Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Precision drug REPurpOsing For EUrope and the world

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

REPO4EU Open Science Strategy (opens in new window)
Initial whitepaper on a virtual EU biobank platform for patient recruitment pilots (opens in new window)
Phase I II biometrics compendium (opens in new window)
REPO4EU Impact Master Plan Document detailing the project s official dissemination and communication plans and the outline of target groups and their segments for community building purposes (opens in new window)

REPO4EU Impact Master Plan – Document detailing the project’s official dissemination and communication plans, and the outline of target groups and their segments for community building purposes.

Phase II online compendium (opens in new window)
Generic guideline for conducting an extended FtO analysis and FtO analyses for all intended clinical trials (opens in new window)
An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing, and their objectives and expectations regarding FtO, IP and BD (opens in new window)
Initial whitepaper on rational and first selection of animal models for drug repurposing (opens in new window)
Initial whitepaper on rational for a wet-lab technology platform for patient recruitment (opens in new window)
Initial whitepaper on rational for an AI technology platform for patient recruitment (opens in new window)
Whitepaper on the platform knowledge base and data standards for in silico drug repurposing (opens in new window)

Whitepaper on the platform knowledge base & data standards for in silico drug repurposing

Initial whitepaper on rational and first selection of cell models for drug repurposing (opens in new window)

Publications

A system perspective on drug response (opens in new window)

Author(s): Vlad Elgart, Joseph Loscalzo
Published in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.70128

Artificial Intelligence and Network Medicine: Path to Precision Medicine (opens in new window)

Author(s): Lucia Altucci, Lina Badimon, Jean-Luc Balligand, Jan Baumbach, Alberico L. Catapano, Feixong Cheng, Dawn DeMeo, Rajat Gupta, Marcus Hacker, Yang-Yu Liu, Joseph Loscalzo, Sabrina Maniscalco, Jörg Menche, Giulia Menichetti, Paolo Parini, Harald H. H. W. Schmidt, Marinka Zitnik
Published in: NEJM AI, Issue 2, 2025, ISSN 2836-9386
Publisher: Massachusetts Medical Society
DOI: 10.1056/AIRA2401229

Seminars in Immunopathology (opens in new window)

Author(s): Szepanowski RD, Haupeltshofer S, Vonhof SE, Frank B, Kleinschnitz C, Casas AI
Published in: Seminars in Immunopathology, Issue 45, 2023, ISSN 1863-2297
Publisher: Springer
DOI: 10.1007/s00281-023-00994-4

Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing (opens in new window)

Author(s): Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R Pico, Rudolf T Pillich, Julian M Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva, Jan Baumbach
Published in: Nucleic Acids Research, Issue 52, 2024, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE388

De Novo exposomic geospatial assembly of chronic disease regions with machine learning & network analysis (opens in new window)

Author(s): Andrew Deonarine, Ayushi Batwara, Roy Wada, Puneet Sharma, Joseph Loscalzo, Bisola Ojikutu, Kathryn Hall
Published in: eBioMedicine, Issue 112, 2025, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105575

BMC Bioinformatics (opens in new window)

Author(s): Fernando M. Delgado-Chaves; Ferdinand Spurny; Tanja Laske; Mhaned Oubounyt; Jan Baumbach
Published in: BMC Bioinformatics, 2025, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/S12859-025-06162-9

Journal of Alzheimer's Disease (opens in new window)

Author(s): Mayra Pacheco Pachado, Ana I Casas, Mahmoud H Elbatreek, Cristian Nogales, Emre Guney, Alberto J Espay, Harald H H W Schmidt
Published in: Journal of Alzheimer’s Disease, Issue 96, 2023, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/JAD-230694

Trends in use, spending, and prices of doxepin for insomnia (opens in new window)

Author(s): Christopher Cai; Aaron Kesselheim; Benjamin Rome
Published in: JAMA, 2025, ISSN 1538-3598
Publisher: American Medical Association
DOI: 10.58647/DRUGARXIV.PR000023.V1

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics (opens in new window)

Author(s): Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List
Published in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.17395

Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis (opens in new window)

Author(s): Farzaneh Firoozbakht; Maria Louise Elkjaer; Diane E. Handy; Rui-Sheng Wang; Zoe Chervontseva; Matthias Rarey; Joseph Loscalzo; Jan Baumbach; Olga Tsoy
Published in: Cell Reports Methods, 2025, ISSN 2667-2375
Publisher: Cell Rep. Methods
DOI: 10.1016/J.CRMETH.2025.100990

Digital twins as global learning health and disease models for preventive and personalized medicine (opens in new window)

Author(s): Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson
Published in: Genome Medicine, Issue 17, 2025, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01435-7

Molecular interaction networks and drug development: novel approach to drug target identification and drug repositioning (opens in new window)

Author(s): Loscalzo J
Published in: FASEB J, Issue 37, 2023, ISSN 1530-6860
Publisher: Wiley
DOI: 10.1096/fj.202201683R

Transforming literature screening: The emerging role of large language models in systematic reviews (opens in new window)

Author(s): Fernando M. Delgado-Chaves, Matthew J. Jennings, Antonio Atalaia, Justus Wolff, Rita Horvath, Zeinab M. Mamdouh, Jan Baumbach, Linda Baumbach
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2411962122

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool (opens in new window)

Author(s): Teebah Abu-Zahra; Sabine Grimm; Mirre Scholte; Manuela Joore
Published in: PharmacoEconomics, 2025, ISSN 1179-2027
Publisher: Springer
DOI: 10.58647/DRUGARXIV.PR000029.V1

Multiomics network medicine approaches to precision medicine.... (opens in new window)

Author(s): Wang RS, Maron BA, Loscalzo J
Published in: Arterioscler Thromb Vasc Biol, Issue 43, 2023, ISSN 1079-5642
Publisher: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318731

Nature Biotechnology (opens in new window)

Author(s): Lobentanzer, Sebastian; Feng, Shaohong; Bruderer, Noah; Maier, Andreas; Díaz, Adrián G.; Strange, Amy; Ismail, Anis; Kulaga, Anton; Dugourd, Aurelien; Zdrazil, Barbara; Chassagnol, Bastien; Pommier, Cyril; Lucarelli, Daniele; McDonagh, Ellen M.; Verkinderen, Emma; Delgado-Chaves, Fernando M.; Fuellen, Georg; Sonntag, Hannah; Menger, Jonatan; Christiaen, Lionel; Geistlinger, Ludwig; Zetsche, Luna Zacharias; Engelke, Marlis; McNutt, Megan; Harrison, Melissa; Hizli, Melissa; Usanov, Nikolai; Baracho, Patrick; Beier, Sebastian; Boeing, Stefan; Muranen, Taru A.; Le, Trang T.; Dragan, Valeriia; Zhou, Xiao-Ran; Nielsen-Tehranchian, Yasmin; Song, Yuyao; Wang, Cankun; Baumbach, Jan; Abreu-Vicente, Jorge; Krehl, Nils; Ma, Qin; Lemberger, Thomas; Saez-Rodriguez, Julio
Published in: Nature Biotechnology, 2025, ISSN 1087-0156
Publisher: Nat. Biotechnol.
DOI: 10.34734/FZJ-2025-01790

Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment (opens in new window)

Author(s): Alexander G. Grønning, Sebastian E. Vonhof, Mahmoud Elbatreek, Anna Hamker, Rebecca D. Szepanowski, Svenja C. Erkelenz, Friederike Langhauser, Javier Egea, Manuela G. Lopez, Jan Baumbach, Christoph Kleinschnitz, Ana I. Casas
Published in: Biomedicine & Pharmacotherapy, Issue 183, 2025, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117829

scDrugPrio: a framework for analysis of single-cell transcriptomics.... (opens in new window)

Author(s): Schaefer S, Smelik M, Sysoev O, Zhao Y, Eklund D, et al.
Published in: Genome Med, Issue 16, 2024, ISSN 1756-994X
Publisher: (London) BioMed Central
DOI: 10.1101/2023.11.08.566249

Network‐based precision medicine and systems pharmacology (opens in new window)

Author(s): Arvind K. Pandey, Susan Dina Ghiassian, Joseph Loscalzo
Published in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.70184

Revising EU pharmaceutical legislation: will it foster drug repurposing? (opens in new window)

Author(s): Mirre Scholte, Sabine E. Grimm, Bianca Pauly, Frank Verbeeck, Anna M.G. Pasmooij, Barend Bouma, Jorika van Duijn-Wiersma, Emre Guney, Aaron S. Kesselheim, Harald H.H.W. Schmidt, Manuela A. Joore
Published in: Drug Discovery Today, Issue 30, 2025, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104286

Repurposing drugs for the treatment of COVID-19.... (opens in new window)

Author(s): Wang RS, Loscalzo J
Published in: Circ Res, Issue 132, 2023, ISSN 0009-7330
Publisher: Lippincott, Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.122.321879

Phenomics and robust multiomics data for cardiovascular disease subtyping (opens in new window)

Author(s): Maiorino E, Loscalzo J
Published in: Arterioscler Thromb Vasc Biol, Issue 43, 2023, ISSN 1079-5642
Publisher: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318892

Drug Discovery Today (opens in new window)

Author(s): Teebah Abu-Zahra; Sabine E. Grimm; Mirre Scholte; Adam J.N. Raymakers; Aaron S. Kesselheim; Manuela Joore
Published in: Drug Discovery Today, 2024, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104008

Machine learning-based integration of network features and chemical structures of compounds.... (opens in new window)

Author(s): Spaeth J, Wang RS, Humphrey M, Baumbach J, Loscalzo J
Published in: CPT Pharmacometrics Syst Pharmacol, Issue 13, 2024, ISSN 2163-8306
Publisher: Wiley
DOI: 10.1002/psp4.13076

HTA181 How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework (opens in new window)

Author(s): Abu-Zahra, T.; Grimm, S.; Scholte, M.; Joore, M.
Published in: Value in Health, 2023
Publisher: Elsevier
DOI: 10.1016/J.JVAL.2023.09.1865

How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework (opens in new window)

Author(s): T. Abu-Zahra, S. Grimm, M. Scholte, M. Joore
Published in: Value in Health, 2023
Publisher: ElSevier
DOI: 10.1016/j.jval.2023.09.1865

NeDRex-Web: An Interactive Web Tool for Drug Repurposing by Exploring Heterogeneous Molecular Networks (opens in new window)

Author(s): Andreas Maier, Mahdie Rafiei, Elisa Anastasi, Olga Zolotareva, James Skelton, Maria L. Elkjaer, Ana I. Casas, Cristian Nogales, Harald H. H. W. Schmidt, Tim Kacprowski, David B. Blumenthal, Anil Wipat, Sepideh Sadegh, Jan Baumbach
Published in: 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2025
Publisher: IEEE
DOI: 10.1109/BIBM62325.2024.10822390

A regulatory roadmap for repurposing: comparing pathways for making repurposed drugs available in the EU, UK, and US (opens in new window)

Author(s): Mirre Scholte; Liam Bendicksen; Sabine E. Grimm; Teebah Abu-Zahra; Bianca Pauly; Manuela Joore; Aaron S. Kesselheim
Published in: Journal of Law, Medicine & Ethics, 2024
Publisher: Cambridge University Press
DOI: 10.1017/JME.2024.171

CAUSAL DISCOVERY : FINDING COMMON LATENT CAUSES

Author(s): Xanthopoulou-Koukogia, K.
Published in: 2023
Publisher: University Twente

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available

My booklet 0 0