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CORDIS - EU research results
CORDIS

Precision drug REPurpOsing For EUrope and the world

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

REPO4EU Open Science Strategy (opens in new window)
Initial whitepaper on a virtual EU biobank platform for patient recruitment pilots (opens in new window)
Phase I II biometrics compendium (opens in new window)
An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing and their objectives and expectations regarding FtO IP and BD (opens in new window)

An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing, and their objectives and expectations regarding FtO, IP and BD

REPO4EU Impact Master Plan Document detailing the project s official dissemination and communication plans and the outline of target groups and their segments for community building purposes (opens in new window)

REPO4EU Impact Master Plan – Document detailing the project’s official dissemination and communication plans, and the outline of target groups and their segments for community building purposes.

Phase II online compendium (opens in new window)
Generic guideline for conducting an extended FtO analysis and FtO analyses for all intended clinical trials (opens in new window)
Initial whitepaper on rational and first selection of animal models for drug repurposing (opens in new window)
Initial whitepaper on rational for a wet-lab technology platform for patient recruitment (opens in new window)
Initial whitepaper on preclinical drug testing models for repurposing (opens in new window)
1st Report on publishing activities with alternative metrics (opens in new window)
Initial whitepaper on rational for an AI technology platform for patient recruitment (opens in new window)
Whitepaper on the platform knowledge base and data standards for in silico drug repurposing (opens in new window)

Whitepaper on the platform knowledge base & data standards for in silico drug repurposing

Initial whitepaper on rational and first selection of cell models for drug repurposing (opens in new window)

Publications

Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations (opens in new window)

Author(s): Rui-Sheng Wang, Joseph Loscalzo
Published in: Circulation Research, Issue 132, 2024, ISSN 0009-7330
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.122.321879

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes (opens in new window)

Author(s): Mayra Pacheco Pachado, Ana I Casas, Mahmoud H Elbatreek, Cristian Nogales, Emre Guney, Alberto J Espay, Harald H H W Schmidt
Published in: Journal of Alzheimer 's Disease, Issue 96, 2023, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/JAD-230694

Transforming literature screening: The emerging role of large language models in systematic reviews (opens in new window)

Author(s): Fernando M. Delgado-Chaves, Matthew J. Jennings, Antonio Atalaia, Justus Wolff, Rita Horvath, Zeinab M. Mamdouh, Jan Baumbach, Linda Baumbach
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2411962122

De Novo exposomic geospatial assembly of chronic disease regions with machine learning & network analysis (opens in new window)

Author(s): Andrew Deonarine, Ayushi Batwara, Roy Wada, Puneet Sharma, Joseph Loscalzo, Bisola Ojikutu, Kathryn Hall
Published in: eBioMedicine, Issue 112, 2025, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105575

Explainable drug repurposing via path based knowledge graph completion (opens in new window)

Author(s): Ana Jiménez, María José Merino, Juan Parras, Santiago Zazo
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-67163-X

Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases (opens in new window)

Author(s): Wang RS, Maron BA, Loscalzo J
Published in: Arterioscl er Thromb Vasc Biol, Issue 43, 2023, ISSN 1079-5642
Publisher: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318731

Phenomics and Robust Multiomics Data for Cardiovascular Disease Subtyping (opens in new window)

Author(s): Enrico Maiorino, Joseph Loscalzo
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 43, 2024, ISSN 1079-5642
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/ATVBAHA.122.318892

Molecular interaction networks and drug development: Novel approach to drug target identification and drug repositioning (opens in new window)

Author(s): Joseph Loscalzo
Published in: The FASEB Journal, Issue 37, 2025, ISSN 0892-6638
Publisher: Wiley
DOI: 10.1096/FJ.202201683R

Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke (opens in new window)

Author(s): Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H.
Published in: Journal of the American Heart Association, Issue 14, 2025, ISSN 2047-9980
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/JAHA.124.039098

Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis (opens in new window)

Author(s): Farzaneh Firoozbakht, Maria Louise Elkjaer, Diane E. Handy, Rui-Sheng Wang, Zoe Chervontseva, Matthias Rarey, Joseph Loscalzo, Jan Baumbach, Olga Tsoy
Published in: Cell Reports Methods, Issue 5, 2025, ISSN 2667-2375
Publisher: Elsevier BV
DOI: 10.1016/J.CRMETH.2025.100990

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics (opens in new window)

Author(s): Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List
Published in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.17395

A Regulatory Roadmap for Repurposing: Comparing Pathways for Making Repurposed Drugs Available In The EU, UK, And US (opens in new window)

Author(s): Mirre Scholte, Liam Bendicksen, Sabine E. Grimm, Teebah Abu-Zahra, Bianca Pauly, Manuela Joore, Aaron S. Kesselheim
Published in: Journal of Law, Medicine & Ethics, Issue 52, 2025, ISSN 1073-1105
Publisher: Cambridge University Press (CUP)
DOI: 10.1017/JME.2024.171

Digital twins as global learning health and disease models for preventive and personalized medicine (opens in new window)

Author(s): Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson
Published in: Genome Medicine, Issue 17, 2025, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01435-7

A system perspective on drug response (opens in new window)

Author(s): Vlad Elgart, Joseph Loscalzo
Published in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Publisher: Wiley
DOI: 10.1111/BPH.70128

Trends in Fills, Spending, and Prices of Doxepin for Insomnia (opens in new window)

Author(s): Christopher L. Cai, Aaron S. Kesselheim, Benjamin N. Rome
Published in: JAMA, Issue 333, 2025, ISSN 0098-7484
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMA.2024.27526

Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease (opens in new window)

Author(s): Daniel Sedding, Tim M. Schmidt, Heike Bähre, Udo Bavendiek, Ana I. Casas, Suzi Chen, Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Frank Gutzki, Andreas Hahn, Pamela Kleikers, Thomas Krahn, Cecilia Macchiusi
Published in: JACC: Advances, Issue 4, 2025, ISSN 2772-963X
Publisher: Elsevier BV
DOI: 10.1016/J.JACADV.2025.101590

Thromboinflammatory challenges in stroke pathophysiology (opens in new window)

Author(s): R.D Szepanowski, S Haupeltshofer, S.E Vonhof, B Frank, C Kleinschnitz, A.I Casas
Published in: Seminars in Immunopathology, Issue 45, 2023, ISSN 1863-2297
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00281-023-00994-4

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool (opens in new window)

Author(s): Teebah Abu-Zahra, Sabine E. Grimm, Mirre Scholte, Manuela Joore
Published in: PharmacoEconomics, Issue 43, 2025, ISSN 1170-7690
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S40273-025-01515-X

A platform for the biomedical application of large language models (opens in new window)

Author(s): Sebastian Lobentanzer, Shaohong Feng, Noah Bruderer, Andreas Maier, null null, Adrián G. Díaz, Amy Strange, Anis Ismail, Anton Kulaga, Aurelien Dugourd, Barbara Zdrazil, Bastien Chassagnol, Cyril Po
Published in: Nature Biotechnology, Issue 43, 2025, ISSN 1087-0156
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02534-3

Revising EU pharmaceutical legislation: will it foster drug repurposing? (opens in new window)

Author(s): Mirre Scholte, Sabine E. Grimm, Bianca Pauly, Frank Verbeeck, Anna M.G. Pasmooij, Barend Bouma, Jorika van Duijn-Wiersma, Emre Guney, Aaron S. Kesselheim, Harald H.H.W. Schmidt, Manuela A. Joore
Published in: Drug Discovery Today, Issue 30, 2025, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104286

Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer (opens in new window)

Author(s): Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger, Romana Netea-Maier, Susanne I. Wudy, Christina Ludwig, Markus List, Benedikt Kirchner, Marlene Reithmair, Mi
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-18319-W

Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment (opens in new window)

Author(s): Alexander G. Grønning, Sebastian E. Vonhof, Mahmoud Elbatreek, Anna Hamker, Rebecca D. Szepanowski, Svenja C. Erkelenz, Friederike Langhauser, Javier Egea, Manuela G. Lopez, Jan Baumbach, Christoph K
Published in: Biomedicine & Pharmacotherapy, Issue 183, 2025, ISSN 0753-3322
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117829

Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing (opens in new window)

Author(s): Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R Pico, Rudolf T Pillich, Julian M Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva, Jan Baumbach
Published in: Nucleic Acids Research, Issue 52, 2024, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE388

DRaCOon: a novel algorithm for pathway-level differential co-expression analysis in transcriptomics (opens in new window)

Author(s): Fernando M. Delgado-Chaves, Ferdinand Spurny, Tanja Laske, Mhaned Oubounyt, Jan Baumbach
Published in: BMC Bioinformatics, Issue 26, 2025, ISSN 1471-2105
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12859-025-06162-9

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases (opens in new window)

Author(s): Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Published in: Genome Medicine, Issue 16, 2024, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-024-01314-7

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool (opens in new window)

Author(s): Teebah Abu-Zahra; Sabine Grimm; Mirre Scholte; Manuela Joore
Published in: PharmacoEconomics, 2025
DOI: 10.58647/DRUGARXIV.PR000029.V1

HTA181 How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework (opens in new window)

Author(s): T. Abu-Zahra, S. Grimm, M. Scholte, M. Joore
Published in: Value in Health, Issue 26, 2025, ISSN 1098-3015
Publisher: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104008

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