Strengthening the European Chain of sUpply for next generation medical RadionuclidEs

Informations projet

SECURE

N° de convention de subvention: 101061230

Projet clôturé

Date de signature de la CE 23 Mai 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2025

Financé au titre de

• Euratom Research and Training Programme (EURATOM)

Coût total

€ 3 657 175,00

Contribution de l’UE

€ 3 630 425,50

Coordonné par

NARODOWE CENTRUM BADAN JADROWYCH
Poland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (8)

Report on quality control performed on W-188/Re-188 for use in radiolabelling studies
Report and prototypes of low density or hollow tungsten metal targets
Recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Document summarizing recommendations for minimization of radiation exposure in the isotope chain / recommendations on (cost) effective measures for optimization

Report on neutron diffraction results and thermal calculations of tungsten oxide targets
Report on the dissolution of unirradiated low density or hollow tungsten metal targets
Report on metal targets and associated dissolution strategy
"Prototype and report on process to set up a device (""R&D generator"") for small-scale harvesting of Re-188 from a W-188 solution"

Prototype and report on process to set up a device (“R&D generator”) for small-scale harvesting of Re-188 from a W-188 solution

Recommendations on clinical applications of alpha particle therapy

Document summarizing recommendations on clinical applications of alpha particle therapy

Data Management Plan (1)

Data Management Plan

Data Management Plan - basic overview of the expected data created in frame of the project and the way the data will be stored, shared and processed.

Websites, patent fillings, videos etc. (2)

Webpage under ENEN website

Project website serving as key dissemination channel will be created as sub-page of ENEN website.

Identity package

Project visual identity materials - logo, templates etc.

Other (1)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle)

Supply of W-188 solutions or Re-188 product for non-profit R&D purposes (repeated after each BR2 cycle) to the project.

Publications

Peer reviewed articles (12)

Cysteine-selective [¹⁸⁸Re]Re(<scp>v</scp>) radiolabelling of a Nanobody® for targeted radionuclide therapy using a “chelate-then-click” approach

Auteurs: Diana R. Melis, Charlotte Segers, Jasmien Wellens, Michiel Van de Voorde, Olivier Blacque, Maarten Ooms, Gilles Gasser, Tomas Opsomer
Publié dans: Chemical Science, Numéro 16, 2025, ISSN 2041-6520
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4SC07743A

Radiopharmaceuticals for Pancreatic Cancer: A Review of Current Approaches and Future Directions

Auteurs: Sara Calistri, Giuseppe Ottaviano, Alberto Ubaldini
Publié dans: Pharmaceuticals, Numéro 17, 2024, ISSN 1424-8247
Éditeur: MDPI AG
DOI: 10.3390/PH17101314

Semi-Supervised Learning for Dose Prediction in Targeted Radionuclide: A Synthetic Data Study

Auteurs: Jing Zhang, Alexandre Bousse, Chi-Hieu Pham, Kuangyu Shi, Julien Bert
Publié dans: Physics in Medicine and Biology, Numéro 112, 2025, ISSN 1361-6560
Éditeur: IOP Publishing
DOI: 10.48550/ARXIV.2503.05367

Pharmaceuticals

Auteurs: Wael Jalloul, Vlad Ghizdovat, Cati Raluca Stolniceanu, Teodor Ionescu, Irena Cristina Grierosu, Ioana Pavaleanu, Mihaela Moscalu, Cipriana Stefanescu
Publié dans: Pharmaceuticals, Numéro Volume 16, Numéro 12, 2023, ISSN 1424-8247
Éditeur: Pharmaceuticals
DOI: 10.3390/ph16121679

Two-step extraction chromatography separation of 161Tb from 160Gd-enriched irradiated target material and verification of the [161Tb]TbCl3 suitability for radiolabelling

Auteurs: Małgorzata Żółtowska, Dariusz Pawlak, Izabela Cieszykowska, Paweł Saganowski, Natalia Lisowska, Anna Filiks, Renata Mikołajczak
Publié dans: Applied Radiation and Isotopes, Numéro 226, 2025, ISSN 0969-8043
Éditeur: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112144

Recommendations on the Clinical Application and Future Potential of α-Particle Therapy: A Comprehensive Review of the Results from the SECURE Project

Auteurs: Valentina Di Iorio, Anna Sarnelli, Stefano Boschi, Maddalena Sansovini, Rosa Maria Genovese, Cipriana Stefanescu, Vlad Ghizdovat, Wael Jalloul, Jennifer Young, Jane Sosabowski, Petra Kolenc, Rachel Roberts, Govert de With, Dimitris Visvikis, Renata Mikolajczak
Publié dans: Pharmaceuticals, Numéro 18, 2025, ISSN 1424-8247
Éditeur: MDPI AG
DOI: 10.3390/PH18101578

Targeted alpha therapy in the clinical practice: radiation protection considerations

Auteurs: Anna Sarnelli, Emilio Mezzenga, Robert P. Kollaard, Ellis G. Winters, Govert De With, Renata Mikołajczak
Publié dans: The European Physical Journal Plus, Numéro 140, 2025, ISSN 2190-5444
Éditeur: Springer Science and Business Media LLC
DOI: 10.1140/EPJP/S13360-025-06709-Y

Development of non-carrier added Au-199 production procedure from neutron-irradiated Pt targets

Auteurs: Leja Rovan Stiplošek, Radojko Jaćimović, Tea Zuliani, Tjaša Žerdoner, Ulli Köster, Mariella Van Ginkel, Michele Toma, Marko Štrok
Publié dans: Applied Radiation and Isotopes, Numéro 226, 2025, ISSN 0969-8043
Éditeur: Elsevier BV
DOI: 10.1016/J.APRADISO.2025.112244

Advancing targeted radionuclide therapy in nuclear medicine – A future perspective

Auteurs: Govert de With, Tim Tinsley, Renata Mikolajczak, Ronald Schram, Dimitris Visvikis, Camila Boix, Gabriel Lazaro Pavel, Marco Capogni, Sarah Baatout, Niloefar Ahmadi Bidakhvidi
Publié dans: EANM Innovation, Numéro 1, 2025, ISSN 3051-2913
Éditeur: Elsevier BV
DOI: 10.1016/J.EANMI.2025.100007

Targeted Alpha Therapy: Exploring the Clinical Insights into [225Ac]Ac-PSMA and Its Relevance Compared with [177Lu]Lu-PSMA in Advanced Prostate Cancer Management

Auteurs: Wael Jalloul, Vlad Ghizdovat, Alexandra Saviuc, Despina Jalloul, Irena Cristina Grierosu, Cipriana Stefanescu
Publié dans: Pharmaceuticals, Numéro 18, 2025, ISSN 1424-8247
Éditeur: MDPI AG
DOI: 10.3390/PH18081215

Alpha Atlas: Mapping global production of α-emitting radionuclides for targeted alpha therapy

Auteurs: Marianna Tosato, Chiara Favaretto, Janke Kleynhans, Andrew R. Burgoyne, Jean-François Gestin, Nicholas P. van der Meulen, Amirreza Jalilian, Ulli Köster, Mattia Asti, Valery Radchenko
Publié dans: Nuclear Medicine and Biology, Numéro 142-143, 2025, ISSN 0969-8051
Éditeur: Elsevier BV
DOI: 10.1016/J.NUCMEDBIO.2024.108990

European Physical Journal Plus

Auteurs: Anna Sarnelli; Emilio Mezzenga; Robert P. Kollaard; Ellis G. Winters; Govert De With; Renata Mikołajczak
Publié dans: The European Physical Journal Plus, 2025, ISSN 2190-5444
Éditeur: EDP Sciences, Springer Science+Business Media, Società Italiana di Fisica
DOI: 10.1140/EPJP/S13360-025-06709-Y

Conference proceedings (3)

Preparation, chemical–physical characterization of composite hydro-gels – nanoparticles of Ag and Ag2MoO4. Stability analysis and biomedical applications

Auteurs: Sara Calistri, Alberto Ubaldini, Antonietta Rizzo, Alessandra Strafella, Chiara Ciantelli, Carmela Maria Cellamare
Publié dans: Proceedings of the Nanotech France 2024 International Conference Paris, France – June 05 – 07, 2024 C10, 2024
Éditeur: Setcor
DOI: 10.26799/CP-NANOTECH-FRANCE-2024_X

Activation of radioisotopes used for medical purposes in the Budapest Neutron Centre

Auteurs: Noémi Anna Buczkó, Boglárka Maróti, Zoltán Kis, Katalin Gméling, László Szentmiklósi
Publié dans: Book of Abstracts - RAD 2025 Conference, 2025
Éditeur: RAD Centre, Niš, Serbia
DOI: 10.21175/RAD.ABSTR.BOOK.2025.26.2_X

Pre-therapy dose prediction in targeted radionuclide therapy using semi-supervised learning: An in-silico preliminary study

Auteurs: J. Zhang, A. Bousse, Y. Li, S. Xue, K. Shi, D. Visvikis, J. Bert
Publié dans: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD), 2024
Éditeur: IEEE
DOI: 10.1109/NSS/MIC/RTSD57108.2024.10655434