NOVA Institute for Medical Systems Biology

Informations projet

NIMSB

N° de convention de subvention: 101060346

DOI

10.3030/101060346

Date de signature de la CE 4 Mai 2023

Date de début 1 Septembre 2023

Date de fin 31 Août 2029

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 14 992 000,00

Contribution de l’UE

€ 14 992 000,00

Coordonné par

NOVA IMSB NOVA INSTITUTE FOR MEDICAL SYSTEMS BIOLOGY ASSOCIACAO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Gender Equality and Inclusivity plan

D18 (6 mo): Gender Equality and Inclusivity plan.

Educational programs

D7 (18 mo): Regulations for educational programmes.

Open Science policies

D16 (12 mo): Open Science policies.

IP regulations and policies

D9 (18 mo): IP regulations and policies.

Innovation programs

D8 (18 mo): Report on Innovation programs.

Creating NIMSB

D1 (12 mo): Report on creating NIMSB (including by-laws), selection of the director, and initial set-up of organisational and administrative structures.

Data Management Plan (1)

Data Management plan

D13 (6 mo): Data Management plan.

Publications

Peer reviewed articles (15)

In silico prediction of the permeability of phytochemicals across the blood-brain barrier

Auteurs: Diogo Carregosa, Iris Moreira, Diogo Rasteiro, Leonardo Vanneschi, Cláudia Nunes dos Santos
Publié dans: Frontiers in Drug Discovery, Numéro 6, 2026, ISSN 2674-0338
Éditeur: Frontiers Media SA
DOI: 10.3389/FDDSV.2026.1939611

Modified Mediterranean diet effects on Parkinson’s disease (MED-PARK): a single-centre randomised controlled trial protocol

Auteurs: Elenamaria Pirovano, Franca Marino, Elena Rossi, Andrea Gennari, Emanuela Rasini, Margherita Uslenghi, Inês Figueira, Licia Iacoviello, Marco Ferrari, Marco Cosentino
Publié dans: BMJ Open, Numéro 15, 2025, ISSN 2044-6055
Éditeur: BMJ
DOI: 10.1136/BMJOPEN-2025-101946

“Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson’s disease”

Auteurs: Laura Muñoz-Delgado, Caroline H. Williams-Gray, Gaetan Garraux, Diego Clemente, Özgür Öztop Çakmak, Julia C. Greenland, Inês Figueira, Isabel Machín-Díaz, Elenamaria Pirovano, Alessia di Flora, Clotilde Tournerie, Stamatia Papoutsopoulou, Sibel Ertan, Pablo Mir, Cristoforo Comi
Publié dans: npj Parkinson's Disease, Numéro 11, 2025, ISSN 2373-8057
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41531-025-01146-1

Longitudinal integration of microbiota and metabolomics reveals (poly)phenols-driven gut ecosystem dynamics

Auteurs: Catarina J. G. Pinto, Carlos Pita, Rafael Carecho, Natasa Loncarevic, María Ángeles Ávila-Gálvez, Juan Carlos Espín, Antonio González-Sarrías, Joana Séneca, David Berry, Cláudia Nunes dos Santos
Publié dans: Frontiers in Nutrition, Numéro 13, 2026, ISSN 2296-861X
Éditeur: Frontiers Media SA
DOI: 10.3389/FNUT.2026.1858875

The transformative impact of stem cell core facilities in biomedical research

Auteurs: Barbara Corneo, Giovanni Faga, Inês Figueira, Jacopo Zasso, Wenli Yang, Katrin Neuman, Pia A. Johansson, Lyn Healy, Laurence M. Daheron, Melanie Generali, Ole Pless, Ras Trokovic, Laurent David, Mehrnaz Gazhvini, Laura Batlle-Morera
Publié dans: Stem Cell Reports, Numéro 21, 2026, ISSN 2213-6711
Éditeur: Elsevier BV
DOI: 10.1016/J.STEMCR.2026.103047

Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics

Auteurs: Patrícia Porfírio-Rodrigues, Telmo Pereira, Antonio Jacinto, Lara Carvalho
Publié dans: Journal of Cell Science, Numéro 138, 2025, ISSN 0021-9533
Éditeur: The Company of Biologists
DOI: 10.1242/JCS.263674

Lactucopicrin:A Sesquiterpene Lactone with Anti-InflammatoryActivity Modulates the Crosstalk between NF-kB and AHR Pathways

Auteurs: María Ángeles Ávila-Gálvez, Catarina J G Pinto, Carlos Rafael-Pita, Inês P. Silva, Aleksandra T. Janowska, Sérgio Marinho, Rory Saitch, Yilong Lian, Pakavarin Louphrasitthiphol, Jonas Protze, Gerd Krause, Pedro Moura-Alves, Cláudia Nunes dos Santos
Publié dans: Journal of Medicinal Chemistry, Numéro 68, 2026, ISSN 0022-2623
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.JMEDCHEM.5C02294

ReScale4DL: balancing pixel and contextual information for enhanced bioimage segmentation

Auteurs: Mariana G. Ferreira, Bruno M. Saraiva, António D. Brito, Mariana G. Pinho, Ricardo Henriques, Estibaliz Gómez-de-Mariscal
Publié dans: Nature Communications, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77930-1

Urolithins and their phase II conjugates cross the blood–brain barrier and exert a stimulus-dependent anti-inflammatory effect on microglial cells by inhibiting NF-κB nuclear translocation

Auteurs: Beatriz Garay-Mayol, Juan Antonio Giménez-Bastida, Diego José López-Cánovas, Sabrina Poveda-Lora, Silvia Navarro-Orcajada, María Alexandra Brito, Claudia Nunes dos Santos, Juan Carlos Espín, María Ángeles Ávila-Gálvez, Antonio González-Sarrías
Publié dans: Food & Function, Numéro 16, 2025, ISSN 2042-6496
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5FO03678J

Communicating science matters: positive evidence from the BASCOE study, a quantitative study from Brain Awareness Week outreach activities

Auteurs: Carlos Pita, Inês P. Silva, Ana Rita Colaço, Margarida Brotas, Beatriz Felgueiras, Beatriz Nogueira, Olga Carreira, Ana F. Fonseca, Mariana Castro, Adriana Capucho, Gonçalo Melo, Fátima O. Martins, Gabriela Ribeiro, Conceição Calhau, Sandra Tenreiro, Hugo Vicente Miranda, Silvia Vilares Conde, César S. Mendes, Cláudia Nunes dos Santos, Nuno Mendonça, Maria Serrano Correia, Nuno Miguel Gonçalves, Nataša Lončarević
Publié dans: Frontiers in Communication, Numéro 11, 2026, ISSN 2297-900X
Éditeur: Frontiers Media SA
DOI: 10.3389/FCOMM.2026.1721770

Modulation of the ubiquitin-proteasome system by circulating (poly)phenol-derived metabolites: implications for chronic diseases

Auteurs: Sofia Ferreira, Regina Menezes, Ioannis P. Trougakos, Sentiljana Gumeni, Victor M. Bolanos-Garcia, Cláudia Nunes dos Santos, María Ángeles Ávila-Gálvez
Publié dans: The Journal of Nutritional Biochemistry, Numéro 147, 2026, ISSN 0955-2863
Éditeur: Elsevier BV
DOI: 10.1016/J.JNUTBIO.2025.110127

Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management

Auteurs: Melanie S. Matos, Maria Ángeles Ávila-Gálvez, Antonio Gonzáles-Sarrias, Nuno-Valério Silva, Carolina Lage Crespo, António Jacinto, Ana Teresa Serra, Ana A. Matias, Cláudia Nunes dos Santos
Publié dans: Food & Function, Numéro 15, 2024, ISSN 2042-6496
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4FO01446D

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Auteurs: Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto
Publié dans: iScience, Numéro 29, 2026, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/J.ISCI.2026.114792

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Auteurs: Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto
Publié dans: iScience, Numéro 29, 2026, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/J.ISCI.2026.114792

Non-pharmacological interventions modulating immune response in Parkinson's disease: where do we stand for future preventive approaches

Auteurs: Elenamaria Pirovano, Inês P. Silva, Marta Camacho, Asuman Çanak, Busra Aktas, David Crompton, Evrim Gökçe, Fu-Miao Tan, Franca Marino, Josefa Domingos, Mafalda F. Almeida, Cristoforo Comi, Milorad Dragic, Inês Figueira
Publié dans: Neurochemistry International, Numéro 199, 2026, ISSN 0197-0186
Éditeur: Elsevier BV
DOI: 10.1016/J.NEUINT.2026.106211

Other (1)

Portuguese Language translation revision and editing of The ISSCR Guide to Stem Cell Treatments (Guia para Tratamentos Baseados em Células Estaminais da ISSCR (Português de Portugal)

Auteurs: Figueira l, Inácio JM, Bernardino L, Terrasso AP, Solá S, Arez M, dos Santos JC
Publié dans: 2025
Éditeur: International Society for Stem Cell Research