CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.
Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .
Rezultaty
The external clinical andvisory board will be appointed and consulted for every clinical action performed in the clinical trials planned to be executed in the project.
From intranasal SARS-CoV-2 challenge to persistence in the brain (odnośnik otworzy się w nowym oknie)Using in vivo mouse models, we will clarify the routes and mechanisms of SARS-CoV-2 entry and spread in neurons, the spread in the CNS and the effect of neuronal infection on the brain parenchyma. To achieve this, we will use wild type viruses and recombinant virus expressing fluorescent reporters or specific mutations.
Mechanism and effects of SARS-CoV-2 infection in murine and human neurons co-cultured with glial cells (odnośnik otworzy się w nowym oknie)Using in vitro models, we will clarify whether SARS-CoV-2 can productively infect neurons and glial cells and will determine whether specific viral mutations are required to achieve this. We will also determine the direct viral effect on the infected cells, at morphological and metabolic level.
Platelet and coagulation markers & Virus sequence analysis (odnośnik otworzy się w nowym oknie)The different SARS-CoV-2 virus strains are studied with reference to blood clotting potential.
Results of the AIR trial (odnośnik otworzy się w nowym oknie)This deliverable will report the outcomes of the AIR trial, the results of the effectiveness of the self-management and digital interventions.
First version of CDE strategy (odnośnik otworzy się w nowym oknie)This document presents the first version of the dedicated LongCOVID Communication, Dissemination and Exploitation strategy based on the preliminary plan and KPIs included in the LongCOVID proposal. D8.1 identifies the different stakeholders along the whole value chain, their targeted dissemination activities and the set of tools to be used. From an exploitation perspective, this document presents the general strategy for the exploitation management of the project.
Report on ethics (odnośnik otworzy się w nowym oknie)The deliverable will report on all activities related to the ethics and AI development process. This will include identified and implemented requirements related to EU Ethics Guidelines for Trustworthy AI, the appointment of the advisory board and the interim update on the implementation of AI principles within the project.
Report on epidemiology and commonness between Finland and Netherlands (odnośnik otworzy się w nowym oknie)We will gather together epidemiological evidence from Finland and the Netherlands to estimate the incidence of long Covid and its effect on the work ability of patients.
Providing SARS-COV2 RT-PCR results on Serotyping and Virus Characteristics (odnośnik otworzy się w nowym oknie)The samples from Finnish LC patients (e.g. stool samples) will be analyzed for presense of SARS-COV-2 RNA and the viral genome in positive samples will be determined and charcteristics of any genetic changes analyzed. The antibody responses towards main SARS-CoV2 antigens, including neutralizing antibody responses, in LC and non-LC patients will be analyzed and compared.
Clinical study: Report of posting results (odnośnik otworzy się w nowym oknie)In this deliverable we will report where and how, in which meetings, conferences and publications, the results of the clinical study have been posted.
Data Management Plan (odnośnik otworzy się w nowym oknie)The Data Management Plan (DMP) will address the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable. It will describe what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved. We will use the latest template and guidelines provided by the Horizon Europe program and Online Manual.
Clinical study: Mid-term recruitment report (odnośnik otworzy się w nowym oknie)We will provide a midterm recruitment report of the clinical studies that are recruiting within the project, including results from an intermediate data analysis to be performed to reveal if the enrolment of patients is according to schedule and to assess, whether the distribution of patients is according to the predicted sex ratio.
LT will analyze up to 3000 plasma samples from Cohorts 1-5 to identify multiparametric lipidome signatures that differentiate between SARS Cov-2 infected recovered and LC patients. LT will try to stratify LC into possible subgroups on the basis of the lipidome and available clinical data.
Immunophenotyping analysis report (odnośnik otworzy się w nowym oknie)We will describe differences in white blood cell immunophenotyping between Long COVID-patients and patients recovering normally after Long COVID infection.
The deliverable envisions the base structure of the database with the definition of the endpoints to retrieve, send and store the data of LC cohort data. The API will be documented in Swagger and continuously updated as soon as new datapoints will be defined during the project runtime.
This deliverable describes the website created for external communication about the LongCOVID project, presenting an overview of all sections and functionalities.
Publikacje
Autorzy:
Tatiana Posharina, Mikko Varonen, Hanna Jarva, Mari Kanerva, Helena Liira, Sini M Laakso
Opublikowane w:
Brain, Behavior, and Immunity, Numer 129, 2025, ISSN 0889-1591
Wydawca:
Elsevier BV
DOI:
10.1016/J.BBI.2025.05.026
Autorzy:
Hélène Virrantaus, Helena Liira, Tatiana Posharina, Aleksandra Sulg, Teemu Mäntylä, Mari Kanerva, Sini Laakso, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Opublikowane w:
BMJ Open, 2023, ISSN 2044-6055
Wydawca:
BMJ Publishing Group Ltd.
DOI:
10.1136/BMJOPEN-2023-072935
Autorzy:
Piia Karisola, Mari Kanerva, Aki Vuokko, Helena Liira, Shuyuan Wang, Kirsi Kvarnström, Mikko Varonen, Hille Suojalehto, Harri Alenius
Opublikowane w:
Frontiers in Immunology, Numer 16, 2025, ISSN 1664-3224
Wydawca:
Frontiers Media SA
DOI:
10.3389/FIMMU.2025.1500997
Autorzy:
Lee Tatham; Anja Kipar; Jo Sharp; Edyta Kijak; Joanne Herriott; Megan Neary; Helen Box; Eduardo Gallardo Toledo; Anthony Valentijn; Helen Cox; Henry Pertinez; Paul Curley; Usman Arshad; Rajith Kumar Reddy Rajoli; Steve Rannard; James P. Stewart; Andrew Owen
Opublikowane w:
Microbiology Spectrum, 2024, ISSN 2165-0497
Wydawca:
American Society for Microbiology
DOI:
10.1128/SPECTRUM.03916-23
Autorzy:
Anu Kantele, Juuso Paajanen, Jukka-Pekka Pietilä, Olli Vapalahti, Sari H. Pakkanen, Tinja Lääveri
Opublikowane w:
New Microbes and New Infections, Numer 56, 2023, ISSN 2052-2975
Wydawca:
Elsevier BV
DOI:
10.1016/J.NMNI.2023.101209
Autorzy:
Simon De Neck, Rebekah Penrice-Randal, Jordan J. Clark et al.
Opublikowane w:
Viruses, 2023, ISSN 1999-4915
Wydawca:
MDPI
DOI:
10.3390/v15081637
Autorzy:
Ravi Ojha, Anmin Jiang, Elina Mäntylä, Tania Quirin, Naphak Modhira, Robert Witte, Arnaud Gaudin, Lisa De Zanetti, Rachel Sarah Gormal, Maija Vihinen-Ranta, Jason Mercer, Maarit Suomalainen, Urs F. Greber, Yohei Yamauchi, Pierre-Yves Lozach, Ari Helenius, Olli Vapalahti, Paul Young, Daniel Watterson, Frédéric A. Meunier, Merja Joensuu, Giuseppe Balistreri
Opublikowane w:
PLOS Pathogens, Numer 20, 2024, ISSN 1553-7374
Wydawca:
Public Library of Science (PLoS)
DOI:
10.1371/JOURNAL.PPAT.1012690
Autorzy:
Vilma Lammi, Tomoko Nakanishi, Samuel E. Jones, Shea J. Andrews, Juha Karjalainen, Beatriz Cortés, Heath E. O’Brien, Ana Ochoa-Guzman, Brian E. Fulton-Howard, Martin Broberg, Hele H. Haapaniemi, Masahiro Kanai, Matti Pirinen, Axel Schmidt, Ruth E. Mitchell, Abdou Mousas, Massimo Mangino, Alicia Huerta-Chagoya, Nasa Sinnott-Armstrong, Elizabeth T. Cirulli, Marc Vaudel, Alex S. F. Kwong, Amit K. Maiti, Minttu M. Marttila, Daniel C. Posner, Alexis A. Rodriguez, Chiara Batini, Francesca Minnai, Anna R. Dearman, C. A. Robert Warmerdam, Celia B. Sequeros, Thomas W. Winkler, Daniel M. Jordan, Raimonds Rešcenko, Lorenzo Miano, Jacqueline M. Lane, Ryan K. Chung, Beatriz Guillen-Guio, Olivia C. Leavy, Laura Carvajal-Silva, Kevin Aguilar-Valdés, Erika Frangione, Lindsay Guare, Ekaterina Vergasova, Eirini Marouli, Pasquale Striano, Ummu Afeera Zainulabid, Ashutosh Kumar, Hajar Fauzan Ahmad, Ryuya Edahiro, Shuhei Azekawa, null null, null null, Mari E. K. Niemi, null null, null null, Janick St-Cyr, Darin Adra, Madeleine Durand, David Bujold, Guillaume Bourque, Ariane Boisclair, Mylene Bertrand, Daniel Auld, Laetitia Laurent, Solomia Yanishevsky, G. Mark Lathrop, Fangyi Shi, Simon Rousseau, Jiannis Ragoussis, Danielle Perley, Vincent Mooser, David R. Morrison, null null, Daniella Balla, Julia Heggemann, Sonja Schultz, Pari Behzad, Markus M. Nöthen, Abigail Miller, Max C. Pensel, Carlo Maj, null null, Kelly Cho, Tianxi Cai, Sudha K. Iyengar, null null, Carlos A. Aguilar Salinas, Seung Hyuk T. Lee, Hortensia Moreno-Macias, Päivi Pajukanta, Michelle Duran-Gomez, null null, Lill Trogstad, null null, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Colleen M. Kripke, null null, Sergi Papiol, Jens Wiltfang, Jochen Schneider, Thomas G. Schulze, Christof Winter, Ewa Wallin, Robert Frithiof, Fanny Senner, Christoph D. Spinner, Ulrike Protzer, Mattia Cordioli, Nikola S. Mueller, Andreas Dinkel, Janos L. Kalman, Tomislav Maricic, Kristina Adorjan, Miklos Lipcsey, Lisa Fricke, Ing-Marie Larsson, Urs Heilbronner, Monika Budde, Johanna Erber, null null, null null, Nicholas R. Harvey, null null, Vince Forgetta, null null, Benedict Hignell, null null, Yolanda Espinosa-Parrilla, Juan M. Saez Hidalgo, Estefania Nova-Lamperti, Scarlett Gutiérrez-Richards, Gerardo Donoso, Leslie C. Cerpa, Cesar A. Echeverria, Camilo Cabrera, Pamela Bocchieri, Macarena Fuentes-Guajardo, Christian A. Muñoz, Karen Y. Oróstica, Alvaro Figueroa, Lissette G. Guajardo, Iskra A. Signore, Virginia A. Monardes-Ramírez, Eduardo A. Tobar-Calfucoy, Luis A. Quiñones, Cristian E. Yáñez, Daniela Zapata-Contreras, Paula Zuñiga-Pacheco, Romina Quiroga, Matías F. Martínez, Teresa A. Alarcon, Andrea X. Silva, Carolina S. Selman, Sergio Sanhueza, Rocío Retamales-Ortega, Tamara V. Arévalo, Eduardo Lamoza, Héctor Valenzuela-Jorquera, null null, Maria Sophia Donaire, Sannidhi Sarvadhavabhatla, null null, Sisse R. Ostrowski, Søren Brunak, David Westergaard, Bjarke Feenstra, Anne Sofie B. Mortensen, null null, Anna L. Guyatt, null null, Rafael de Cid, Susana Iraola-Guzmán, Gemma Moncunill, Alba Blasco, Judith Garcia-Aymerich, Natalia Blay, Carlota Dobaño, Anna Carreras, Xavier Farré, Manolis Kogevinas, Gemma Castaño-Vinyals, null null, Simone Furini, Chiara Fallerini, Kristina Zguro, Margherita Baldassarri, Francesca Colombo, null null, Thompson Hannah, null null, Anna Ilinskaya, Michil Trofimov, Layal Shaheen, Nikolay Plotnikov, Anna Kim, Dmitrii Kharitonov, Valery Ilinsky, Alexei Kamelin, null null, Francisco Tanudjaja, Efren Sandoval, Nicole L. Washington, Simon White, Iva Neveux, Shaun Dabe, Alexandre Bolze, Kelly M. Schiabor Barrett, null null, Eirini Christaki, Haralampos Milionis, Ioanna Tzoulaki, Angelos Liontos, Evangelos Evangelou, Evangelia Ntzani, null null, Rasoul Aliannejad, Vahideh Zarei, Nastaran Soltani, Bahareh Sharififard, Hengameh Ansari Tadi, Ali Amirsavadkouhi, null null, Ho NamKoong, null null, null null, Ryan C. Thompson, Alexander W. Charney, Laura G.
Opublikowane w:
Nature Genetics, 2025, ISSN 1061-4036
Wydawca:
Springer Science and Business Media LLC
DOI:
10.1038/S41588-025-02100-W
Autorzy:
Pinja Kettunen, Angelina Lesnikova, Noora Räsänen et al.
Opublikowane w:
Journal of Virology, 2023, ISSN 1098-5514
Wydawca:
American Society for Microbiology
DOI:
10.1128/jvi.00144-23
Autorzy:
Velina Vangelova-Korpinen, Helena Liira, Samu N. Kurki, Markku Sainio, Antti Malmivaara, Mari Kanerva, Jan-Henry Stenberg, Mikko Varonen, Mikko Venäläinen, Piia Vuorela, Jari Arokoski
Opublikowane w:
PLOS ONE, Numer 20, 2025, ISSN 1932-6203
Wydawca:
Public Library of Science (PLoS)
DOI:
10.1371/JOURNAL.PONE.0316169
Autorzy:
Sanna Stålnacke, Helena Liira, Velina Vangelova-Korpinen, Hélène Virrantaus, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Antti Malmivaara, Aki Vuokko, Mikko Varonen, Mikko Venäläinen, Jari Arokoski
Opublikowane w:
Scandinavian Journal of Primary Health Care, Numer 43, 2025, ISSN 0281-3432
Wydawca:
Informa UK Limited
DOI:
10.1080/02813432.2024.2410986
Autorzy:
Helena Liira, Paul Garner, Antti Malmivaara, Mari Kanerva, Kirsi Kvarnström, Markku Sainio, Mikko Varonen, Mikko Venäläinen, Aki Vuokko, Jari Arokoski
Opublikowane w:
Journal of Psychosomatic Research, Numer 182, 2024, ISSN 0022-3999
Wydawca:
Elsevier BV
DOI:
10.1016/J.JPSYCHORES.2024.111808
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