Chemometric histopathology via coherent Raman imaging for precision medicine

Project Information

CHARM

Grant agreement ID: 101058004

DOI

10.3030/101058004

EC signature date 22 March 2022

Start date 1 May 2022

End date 31 October 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 2 441 979,25

EU contribution

€ 2 441 979,00

Coordinated by

CAMBRIDGE RAMAN IMAGING SRL
Italy

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Deliverables

Documents, reports (1)

Press and Media visibility (M6)

Report on communication activities to boost project visibility on national and international press and media

Websites, patent fillings, videos etc. (1)

Website and project logo

Project website active

Publications

Peer reviewed articles (14)

Control of Raman Scattering Quantum Interference Pathways in Graphene

Author(s): Xue Chen, Sven Reichardt, Miao-Ling Lin, Yu-Chen Leng, Yan Lu, Heng Wu, Rui Mei, Ludger Wirtz, Xin Zhang, Andrea C. Ferrari, Ping-Heng Tan
Published in: ACS Nano, Issue 17(6):5956-5962, 2023, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c00180

Compact terahertz harmonic generation in the Reststrahlenband using a graphene-embedded metallic split ring resonator array

Author(s): Di Gaspare A, Song C, Schiattarella C, Li LH, Salih M, Giles Davies A, Linfield EH, Zhang J, Balci O, Ferrari AC, Dhillon S
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.1038/s41467-024-45267-2

Terahertz near-field microscopy of metallic circular split ring resonators with graphene in the gap

Author(s): Schiattarella C, Di Gaspare A, Viti L, Justo Guerrero MA, Li LH, Salih M, Davies AG, Linfield EH, Zhang J, Ramezani H, Ferrari AC
Published in: Scientific Reports, Issue 14(1):16227, 2024, ISSN 2045-2322
Publisher: Nature Portfolio
DOI: 10.1038/s41598-024-62787-5

Estimation of biological variance in coherent Raman microscopy data of two cell lines using chemometrics

Author(s): Junjuri R, Calvarese M, Vafaeinezhad M, Vernuccio F, Ventura M, Meyer-Zedler T, Gavazzoni B, Polli D, Vanna R, Bongarzone I, Ghislanzoni S
Published in: Analyst, Issue 149:4395–4406, 2024, ISSN 1364-5528
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4an00648h

Controlled Growth of Single‐Crystal Graphene Wafers on Twin‐Boundary‐Free Cu (111) Substrates

Author(s): Zhu Y, Zhang J, Cheng T, Tang J, Duan H, Hu Z, Shao J, Wang S, Wei M, Wu H, Li A
Published in: Advanced Materials, Issue 36(17):2308802, 2024, ISSN 1521-4095
Publisher: Wiley-VCH
DOI: 10.1002/adma.202308802

A novel interpretable machine learning algorithm to identify optimal parameter space for cancer growth

Author(s): Helena Coggan; Helena Andres Terre; Pietro Liò
Published in: Frontiers in Big Data, Issue 5, 2022, ISSN 2624-909X
Publisher: Frontiers Media
DOI: 10.3389/fdata.2022.941451

SESAM mode-locked Nd:fiber laser at 920 nm for nonlinear optical microscopy

Author(s): Fedele Pisani, Gabriele Di Noia, Francesco Crisafi, Matteo Negro, Giulio Cerullo, Gianluca Galzerano
Published in: Optics Express, Issue 33, 2025, ISSN 1094-4087
Publisher: Optica Publishing Group
DOI: 10.1364/OE.557820

Short pulse generation from a graphene-coupled passively mode-locked terahertz laser

Author(s): Riccardi E, Pistore V, Kang S, Seitner L, De Vetter A, Jirauschek C, Mangeney J, Li L, Davies AG, Linfield EH, Ferrari AC
Published in: Nature Photonics, Issue (7):607-14, 2023, ISSN 1749-4893
Publisher: Nature Publishing Group
DOI: 10.1038/s41566-023-01195-z

Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation

Author(s): Lai, Chenting; Calvarese, Matteo; Reichwald, Karl; Bae, Hyeonsoo; Vafaeinezhad, Mohammadsadegh; Meyer-Zedler, Tobias; Hoffmann, Franziska; Mühlig, Anna; Eidam, Tino; Stutzki, Fabian; Messerschmidt, Bernhard; Gross, Herbert; Schmitt, Michael; Guntinas-Lichius, Orlando; Popp, Jürgen
Published in: Journal of Biomedical Optics, Issue 28,6: 066004, 2023, ISSN 1083-3668
Publisher: Journal of Biomedical Optics
DOI: 10.1117/1.JBO.28.6.066004

Phononics of graphene, layered materials, and heterostructures

Author(s): Ferrari AC, Balandin AA. Phononics of graphene, layered materials, and heterostructures
Published in: Applied Physics Letters, Issue 122(7), 2023, ISSN 1077-3118
Publisher: American Institute of Physics
DOI: 10.1063/5.0144480

Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography

Author(s): Arianna Bresci; Koseki J. Kobayashi-Kirschvink; Giulio Cerullo; Renzo Vanna; Peter T. C. So; Dario Polli; Jeon Woong Kang
Published in: Communications Biology, Issue 7(1):785, 2024, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-024-06496-9

Self‐Induced Mode‐Locking in Electrically Pumped Far‐Infrared Random Lasers

Author(s): Di Gaspare A, Pistore V, Riccardi E, Pogna EA, Beere HE, Ritchie DA, Li L, Davies AG, Linfield EH, Ferrari AC, Vitiello MS
Published in: Advanced Science, Issue 10(9):2206824, 2023, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202206824

Intraoperative Assessment of Tumor Margins in Tissue Sections with Hyperspectral Imaging and Machine Learning

Author(s): David Pertzborn; Hoang-Ngan Nguyen; Katharina Hüttmann; Jonas Prengel; Günther Ernst; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Franziska Hoffmann
Published in: Cancers, Issue 15(1), 213, 2022, ISSN 2072-6694
Publisher: MDPI
DOI: 10.3390/cancers15010213

High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach

Author(s): Renzo Vanna, Andrea Masella, Manuela Bazzarelli, Paola Ronchi, Aufried Lenferink, Cristina Tresoldi, Carlo Morasso, Marzia Bedoni, Giulio Cerullo, Dario Polli, Fabio Ciceri, Giulia De Poli, Matteo Bregonzio, and Cees Otto
Published in: Analytical Chemistry, Issue 96(23):9468-9477, 2024, ISSN 1520-6882
Publisher: ACS Publications (United States)
DOI: 10.1021/acs.analchem.4c00787

Book chapters (1)

Raman spectroscopy of graphene and related materials

Author(s): Anna K. Ott, Andrea C. Ferrari
Published in: Encyclopedia of Condensed Matter Physics (Second Edition), Issue 2:233–247, 2024, ISBN 978-0-323-91408-6
Publisher: Academic Press
DOI: 10.1016/B978-0-323-90800-9.00252-3

Other (1)

Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation

Author(s): Lai, Chenting; Calvarese, Matteo; Reichwald, Karl; Bae, Hyeonsoo; Vafaeinezhad, Mohammadsadegh; Meyer-Zedler, Tobias; Hoffmann, Franziska; Mühlig, Anna; Eidam, Tino; Stutzki, Fabian; Messerschmidt, Bernhard; Gross, Herbert; Schmitt, Michael; Guntinas-Lichius, Orlando; Popp, Jürgen
Published in: Journal of Biomedical Optics, 2023, ISSN 1560-2281
Publisher: SPIE
DOI: 10.1117/1.JBO.28.6.066004

Conference proceedings (2)

A compact, turn-key platform for multiplex stimulated Raman scattering microscopy

Author(s): Francesco Crisafi, Benedetta Talone, Andrea Ragni, Gabriele Di Noia, Mujeeb Rahman, Jing He, Jeremiah Marcellino, Goutam Kar, Yarjan Samad, Boyang Mao, Renzo Vanna, Franziska Hoffmann, Orlando Guntinas-Lichius, Sze Y. Set, Andrea C. Ferrari, Giulio Cerullo, Matteo Negro
Published in: Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, 2024
Publisher: SPIE
DOI: 10.1117/12.3002592

Plug-and-play stimulated Raman microscopy system for broadband coherent vibrational imaging

Author(s): Crisafi F, Talone B, Ragni A, Di Noia G, Rahman M, He J, Marcellino J, Kar G, Samad Y, Mao B, Vanna R
Published in: he European Conference on Lasers and Electro-Optics, 2024, ISBN 979-8-3503-4599-5
Publisher: Optica Publishing Group

Intellectual Property Rights

Patent (1)

AN OPTICAL CIRCUIT ARRANGEMENT

Application/Publication number: 20 23052061
Date: 2023-08-03
Applicant(s): CAMBRIDGE RAMAN IMAGING SRL