Project description DEENESFRITPL International study to validate AI for the prediction of treatment response in breast cancer Radiomics is a quantitative approach to medical imaging that extracts information not accessible through traditional visual inspection of generated images, particularly in oncology. The aim of the EU-funded RadioVal project is to evaluate the potential of radiomics to predict response to neoadjuvant chemotherapy in breast cancer patients, using AI. The project will leverage large imaging repositories and results generated by previous EU-funded projects. Furthermore, RadioVal will implement a multi-faceted evaluation of radiomics AI tools in eight hospitals across Europe and beyond, to test their technical robustness, algorithmic fairness, as well as usability and acceptance in clinical setting. The results are expected to increased trust in AI-driven clinical decision-making, and reduce over-treatment and improve clinical outcome for breast cancer patients. Show the project objective Hide the project objective Objective Breast cancer is now the most common cancer worldwide, surpassing lung cancer in 2020 for the first time. It is responsible for almost 30% of all cancers in women and current trends show its increasing incidence. Neoadjuvant chemotherapy (NAC) has shown promise in reducing mortality for advanced cases, but the therapy is associated with a high rate of over-treatment, as well as with significant side effects for the patients. For predicting NAC respondents and improving patient selection, artificial intelligence (AI) approaches based on radiomics have shown promising preclinical evidence, but existing studies have mostly focused on evaluating model accuracy, all-too-often in homogeneous populations.RadioVal is the first multi-centre, multi-continental and multi-faceted clinical validation of radiomics-driven estimation of NAC response in breast cancer. The project builds on the repositories, tools and results of five EU-funded projects from the AI for Health Imaging (AI4HI) Network, including a large multi-centre cancer imaging dataset on NAC treatment in breast cancer. To test applicability as well as transferability, the validation with take place in eight clinical centres from three high-income EU countries (Sweden, Austria, Spain), two emerging EU countries (Poland, Croatia), and three countries from South America (Argentina), North Africa (Egypt) and Eurasia (Turkey). RadioVal will develop a comprehensive and standardised methodological framework for multi-faceted radiomics evaluation based on the FUTURE-AI Guidelines, to assess Fairness, Universality, Traceability, Usability, Robustness and Explainability. Furthermore, the project will introduce new tools to enable transparent and continuous evaluation and monitoring of the radiomics tools over time. The RadioVal study will be implemented through a multi-stakeholder approach, taking into account clinical and healthcare needs, as well as socio-ethical and regulatory requirements from day one. Fields of science natural sciencescomputer and information sciencesartificial intelligencemedical and health sciencesclinical medicineoncologylung cancermedical and health sciencesclinical medicineoncologybreast cancerengineering and technologymedical engineeringdiagnostic imaging Keywords Breast cancer treatment planning radiomics artificial intelligence clinical validation trustworthiness Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine Topic(s) HORIZON-HLTH-2021-DISEASE-04-04 - Clinical validation of artificial intelligence (AI) solutions for treatment and care Call for proposal HORIZON-HLTH-2021-DISEASE-04 See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator UNIVERSITAT DE BARCELONA Net EU contribution € 801 250,00 Address Gran via de les corts catalanes 585 08007 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (15) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT MAASTRICHT Netherlands Net EU contribution € 408 125,00 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 QUIBIM SOCIEDAD LIMITADA Spain Net EU contribution € 412 500,00 Address Avenida de aragon 30 planta 13 letra i 46021 Valencia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IDRYMA TECHNOLOGIAS KAI EREVNAS Greece Net EU contribution € 501 250,00 Address N plastira str 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MAGGIOLI SPA Italy Net EU contribution € 475 000,00 Address Via del carpino 8 47822 Santarcangelo di romagna See on map Region Nord-Est Emilia-Romagna Rimini Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SHINE 2EUROPE LDA Portugal Net EU contribution € 308 750,00 Address Rua camara pestana lote 3 1df 3030-163 Coimbra See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Centro (PT) Região de Coimbra Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NHG FINLAND OY Finland Net EU contribution € 405 875,00 Address Vattuniemenranta 2 00210 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA Spain Net EU contribution € 502 750,00 Address Av fernando abril martorell 106 46026 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 399 985,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GDANSKI UNIWERSYTET MEDYCZNY Poland Net EU contribution € 318 750,00 Address Ulica m sklodowskiej curie 3a 80210 Gdansk See on map Region Makroregion północny Pomorskie Trójmiejski Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET Croatia Net EU contribution € 250 000,00 Address Salata 3 10 000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 250 000,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HACETTEPE UNIVERSITESI Türkiye Net EU contribution € 202 500,00 Address Hacettepe universitesi beytepe kampusu rektorluk binasi 06800 Cankaya ankara See on map Region Batı Anadolu Ankara Ankara Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ALEXANDER FLEMING SA Argentina Net EU contribution € 184 466,00 Address Carmer 1180 C1426NZ Buenos aires See on map Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AIN SHAMS UNIVERSITY Egypt Net EU contribution € 145 500,00 Address Ramsses street 11566 Abassyia cairo See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Austria Net EU contribution € 271 875,00 Address Am gestade 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00