Project description
Innovative screening for drug efficacy modulation by circadian clocks
The internal circadian clocks set the timing for circadian rhythms, regulating human body processes such as sleep/wake cycles, hormonal activity, temperature rhythm, and eating and digesting. The disruption of circadian clocks is associated with a broad spectrum of diseases, from sleep disorders to cancer. Therapeutic drug targets could be influenced by circadian clocks, and the timing of drug administration can maximise the drug’s efficacy. The EU-funded CircaSCOPE project proposes an innovative high throughput methodology for the construction of high-resolution phase transition curves for the screening of clock-modulating drugs. The developed methodology will improve drug discovery, targeting diseases associated with circadian disruption, and identifying drugs with the side effects affecting the clocks.
Fields of science
- medical and health sciencesclinical medicinepsychiatrysleep disorders
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinepathology
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-AG-LS - HORIZON Lump Sum Grant
Coordinator
7610001 Rehovot
Israel
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