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Precision drug REPurpOsing For EUrope and the world

Project description

Innovative platform for precision drug repurposing

Drug repurposing investigates the use of existing drugs for new therapeutic purposes. Thus, it reduces the time and costs of drug development. However, it is often accidental and less effective than classical drug discovery. Both discovery and repurposing suffer from the same knowledge gap, whereby diseases are not understood from a mechanistic perspective and are treated symptomatically in an imprecise manner. The EU-funded REPO4EU project will establish a comprehensive European/global platform for validated precision drug repurposing open to stakeholders for information, multimedia training, matchmaking and cooperation. The project, consisting of world-leading scientists, will redefine diseases using a mechanism-based approach, applying advanced bioinformatics and AI to real-world Big Data.

Objective

Here we, a group of long-standing collaborators in innovative drug repurposing, propose to build REPO4EU, a comprehensive European/global platform for validated precision drug repurposing open to stakeholders for information, multimedia training, matchmaking and cooperation. Drug repurposing reduces the time and costs of drug development but is often serendipitous and less effective than classical drug discovery. Both, discovery and repurposing, suffer from the same knowledge gap that diseases are mechanistically not understood and treated symptomatically in an imprecise manner. Our team of world-leading scientists overcome this by breakthroughs in advanced bioinformatics and artificial intelligence (AI) on real-world big data to redefine diseases in a mechanism-based manner. Patients are still identified by symptom, but stratified according to causal mechanism, the endotype. Trials are small, precise, innovatively designed, prioritising, in coordination with regulators, payers and investors, patient-defined outcomes with high safety and operational excellence. This revolutionary new era of medicine will allow unprecedented efficacy and cost-effectiveness. The promiscuity of small molecules and recently expanded knowledge of protein structures are exploited by cheminformatics and deep learning to repurpose drugs beyond their original target. At any level of the development chain, even for classic projects, REPO4EU provides expertise and matchmaking for freedom-to-operate, intellectual property, reformulation and value-creation, specialised in drug repurposing. Within 5 years, REPO4EU will establish a first-in-class coherent and innovative web-based platform for safe and efficient drug repurposing for all types of high unmet medical need indications to all European researchers and SMEs with a unique Open Science concept, ensuring global medical impact. Finally, within a 2-year interphase, REPO4EU will be converted into a sustainable European infrastructure.

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Coordinator

UNIVERSITEIT MAASTRICHT
Net EU contribution
€ 4 124 456,00
Address
Minderbroedersberg 4
6200 MD Maastricht
Netherlands

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Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (26)

Partners (1)