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Pre-commercialization of circadian clock-drug interactions screening tool for therapeutic applications

Project description

Innovative screening for drug efficacy modulation by circadian clocks

The internal circadian clocks set the timing for circadian rhythms, regulating human body processes such as sleep/wake cycles, hormonal activity, temperature rhythm, and eating and digesting. The disruption of circadian clocks is associated with a broad spectrum of diseases, from sleep disorders to cancer. Therapeutic drug targets could be influenced by circadian clocks, and the timing of drug administration can maximise the drug’s efficacy. The EU-funded CircaSCOPE project proposes an innovative high throughput methodology for the construction of high-resolution phase transition curves for the screening of clock-modulating drugs. The developed methodology will improve drug discovery, targeting diseases associated with circadian disruption, and identifying drugs with the side effects affecting the clocks.


Net EU contribution
€ 150 000,00
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Other funding
No data