Strengthening the European Chain of sUpply for next generation medical RadionuclidEs

Información del proyecto

SECURE

Identificador del acuerdo de subvención: 101061230

Proyecto cerrado

Fecha de la firma de la CE 23 Mayo 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• Euratom Research and Training Programme (EURATOM)

Coste total

€ 3 657 175,00

Aportación de la UE

€ 3 630 425,50

Coordinado por

NARODOWE CENTRUM BADAN JADROWYCH
Poland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (8)

Report on quality control performed on W-188/Re-188 for use in radiolabelling studies
Report and prototypes of low density or hollow tungsten metal targets
Recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Document summarizing recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Report on neutron diffraction results and thermal calculations of tungsten oxide targets
Report on the dissolution of unirradiated low density or hollow tungsten metal targets
Report on metal targets and associated dissolution strategy
"Prototype and report on process to set up a device (""R&D generator"") for small-scale harvesting of Re-188 from a W-188 solution"

Prototype and report on process to set up a device (“R&D generator”) for small-scale harvesting of Re-188 from a W-188 solution

Recommendations on clinical applications of alpha particle therapy

Document summarizing recommendations on clinical applications of alpha particle therapy

Data Management Plan (1)

Data Management Plan

Data Management Plan - basic overview of the expected data created in frame of the project and the way the data will be stored, shared and processed.

Websites, patent fillings, videos etc. (2)

Webpage under ENEN website

Project website serving as key dissemination channel will be created as sub-page of ENEN website.

Identity package

Project visual identity materials - logo, templates etc.

Other (1)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle) to the project.

Publicaciones

Peer reviewed articles (12)

Cysteine-selective [¹⁸⁸Re]Re(<scp>v</scp>) radiolabelling of a Nanobody® for targeted radionuclide therapy using a “chelate-then-click” approach

Autores: Diana R. Melis, Charlotte Segers, Jasmien Wellens, Michiel Van de Voorde, Olivier Blacque, Maarten Ooms, Gilles Gasser, Tomas Opsomer
Publicado en: Chemical Science, Edición 16, 2025, ISSN 2041-6520
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4SC07743A

Radiopharmaceuticals for Pancreatic Cancer: A Review of Current Approaches and Future Directions

Autores: Sara Calistri, Giuseppe Ottaviano, Alberto Ubaldini
Publicado en: Pharmaceuticals, Edición 17, 2024, ISSN 1424-8247
Editor: MDPI AG
DOI: 10.3390/PH17101314

Semi-Supervised Learning for Dose Prediction in Targeted Radionuclide: A Synthetic Data Study

Autores: Jing Zhang, Alexandre Bousse, Chi-Hieu Pham, Kuangyu Shi, Julien Bert
Publicado en: Physics in Medicine and Biology, Edición 112, 2025, ISSN 1361-6560
Editor: IOP Publishing
DOI: 10.48550/ARXIV.2503.05367

Pharmaceuticals

Autores: Wael Jalloul, Vlad Ghizdovat, Cati Raluca Stolniceanu, Teodor Ionescu, Irena Cristina Grierosu, Ioana Pavaleanu, Mihaela Moscalu, Cipriana Stefanescu
Publicado en: Pharmaceuticals, Edición Volume 16, Edición 12, 2023, ISSN 1424-8247
Editor: Pharmaceuticals
DOI: 10.3390/ph16121679

Two-step extraction chromatography separation of 161Tb from 160Gd-enriched irradiated target material and verification of the [161Tb]TbCl3 suitability for radiolabelling

Autores: Małgorzata Żółtowska, Dariusz Pawlak, Izabela Cieszykowska, Paweł Saganowski, Natalia Lisowska, Anna Filiks, Renata Mikołajczak
Publicado en: Applied Radiation and Isotopes, Edición 226, 2025, ISSN 0969-8043
Editor: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112144

Recommendations on the Clinical Application and Future Potential of α-Particle Therapy: A Comprehensive Review of the Results from the SECURE Project

Autores: Valentina Di Iorio, Anna Sarnelli, Stefano Boschi, Maddalena Sansovini, Rosa Maria Genovese, Cipriana Stefanescu, Vlad Ghizdovat, Wael Jalloul, Jennifer Young, Jane Sosabowski, Petra Kolenc, Rachel Roberts, Govert de With, Dimitris Visvikis, Renata Mikolajczak
Publicado en: Pharmaceuticals, Edición 18, 2025, ISSN 1424-8247
Editor: MDPI AG
DOI: 10.3390/PH18101578

Targeted alpha therapy in the clinical practice: radiation protection considerations

Autores: Anna Sarnelli, Emilio Mezzenga, Robert P. Kollaard, Ellis G. Winters, Govert De With, Renata Mikołajczak
Publicado en: The European Physical Journal Plus, Edición 140, 2025, ISSN 2190-5444
Editor: Springer Science and Business Media LLC
DOI: 10.1140/EPJP/S13360-025-06709-Y

Development of non-carrier added Au-199 production procedure from neutron-irradiated Pt targets

Autores: Leja Rovan Stiplošek, Radojko Jaćimović, Tea Zuliani, Tjaša Žerdoner, Ulli Köster, Mariella Van Ginkel, Michele Toma, Marko Štrok
Publicado en: Applied Radiation and Isotopes, Edición 226, 2025, ISSN 0969-8043
Editor: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112244

Advancing targeted radionuclide therapy in nuclear medicine – A future perspective

Autores: Govert de With, Tim Tinsley, Renata Mikolajczak, Ronald Schram, Dimitris Visvikis, Camila Boix, Gabriel Lazaro Pavel, Marco Capogni, Sarah Baatout, Niloefar Ahmadi Bidakhvidi
Publicado en: EANM Innovation, Edición 1, 2025, ISSN 3051-2913
Editor: Elsevier BV
DOI: 10.1016/J.EANMI.2025.100007

Targeted Alpha Therapy: Exploring the Clinical Insights into [225Ac]Ac-PSMA and Its Relevance Compared with [177Lu]Lu-PSMA in Advanced Prostate Cancer Management

Autores: Wael Jalloul, Vlad Ghizdovat, Alexandra Saviuc, Despina Jalloul, Irena Cristina Grierosu, Cipriana Stefanescu
Publicado en: Pharmaceuticals, Edición 18, 2025, ISSN 1424-8247
Editor: MDPI AG
DOI: 10.3390/PH18081215

Alpha Atlas: Mapping global production of α-emitting radionuclides for targeted alpha therapy

Autores: Marianna Tosato, Chiara Favaretto, Janke Kleynhans, Andrew R. Burgoyne, Jean-François Gestin, Nicholas P. van der Meulen, Amirreza Jalilian, Ulli Köster, Mattia Asti, Valery Radchenko
Publicado en: Nuclear Medicine and Biology, Edición 142-143, 2025, ISSN 0969-8051
Editor: Elsevier BV
DOI: 10.1016/J.NUCMEDBIO.2024.108990

European Physical Journal Plus

Autores: Anna Sarnelli; Emilio Mezzenga; Robert P. Kollaard; Ellis G. Winters; Govert De With; Renata Mikołajczak
Publicado en: The European Physical Journal Plus, 2025, ISSN 2190-5444
Editor: EDP Sciences, Springer Science+Business Media, Società Italiana di Fisica
DOI: 10.1140/EPJP/S13360-025-06709-Y

Conference proceedings (3)

Preparation, chemical–physical characterization of composite hydro-gels – nanoparticles of Ag and Ag2MoO4. Stability analysis and biomedical applications

Autores: Sara Calistri, Alberto Ubaldini, Antonietta Rizzo, Alessandra Strafella, Chiara Ciantelli, Carmela Maria Cellamare
Publicado en: Proceedings of the Nanotech France 2024 International Conference Paris, France – June 05 – 07, 2024 C10, 2024
Editor: Setcor
DOI: 10.26799/CP-NANOTECH-FRANCE-2024_X

Activation of radioisotopes used for medical purposes in the Budapest Neutron Centre

Autores: Noémi Anna Buczkó, Boglárka Maróti, Zoltán Kis, Katalin Gméling, László Szentmiklósi
Publicado en: Book of Abstracts - RAD 2025 Conference, 2025
Editor: RAD Centre, Niš, Serbia
DOI: 10.21175/RAD.ABSTR.BOOK.2025.26.2_X

Pre-therapy dose prediction in targeted radionuclide therapy using semi-supervised learning: An in-silico preliminary study

Autores: J. Zhang, A. Bousse, Y. Li, S. Xue, K. Shi, D. Visvikis, J. Bert
Publicado en: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD), 2024
Editor: IEEE
DOI: 10.1109/NSS/MIC/RTSD57108.2024.10655434