Chemometric histopathology via coherent Raman imaging for precision medicine

Informazioni relative al progetto

CHARM

ID dell’accordo di sovvenzione: 101058004

DOI

10.3030/101058004

Progetto chiuso

Data della firma CE 22 Marzo 2022

Data di avvio 1 Maggio 2022

Data di completamento 31 Ottobre 2025

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 2 441 980,00

Contributo UE

€ 2 441 979,00

Coordinato da

CAMBRIDGE RAMAN IMAGING SRL
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Press and Media visibility (M6)

Report on communication activities to boost project visibility on national and international press and media

Websites, patent fillings, videos etc. (1)

Website and project logo

Project website active

Pubblicazioni

Peer reviewed articles (18)

Control of Raman Scattering Quantum Interference Pathways in Graphene

Autori: Xue Chen, Sven Reichardt, Miao-Ling Lin, Yu-Chen Leng, Yan Lu, Heng Wu, Rui Mei, Ludger Wirtz, Xin Zhang, Andrea C. Ferrari, Ping-Heng Tan
Pubblicato in: ACS Nano, Numero 17(6):5956-5962, 2023, ISSN 1936-086X
Editore: American Chemical Society
DOI: 10.1021/acsnano.3c00180

Compact terahertz harmonic generation in the Reststrahlenband using a graphene-embedded metallic split ring resonator array

Autori: Di Gaspare A, Song C, Schiattarella C, Li LH, Salih M, Giles Davies A, Linfield EH, Zhang J, Balci O, Ferrari AC, Dhillon S
Pubblicato in: Nature Communications, 2024, ISSN 2041-1723
Editore: Nature Portfolio
DOI: 10.1038/s41467-024-45267-2

Artificial Intelligence-Powered Raman Spectroscopy through Open Science and FAIR Principles

Autori: Nicolas Coca-Lopez, Victor Alcolea-Rodriguez, Miguel A. Bañares, Sandor Brockhauser, Julien Gorenflot, Alex Henderson, Ron Hildebrandt, Nina Jeliazkova, Nikolay Kochev, Enrique Lozano Diz, Zdenek Pil
Pubblicato in: ACS Nano, Numero 19, 2025, ISSN 1936-0851
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.5C09165

Terahertz near-field microscopy of metallic circular split ring resonators with graphene in the gap

Autori: Schiattarella C, Di Gaspare A, Viti L, Justo Guerrero MA, Li LH, Salih M, Davies AG, Linfield EH, Zhang J, Ramezani H, Ferrari AC
Pubblicato in: Scientific Reports, Numero 14(1):16227, 2024, ISSN 2045-2322
Editore: Nature Portfolio
DOI: 10.1038/s41598-024-62787-5

Estimation of biological variance in coherent Raman microscopy data of two cell lines using chemometrics

Autori: Junjuri R, Calvarese M, Vafaeinezhad M, Vernuccio F, Ventura M, Meyer-Zedler T, Gavazzoni B, Polli D, Vanna R, Bongarzone I, Ghislanzoni S
Pubblicato in: Analyst, Numero 149:4395–4406, 2024, ISSN 1364-5528
Editore: Royal Society of Chemistry
DOI: 10.1039/d4an00648h

Controlled Growth of Single‐Crystal Graphene Wafers on Twin‐Boundary‐Free Cu (111) Substrates

Autori: Zhu Y, Zhang J, Cheng T, Tang J, Duan H, Hu Z, Shao J, Wang S, Wei M, Wu H, Li A
Pubblicato in: Advanced Materials, Numero 36(17):2308802, 2024, ISSN 1521-4095
Editore: Wiley-VCH
DOI: 10.1002/adma.202308802

A novel interpretable machine learning algorithm to identify optimal parameter space for cancer growth

Autori: Helena Coggan; Helena Andres Terre; Pietro Liò
Pubblicato in: Frontiers in Big Data, Numero 5, 2022, ISSN 2624-909X
Editore: Frontiers Media
DOI: 10.3389/fdata.2022.941451

Real-Time Intraoperative Decision-Making in Head and Neck Tumor Surgery: A Histopathologically Grounded Hyperspectral Imaging and Deep Learning Approach

Autori: Ayman Bali, Saskia Wolter, Daniela Pelzel, Ulrike Weyer, Tiago Azevedo, Pietro Lio, Mussab Kouka, Katharina Geißler, Thomas Bitter, Günther Ernst, Anna Xylander, Nadja Ziller, Anna Mühlig, Ferdinand von Eggeling, Orlando Guntinas-Lichius, David Pertzborn
Pubblicato in: Cancers, Numero 17, 2025, ISSN 2072-6694
Editore: MDPI AG
DOI: 10.3390/CANCERS17101617

Graphene Phase Modulators Operating in the Transparency Regime

Autori: Hannah F. Y. Watson, Alfonso Ruocco, Matteo Tiberi, Jakob E. Muench, Osman Balci, Sachin M. Shinde, Sandro Mignuzzi, Marianna Pantouvaki, Dries Van Thourhout, Roman Sordan, Andrea Tomadin, Vito Sorianello, Marco Romagnoli, Andrea C. Ferrari
Pubblicato in: ACS Nano, Numero 18, 2024, ISSN 1936-0851
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.4C02292

SESAM mode-locked Nd:fiber laser at 920 nm for nonlinear optical microscopy

Autori: Fedele Pisani, Gabriele Di Noia, Francesco Crisafi, Matteo Negro, Giulio Cerullo, Gianluca Galzerano
Pubblicato in: Optics Express, Numero 33, 2025, ISSN 1094-4087
Editore: Optica Publishing Group
DOI: 10.1364/OE.557820

Short pulse generation from a graphene-coupled passively mode-locked terahertz laser

Autori: Riccardi E, Pistore V, Kang S, Seitner L, De Vetter A, Jirauschek C, Mangeney J, Li L, Davies AG, Linfield EH, Ferrari AC
Pubblicato in: Nature Photonics, Numero (7):607-14, 2023, ISSN 1749-4893
Editore: Nature Publishing Group
DOI: 10.1038/s41566-023-01195-z

Establishment of a clinical workflow for in vivo Raman spectroscopy during head and neck cancer surgery

Autori: Ayman Bali, Thomas Bitter, Mussab Kouka, Jonas Ballmaier, Ines Latka, Florian Windirsch, David Pertzborn, Nadja Ziller, Marcela Mafra, Nikolaus Gaßler, Jürgen Popp, Anna Mühlig, Ferdinand von Eggeling, Orlando Guntinas-Lichius, Iwan W. Schie
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-08222-9

Phononics of graphene, layered materials, and heterostructures

Autori: Ferrari AC, Balandin AA. Phononics of graphene, layered materials, and heterostructures
Pubblicato in: Applied Physics Letters, Numero 122(7), 2023, ISSN 1077-3118
Editore: American Institute of Physics
DOI: 10.1063/5.0144480

Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation

Autori: Chenting Lai, Matteo Calvarese, Karl Reichwald, Hyeonsoo Bae, Mohammadsadegh Vafaeinezhad, Tobias Meyer-Zedler, Franziska Hoffmann, Anna Mühlig, Tino Eidam, Fabian Stutzki, Bernhard Messerschmidt, Herbert Gross, Michael Schmitt, Orlando Guntinas-Lichius, Jürgen Popp
Pubblicato in: Journal of Biomedical Optics, Numero 28, 2024, ISSN 1083-3668
Editore: SPIE-Intl Soc Optical Eng
DOI: 10.1117/1.JBO.28.6.066004

Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography

Autori: Arianna Bresci; Koseki J. Kobayashi-Kirschvink; Giulio Cerullo; Renzo Vanna; Peter T. C. So; Dario Polli; Jeon Woong Kang
Pubblicato in: Communications Biology, Numero 7(1):785, 2024, ISSN 2399-3642
Editore: Nature Portfolio
DOI: 10.1038/s42003-024-06496-9

Self‐Induced Mode‐Locking in Electrically Pumped Far‐Infrared Random Lasers

Autori: Di Gaspare A, Pistore V, Riccardi E, Pogna EA, Beere HE, Ritchie DA, Li L, Davies AG, Linfield EH, Ferrari AC, Vitiello MS
Pubblicato in: Advanced Science, Numero 10(9):2206824, 2023, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202206824

Intraoperative Assessment of Tumor Margins in Tissue Sections with Hyperspectral Imaging and Machine Learning

Autori: David Pertzborn; Hoang-Ngan Nguyen; Katharina Hüttmann; Jonas Prengel; Günther Ernst; Orlando Guntinas-Lichius; Ferdinand von Eggeling; Franziska Hoffmann
Pubblicato in: Cancers, Numero 15(1), 213, 2022, ISSN 2072-6694
Editore: MDPI
DOI: 10.3390/cancers15010213

High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach

Autori: Renzo Vanna, Andrea Masella, Manuela Bazzarelli, Paola Ronchi, Aufried Lenferink, Cristina Tresoldi, Carlo Morasso, Marzia Bedoni, Giulio Cerullo, Dario Polli, Fabio Ciceri, Giulia De Poli, Matteo Bregonzio, and Cees Otto
Pubblicato in: Analytical Chemistry, Numero 96(23):9468-9477, 2024, ISSN 1520-6882
Editore: ACS Publications (United States)
DOI: 10.1021/acs.analchem.4c00787

Book chapters (1)

Raman spectroscopy of graphene and related materials

Autori: Anna K. Ott, Andrea C. Ferrari
Pubblicato in: Encyclopedia of Condensed Matter Physics (Second Edition), Numero 2:233–247, 2024, ISBN 978-0-323-91408-6
Editore: Academic Press
DOI: 10.1016/B978-0-323-90800-9.00252-3

Conference proceedings (2)

A compact, turn-key platform for multiplex stimulated Raman scattering microscopy

Autori: Francesco Crisafi, Benedetta Talone, Andrea Ragni, Gabriele Di Noia, Mujeeb Rahman, Jing He, Jeremiah Marcellino, Goutam Kar, Yarjan Samad, Boyang Mao, Renzo Vanna, Franziska Hoffmann, Orlando Guntinas-Lichius, Sze Y. Set, Andrea C. Ferrari, Giulio Cerullo, Matteo Negro
Pubblicato in: Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, 2024
Editore: SPIE
DOI: 10.1117/12.3002592

Plug-and-play stimulated Raman microscopy system for broadband coherent vibrational imaging

Autori: Crisafi F, Talone B, Ragni A, Di Noia G, Rahman M, He J, Marcellino J, Kar G, Samad Y, Mao B, Vanna R
Pubblicato in: he European Conference on Lasers and Electro-Optics, 2024, ISBN 979-8-3503-4599-5
Editore: Optica Publishing Group

Diritti di proprietà intellettuale

Patent (1)

AN OPTICAL CIRCUIT ARRANGEMENT

Numero candidatura/pubblicazione: 20 23052061
Data: 2023-08-03
Candidato/i: CAMBRIDGE RAMAN IMAGING SRL