Precision drug REPurpOsing For EUrope and the world

Informazioni relative al progetto

REPO4EU

ID dell’accordo di sovvenzione: 101057619

DOI

10.3030/101057619

Data della firma CE 24 Maggio 2022

Data di avvio 1 Settembre 2022

Data di completamento 31 Agosto 2029

Finanziato da

• Health

Costo totale

€ 22 982 612,00

Contributo UE

€ 22 982 612,00

Coordinato da

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (12)

REPO4EU Open Science Strategy
Initial whitepaper on a virtual EU biobank platform for patient recruitment pilots
Phase I II biometrics compendium
REPO4EU Impact Master Plan Document detailing the project s official dissemination and communication plans and the outline of target groups and their segments for community building purposes

REPO4EU Impact Master Plan – Document detailing the project’s official dissemination and communication plans, and the outline of target groups and their segments for community building purposes.

Phase II online compendium
Generic guideline for conducting an extended FtO analysis and FtO analyses for all intended clinical trials
An inventory of internal and external initial external stakeholder survey to collect needs in drug repurposing, and their objectives and expectations regarding FtO, IP and BD
Initial whitepaper on rational and first selection of animal models for drug repurposing
Initial whitepaper on rational for a wet-lab technology platform for patient recruitment
Initial whitepaper on rational for an AI technology platform for patient recruitment
Whitepaper on the platform knowledge base and data standards for in silico drug repurposing

Whitepaper on the platform knowledge base & data standards for in silico drug repurposing

Initial whitepaper on rational and first selection of cell models for drug repurposing

Other (1)

Publishing portal launch

Pubblicazioni

Peer reviewed articles (24)

A system perspective on drug response

Autori: Vlad Elgart, Joseph Loscalzo
Pubblicato in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.70128

Artificial Intelligence and Network Medicine: Path to Precision Medicine

Autori: Lucia Altucci, Lina Badimon, Jean-Luc Balligand, Jan Baumbach, Alberico L. Catapano, Feixong Cheng, Dawn DeMeo, Rajat Gupta, Marcus Hacker, Yang-Yu Liu, Joseph Loscalzo, Sabrina Maniscalco, Jörg Menche, Giulia Menichetti, Paolo Parini, Harald H. H. W. Schmidt, Marinka Zitnik
Pubblicato in: NEJM AI, Numero 2, 2025, ISSN 2836-9386
Editore: Massachusetts Medical Society
DOI: 10.1056/AIRA2401229

Seminars in Immunopathology

Autori: Szepanowski RD, Haupeltshofer S, Vonhof SE, Frank B, Kleinschnitz C, Casas AI
Pubblicato in: Seminars in Immunopathology, Numero 45, 2023, ISSN 1863-2297
Editore: Springer
DOI: 10.1007/s00281-023-00994-4

Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing

Autori: Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D Bader, Sylvie Baier, David B Blumenthal, Jing Chen, Maria L Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R Pico, Rudolf T Pillich, Julian M Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva, Jan Baumbach
Pubblicato in: Nucleic Acids Research, Numero 52, 2024, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE388

De Novo exposomic geospatial assembly of chronic disease regions with machine learning & network analysis

Autori: Andrew Deonarine, Ayushi Batwara, Roy Wada, Puneet Sharma, Joseph Loscalzo, Bisola Ojikutu, Kathryn Hall
Pubblicato in: eBioMedicine, Numero 112, 2025, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/J.EBIOM.2025.105575

BMC Bioinformatics

Autori: Fernando M. Delgado-Chaves; Ferdinand Spurny; Tanja Laske; Mhaned Oubounyt; Jan Baumbach
Pubblicato in: BMC Bioinformatics, 2025, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/S12859-025-06162-9

Journal of Alzheimer's Disease

Autori: Mayra Pacheco Pachado, Ana I Casas, Mahmoud H Elbatreek, Cristian Nogales, Emre Guney, Alberto J Espay, Harald H H W Schmidt
Pubblicato in: Journal of Alzheimer’s Disease, Numero 96, 2023, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/JAD-230694

Trends in use, spending, and prices of doxepin for insomnia

Autori: Christopher Cai; Aaron Kesselheim; Benjamin Rome
Pubblicato in: JAMA, 2025, ISSN 1538-3598
Editore: American Medical Association
DOI: 10.58647/DRUGARXIV.PR000023.V1

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

Autori: Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List
Pubblicato in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.17395

Exploring common mechanisms of adverse drug reactions and disease phenotypes through network-based analysis

Autori: Farzaneh Firoozbakht; Maria Louise Elkjaer; Diane E. Handy; Rui-Sheng Wang; Zoe Chervontseva; Matthias Rarey; Joseph Loscalzo; Jan Baumbach; Olga Tsoy
Pubblicato in: Cell Reports Methods, 2025, ISSN 2667-2375
Editore: Cell Rep. Methods
DOI: 10.1016/J.CRMETH.2025.100990

Digital twins as global learning health and disease models for preventive and personalized medicine

Autori: Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson
Pubblicato in: Genome Medicine, Numero 17, 2025, ISSN 1756-994X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01435-7

Molecular interaction networks and drug development: novel approach to drug target identification and drug repositioning

Autori: Loscalzo J
Pubblicato in: FASEB J, Numero 37, 2023, ISSN 1530-6860
Editore: Wiley
DOI: 10.1096/fj.202201683R

Transforming literature screening: The emerging role of large language models in systematic reviews

Autori: Fernando M. Delgado-Chaves, Matthew J. Jennings, Antonio Atalaia, Justus Wolff, Rita Horvath, Zeinab M. Mamdouh, Jan Baumbach, Linda Baumbach
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2411962122

Can We Make Health Economic Decision Models as Simple as Possible, But Not Simpler? Introducing SMART tool

Autori: Teebah Abu-Zahra; Sabine Grimm; Mirre Scholte; Manuela Joore
Pubblicato in: PharmacoEconomics, 2025, ISSN 1179-2027
Editore: Springer
DOI: 10.58647/DRUGARXIV.PR000029.V1

Multiomics network medicine approaches to precision medicine....

Autori: Wang RS, Maron BA, Loscalzo J
Pubblicato in: Arterioscler Thromb Vasc Biol, Numero 43, 2023, ISSN 1079-5642
Editore: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318731

Nature Biotechnology

Autori: Lobentanzer, Sebastian; Feng, Shaohong; Bruderer, Noah; Maier, Andreas; Díaz, Adrián G.; Strange, Amy; Ismail, Anis; Kulaga, Anton; Dugourd, Aurelien; Zdrazil, Barbara; Chassagnol, Bastien; Pommier, Cyril; Lucarelli, Daniele; McDonagh, Ellen M.; Verkinderen, Emma; Delgado-Chaves, Fernando M.; Fuellen, Georg; Sonntag, Hannah; Menger, Jonatan; Christiaen, Lionel; Geistlinger, Ludwig; Zetsche, Luna Zacharias; Engelke, Marlis; McNutt, Megan; Harrison, Melissa; Hizli, Melissa; Usanov, Nikolai; Baracho, Patrick; Beier, Sebastian; Boeing, Stefan; Muranen, Taru A.; Le, Trang T.; Dragan, Valeriia; Zhou, Xiao-Ran; Nielsen-Tehranchian, Yasmin; Song, Yuyao; Wang, Cankun; Baumbach, Jan; Abreu-Vicente, Jorge; Krehl, Nils; Ma, Qin; Lemberger, Thomas; Saez-Rodriguez, Julio
Pubblicato in: Nature Biotechnology, 2025, ISSN 1087-0156
Editore: Nat. Biotechnol.
DOI: 10.34734/FZJ-2025-01790

Unveiling the interplay between soluble guanylate cyclase activation and redox signalling in stroke pathophysiology and treatment

Autori: Alexander G. Grønning, Sebastian E. Vonhof, Mahmoud Elbatreek, Anna Hamker, Rebecca D. Szepanowski, Svenja C. Erkelenz, Friederike Langhauser, Javier Egea, Manuela G. Lopez, Jan Baumbach, Christoph Kleinschnitz, Ana I. Casas
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 183, 2025, ISSN 0753-3322
Editore: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.117829

scDrugPrio: a framework for analysis of single-cell transcriptomics....

Autori: Schaefer S, Smelik M, Sysoev O, Zhao Y, Eklund D, et al.
Pubblicato in: Genome Med, Numero 16, 2024, ISSN 1756-994X
Editore: (London) BioMed Central
DOI: 10.1101/2023.11.08.566249

Network‐based precision medicine and systems pharmacology

Autori: Arvind K. Pandey, Susan Dina Ghiassian, Joseph Loscalzo
Pubblicato in: British Journal of Pharmacology, 2025, ISSN 0007-1188
Editore: Wiley
DOI: 10.1111/BPH.70184

Revising EU pharmaceutical legislation: will it foster drug repurposing?

Autori: Mirre Scholte, Sabine E. Grimm, Bianca Pauly, Frank Verbeeck, Anna M.G. Pasmooij, Barend Bouma, Jorika van Duijn-Wiersma, Emre Guney, Aaron S. Kesselheim, Harald H.H.W. Schmidt, Manuela A. Joore
Pubblicato in: Drug Discovery Today, Numero 30, 2025, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104286

Repurposing drugs for the treatment of COVID-19....

Autori: Wang RS, Loscalzo J
Pubblicato in: Circ Res, Numero 132, 2023, ISSN 0009-7330
Editore: Lippincott, Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.122.321879

Phenomics and robust multiomics data for cardiovascular disease subtyping

Autori: Maiorino E, Loscalzo J
Pubblicato in: Arterioscler Thromb Vasc Biol, Numero 43, 2023, ISSN 1079-5642
Editore: Lippincott, Williams & Wilkins
DOI: 10.1161/ATVBAHA.122.318892

Drug Discovery Today

Autori: Teebah Abu-Zahra; Sabine E. Grimm; Mirre Scholte; Adam J.N. Raymakers; Aaron S. Kesselheim; Manuela Joore
Pubblicato in: Drug Discovery Today, 2024, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/J.DRUDIS.2024.104008

Machine learning-based integration of network features and chemical structures of compounds....

Autori: Spaeth J, Wang RS, Humphrey M, Baumbach J, Loscalzo J
Pubblicato in: CPT Pharmacometrics Syst Pharmacol, Numero 13, 2024, ISSN 2163-8306
Editore: Wiley
DOI: 10.1002/psp4.13076

Conference proceedings (3)

HTA181 How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework

Autori: Abu-Zahra, T.; Grimm, S.; Scholte, M.; Joore, M.
Pubblicato in: Value in Health, 2023
Editore: Elsevier
DOI: 10.1016/J.JVAL.2023.09.1865

How Can Health Technology Assessment Help in Addressing Drug Repurposing Challenges? A Conceptual Framework

Autori: T. Abu-Zahra, S. Grimm, M. Scholte, M. Joore
Pubblicato in: Value in Health, 2023
Editore: ElSevier
DOI: 10.1016/j.jval.2023.09.1865

NeDRex-Web: An Interactive Web Tool for Drug Repurposing by Exploring Heterogeneous Molecular Networks

Autori: Andreas Maier, Mahdie Rafiei, Elisa Anastasi, Olga Zolotareva, James Skelton, Maria L. Elkjaer, Ana I. Casas, Cristian Nogales, Harald H. H. W. Schmidt, Tim Kacprowski, David B. Blumenthal, Anil Wipat, Sepideh Sadegh, Jan Baumbach
Pubblicato in: 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2025
Editore: IEEE
DOI: 10.1109/BIBM62325.2024.10822390

Other (1)

A regulatory roadmap for repurposing: comparing pathways for making repurposed drugs available in the EU, UK, and US

Autori: Mirre Scholte; Liam Bendicksen; Sabine E. Grimm; Teebah Abu-Zahra; Bianca Pauly; Manuela Joore; Aaron S. Kesselheim
Pubblicato in: Journal of Law, Medicine & Ethics, 2024
Editore: Cambridge University Press
DOI: 10.1017/JME.2024.171

Thesis and dissertations (1)

CAUSAL DISCOVERY : FINDING COMMON LATENT CAUSES

Autori: Xanthopoulou-Koukogia, K.
Pubblicato in: 2023
Editore: University Twente