NOVA Institute for Medical Systems Biology

Informazioni relative al progetto

NIMSB

ID dell’accordo di sovvenzione: 101060346

DOI

10.3030/101060346

Data della firma CE 4 Maggio 2023

Data di avvio 1 Settembre 2023

Data di completamento 31 Agosto 2029

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 14 992 000,00

Contributo UE

€ 14 992 000,00

Coordinato da

NOVA IMSB NOVA INSTITUTE FOR MEDICAL SYSTEMS BIOLOGY ASSOCIACAO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Gender Equality and Inclusivity plan

D18 (6 mo): Gender Equality and Inclusivity plan.

Educational programs

D7 (18 mo): Regulations for educational programmes.

Open Science policies

D16 (12 mo): Open Science policies.

IP regulations and policies

D9 (18 mo): IP regulations and policies.

Innovation programs

D8 (18 mo): Report on Innovation programs.

Creating NIMSB

D1 (12 mo): Report on creating NIMSB (including by-laws), selection of the director, and initial set-up of organisational and administrative structures.

Data Management Plan (1)

Data Management plan

D13 (6 mo): Data Management plan.

Pubblicazioni

Peer reviewed articles (15)

In silico prediction of the permeability of phytochemicals across the blood-brain barrier

Autori: Diogo Carregosa, Iris Moreira, Diogo Rasteiro, Leonardo Vanneschi, Cláudia Nunes dos Santos
Pubblicato in: Frontiers in Drug Discovery, Numero 6, 2026, ISSN 2674-0338
Editore: Frontiers Media SA
DOI: 10.3389/FDDSV.2026.1939611

Modified Mediterranean diet effects on Parkinson’s disease (MED-PARK): a single-centre randomised controlled trial protocol

Autori: Elenamaria Pirovano, Franca Marino, Elena Rossi, Andrea Gennari, Emanuela Rasini, Margherita Uslenghi, Inês Figueira, Licia Iacoviello, Marco Ferrari, Marco Cosentino
Pubblicato in: BMJ Open, Numero 15, 2025, ISSN 2044-6055
Editore: BMJ
DOI: 10.1136/BMJOPEN-2025-101946

“Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson’s disease”

Autori: Laura Muñoz-Delgado, Caroline H. Williams-Gray, Gaetan Garraux, Diego Clemente, Özgür Öztop Çakmak, Julia C. Greenland, Inês Figueira, Isabel Machín-Díaz, Elenamaria Pirovano, Alessia di Flora, Clotilde Tournerie, Stamatia Papoutsopoulou, Sibel Ertan, Pablo Mir, Cristoforo Comi
Pubblicato in: npj Parkinson's Disease, Numero 11, 2025, ISSN 2373-8057
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41531-025-01146-1

Longitudinal integration of microbiota and metabolomics reveals (poly)phenols-driven gut ecosystem dynamics

Autori: Catarina J. G. Pinto, Carlos Pita, Rafael Carecho, Natasa Loncarevic, María Ángeles Ávila-Gálvez, Juan Carlos Espín, Antonio González-Sarrías, Joana Séneca, David Berry, Cláudia Nunes dos Santos
Pubblicato in: Frontiers in Nutrition, Numero 13, 2026, ISSN 2296-861X
Editore: Frontiers Media SA
DOI: 10.3389/FNUT.2026.1858875

The transformative impact of stem cell core facilities in biomedical research

Autori: Barbara Corneo, Giovanni Faga, Inês Figueira, Jacopo Zasso, Wenli Yang, Katrin Neuman, Pia A. Johansson, Lyn Healy, Laurence M. Daheron, Melanie Generali, Ole Pless, Ras Trokovic, Laurent David, Mehrnaz Gazhvini, Laura Batlle-Morera
Pubblicato in: Stem Cell Reports, Numero 21, 2026, ISSN 2213-6711
Editore: Elsevier BV
DOI: 10.1016/J.STEMCR.2026.103047

Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics

Autori: Patrícia Porfírio-Rodrigues, Telmo Pereira, Antonio Jacinto, Lara Carvalho
Pubblicato in: Journal of Cell Science, Numero 138, 2025, ISSN 0021-9533
Editore: The Company of Biologists
DOI: 10.1242/JCS.263674

Lactucopicrin:A Sesquiterpene Lactone with Anti-InflammatoryActivity Modulates the Crosstalk between NF-kB and AHR Pathways

Autori: María Ángeles Ávila-Gálvez, Catarina J G Pinto, Carlos Rafael-Pita, Inês P. Silva, Aleksandra T. Janowska, Sérgio Marinho, Rory Saitch, Yilong Lian, Pakavarin Louphrasitthiphol, Jonas Protze, Gerd Krause, Pedro Moura-Alves, Cláudia Nunes dos Santos
Pubblicato in: Journal of Medicinal Chemistry, Numero 68, 2026, ISSN 0022-2623
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.JMEDCHEM.5C02294

ReScale4DL: balancing pixel and contextual information for enhanced bioimage segmentation

Autori: Mariana G. Ferreira, Bruno M. Saraiva, António D. Brito, Mariana G. Pinho, Ricardo Henriques, Estibaliz Gómez-de-Mariscal
Pubblicato in: Nature Communications, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77930-1

Urolithins and their phase II conjugates cross the blood–brain barrier and exert a stimulus-dependent anti-inflammatory effect on microglial cells by inhibiting NF-κB nuclear translocation

Autori: Beatriz Garay-Mayol, Juan Antonio Giménez-Bastida, Diego José López-Cánovas, Sabrina Poveda-Lora, Silvia Navarro-Orcajada, María Alexandra Brito, Claudia Nunes dos Santos, Juan Carlos Espín, María Ángeles Ávila-Gálvez, Antonio González-Sarrías
Pubblicato in: Food & Function, Numero 16, 2025, ISSN 2042-6496
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5FO03678J

Communicating science matters: positive evidence from the BASCOE study, a quantitative study from Brain Awareness Week outreach activities

Autori: Carlos Pita, Inês P. Silva, Ana Rita Colaço, Margarida Brotas, Beatriz Felgueiras, Beatriz Nogueira, Olga Carreira, Ana F. Fonseca, Mariana Castro, Adriana Capucho, Gonçalo Melo, Fátima O. Martins, Gabriela Ribeiro, Conceição Calhau, Sandra Tenreiro, Hugo Vicente Miranda, Silvia Vilares Conde, César S. Mendes, Cláudia Nunes dos Santos, Nuno Mendonça, Maria Serrano Correia, Nuno Miguel Gonçalves, Nataša Lončarević
Pubblicato in: Frontiers in Communication, Numero 11, 2026, ISSN 2297-900X
Editore: Frontiers Media SA
DOI: 10.3389/FCOMM.2026.1721770

Modulation of the ubiquitin-proteasome system by circulating (poly)phenol-derived metabolites: implications for chronic diseases

Autori: Sofia Ferreira, Regina Menezes, Ioannis P. Trougakos, Sentiljana Gumeni, Victor M. Bolanos-Garcia, Cláudia Nunes dos Santos, María Ángeles Ávila-Gálvez
Pubblicato in: The Journal of Nutritional Biochemistry, Numero 147, 2026, ISSN 0955-2863
Editore: Elsevier BV
DOI: 10.1016/J.JNUTBIO.2025.110127

Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management

Autori: Melanie S. Matos, Maria Ángeles Ávila-Gálvez, Antonio Gonzáles-Sarrias, Nuno-Valério Silva, Carolina Lage Crespo, António Jacinto, Ana Teresa Serra, Ana A. Matias, Cláudia Nunes dos Santos
Pubblicato in: Food & Function, Numero 15, 2024, ISSN 2042-6496
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4FO01446D

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Autori: Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto
Pubblicato in: iScience, Numero 29, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2026.114792

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

Autori: Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto
Pubblicato in: iScience, Numero 29, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2026.114792

Non-pharmacological interventions modulating immune response in Parkinson's disease: where do we stand for future preventive approaches

Autori: Elenamaria Pirovano, Inês P. Silva, Marta Camacho, Asuman Çanak, Busra Aktas, David Crompton, Evrim Gökçe, Fu-Miao Tan, Franca Marino, Josefa Domingos, Mafalda F. Almeida, Cristoforo Comi, Milorad Dragic, Inês Figueira
Pubblicato in: Neurochemistry International, Numero 199, 2026, ISSN 0197-0186
Editore: Elsevier BV
DOI: 10.1016/J.NEUINT.2026.106211

Other (1)

Portuguese Language translation revision and editing of The ISSCR Guide to Stem Cell Treatments (Guia para Tratamentos Baseados em Células Estaminais da ISSCR (Português de Portugal)

Autori: Figueira l, Inácio JM, Bernardino L, Terrasso AP, Solá S, Arez M, dos Santos JC
Pubblicato in: 2025
Editore: International Society for Stem Cell Research