Virginia A. Monardes-Ramírez, Eduardo A. Tobar-Calfucoy, Luis A. Quiñones, Cristian E. Yáñez, Daniela Zapata-Contreras, Paula Zuñiga-Pacheco, Romina Quiroga, Matías F. Martínez, Teresa A. Alarcon, Andrea X. Silva, Carolina S. Selman, Sergio Sanhueza, Rocío Retamales-Ortega, Tamara V. Arévalo, Eduardo Lamoza, Héctor Valenzuela-Jorquera, null null, Maria Sophia Donaire, Sannidhi Sarvadhavabhatla, null null, Sisse R. Ostrowski, Søren Brunak, David Westergaard, Bjarke Feenstra, Anne Sofie B. Mortensen, null null, Anna L. Guyatt, null null, Rafael de Cid, Susana Iraola-Guzmán, Gemma Moncunill, Alba Blasco, Judith Garcia-Aymerich, Natalia Blay, Carlota Dobaño, Anna Carreras, Xavier Farré, Manolis Kogevinas, Gemma Castaño-Vinyals, null null, Simone Furini, Chiara Fallerini, Kristina Zguro, Margherita Baldassarri, Francesca Colombo, null null, Thompson Hannah, null null, Anna Ilinskaya, Michil Trofimov, Layal Shaheen, Nikolay Plotnikov, Anna Kim, Dmitrii Kharitonov, Valery Ilinsky, Alexei Kamelin, null null, Francisco Tanudjaja, Efren Sandoval, Nicole L. Washington, Simon White, Iva Neveux, Shaun Dabe, Alexandre Bolze, Kelly M. Schiabor Barrett, null null, Eirini Christaki, Haralampos Milionis, Ioanna Tzoulaki, Angelos Liontos, Evangelos Evangelou, Evangelia Ntzani, null null, Rasoul Aliannejad, Vahideh Zarei, Nastaran Soltani, Bahareh Sharififard, Hengameh Ansari Tadi, Ali Amirsavadkouhi, null null, Ho NamKoong, null null, null null, Ryan C. Thompson, Alexander W. Charney, Laura G.
Publié dans: Nature Genetics, 2025, ISSN 1061-4036
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41588-025-02100-W

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Auteurs: Pinja Kettunen, Angelina Lesnikova, Noora Räsänen et al.
Publié dans: Journal of Virology, 2023, ISSN 1098-5514
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00144-23

Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial

Auteurs: Velina Vangelova-Korpinen, Helena Liira, Samu N. Kurki, Markku Sainio, Antti Malmivaara, Mari Kanerva, Jan-Henry Stenberg, Mikko Varonen, Mikko Venäläinen, Piia Vuorela, Jari Arokoski
Publié dans: PLOS ONE, Numéro 20, 2025, ISSN 1932-6203
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0316169

Functioning of post-COVID-19 patients: a cross-sectional study at the outpatient clinic for long-term effects

Auteurs: Sanna Stålnacke, Helena Liira, Velina Vangelova-Korpinen, Hélène Virrantaus, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Publié dans: Scandinavian Journal of Primary Health Care, Numéro 43, 2025, ISSN 0281-3432
Éditeur: Informa UK Limited
DOI: 10.1080/02813432.2024.2410986

Prognosis of patients with post-Covid-19 condition: Prospective cohort cluster analysis at one year

Auteurs: Helena Liira, Paul Garner, Antti Malmivaara, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Mikko Varonen, Mikko Venäläinen, Aki Vuokko, Jari Arokoski
Publié dans: Journal of Psychosomatic Research, Numéro 182, 2024, ISSN 0022-3999
Éditeur: Elsevier BV
DOI: 10.1016/J.JPSYCHORES.2024.111808