Precision drug REPurpOsing For EUrope and the world

Informations projet

REPO4EU

N° de convention de subvention: 101057619

DOI

10.3030/101057619

Date de signature de la CE 24 Mai 2022

Date de début 1 Septembre 2022

Date de fin 31 Août 2029

Financé au titre de

• Health

Coût total

€ 22 982 612,00

Contribution de l’UE

€ 22 982 612,00

Coordonné par

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (14)

REPO4EU Open Science Strategy
Initial whitepaper on a virtual EU biobank platform for patient recruitment pilots
Phase I II biometrics compendium
An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing and their objectives and expectations regarding FtO IP and BD

An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing, and their objectives and expectations regarding FtO, IP and BD

REPO4EU Impact Master Plan Document detailing the project s official dissemination and communication plans and the outline of target groups and their segments for community building purposes

REPO4EU Impact Master Plan – Document detailing the project’s official dissemination and communication plans, and the outline of target groups and their segments for community building purposes.

Phase II online compendium
Generic guideline for conducting an extended FtO analysis and FtO analyses for all intended clinical trials
Initial whitepaper on rational and first selection of animal models for drug repurposing
Initial whitepaper on rational for a wet-lab technology platform for patient recruitment
Initial whitepaper on preclinical drug testing models for repurposing
1st Report on publishing activities with alternative metrics
Initial whitepaper on rational for an AI technology platform for patient recruitment
Whitepaper on the platform knowledge base and data standards for in silico drug repurposing

Whitepaper on the platform knowledge base & data standards for in silico drug repurposing

Initial whitepaper on rational and first selection of cell models for drug repurposing

Demonstrators, pilots, prototypes (1)

RepoScope training snapshot available

Other (2)

A White paper on the challenges of Open Science to Research Integrity and Research Ethics
Publishing portal launch

Publications

Peer reviewed articles (25)

Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations

Auteurs: Rui-Sheng Wang, Joseph Loscalzo
Publié dans: Circulation Research, Numéro 132, 2024, ISSN 0009-7330
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.122.321879

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes

Auteurs: Mayra Pacheco Pachado, Ana I Casas, Mahmoud H Elbatreek, Cristian Nogales, Emre Guney, Alberto J Espay, Harald H H W Schmidt
Publié dans: Journal of Alzheimer 's Disease, Numéro 96, 2023, ISSN 1387-2877
Éditeur: IOS Press
DOI: 10.3233/JAD-230694

Transforming literature screening: The emerging role of large language models in systematic reviews

Auteurs: Fernando M. Delgado-Chaves, Matthew J. Jennings, Antonio Atalaia, Justus Wolff, Rita Horvath, Zeinab M. Mamdouh, Jan Baumbach, Linda Baumbach
Publié dans: Proceedings of the National Academy of Sciences, Numéro 122, 2025, ISSN 0027-8424
Éditeur: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2411962122

De Novo exposomic geospatial assembly of chronic disease regions with machine learning & network analysis

Auteurs: Andrew Deonarine, Ayushi Batwara, Roy Wada, Puneet Sharma, Joseph Loscalzo, Bisola Ojikutu, Kathryn Hall
Publié dans: eBioMedicine, Numéro 112, 2025, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105575

Explainable drug repurposing via path based knowledge graph completion

Auteurs: Ana Jiménez, María José Merino, Juan Parras, Santiago Zazo
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-67163-X

Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases

Auteurs: Wang RS, Maron BA, Loscalzo J
Publié dans: Arterioscl er Thromb Vasc Biol, Numéro 43, 2023, ISSN 1079-5642
Éditeur: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318731

Phenomics and Robust Multiomics Data for Cardiovascular Disease Subtyping

Auteurs: Enrico Maiorino, Joseph Loscalzo
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 43, 2024, ISSN 1079-5642
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/ATVBAHA.122.318892

Molecular interaction networks and drug development: Novel approach to drug target identification and drug repositioning

Auteurs: Joseph Loscalzo
Publié dans: The FASEB Journal, Numéro 37, 2025, ISSN 0892-6638
Éditeur: Wiley
DOI: 10.1096/FJ.202201683R

Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke

Auteurs: Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H.
Publié dans: Journal of the American Heart Association, Numéro 14, 2025, ISSN 2047-9980
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/JAHA.124.039098

Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis

Auteurs: Farzaneh Firoozbakht, Maria Louise Elkjaer, Diane E. Handy, Rui-Sheng Wang, Zoe Chervontseva, Matthias Rarey, Joseph Loscalzo, Jan Baumbach, Olga Tsoy
Publié dans: Cell Reports Methods, Numéro 5, 2025, ISSN 2667-2375
Éditeur: Elsevier BV
DOI: 10.1016/J.CRMETH.2025.100990

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

Auteurs: Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List
Publié dans: British Journal of Pharmacology, 2024, ISSN 0007-1188
Éditeur: Wiley
DOI: 10.1111/BPH.17395

A Regulatory Roadmap for Repurposing: Comparing Pathways for Making Repurposed Drugs Available In The EU, UK, And US

Auteurs: Mirre Scholte, Liam Bendicksen, Sabine E. Grimm, Teebah Abu-Zahra, Bianca Pauly, Manuela Joore, Aaron S. Kesselheim
Publié dans: Journal of Law, Medicine & Ethics, Numéro 52, 2025, ISSN 1073-1105
Éditeur: Cambridge University Press (CUP)
DOI: 10.1017/JME.2024.171

Digital twins as global learning health and disease models for preventive and personalized medicine

Auteurs: Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson
Publié dans: Genome Medicine, Numéro 17, 2025, ISSN 1756-994X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01435-7

A system perspective on drug response

Auteurs: Vlad Elgart, Joseph Loscalzo
Publié dans: British Journal of Pharmacology, 2025, ISSN 0007-1188
Éditeur: Wiley
DOI: 10.1111/BPH.70128

Trends in Fills, Spending, and Prices of Doxepin for Insomnia

Auteurs: Christopher L. Cai, Aaron S. Kesselheim, Benjamin N. Rome
Publié dans: JAMA, Numéro 333, 2025, ISSN 0098-7484
Éditeur: American Medical Association (AMA)
DOI: 10.1001/JAMA.2024.27526

Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease

Auteurs: Daniel Sedding, Tim M. Schmidt, Heike Bähre, Udo Bavendiek, Ana I. Casas, Suzi Chen, Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Frank Gutzki, Andreas Hahn, Pamela Kleikers, Thomas Krahn, Cecilia Macchiusi
Publié dans: JACC: Advances, Numéro 4, 2025, ISSN 2772-963X
Éditeur: Elsevier BV
DOI: 10.1016/J.JACADV.2025.101590

Thromboinflammatory challenges in stroke pathophysiology

Auteurs: R.D Szepanowski, S Haupeltshofer, S.E Vonhof, B Frank, C Kleinschnitz, A.I Casas
Publié dans: Seminars in Immunopathology, Numéro 45, 2023, ISSN 1863-2297
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00281-023-00994-4

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool

Auteurs: Teebah Abu-Zahra, Sabine E. Grimm, Mirre Scholte, Manuela Joore
Publié dans: PharmacoEconomics, Numéro 43, 2025, ISSN 1170-7690
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S40273-025-01515-X

A platform for the biomedical application of large language models

Auteurs: Sebastian Lobentanzer, Shaohong Feng, Noah Bruderer, Andreas Maier, null null, Adrián G. Díaz, Amy Strange, Anis Ismail, Anton Kulaga, Aurelien Dugourd, Barbara Zdrazil, Bastien Chassagnol, Cyril Po
Publié dans: Nature Biotechnology, Numéro 43, 2025, ISSN 1087-0156
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02534-3

Revising EU pharmaceutical legislation: will it foster drug repurposing?

Auteurs: Mirre Scholte, Sabine E. Grimm, Bianca Pauly, Frank Verbeeck, Anna M.G. Pasmooij, Barend Bouma, Jorika van Duijn-Wiersma, Emre Guney, Aaron S. Kesselheim, Harald H.H.W. Schmidt, Manuela A. Joore
Publié dans: Drug Discovery Today, Numéro 30, 2025, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104286

Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer

Auteurs: Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger, Romana Netea-Maier, Susanne I. Wudy, Christina Ludwig, Markus List, Benedikt Kirchner, Marlene Reithmair, Mi
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-18319-W

Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment

Auteurs: Alexander G. Grønning, Sebastian E. Vonhof, Mahmoud Elbatreek, Anna Hamker, Rebecca D. Szepanowski, Svenja C. Erkelenz, Friederike Langhauser, Javier Egea, Manuela G. Lopez, Jan Baumbach, Christoph K
Publié dans: Biomedicine & Pharmacotherapy, Numéro 183, 2025, ISSN 0753-3322
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117829

Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing

Auteurs: Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R Pico, Rudolf T Pillich, Julian M Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva, Jan Baumbach
Publié dans: Nucleic Acids Research, Numéro 52, 2024, ISSN 0305-1048
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE388

DRaCOon: a novel algorithm for pathway-level differential co-expression analysis in transcriptomics

Auteurs: Fernando M. Delgado-Chaves, Ferdinand Spurny, Tanja Laske, Mhaned Oubounyt, Jan Baumbach
Publié dans: BMC Bioinformatics, Numéro 26, 2025, ISSN 1471-2105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12859-025-06162-9

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases

Auteurs: Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Publié dans: Genome Medicine, Numéro 16, 2024, ISSN 1756-994X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13073-024-01314-7

Other (1)

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool

Auteurs: Teebah Abu-Zahra; Sabine Grimm; Mirre Scholte; Manuela Joore
Publié dans: PharmacoEconomics, 2025
DOI: 10.58647/DRUGARXIV.PR000029.V1

Conference proceedings (1)

HTA181 How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework

Auteurs: T. Abu-Zahra, S. Grimm, M. Scholte, M. Joore
Publié dans: Value in Health, Numéro 26, 2025, ISSN 1098-3015
Éditeur: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104008