Precision drug REPurpOsing For EUrope and the world

Informazioni relative al progetto

REPO4EU

ID dell’accordo di sovvenzione: 101057619

DOI

10.3030/101057619

Data della firma CE 24 Maggio 2022

Data di avvio 1 Settembre 2022

Data di completamento 31 Agosto 2029

Finanziato da

• Health

Costo totale

€ 22 982 612,00

Contributo UE

€ 22 982 612,00

Coordinato da

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (14)

REPO4EU Open Science Strategy
Initial whitepaper on a virtual EU biobank platform for patient recruitment pilots
Phase I II biometrics compendium
An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing and their objectives and expectations regarding FtO IP and BD

An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing, and their objectives and expectations regarding FtO, IP and BD

REPO4EU Impact Master Plan Document detailing the project s official dissemination and communication plans and the outline of target groups and their segments for community building purposes

REPO4EU Impact Master Plan – Document detailing the project’s official dissemination and communication plans, and the outline of target groups and their segments for community building purposes.

Phase II online compendium
Generic guideline for conducting an extended FtO analysis and FtO analyses for all intended clinical trials
Initial whitepaper on rational and first selection of animal models for drug repurposing
Initial whitepaper on rational for a wet-lab technology platform for patient recruitment
Initial whitepaper on preclinical drug testing models for repurposing
1st Report on publishing activities with alternative metrics
Initial whitepaper on rational for an AI technology platform for patient recruitment
Whitepaper on the platform knowledge base and data standards for in silico drug repurposing

Whitepaper on the platform knowledge base & data standards for in silico drug repurposing

Initial whitepaper on rational and first selection of cell models for drug repurposing

Demonstrators, pilots, prototypes (1)

RepoScope training snapshot available

Other (2)

A White paper on the challenges of Open Science to Research Integrity and Research Ethics
Publishing portal launch

Pubblicazioni

Peer reviewed articles (25)

Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations

Autori: Rui-Sheng Wang, Joseph Loscalzo
Pubblicato in: Circulation Research, Numero 132, 2024, ISSN 0009-7330
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.122.321879

Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes

Autori: Mayra Pacheco Pachado, Ana I Casas, Mahmoud H Elbatreek, Cristian Nogales, Emre Guney, Alberto J Espay, Harald H H W Schmidt
Pubblicato in: Journal of Alzheimer 's Disease, Numero 96, 2023, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/JAD-230694

Transforming literature screening: The emerging role of large language models in systematic reviews

Autori: Fernando M. Delgado-Chaves, Matthew J. Jennings, Antonio Atalaia, Justus Wolff, Rita Horvath, Zeinab M. Mamdouh, Jan Baumbach, Linda Baumbach
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2411962122

De Novo exposomic geospatial assembly of chronic disease regions with machine learning & network analysis

Autori: Andrew Deonarine, Ayushi Batwara, Roy Wada, Puneet Sharma, Joseph Loscalzo, Bisola Ojikutu, Kathryn Hall
Pubblicato in: eBioMedicine, Numero 112, 2025, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105575

Explainable drug repurposing via path based knowledge graph completion

Autori: Ana Jiménez, María José Merino, Juan Parras, Santiago Zazo
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-67163-X

Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases

Autori: Wang RS, Maron BA, Loscalzo J
Pubblicato in: Arterioscl er Thromb Vasc Biol, Numero 43, 2023, ISSN 1079-5642
Editore: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318731

Phenomics and Robust Multiomics Data for Cardiovascular Disease Subtyping

Autori: Enrico Maiorino, Joseph Loscalzo
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 43, 2024, ISSN 1079-5642
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/ATVBAHA.122.318892

Molecular interaction networks and drug development: Novel approach to drug target identification and drug repositioning

Autori: Joseph Loscalzo
Pubblicato in: The FASEB Journal, Numero 37, 2025, ISSN 0892-6638
Editore: Wiley
DOI: 10.1096/FJ.202201683R

Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke

Autori: Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H.
Pubblicato in: Journal of the American Heart Association, Numero 14, 2025, ISSN 2047-9980
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/JAHA.124.039098

Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis

Autori: Farzaneh Firoozbakht, Maria Louise Elkjaer, Diane E. Handy, Rui-Sheng Wang, Zoe Chervontseva, Matthias Rarey, Joseph Loscalzo, Jan Baumbach, Olga Tsoy
Pubblicato in: Cell Reports Methods, Numero 5, 2025, ISSN 2667-2375
Editore: Elsevier BV
DOI: 10.1016/J.CRMETH.2025.100990

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

Autori: Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List
Pubblicato in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.17395

A Regulatory Roadmap for Repurposing: Comparing Pathways for Making Repurposed Drugs Available In The EU, UK, And US

Autori: Mirre Scholte, Liam Bendicksen, Sabine E. Grimm, Teebah Abu-Zahra, Bianca Pauly, Manuela Joore, Aaron S. Kesselheim
Pubblicato in: Journal of Law, Medicine & Ethics, Numero 52, 2025, ISSN 1073-1105
Editore: Cambridge University Press (CUP)
DOI: 10.1017/JME.2024.171

Digital twins as global learning health and disease models for preventive and personalized medicine

Autori: Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson
Pubblicato in: Genome Medicine, Numero 17, 2025, ISSN 1756-994X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01435-7

A system perspective on drug response

Autori: Vlad Elgart, Joseph Loscalzo
Pubblicato in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.70128

Trends in Fills, Spending, and Prices of Doxepin for Insomnia

Autori: Christopher L. Cai, Aaron S. Kesselheim, Benjamin N. Rome
Pubblicato in: JAMA, Numero 333, 2025, ISSN 0098-7484
Editore: American Medical Association (AMA)
DOI: 10.1001/JAMA.2024.27526

Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease

Autori: Daniel Sedding, Tim M. Schmidt, Heike Bähre, Udo Bavendiek, Ana I. Casas, Suzi Chen, Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Frank Gutzki, Andreas Hahn, Pamela Kleikers, Thomas Krahn, Cecilia Macchiusi
Pubblicato in: JACC: Advances, Numero 4, 2025, ISSN 2772-963X
Editore: Elsevier BV
DOI: 10.1016/J.JACADV.2025.101590

Thromboinflammatory challenges in stroke pathophysiology

Autori: R.D Szepanowski, S Haupeltshofer, S.E Vonhof, B Frank, C Kleinschnitz, A.I Casas
Pubblicato in: Seminars in Immunopathology, Numero 45, 2023, ISSN 1863-2297
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00281-023-00994-4

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool

Autori: Teebah Abu-Zahra, Sabine E. Grimm, Mirre Scholte, Manuela Joore
Pubblicato in: PharmacoEconomics, Numero 43, 2025, ISSN 1170-7690
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S40273-025-01515-X

A platform for the biomedical application of large language models

Autori: Sebastian Lobentanzer, Shaohong Feng, Noah Bruderer, Andreas Maier, null null, Adrián G. Díaz, Amy Strange, Anis Ismail, Anton Kulaga, Aurelien Dugourd, Barbara Zdrazil, Bastien Chassagnol, Cyril Po
Pubblicato in: Nature Biotechnology, Numero 43, 2025, ISSN 1087-0156
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41587-024-02534-3

Revising EU pharmaceutical legislation: will it foster drug repurposing?

Autori: Mirre Scholte, Sabine E. Grimm, Bianca Pauly, Frank Verbeeck, Anna M.G. Pasmooij, Barend Bouma, Jorika van Duijn-Wiersma, Emre Guney, Aaron S. Kesselheim, Harald H.H.W. Schmidt, Manuela A. Joore
Pubblicato in: Drug Discovery Today, Numero 30, 2025, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104286

Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer

Autori: Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger, Romana Netea-Maier, Susanne I. Wudy, Christina Ludwig, Markus List, Benedikt Kirchner, Marlene Reithmair, Mi
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-18319-W

Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment

Autori: Alexander G. Grønning, Sebastian E. Vonhof, Mahmoud Elbatreek, Anna Hamker, Rebecca D. Szepanowski, Svenja C. Erkelenz, Friederike Langhauser, Javier Egea, Manuela G. Lopez, Jan Baumbach, Christoph K
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 183, 2025, ISSN 0753-3322
Editore: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117829

Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing

Autori: Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R Pico, Rudolf T Pillich, Julian M Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva, Jan Baumbach
Pubblicato in: Nucleic Acids Research, Numero 52, 2024, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE388

DRaCOon: a novel algorithm for pathway-level differential co-expression analysis in transcriptomics

Autori: Fernando M. Delgado-Chaves, Ferdinand Spurny, Tanja Laske, Mhaned Oubounyt, Jan Baumbach
Pubblicato in: BMC Bioinformatics, Numero 26, 2025, ISSN 1471-2105
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12859-025-06162-9

scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases

Autori: Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Pubblicato in: Genome Medicine, Numero 16, 2024, ISSN 1756-994X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13073-024-01314-7

Other (1)

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool

Autori: Teebah Abu-Zahra; Sabine Grimm; Mirre Scholte; Manuela Joore
Pubblicato in: PharmacoEconomics, 2025
DOI: 10.58647/DRUGARXIV.PR000029.V1

Conference proceedings (1)

HTA181 How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework

Autori: T. Abu-Zahra, S. Grimm, M. Scholte, M. Joore
Pubblicato in: Value in Health, Numero 26, 2025, ISSN 1098-3015
Editore: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104008