Strengthening the European Chain of sUpply for next generation medical RadionuclidEs

Informazioni relative al progetto

SECURE

ID dell’accordo di sovvenzione: 101061230

Progetto chiuso

Data della firma CE 23 Maggio 2022

Data di avvio 1 Ottobre 2022

Data di completamento 30 Settembre 2025

Finanziato da

• Euratom Research and Training Programme (EURATOM)

Costo totale

€ 3 657 175,00

Contributo UE

€ 3 630 425,50

Coordinato da

NARODOWE CENTRUM BADAN JADROWYCH
Poland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (8)

Report on quality control performed on W-188/Re-188 for use in radiolabelling studies
Report and prototypes of low density or hollow tungsten metal targets
Recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Document summarizing recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Report on neutron diffraction results and thermal calculations of tungsten oxide targets
Report on the dissolution of unirradiated low density or hollow tungsten metal targets
Report on metal targets and associated dissolution strategy
"Prototype and report on process to set up a device (""R&D generator"") for small-scale harvesting of Re-188 from a W-188 solution"

Prototype and report on process to set up a device (“R&D generator”) for small-scale harvesting of Re-188 from a W-188 solution

Recommendations on clinical applications of alpha particle therapy

Document summarizing recommendations on clinical applications of alpha particle therapy

Data Management Plan (1)

Data Management Plan

Data Management Plan - basic overview of the expected data created in frame of the project and the way the data will be stored, shared and processed.

Websites, patent fillings, videos etc. (2)

Webpage under ENEN website

Project website serving as key dissemination channel will be created as sub-page of ENEN website.

Identity package

Project visual identity materials - logo, templates etc.

Other (1)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle) to the project.

Pubblicazioni

Peer reviewed articles (12)

Cysteine-selective [¹⁸⁸Re]Re(<scp>v</scp>) radiolabelling of a Nanobody® for targeted radionuclide therapy using a “chelate-then-click” approach

Autori: Diana R. Melis, Charlotte Segers, Jasmien Wellens, Michiel Van de Voorde, Olivier Blacque, Maarten Ooms, Gilles Gasser, Tomas Opsomer
Pubblicato in: Chemical Science, Numero 16, 2025, ISSN 2041-6520
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4SC07743A

Radiopharmaceuticals for Pancreatic Cancer: A Review of Current Approaches and Future Directions

Autori: Sara Calistri, Giuseppe Ottaviano, Alberto Ubaldini
Pubblicato in: Pharmaceuticals, Numero 17, 2024, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/PH17101314

Semi-Supervised Learning for Dose Prediction in Targeted Radionuclide: A Synthetic Data Study

Autori: Jing Zhang, Alexandre Bousse, Chi-Hieu Pham, Kuangyu Shi, Julien Bert
Pubblicato in: Physics in Medicine and Biology, Numero 112, 2025, ISSN 1361-6560
Editore: IOP Publishing
DOI: 10.48550/ARXIV.2503.05367

Pharmaceuticals

Autori: Wael Jalloul, Vlad Ghizdovat, Cati Raluca Stolniceanu, Teodor Ionescu, Irena Cristina Grierosu, Ioana Pavaleanu, Mihaela Moscalu, Cipriana Stefanescu
Pubblicato in: Pharmaceuticals, Numero Volume 16, Numero 12, 2023, ISSN 1424-8247
Editore: Pharmaceuticals
DOI: 10.3390/ph16121679

Two-step extraction chromatography separation of 161Tb from 160Gd-enriched irradiated target material and verification of the [161Tb]TbCl3 suitability for radiolabelling

Autori: Małgorzata Żółtowska, Dariusz Pawlak, Izabela Cieszykowska, Paweł Saganowski, Natalia Lisowska, Anna Filiks, Renata Mikołajczak
Pubblicato in: Applied Radiation and Isotopes, Numero 226, 2025, ISSN 0969-8043
Editore: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112144

Recommendations on the Clinical Application and Future Potential of α-Particle Therapy: A Comprehensive Review of the Results from the SECURE Project

Autori: Valentina Di Iorio, Anna Sarnelli, Stefano Boschi, Maddalena Sansovini, Rosa Maria Genovese, Cipriana Stefanescu, Vlad Ghizdovat, Wael Jalloul, Jennifer Young, Jane Sosabowski, Petra Kolenc, Rachel Roberts, Govert de With, Dimitris Visvikis, Renata Mikolajczak
Pubblicato in: Pharmaceuticals, Numero 18, 2025, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/PH18101578

Targeted alpha therapy in the clinical practice: radiation protection considerations

Autori: Anna Sarnelli, Emilio Mezzenga, Robert P. Kollaard, Ellis G. Winters, Govert De With, Renata Mikołajczak
Pubblicato in: The European Physical Journal Plus, Numero 140, 2025, ISSN 2190-5444
Editore: Springer Science and Business Media LLC
DOI: 10.1140/EPJP/S13360-025-06709-Y

Development of non-carrier added Au-199 production procedure from neutron-irradiated Pt targets

Autori: Leja Rovan Stiplošek, Radojko Jaćimović, Tea Zuliani, Tjaša Žerdoner, Ulli Köster, Mariella Van Ginkel, Michele Toma, Marko Štrok
Pubblicato in: Applied Radiation and Isotopes, Numero 226, 2025, ISSN 0969-8043
Editore: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112244

Advancing targeted radionuclide therapy in nuclear medicine – A future perspective

Autori: Govert de With, Tim Tinsley, Renata Mikolajczak, Ronald Schram, Dimitris Visvikis, Camila Boix, Gabriel Lazaro Pavel, Marco Capogni, Sarah Baatout, Niloefar Ahmadi Bidakhvidi
Pubblicato in: EANM Innovation, Numero 1, 2025, ISSN 3051-2913
Editore: Elsevier BV
DOI: 10.1016/J.EANMI.2025.100007

Targeted Alpha Therapy: Exploring the Clinical Insights into [225Ac]Ac-PSMA and Its Relevance Compared with [177Lu]Lu-PSMA in Advanced Prostate Cancer Management

Autori: Wael Jalloul, Vlad Ghizdovat, Alexandra Saviuc, Despina Jalloul, Irena Cristina Grierosu, Cipriana Stefanescu
Pubblicato in: Pharmaceuticals, Numero 18, 2025, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/PH18081215

Alpha Atlas: Mapping global production of α-emitting radionuclides for targeted alpha therapy

Autori: Marianna Tosato, Chiara Favaretto, Janke Kleynhans, Andrew R. Burgoyne, Jean-François Gestin, Nicholas P. van der Meulen, Amirreza Jalilian, Ulli Köster, Mattia Asti, Valery Radchenko
Pubblicato in: Nuclear Medicine and Biology, Numero 142-143, 2025, ISSN 0969-8051
Editore: Elsevier BV
DOI: 10.1016/J.NUCMEDBIO.2024.108990

European Physical Journal Plus

Autori: Anna Sarnelli; Emilio Mezzenga; Robert P. Kollaard; Ellis G. Winters; Govert De With; Renata Mikołajczak
Pubblicato in: The European Physical Journal Plus, 2025, ISSN 2190-5444
Editore: EDP Sciences, Springer Science+Business Media, Società Italiana di Fisica
DOI: 10.1140/EPJP/S13360-025-06709-Y

Conference proceedings (3)

Preparation, chemical–physical characterization of composite hydro-gels – nanoparticles of Ag and Ag2MoO4. Stability analysis and biomedical applications

Autori: Sara Calistri, Alberto Ubaldini, Antonietta Rizzo, Alessandra Strafella, Chiara Ciantelli, Carmela Maria Cellamare
Pubblicato in: Proceedings of the Nanotech France 2024 International Conference Paris, France – June 05 – 07, 2024 C10, 2024
Editore: Setcor
DOI: 10.26799/CP-NANOTECH-FRANCE-2024_X

Activation of radioisotopes used for medical purposes in the Budapest Neutron Centre

Autori: Noémi Anna Buczkó, Boglárka Maróti, Zoltán Kis, Katalin Gméling, László Szentmiklósi
Pubblicato in: Book of Abstracts - RAD 2025 Conference, 2025
Editore: RAD Centre, Niš, Serbia
DOI: 10.21175/RAD.ABSTR.BOOK.2025.26.2_X

Pre-therapy dose prediction in targeted radionuclide therapy using semi-supervised learning: An in-silico preliminary study

Autori: J. Zhang, A. Bousse, Y. Li, S. Xue, K. Shi, D. Visvikis, J. Bert
Pubblicato in: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD), 2024
Editore: IEEE
DOI: 10.1109/NSS/MIC/RTSD57108.2024.10655434