The Gene Therapy CoE at the Center of Portugal

Project Information

GeneT

Grant agreement ID: 101059981

DOI

10.3030/101059981

EC signature date 31 July 2023

Start date 1 January 2024

End date 31 December 2029

Funded under

• Widening participation and spreading excellence

Total cost

€ 14 003 705,00

EU contribution

€ 14 003 705,00

Coordinated by

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan (updatable)

Data Management Plan (DMP)

Documents, reports (3)

GeneT bylaws and internal regulations

GeneT CoE bylaws and internal regulations

CDP, Education & Training strategy

Career Development Plan (CDP) and Education & Training strategy handbook

Appointment of the IC (dispatch)

Dispatch for the oppointment of the Installation Committee (IC)

Websites, patent fillings, videos etc. (2)

DEC Plan (updatable)

Dissemination, Exploitation and Communication (DEC) Plan

GeneT brand & visual identity booklet plus GeneT website online

GeneT brand & visual identity booklet together with the GeneT website functional and online.

Publications

Peer reviewed articles (8)

Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients

Author(s): Audrey Iskandar, Maresa Buchholz, Iris Blotenberg, Tanja Schmitz-Hübsch, Jennifer Faber, Heike Jacobi, Feng Xie, Marcus Grobe-Einsler, Thomas Klockgether, Bernhard Michalowsky, null null, Kathrin Reetz, Mafalda Raponso, Carlos Gonzales, Berkan Koyak, Demet Oender, Luís Pereira de Almeida, Patrick Silva, Joana Afonso Ribeiro, Andreas Thieme, Friedrich Erdlenbruch, Jeroen de Vries, Chiadikaobi Onyike, Paola Giunti, Hector Garcia-Moreno, Gülin Öz, Almut Turid Bischoff, Bart van de Warrenburg, Judith van Gaalen, Jon Infante, Leire Manrique, Ludger Schöls, Olaf Riess, Sophie Tezenas du Montcel, Peter Bauer, Paola Giunti, Arron Cook, Robyn Labrum, Michael H. Parkinson, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Maria Rakowicz, Anna Sulek, Anna Sobanska, Holger Hengel, Laszlo Baliko, Bela Melegh, Alessandro Filla, Antonella Antenora, José Berciano, Dagmar Timmann, Sandra Szymanski, Sylvia Boesch, Jun-Suk Kang, Massimo Padolfo, Jörg B. Schulz, Sonia Molho, Alhassane Diallo
Published in: Journal of Neurology, Issue 272, 2025, ISSN 0340-5354
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00415-025-13024-0

Editorial: Mesenchymal and induced-pluripotent stem cells as models to study biological processes

Author(s): Melvin A. Ambele, Catarina O. Miranda
Published in: Frontiers in Genetics, Issue 15, 2024, ISSN 1664-8021
Publisher: Frontiers Media SA
DOI: 10.3389/FGENE.2024.1439306

Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads

Author(s): Kevin Leandro, David Rufino-Ramos, Koen Breyne, Emilio Di Ianni, Sara M. Lopes, Rui Jorge Nobre, Benjamin P. Kleinstiver, Pedro R.L. Perdigão, Xandra O. Breakefield, Luís Pereira de Almeida
Published in: Advanced Drug Delivery Reviews, Issue 211, 2024, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/J.ADDR.2024.115346

Differential impact of mutant Ataxin-3 in hindbrain regions: further evidence of white matter loss as a core pathological feature

Author(s): Carina Henriques, Marta Silva, António Silva, David Rufino-Ramos, Miguel Monteiro Lopes, Romina Aron Badin, Philippe Hantraye, Luís Pereira de Almeida, Rui Jorge Nobre
Published in: Experimental Neurology, Issue 393, 2025, ISSN 0014-4886
Publisher: Elsevier BV
DOI: 10.1016/J.EXPNEUROL.2025.115413

Exploring TLR agonists as adjuvants for COVID-19 oral vaccines

Author(s): Felix, Paulo; Melo, Alexandra A.; Costa, Joao Panao; Colaco, Mariana; Pereira, Dina; Nunez, Jisette; de Almeida, Luis Pereira; Borges, Olga
Published in: Vaccine, 2025, ISSN 0264-410X
Publisher: ELSEVIER SCI LTD
DOI: 10.1016/J.VACCINE.2025.127078

Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol

Author(s): Lopes, Miguel M.; Lopes, Sara M.; Baganha, Rafael; Henriques, Carina; Silva, Ana C.; Lobo, Diana D.; Cortes, Luisa; de Almeida, Luis Pereira; Nobre, Rui Jorge
Published in: JOURNAL OF VISUALIZED EXPERIMENTS, 2024, ISSN 1940-087X
Publisher: JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/66550

Autophagy- and oxidative stress-related protein deregulation mediated by extracellular vesicles of human MJD/SCA3 iPSC-derived neuroepithelial stem cells and differentiated neural cultures

Author(s): Liliana S. Mendonça, Ricardo Moreira, Daniel Henriques, Mónica Zuzarte, Teresa M. Ribeiro-Rodrigues, Henrique Girão, Luís Pereira de Almeida
Published in: Cell Death & Disease, Issue 16, 2025, ISSN 2041-4889
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41419-025-07659-0

Molecular therapy for polyQ disorders: from bench to clinical trials

Author(s): João de Sousa-Lourenço, Ana C. Silva, Luís Pereira de Almeida, Rui J. Nobre
Published in: Trends in Molecular Medicine, Issue 30, 2024, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/J.MOLMED.2024.05.004

Thesis and dissertations (3)

Design of Functionalized Chitosan-DNA Complexes and Nanoparticles for Nasal Immunization against SARS-CoV-2

Author(s): Colaço, Mariana Raquel Antunes
Published in: 2025
Publisher: University of Coimbra

Development of polymeric membranes for the prevention of post-operative tendon adhesions

Author(s): Saraiva, Sofia Teixeira
Published in: 2024
Publisher: University of Coimbra

Unraveling Neurovascular Dysfunctions in Machado-Joseph Disease: Mesenchymal Stromal Cells as a Promising Therapy

Author(s): Barros, Maria Inês Veiga de Almeida
Published in: 2024
Publisher: Universidade de Coimbra

Intellectual Property Rights

Patent (6)

CRISPR-CAS9 BASED TOOLS: POTENTIAL NOVEL THERAPEUTIC APPROACHES FOR MACHADO-JOSEPH DISEASE

Application/Publication number: 20 24059800
Date: 2024-10-07
Applicant(s): UNIVERSIDADE DE COIMBRA

HUMAN PAPILLOMAVIRUS DETECTION KIT

Application/Publication number: 20 09000015
Date: 2009-03-18
Applicant(s): UNIVERSIDADE DE COIMBRA

MOLÉCULAS PREDITIVAS DE POTÊNCIA TERAPÊUTICA CELULAR

Application/Publication number: 11 758021
Date: 2021-11-17
Applicant(s): UNIVERSIDADE DE COIMBRA

DOUBLE STRANDED RNA AND USES THEREOF

Application/Publication number: 20 706805
Date: 2020-01-09
Applicant(s): UNIVERSIDADE DE COIMBRA

OLIGONUCLEOTIDE PRIMERS FOR THE CHARACTERIZATION OF THE CAG TRACT AND MEASUREMENT OF MUTANT MRNA IN THE CONTEXT OF POLYGLUTAMINE DISORDERS

Application/Publication number: 20 824634
Date: 2020-11-13
Applicant(s): UNIVERSIDADE DE COIMBRA

EXPRESSION VECTOR FOR CHOLESTEROL 24-HYDROLASE IN THERAPY OF POLYGLUTAMINE REPEAT SPINOCEREBELLAR ATAXIAS

Application/Publication number: 18 704898
Date: 2018-01-30
Applicant(s): UNIVERSIDADE DE COIMBRA

Trademark (3)

GENET GENE THERAPY CENTER OF EXCELENCE PORTUGAL

Application/Publication number: GeneT 1824211
Date: 2024-06-28
Applicant(s): UNIVERSIDADE DE COIMBRA

GENET GENE THERAPY CENTER OF EXCELENCE PORTUGAL

Application/Publication number: PT 718981
Date: 2024-01-31
Applicant(s): UNIVERSIDADE DE COIMBRA

GENET GENE THERAPY CENTER OF EXCELLENCE PORTUGAL

Application/Publication number: WO 0000001824211
Date: 2024-02-14
Applicant(s): UNIVERSIDADE DE COIMBRA