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International Clinical Validation of Radiomics Artificial Intelligence for Breast Cancer Treatment Planning

Objective

Breast cancer is now the most common cancer worldwide, surpassing lung cancer in 2020 for the first time. It is responsible for almost 30% of all cancers in women and current trends show its increasing incidence. Neoadjuvant chemotherapy (NAC) has shown promise in reducing mortality for advanced cases, but the therapy is associated with a high rate of over-treatment, as well as with significant side effects for the patients. For predicting NAC respondents and improving patient selection, artificial intelligence (AI) approaches based on radiomics have shown promising preclinical evidence, but existing studies have mostly focused on evaluating model accuracy, all-too-often in homogeneous populations.

RadioVal is the first multi-centre, multi-continental and multi-faceted clinical validation of radiomics-driven estimation of NAC response in breast cancer. The project builds on the repositories, tools and results of five EU-funded projects from the AI for Health Imaging (AI4HI) Network, including a large multi-centre cancer imaging dataset on NAC treatment in breast cancer. To test applicability as well as transferability, the validation with take place in eight clinical centres from three high-income EU countries (Sweden, Austria, Spain), two emerging EU countries (Poland, Croatia), and three countries from South America (Argentina), North Africa (Egypt) and Eurasia (Turkey).

RadioVal will develop a comprehensive and standardised methodological framework for multi-faceted radiomics evaluation based on the FUTURE-AI Guidelines, to assess Fairness, Universality, Traceability, Usability, Robustness and Explainability. Furthermore, the project will introduce new tools to enable transparent and continuous evaluation and monitoring of the radiomics tools over time. The RadioVal study will be implemented through a multi-stakeholder approach, taking into account clinical and healthcare needs, as well as socio-ethical and regulatory requirements from day one.

Coordinator

UNIVERSITAT DE BARCELONA
Net EU contribution
€ 801 250,00
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (15)

UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 408 125,00
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
QUIBIM SOCIEDAD LIMITADA
Spain
Net EU contribution
€ 412 500,00
Address
Avenida De Aragon 30 Planta 13 Letra I
46021 Valencia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Comunitat Valenciana Valencia/València
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
Net EU contribution
€ 501 250,00
Address
N Plastira Str 100
70013 Irakleio

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Region
Ηράκλειο Κρήτη Νησιά Αιγαίου
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MAGGIOLI SPA
Italy
Net EU contribution
€ 475 000,00
Address
Via Del Carpino 8
47822 Santarcangelo Di Romagna

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Region
Nord-Est Emilia-Romagna Rimini
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SHINE 2EUROPE LDA
Portugal
Net EU contribution
€ 308 750,00
Address
Rua Camara Pestana Lote 3 1df
3030-163 Coimbra

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Centro (PT) Região de Coimbra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NHG FINLAND OY
Finland
Net EU contribution
€ 405 875,00
Address
Vattuniemenranta 2
00210 Helsinki

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
Net EU contribution
€ 502 750,00
Address
Av Fernando Abril Martorell 106
46026 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 399 985,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
GDANSKI UNIWERSYTET MEDYCZNY
Poland
Net EU contribution
€ 318 750,00
Address
Ulica M Sklodowskiej Curie 3a
80210 Gdansk

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Region
Makroregion północny Pomorskie Trójmiejski
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET
Croatia
Net EU contribution
€ 250 000,00
Address
Salata 3
10 000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 250 000,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HACETTEPE UNIVERSITESI
Turkey
Net EU contribution
€ 202 500,00
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara

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Region
Batı Anadolu Ankara Ankara
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ALEXANDER FLEMING SA
Argentina
Net EU contribution
€ 184 466,00
Address
Carmer 1180
C1426NZ Buenos Aires

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AIN SHAMS UNIVERSITY
Egypt
Net EU contribution
€ 145 500,00
Address
Ramsses Street
11566 Abassyia Cairo

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria
Net EU contribution
€ 271 875,00
Non-EU contribution
€ 0,00