Decision support for prediction and management of Long Covid Syndrome (LCS)

Projektinformationen

Long Covid

ID Finanzhilfevereinbarung: 101057553

DOI

10.3030/101057553

Projekt abgeschlossen

EK-Unterschriftsdatum 23 Mai 2022

Startdatum 1 Juni 2022

Enddatum 31 Mai 2026

Finanziert unter

• Health

Gesamtkosten

€ 6 549 674,79

EU-Beitrag

€ 6 549 673,69

Koordiniert durch

HUS-YHTYMA
Finland

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (12)

Creation and composition of the independent ethics advisory board

The external clinical andvisory board will be appointed and consulted for every clinical action performed in the clinical trials planned to be executed in the project.

From intranasal SARS-CoV-2 challenge to persistence in the brain

Using in vivo mouse models, we will clarify the routes and mechanisms of SARS-CoV-2 entry and spread in neurons, the spread in the CNS and the effect of neuronal infection on the brain parenchyma. To achieve this, we will use wild type viruses and recombinant virus expressing fluorescent reporters or specific mutations.

Mechanism and effects of SARS-CoV-2 infection in murine and human neurons co-cultured with glial cells

Using in vitro models, we will clarify whether SARS-CoV-2 can productively infect neurons and glial cells and will determine whether specific viral mutations are required to achieve this. We will also determine the direct viral effect on the infected cells, at morphological and metabolic level.

Platelet and coagulation markers & Virus sequence analysis

The different SARS-CoV-2 virus strains are studied with reference to blood clotting potential.

Results of the AIR trial

This deliverable will report the outcomes of the AIR trial, the results of the effectiveness of the self-management and digital interventions.

First version of CDE strategy

This document presents the first version of the dedicated LongCOVID Communication, Dissemination and Exploitation strategy based on the preliminary plan and KPIs included in the LongCOVID proposal. D8.1 identifies the different stakeholders along the whole value chain, their targeted dissemination activities and the set of tools to be used. From an exploitation perspective, this document presents the general strategy for the exploitation management of the project.

Report on ethics

The deliverable will report on all activities related to the ethics and AI development process. This will include identified and implemented requirements related to EU Ethics Guidelines for Trustworthy AI, the appointment of the advisory board and the interim update on the implementation of AI principles within the project.

Report on epidemiology and commonness between Finland and Netherlands

We will gather together epidemiological evidence from Finland and the Netherlands to estimate the incidence of long Covid and its effect on the work ability of patients.

Providing SARS-COV2 RT-PCR results on Serotyping and Virus Characteristics

The samples from Finnish LC patients (e.g. stool samples) will be analyzed for presense of SARS-COV-2 RNA and the viral genome in positive samples will be determined and charcteristics of any genetic changes analyzed. The antibody responses towards main SARS-CoV2 antigens, including neutralizing antibody responses, in LC and non-LC patients will be analyzed and compared.

Clinical study: Report of posting results

In this deliverable we will report where and how, in which meetings, conferences and publications, the results of the clinical study have been posted.

Data Management Plan

The Data Management Plan (DMP) will address the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable. It will describe what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved. We will use the latest template and guidelines provided by the Horizon Europe program and Online Manual.

Clinical study: Mid-term recruitment report

We will provide a midterm recruitment report of the clinical studies that are recruiting within the project, including results from an intermediate data analysis to be performed to reveal if the enrolment of patients is according to schedule and to assess, whether the distribution of patients is according to the predicted sex ratio.

Data sets, microdata, etc (2)

Data report on lipidomic plasma analysis

LT will analyze up to 3000 plasma samples from Cohorts 1-5  to identify multiparametric  lipidome signatures  that differentiate between SARS Cov-2 infected recovered and LC patients. LT will try to stratify LC into possible subgroups on the basis of the lipidome and available clinical data.

Immunophenotyping analysis report

We will describe differences in white blood cell immunophenotyping between Long COVID-patients and patients recovering normally after Long COVID infection.

Other (1)

Common data portal for LC cohort data

The deliverable envisions the base structure of the database with the definition of the endpoints to retrieve, send and store the data of LC cohort data. The API will be documented in Swagger and continuously updated as soon as new datapoints will be defined during the project runtime.

Websites, patent fillings, videos etc. (1)

Project website

This deliverable describes the website created for external communication about the LongCOVID project, presenting an overview of all sections and functionalities.

Veröffentlichungen

Peer reviewed articles (19)

Serum antineuronal antibodies in patients with post-COVID-19 condition − association to intensive care

Autoren: Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso
Veröffentlicht in: Brain, Behavior, and Immunity, Ausgabe 129, 2025, ISSN 0889-1591
Herausgeber: Elsevier BV
DOI: 10.1016/J.BBI.2025.05.026

Prognosis of patients with long COVID symptoms: a protocol for a longitudinal cohort study at a primary care referred outpatient clinic in Helsinki, Finland

Autoren: Hélène Virrantaus, Helena Liira, Tatiana Posharina, Aleksandra Sulg, Teemu Mäntylä, Mari Kanerva, Sini Laakso, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Veröffentlicht in: BMJ Open, 2023, ISSN 2044-6055
Herausgeber: BMJ Publishing Group Ltd.
DOI: 10.1136/BMJOPEN-2023-072935

Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study

Autoren: Joel Tuomaala, Maija Saraste, Emma Smith, Matilda Kuusi, Elisabet Westerberg, Eveliina Honkonen, Rahim Kargar, Sini Laaksonen, Jussi Lehto, Amelie Luoma, Markus Matilainen, Olavi Misin, Janne Atosuo, Mari Kanerva, Helena Liira, Sini Laakso, Tatiana Posharina, Virva Saunavaara, Saara Wahlroos, Johan Rajander, Laura Airas
Veröffentlicht in: Journal of Neurology, Ausgabe 273, 2026, ISSN 0340-5354
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S00415-026-13842-W

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

Autoren: Piia Karisola, Mari Kanerva, Aki Vuokko, Helena Liira, Shuyuan Wang, Kirsi Kvarnström, Mikko Varonen, Hille Suojalehto, Harri Alenius
Veröffentlicht in: Frontiers in Immunology, Ausgabe 16, 2025, ISSN 1664-3224
Herausgeber: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1500997

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

Autoren: Lee Tatham; Anja Kipar; Jo Sharp; Edyta Kijak; Joanne Herriott; Megan Neary; Helen Box; Eduardo Gallardo Toledo; Anthony Valentijn; Helen Cox; Henry Pertinez; Paul Curley; Usman Arshad; Rajith Kumar Reddy Rajoli; Steve Rannard; James P. Stewart; Andrew Owen
Veröffentlicht in: Microbiology Spectrum, 2024, ISSN 2165-0497
Herausgeber: American Society for Microbiology
DOI: 10.1128/SPECTRUM.03916-23

Long COVID-associated symptoms prevalent in both SARS-CoV-2 positive and negative individuals: A prospective follow-up study

Autoren: Anu Kantele, Juuso Paajanen, Jukka-Pekka Pietilä, Olli Vapalahti, Sari H. Pakkanen, Tinja Lääveri
Veröffentlicht in: New Microbes and New Infections, Ausgabe 56, 2023, ISSN 2052-2975
Herausgeber: Elsevier BV
DOI: 10.1016/J.NMNI.2023.101209

The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections

Autoren: Simon De Neck, Rebekah Penrice-Randal, Jordan J. Clark et al.
Veröffentlicht in: Viruses, 2023, ISSN 1999-4915
Herausgeber: MDPI
DOI: 10.3390/v15081637

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

Autoren: Ravi Ojha, Anmin Jiang, Elina Mäntylä, Tania Quirin, Naphak Modhira, Robert Witte, Arnaud Gaudin, Lisa De Zanetti, Rachel Sarah Gormal, Maija Vihinen-Ranta, Jason Mercer, Maarit Suomalainen, Urs F. Greber, Yohei Yamauchi, Pierre-Yves Lozach, Ari Helenius, Olli Vapalahti, Paul Young, Daniel Watterson, Frédéric A. Meunier, Merja Joensuu, Giuseppe Balistreri
Veröffentlicht in: PLOS Pathogens, Ausgabe 20, 2024, ISSN 1553-7374
Herausgeber: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1012690

Genome-wide association study of long COVID

Autoren: Vilma Lammi, Tomoko Nakanishi, Samuel E. Jones, Shea J. Andrews, Juha Karjalainen, Beatriz Cortés, Heath E. O’Brien, Ana Ochoa-Guzman, Brian E. Fulton-Howard, Martin Broberg, Hele H. Haapaniemi, Masahiro Kanai, Matti Pirinen, Axel Schmidt, Ruth E. Mitchell, Abdou Mousas, Massimo Mangino, Alicia Huerta-Chagoya, Nasa Sinnott-Armstrong, Elizabeth T. Cirulli, Marc Vaudel, Alex S. F. Kwong, Amit K. Maiti, Minttu M. Marttila, Daniel C. Posner, Alexis A. Rodriguez, Chiara Batini, Francesca Minnai, Anna R. Dearman, C. A. Robert Warmerdam, Celia B. Sequeros, Thomas W. Winkler, Daniel M. Jordan, Raimonds Rešcenko, Lorenzo Miano, Jacqueline M. Lane, Ryan K. Chung, Beatriz Guillen-Guio, Olivia C. Leavy, Laura Carvajal-Silva, Kevin Aguilar-Valdés, Erika Frangione, Lindsay Guare, Ekaterina Vergasova, Eirini Marouli, Pasquale Striano, Ummu Afeera Zainulabid, Ashutosh Kumar, Hajar Fauzan Ahmad, Ryuya Edahiro, Shuhei Azekawa, null null, null null, Mari E. K. Niemi, null null, null null, Janick St-Cyr, Darin Adra, Madeleine Durand, David Bujold, Guillaume Bourque, Ariane Boisclair, Mylene Bertrand, Daniel Auld, Laetitia Laurent, Solomia Yanishevsky, G. Mark Lathrop, Fangyi Shi, Simon Rousseau, Jiannis Ragoussis, Danielle Perley, Vincent Mooser, David R. Morrison, null null, Daniella Balla, Julia Heggemann, Sonja Schultz, Pari Behzad, Markus M. Nöthen, Abigail Miller, Max C. Pensel, Carlo Maj, null null, Kelly Cho, Tianxi Cai, Sudha K. Iyengar, null null, Carlos A. Aguilar Salinas, Seung Hyuk T. Lee, Hortensia Moreno-Macias, Päivi Pajukanta, Michelle Duran-Gomez, null null, Lill Trogstad, null null, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Colleen M. Kripke, null null, Sergi Papiol, Jens Wiltfang, Jochen Schneider, Thomas G. Schulze, Christof Winter, Ewa Wallin, Robert Frithiof, Fanny Senner, Christoph D. Spinner, Ulrike Protzer, Mattia Cordioli, Nikola S. Mueller, Andreas Dinkel, Janos L. Kalman, Tomislav Maricic, Kristina Adorjan, Miklos Lipcsey, Lisa Fricke, Ing-Marie Larsson, Urs Heilbronner, Monika Budde, Johanna Erber, null null, null null, Nicholas R. Harvey, null null, Vince Forgetta, null null, Benedict Hignell, null null, Yolanda Espinosa-Parrilla, Juan M. Saez Hidalgo, Estefania Nova-Lamperti, Scarlett Gutiérrez-Richards, Gerardo Donoso, Leslie C. Cerpa, Cesar A. Echeverria, Camilo Cabrera, Pamela Bocchieri, Macarena Fuentes-Guajardo, Christian A. Muñoz, Karen Y. Oróstica, Alvaro Figueroa, Lissette G. Guajardo, Iskra A. Signore, Virginia A. Monardes-Ramírez, Eduardo A. Tobar-Calfucoy, Luis A. Quiñones, Cristian E. Yáñez, Daniela Zapata-Contreras, Paula Zuñiga-Pacheco, Romina Quiroga, Matías F. Martínez, Teresa A. Alarcon, Andrea X. Silva, Carolina S. Selman, Sergio Sanhueza, Rocío Retamales-Ortega, Tamara V. Arévalo, Eduardo Lamoza, Héctor Valenzuela-Jorquera, null null, Maria Sophia Donaire, Sannidhi Sarvadhavabhatla, null null, Sisse R. Ostrowski, Søren Brunak, David Westergaard, Bjarke Feenstra, Anne Sofie B. Mortensen, null null, Anna L. Guyatt, null null, Rafael de Cid, Susana Iraola-Guzmán, Gemma Moncunill, Alba Blasco, Judith Garcia-Aymerich, Natalia Blay, Carlota Dobaño, Anna Carreras, Xavier Farré, Manolis Kogevinas, Gemma Castaño-Vinyals, null null, Simone Furini, Chiara Fallerini, Kristina Zguro, Margherita Baldassarri, Francesca Colombo, null null, Thompson Hannah, null null, Anna Ilinskaya, Michil Trofimov, Layal Shaheen, Nikolay Plotnikov, Anna Kim, Dmitrii Kharitonov, Valery Ilinsky, Alexei Kamelin, null null, Francisco Tanudjaja, Efren Sandoval, Nicole L. Washington, Simon White, Iva Neveux, Shaun Dabe, Alexandre Bolze, Kelly M. Schiabor Barrett, null null, Eirini Christaki, Haralampos Milionis, Ioanna Tzoulaki, Angelos Liontos, Evangelos Evangelou, Evangelia Ntzani, null null, Rasoul Aliannejad, Vahideh Zarei, Nastaran Soltani, Bahareh Sharififard, Hengameh Ansari Tadi, Ali Amirsavadkouhi, null null, Ho NamKoong, null null, null null, Ryan C. Thompson, Alexander W. Charney, Laura G.
Veröffentlicht in: Nature Genetics, 2025, ISSN 1061-4036
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41588-025-02100-W

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Autoren: Pinja Kettunen, Angelina Lesnikova, Noora Räsänen et al.
Veröffentlicht in: Journal of Virology, 2023, ISSN 1098-5514
Herausgeber: American Society for Microbiology
DOI: 10.1128/jvi.00144-23

Somatic symptom burden and distress in post COVID-19 and persistent physical symptoms: Evidence from combined SSD-12 and PHQ-15 factor analysis

Autoren: Helena Liira, Mikko Varonen, Velina Vangelova-Korpinen, Mikko S. Venäläinen, Jari Arokoski, Kirsi Kvarnström, Aki Vuokko, Antti Malmivaara
Veröffentlicht in: Journal of Psychosomatic Research, Ausgabe 208, 2026, ISSN 0022-3999
Herausgeber: Elsevier BV
DOI: 10.1016/J.JPSYCHORES.2026.112686

Facilitators and barriers for return to work among patients with post-COVID-19 condition: a qualitative interview study

Autoren: Aleksandra Sulg, Aki Vuokko, Kirsi Kvarnström, Mikko Varonen, Antti Malmivaara, Jari Arokoski, Helena Liira
Veröffentlicht in: Scandinavian Journal of Primary Health Care, Ausgabe 44, 2025, ISSN 0281-3432
Herausgeber: Informa UK Limited
DOI: 10.1080/02813432.2025.2525434

Basel Long COVID Cohort Study (BALCoS): protocol of a prospective cohort study

Autoren: Stefan Rohner, Rebekka Schnepper, Gunther Meinlschmidt, Rainer Schaefert, Michael Mayr, Katrin Bopp, Andrea Meienberg
Veröffentlicht in: BMJ Open, Ausgabe 15, 2025, ISSN 2044-6055
Herausgeber: BMJ
DOI: 10.1136/BMJOPEN-2024-093981

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau

Autoren: Pinja Kettunen, Janika Ruuska, Tania Quirin, Ravi Ojha, Saber H. Saber, Julian D.J. Sng, Sean Morrison, Bahaa Al-Mhanawi, Mohammed R. Shaker, Simon De Neck, Anja Kipar, Lassi Paavolainen, Ernst Wolvetang, Merja Joensuu, Jari Koistinaho, Taisia Rolova, Giuseppe Balistreri
Veröffentlicht in: Molecular Therapy Nucleic Acids, Ausgabe 36, 2025, ISSN 2162-2531
Herausgeber: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102726

Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial

Autoren: Velina Vangelova-Korpinen, Helena Liira, Samu N. Kurki, Markku Sainio, Antti Malmivaara, Mari Kanerva, Jan-Henry Stenberg, Mikko Varonen, Mikko Venäläinen, Piia Vuorela, Jari Arokoski
Veröffentlicht in: PLOS ONE, Ausgabe 20, 2025, ISSN 1932-6203
Herausgeber: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0316169

Functioning of post-COVID-19 patients: a cross-sectional study at the outpatient clinic for long-term effects

Autoren: Sanna Stålnacke, Helena Liira, Velina Vangelova-Korpinen, Hélène Virrantaus, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Veröffentlicht in: Scandinavian Journal of Primary Health Care, Ausgabe 43, 2025, ISSN 0281-3432
Herausgeber: Informa UK Limited
DOI: 10.1080/02813432.2024.2410986

Prognosis of patients with post-Covid-19 condition: Prospective cohort cluster analysis at one year

Autoren: Helena Liira, Paul Garner, Antti Malmivaara, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Mikko Varonen, Mikko Venäläinen, Aki Vuokko, Jari Arokoski
Veröffentlicht in: Journal of Psychosomatic Research, Ausgabe 182, 2024, ISSN 0022-3999
Herausgeber: Elsevier BV
DOI: 10.1016/J.JPSYCHORES.2024.111808

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants

Autoren: Frank Geller, Xiaoping Wu, Vilma Lammi, Erik Abner, Jesse Tyler Valliere, Katerina Nastou, Angus Burns, Morten Rasmussen, Niklas Worm Andersson, Liam Quinn, null null, Bitten Aagaard, Karina Banasik, Sofie Bliddal, Lasse Boding, Søren Brunak, Nanna Brøns, Jonas Bybjerg-Grauholm, Lea Arregui Nordahl Christoffersen, Maria Didriksen, Khoa Manh Dinh, Christian Erikstrup, Ulla Feldt-Rasmussen, Kirsten Grønbæk, Kathrine Agergård Kaspersen, Christina Mikkelsen, Claus Henrik Nielsen, Henriette Svarre Nielsen, Susanne Dam Nielsen, Janna Nissen, Celia Burgos Sequeros, Niels Tommerup, Henrik Ullum, null null, null null, Lampros Spiliopoulos, Peter Bager, Anders Hviid, Erik Sørensen, Ole Birger Pedersen, Jacqueline M. Lane, Ria Lassaunière, Hanna M. Ollila, Sisse Rye Ostrowski, Bjarke Feenstra
Veröffentlicht in: Nature Genetics, Ausgabe 58, 2026, ISSN 1061-4036
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41588-025-02484-9

Protocol of the digital long COVID study: A single-center, registry-based, feasibility and clinical evaluation study to investigate a 12-week digital intervention program for people affected by post-COVID-19 condition

Autoren: Stefan Rohner, Rebekka Schnepper, Andrea Meienberg, Katrin Bopp, Michael Mayr, Gunther Meinlschmidt, Rainer Schaefert
Veröffentlicht in: PLOS One, Ausgabe 21, 2026, ISSN 1932-6203
Herausgeber: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0340385