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Chemometric histopathology via coherent Raman imaging for precision medicine

Objective

The CHARM project aims to radically transform the cancer diagnosing process and bring the emerging field of digital histopathology to the next level, introducing a novel technology for tissue analysis, capable to measure the molecular composition of the patient tissue samples and to recognize and classify the tumor in a completely label/stain-free way. The instrument, integrated with artificial intelligence (AI), will offer to histopathologists a reliable, fast and low-cost Clinical Decision Support System (CDSS) for cancer diagnosis and personalized cancer therapy. We will develop a Class C, (IVDR, In-Vitro Diagnostic Regulation) medical device consisting of a turnkey low-cost broadband Coherent Raman Scattering (CRS) microscope (enabled by our patented graphene-based fiber laser technology), named the Chemometric Pathology System (CPS), integrating an AI module based on deep learning, statistics and machine learning. The CPS will be capable of automatically analyzing unstained tissues, providing fast and accurate tumour identification (differentiating normal vs neoplastic tissues) with accuracy >98% and final tumour diagnosis prediction (differentiating and grading histologic subtypes) with accuracy >90%, thus offering to the histopathologist a decision tree compatible with existing clinical protocols but with biomolecular-based objectivity and reduced time to result (TRL6). We will develop a robust business case for the application and ensure the project continuation to higher TRLs and the final market entrance. This proposal builds on the results of the ERC POC project GSYNCOR.

Coordinator

CAMBRIDGE RAMAN IMAGING SRL
Net EU contribution
€ 1 242 383,00
Address
Via Quattro Novembre 24
37126 Verona
Italy

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Region
Nord-Est Veneto Verona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Participants (5)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

IN SRL IMPRESA SOCIALE
Italy
Net EU contribution
€ 191 250,00
Address
Via Carducci 9a
33100 Udine

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Other
Non-EU contribution
€ 0,00
POLITECNICO DI MILANO
Italy
Net EU contribution
€ 385 000,00
Address
Piazza Leonardo Da Vinci 32
20133 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 85 000,00
Address
Piazzale Aldo Moro 7
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITATSKLINIKUM JENA
Germany
Net EU contribution
€ 507 986,00
Address
Kastanienstr.1
07747 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25
TECNOLOGIAS AVANZADAS INSPIRALIA SL
Spain
Net EU contribution
€ 30 360,00
Address
Calle Manuel Tovar 49
28034 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 0,00
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution