Description du projet
Faire progresser la médecine de précision au Portugal
Les maladies chroniques sont de plus en plus répandues, ce qui pèse sur la viabilité des systèmes de soins de santé dans le monde entier. Pour tenter de résoudre ce problème, l’accent est mis de plus en plus sur la prévention des maladies, la sensibilisation et la médecine de précision. Financé par le programme HORIZON, le projet NIMSB soutiendra la création d’un centre d’excellence au sein de l’institut éponyme, le Nova Institute for Medical Systems Biology ou NIMSB, à Lisbonne. L’objectif est d’intégrer des analyses cellulaires avancées, des approches computationnelles et des données multi-omiques pour comprendre les maladies chroniques et concevoir de nouvelles thérapies. Les chercheurs et les cliniciens collaboreront pour développer des modèles quantitatifs et mettre en œuvre des solutions de médecine de précision.
Objectif
The rise of chronic diseases is shaping health policy priorities worldwide. As the population ages, these conditions affect increasing portions of society and are more difficult to manage, causing suffering in patients and their families for many years. Such increasing prevalence is a threat to the sustainability of healthcare systems. Thus, an increasing focus has been put on disease prevention and awareness, as well as on precision medicine. This project will create a new Centre of Excellence, NOVA Institute for Medical Systems Biology (NIMSB), which will use the most advanced cell analytics and experimental in vitro systems, combined with computational approaches to understand and fight chronic diseases. The core of the project will be the integration of multi-omics data from single cells from patient biopsies and derived organoids, bioinformatics and artificial intelligence, cell and molecular biology, and relevant animal model studies, to develop quantitative models that can inform on mechanisms of disease progression. Researchers and clinicians will collaborate to use this knowledge to implement novel precision medicine solutions, aiming to intercept diseases before symptoms develop, and also by improving diagnosis, disease course prediction and response to treatment. NIMSB will contribute to clinical practice improvement not only with technology but also by training the next generation of researchers and medical doctors in precision interceptive medicine and digital-transformation technologies. NOVA Medical School of NOVA University is in a unique position to coordinate the project due to its current drive for restructuring, established reputation as a top Medical School in Portugal, and research focus on chronic diseases. The Max Delbrück Center for Molecular Medicine is the best possible advanced partner, as it is a world leader in this research topic and has recently created the Berlin Institute for Medical Systems Biology, which is a model for NIMSB.
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HORIZON-CSA - HORIZON Coordination and Support ActionsCoordinateur
1099 085 Lisboa
Portugal